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Ehrlich and sarcoma 180 tumour characterisation and early detection by {sup 1}H NMR-based metabonomics of mice serum

Abstract

The success of cancer treatment is directly related to early detection before symptoms emerge, although nowadays few cancers can be detected early. In this sense, {sup 1}H nuclear magnetic resonance ({sup 1}H NMR)-based metabonomics was used to identify metabolic changes in biofluid as a consequence of tumours growing in mice. Through partial least squares discriminant analysis (PLS-DA) analysis of {sup 1}H NMR spectra from serum samples it was possible to diagnose Ehrlich ascites and Sarcoma 180 tumours five and ten days after cell inoculation, respectively. Lipids, lipoproteins and lactate were the main biomarkers at onset as well as in the progress of carcinogenic process. Thus, NMR-based metabonomics can be a valuable tool to study the effects of tumour establishment on the chemical composition of biofluids. (author)
Authors:
Grandizoli, Caroline W.P. da S.; Simonelli, Fabio; Nagata, Noemi; Barison, Andersson; [1]  Carrenho, Luise Z.B.; Francisco, Thais M.G. de; Campos, Francinete R.; [2]  Santana Filho, Arquimedes P. de; Sassaki, Guilherme L.; [3]  Kreuger, Maria R.O. [4] 
  1. Universidade Federal do Parana (UFPR), Curitiba, PR (Brazil). Dept. de Quimica
  2. Universidade Federal do Parana (UFPR), Curitiba, PR (Brazil). Dept. de Farmacia
  3. Universidade Federal do Parana (UFPR), Curitiba, PR (Brazil). Dept. de Bioquimica
  4. Universidade do Vale do Itajai (UNIVALI), (Brazil). Centro de Ciencias da Saude
Publication Date:
May 15, 2014
Product Type:
Journal Article
Resource Relation:
Journal Name: Journal of the Brazilian Chemical Society; Journal Volume: 25; Journal Issue: 5
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; BLOOD SERUM; CARBON 13; CHEMICAL SHIFT; GAS CHROMATOGRAPHY; HYDROGEN 1; NEOPLASMS; NMR SPECTRA; TEMPERATURE DEPENDENCE
OSTI ID:
22255511
Country of Origin:
Brazil
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0103-5053; CODEN: JOCSET; TRN: BR14V1230076705
Availability:
Available from http://www.scielo.br/pdf/jbchs/v25n5/a05v25n5.pdf
Submitting Site:
BRN
Size:
page(s) 841-852
Announcement Date:
Aug 08, 2014

Citation Formats

Grandizoli, Caroline W.P. da S., Simonelli, Fabio, Nagata, Noemi, Barison, Andersson, Carrenho, Luise Z.B., Francisco, Thais M.G. de, Campos, Francinete R., Santana Filho, Arquimedes P. de, Sassaki, Guilherme L., and Kreuger, Maria R.O. Ehrlich and sarcoma 180 tumour characterisation and early detection by {sup 1}H NMR-based metabonomics of mice serum. Brazil: N. p., 2014. Web.
Grandizoli, Caroline W.P. da S., Simonelli, Fabio, Nagata, Noemi, Barison, Andersson, Carrenho, Luise Z.B., Francisco, Thais M.G. de, Campos, Francinete R., Santana Filho, Arquimedes P. de, Sassaki, Guilherme L., & Kreuger, Maria R.O. Ehrlich and sarcoma 180 tumour characterisation and early detection by {sup 1}H NMR-based metabonomics of mice serum. Brazil.
Grandizoli, Caroline W.P. da S., Simonelli, Fabio, Nagata, Noemi, Barison, Andersson, Carrenho, Luise Z.B., Francisco, Thais M.G. de, Campos, Francinete R., Santana Filho, Arquimedes P. de, Sassaki, Guilherme L., and Kreuger, Maria R.O. 2014. "Ehrlich and sarcoma 180 tumour characterisation and early detection by {sup 1}H NMR-based metabonomics of mice serum." Brazil.
@misc{etde_22255511,
title = {Ehrlich and sarcoma 180 tumour characterisation and early detection by {sup 1}H NMR-based metabonomics of mice serum}
author = {Grandizoli, Caroline W.P. da S., Simonelli, Fabio, Nagata, Noemi, Barison, Andersson, Carrenho, Luise Z.B., Francisco, Thais M.G. de, Campos, Francinete R., Santana Filho, Arquimedes P. de, Sassaki, Guilherme L., and Kreuger, Maria R.O.}
abstractNote = {The success of cancer treatment is directly related to early detection before symptoms emerge, although nowadays few cancers can be detected early. In this sense, {sup 1}H nuclear magnetic resonance ({sup 1}H NMR)-based metabonomics was used to identify metabolic changes in biofluid as a consequence of tumours growing in mice. Through partial least squares discriminant analysis (PLS-DA) analysis of {sup 1}H NMR spectra from serum samples it was possible to diagnose Ehrlich ascites and Sarcoma 180 tumours five and ten days after cell inoculation, respectively. Lipids, lipoproteins and lactate were the main biomarkers at onset as well as in the progress of carcinogenic process. Thus, NMR-based metabonomics can be a valuable tool to study the effects of tumour establishment on the chemical composition of biofluids. (author)}
journal = {Journal of the Brazilian Chemical Society}
issue = {5}
volume = {25}
journal type = {AC}
place = {Brazil}
year = {2014}
month = {May}
}