Abstract
Purpose: To develop nomograms for predicting the overall survival (OS) and relapse-free survival (RFS) in patients with extrahepatic bile duct cancer undergoing adjuvant chemoradiation therapy after curative resection. Methods and Materials: From January 1995 through August 2006, a total of 166 consecutive patients underwent curative resection followed by adjuvant chemoradiation therapy. Multivariate analysis using Cox proportional hazards regression was performed, and this Cox model was used as the basis for the nomograms of OS and RFS. We calculated concordance indices of the constructed nomograms and American Joint Committee on Cancer (AJCC) staging system. Results: The OS rate at 2 years and 5 years was 60.8% and 42.5%, respectively, and the RFS rate at 2 years and 5 years was 52.5% and 38.2%, respectively. The model containing age, sex, tumor location, histologic differentiation, perineural invasion, and lymph node involvement was selected for nomograms. The bootstrap-corrected concordance index of the nomogram for OS and RFS was 0.63 and 0.62, respectively, and that of AJCC staging for OS and RFS was 0.50 and 0.52, respectively. Conclusions: We developed nomograms that predicted survival and recurrence better than AJCC staging. With caution, clinicians may use these nomograms as an adjunct to or substitute for AJCC
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Song, Changhoon;
[1]
Kim, Kyubo;
[1]
Chie, Eui Kyu;
[1]
Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul (Korea, Republic of)];
Kim, Jin Ho;
[1]
Jang, Jin-Young;
Kim, Sun Whe;
[2]
Han, Sae-Won;
Oh, Do-Youn;
Im, Seock-Ah;
Kim, Tae-You;
Bang, Yung-Jue;
[3]
Ha, Sung W.;
[1]
Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul (Korea, Republic of)]
- Department of Radiation Oncology, Seoul National University College of Medicine, Seoul (Korea, Republic of)
- Department of Surgery, Seoul National University College of Medicine, Seoul (Korea, Republic of)
- Department of Internal Medicine, Seoul National University College of Medicine, Seoul (Korea, Republic of)
Citation Formats
Song, Changhoon, Kim, Kyubo, Chie, Eui Kyu, Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul (Korea, Republic of)], Kim, Jin Ho, Jang, Jin-Young, Kim, Sun Whe, Han, Sae-Won, Oh, Do-Youn, Im, Seock-Ah, Kim, Tae-You, Bang, Yung-Jue, Ha, Sung W., and Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul (Korea, Republic of)].
Nomogram Prediction of Survival and Recurrence in Patients With Extrahepatic Bile Duct Cancer Undergoing Curative Resection Followed by Adjuvant Chemoradiation Therapy.
United States: N. p.,
2013.
Web.
doi:10.1016/J.IJROBP.2013.06.2041.
Song, Changhoon, Kim, Kyubo, Chie, Eui Kyu, Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul (Korea, Republic of)], Kim, Jin Ho, Jang, Jin-Young, Kim, Sun Whe, Han, Sae-Won, Oh, Do-Youn, Im, Seock-Ah, Kim, Tae-You, Bang, Yung-Jue, Ha, Sung W., & Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul (Korea, Republic of)].
Nomogram Prediction of Survival and Recurrence in Patients With Extrahepatic Bile Duct Cancer Undergoing Curative Resection Followed by Adjuvant Chemoradiation Therapy.
United States.
https://doi.org/10.1016/J.IJROBP.2013.06.2041
Song, Changhoon, Kim, Kyubo, Chie, Eui Kyu, Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul (Korea, Republic of)], Kim, Jin Ho, Jang, Jin-Young, Kim, Sun Whe, Han, Sae-Won, Oh, Do-Youn, Im, Seock-Ah, Kim, Tae-You, Bang, Yung-Jue, Ha, Sung W., and Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul (Korea, Republic of)].
2013.
"Nomogram Prediction of Survival and Recurrence in Patients With Extrahepatic Bile Duct Cancer Undergoing Curative Resection Followed by Adjuvant Chemoradiation Therapy."
United States.
https://doi.org/10.1016/J.IJROBP.2013.06.2041.
