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A flavone derivative from Sesbania sesban leaves and its cytotoxicity against murine leukemia P-388 cells

Journal Article:

Abstract

Sesbania sesban, locally named as Jayanti, is one of Indonesia plants belonging to Fabaceae family. This species is traditionally used by Indonesian people to cure digestive disorders, fever, or headache. Jayanti can grow well in tropical to subtropical region, such as in Asia and Africa. Based on literature, qualitative analysis of the methanol extract of leaves of S. sesban showed that it contained flavonoids, alkaloids, saponins and glycosides. In addition, the activity assay of extracts of different tissues of this species showed antitumor, antimalarial, and antidiabetic activityies (leaves and seed extracts), antioxidants (flower extract), and analgesic (wood extract). Though the extracts of S. sesban parts showed interesting activities, chemical study of those extracts have not been widely reported. Therefore, the objective of this research was to isolate the secondary metabolites from methanol extract of leaves of S. sesban and to determine their cytotoxicity against murine leukemia P-388 cells. One compound has been obtained and identified as 3-hydroxy-4',7-dimethoxyflavone (1), a new isolated compound from nature. This compound was obtained through separation of methanol extract using various chromatographic techniques, such as vacuum liquid chromatography and radial chromatography. The structure elucidation of isolated compound was based on 1D NMR ({sup 1}H-NMR and {sup  More>>
Authors:
Dianhar, Hanhan; Syah, Yana Maolana, E-mail: liadewi@chem.itb.ac.id; Mujahidin, Didin; Hakim, Euis Holisotan, E-mail: liadewi@chem.itb.ac.id; Juliawaty, Lia Dewi, E-mail: liadewi@chem.itb.ac.id [1] 
  1. Natural Product Chemistry Research Group, Organic Chemistry Division, Program Study of Chemistry, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jalan Ganeca 10, Bandung 40132 (Indonesia)
Publication Date:
Mar 24, 2014
Product Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1589; Journal Issue: 1; Conference: ICMNS 2012: 4. international conference on mathematics and natural sciences: Science for health, food and sustainable energy, Bandung (Indonesia), 8-9 Nov 2012; Other Information: (c) 2014 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Subject:
60 APPLIED LIFE SCIENCES; ALKALOIDS; ANALGESICS; ANTIOXIDANTS; FLAVONOIDS; LEAVES; LEUKEMIA; LIQUID COLUMN CHROMATOGRAPHY; METABOLITES; METHANOL; NUCLEAR MAGNETIC RESONANCE; PLANT TISSUES; PLANTS; SAPONINS; TOXICITY
OSTI ID:
22265985
Country of Origin:
United States
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0094-243X; CODEN: APCPCS; TRN: US14A4630087215
Submitting Site:
USN
Size:
page(s) 411-413
Announcement Date:
Sep 26, 2014

Journal Article:

Citation Formats

Dianhar, Hanhan, Syah, Yana Maolana, E-mail: liadewi@chem.itb.ac.id, Mujahidin, Didin, Hakim, Euis Holisotan, E-mail: liadewi@chem.itb.ac.id, and Juliawaty, Lia Dewi, E-mail: liadewi@chem.itb.ac.id. A flavone derivative from Sesbania sesban leaves and its cytotoxicity against murine leukemia P-388 cells. United States: N. p., 2014. Web. doi:10.1063/1.4868831.
Dianhar, Hanhan, Syah, Yana Maolana, E-mail: liadewi@chem.itb.ac.id, Mujahidin, Didin, Hakim, Euis Holisotan, E-mail: liadewi@chem.itb.ac.id, & Juliawaty, Lia Dewi, E-mail: liadewi@chem.itb.ac.id. A flavone derivative from Sesbania sesban leaves and its cytotoxicity against murine leukemia P-388 cells. United States. doi:10.1063/1.4868831.
Dianhar, Hanhan, Syah, Yana Maolana, E-mail: liadewi@chem.itb.ac.id, Mujahidin, Didin, Hakim, Euis Holisotan, E-mail: liadewi@chem.itb.ac.id, and Juliawaty, Lia Dewi, E-mail: liadewi@chem.itb.ac.id. 2014. "A flavone derivative from Sesbania sesban leaves and its cytotoxicity against murine leukemia P-388 cells." United States. doi:10.1063/1.4868831. https://www.osti.gov/servlets/purl/10.1063/1.4868831.
@misc{etde_22265985,
title = {A flavone derivative from Sesbania sesban leaves and its cytotoxicity against murine leukemia P-388 cells}
author = {Dianhar, Hanhan, Syah, Yana Maolana, E-mail: liadewi@chem.itb.ac.id, Mujahidin, Didin, Hakim, Euis Holisotan, E-mail: liadewi@chem.itb.ac.id, and Juliawaty, Lia Dewi, E-mail: liadewi@chem.itb.ac.id}
abstractNote = {Sesbania sesban, locally named as Jayanti, is one of Indonesia plants belonging to Fabaceae family. This species is traditionally used by Indonesian people to cure digestive disorders, fever, or headache. Jayanti can grow well in tropical to subtropical region, such as in Asia and Africa. Based on literature, qualitative analysis of the methanol extract of leaves of S. sesban showed that it contained flavonoids, alkaloids, saponins and glycosides. In addition, the activity assay of extracts of different tissues of this species showed antitumor, antimalarial, and antidiabetic activityies (leaves and seed extracts), antioxidants (flower extract), and analgesic (wood extract). Though the extracts of S. sesban parts showed interesting activities, chemical study of those extracts have not been widely reported. Therefore, the objective of this research was to isolate the secondary metabolites from methanol extract of leaves of S. sesban and to determine their cytotoxicity against murine leukemia P-388 cells. One compound has been obtained and identified as 3-hydroxy-4',7-dimethoxyflavone (1), a new isolated compound from nature. This compound was obtained through separation of methanol extract using various chromatographic techniques, such as vacuum liquid chromatography and radial chromatography. The structure elucidation of isolated compound was based on 1D NMR ({sup 1}H-NMR and {sup 13}C-NMR) and 2D NMR (HMBC). The cytotoxicity of methanol extract and compound 1 against murine leukemia P-388 cells examined through MTT assay showed IC{sub 50} value of 60.04 μg/mL and 5.40 μg/mL, respectively.}
doi = {10.1063/1.4868831}
journal = {AIP Conference Proceedings}
issue = {1}
volume = {1589}
journal type = {AC}
place = {United States}
year = {2014}
month = {Mar}
}