@misc{etde_22267910,
title = {Nomogram Prediction of Survival and Recurrence in Patients With Extrahepatic Bile Duct Cancer Undergoing Curative Resection Followed by Adjuvant Chemoradiation Therapy}
author = {Song, Changhoon, Kim, Kyubo, Chie, Eui Kyu, Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul (Korea, Republic of)], Kim, Jin Ho, Jang, Jin-Young, Kim, Sun Whe, Han, Sae-Won, Oh, Do-Youn, Im, Seock-Ah, Kim, Tae-You, Bang, Yung-Jue, Ha, Sung W., and Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul (Korea, Republic of)]}
abstractNote = {Purpose: To develop nomograms for predicting the overall survival (OS) and relapse-free survival (RFS) in patients with extrahepatic bile duct cancer undergoing adjuvant chemoradiation therapy after curative resection. Methods and Materials: From January 1995 through August 2006, a total of 166 consecutive patients underwent curative resection followed by adjuvant chemoradiation therapy. Multivariate analysis using Cox proportional hazards regression was performed, and this Cox model was used as the basis for the nomograms of OS and RFS. We calculated concordance indices of the constructed nomograms and American Joint Committee on Cancer (AJCC) staging system. Results: The OS rate at 2 years and 5 years was 60.8% and 42.5%, respectively, and the RFS rate at 2 years and 5 years was 52.5% and 38.2%, respectively. The model containing age, sex, tumor location, histologic differentiation, perineural invasion, and lymph node involvement was selected for nomograms. The bootstrap-corrected concordance index of the nomogram for OS and RFS was 0.63 and 0.62, respectively, and that of AJCC staging for OS and RFS was 0.50 and 0.52, respectively. Conclusions: We developed nomograms that predicted survival and recurrence better than AJCC staging. With caution, clinicians may use these nomograms as an adjunct to or substitute for AJCC staging for predicting an individual's prognosis and offering tailored adjuvant therapy.}
doi = {10.1016/J.IJROBP.2013.06.2041}
journal = []
issue = {3}
volume = {87}
journal type = {AC}
place = {United States}
year = {2013}
month = {Nov}
}
title = {Nomogram Prediction of Survival and Recurrence in Patients With Extrahepatic Bile Duct Cancer Undergoing Curative Resection Followed by Adjuvant Chemoradiation Therapy}
author = {Song, Changhoon, Kim, Kyubo, Chie, Eui Kyu, Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul (Korea, Republic of)], Kim, Jin Ho, Jang, Jin-Young, Kim, Sun Whe, Han, Sae-Won, Oh, Do-Youn, Im, Seock-Ah, Kim, Tae-You, Bang, Yung-Jue, Ha, Sung W., and Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul (Korea, Republic of)]}
abstractNote = {Purpose: To develop nomograms for predicting the overall survival (OS) and relapse-free survival (RFS) in patients with extrahepatic bile duct cancer undergoing adjuvant chemoradiation therapy after curative resection. Methods and Materials: From January 1995 through August 2006, a total of 166 consecutive patients underwent curative resection followed by adjuvant chemoradiation therapy. Multivariate analysis using Cox proportional hazards regression was performed, and this Cox model was used as the basis for the nomograms of OS and RFS. We calculated concordance indices of the constructed nomograms and American Joint Committee on Cancer (AJCC) staging system. Results: The OS rate at 2 years and 5 years was 60.8% and 42.5%, respectively, and the RFS rate at 2 years and 5 years was 52.5% and 38.2%, respectively. The model containing age, sex, tumor location, histologic differentiation, perineural invasion, and lymph node involvement was selected for nomograms. The bootstrap-corrected concordance index of the nomogram for OS and RFS was 0.63 and 0.62, respectively, and that of AJCC staging for OS and RFS was 0.50 and 0.52, respectively. Conclusions: We developed nomograms that predicted survival and recurrence better than AJCC staging. With caution, clinicians may use these nomograms as an adjunct to or substitute for AJCC staging for predicting an individual's prognosis and offering tailored adjuvant therapy.}
doi = {10.1016/J.IJROBP.2013.06.2041}
journal = []
issue = {3}
volume = {87}
journal type = {AC}
place = {United States}
year = {2013}
month = {Nov}
}