Abstract
The success of cancer treatment is directly related to early detection before symptoms emerge, although nowadays few cancers can be detected early. In this sense, {sup 1}H nuclear magnetic resonance ({sup 1}H NMR)-based metabonomics was used to identify metabolic changes in biofluid as a consequence of tumours growing in mice. Through partial least squares discriminant analysis (PLS-DA) analysis of {sup 1}H NMR spectra from serum samples it was possible to diagnose Ehrlich ascites and Sarcoma 180 tumours five and ten days after cell inoculation, respectively. Lipids, lipoproteins and lactate were the main biomarkers at onset as well as in the progress of carcinogenic process. Thus, NMR-based metabonomics can be a valuable tool to study the effects of tumour establishment on the chemical composition of biofluids. (author)
Grandizoli, Caroline W.P. da S.;
Simonelli, Fabio;
Nagata, Noemi;
Barison, Andersson;
[1]
Carrenho, Luise Z.B.;
Francisco, Thais M.G. de;
Campos, Francinete R.;
[2]
Santana Filho, Arquimedes P. de;
Sassaki, Guilherme L.;
[3]
Kreuger, Maria R.O.
[4]
- Universidade Federal do Parana (UFPR), Curitiba, PR (Brazil). Dept. de Quimica
- Universidade Federal do Parana (UFPR), Curitiba, PR (Brazil). Dept. de Farmacia
- Universidade Federal do Parana (UFPR), Curitiba, PR (Brazil). Dept. de Bioquimica
- Universidade do Vale do Itajai (UNIVALI), (Brazil). Centro de Ciencias da Saude
Citation Formats
Grandizoli, Caroline W.P. da S., Simonelli, Fabio, Nagata, Noemi, Barison, Andersson, Carrenho, Luise Z.B., Francisco, Thais M.G. de, Campos, Francinete R., Santana Filho, Arquimedes P. de, Sassaki, Guilherme L., and Kreuger, Maria R.O.
Ehrlich and sarcoma 180 tumour characterisation and early detection by {sup 1}H NMR-based metabonomics of mice serum.
Brazil: N. p.,
2014.
Web.
Grandizoli, Caroline W.P. da S., Simonelli, Fabio, Nagata, Noemi, Barison, Andersson, Carrenho, Luise Z.B., Francisco, Thais M.G. de, Campos, Francinete R., Santana Filho, Arquimedes P. de, Sassaki, Guilherme L., & Kreuger, Maria R.O.
Ehrlich and sarcoma 180 tumour characterisation and early detection by {sup 1}H NMR-based metabonomics of mice serum.
Brazil.
Grandizoli, Caroline W.P. da S., Simonelli, Fabio, Nagata, Noemi, Barison, Andersson, Carrenho, Luise Z.B., Francisco, Thais M.G. de, Campos, Francinete R., Santana Filho, Arquimedes P. de, Sassaki, Guilherme L., and Kreuger, Maria R.O.
2014.
"Ehrlich and sarcoma 180 tumour characterisation and early detection by {sup 1}H NMR-based metabonomics of mice serum."
Brazil.
@misc{etde_22255511,
title = {Ehrlich and sarcoma 180 tumour characterisation and early detection by {sup 1}H NMR-based metabonomics of mice serum}
author = {Grandizoli, Caroline W.P. da S., Simonelli, Fabio, Nagata, Noemi, Barison, Andersson, Carrenho, Luise Z.B., Francisco, Thais M.G. de, Campos, Francinete R., Santana Filho, Arquimedes P. de, Sassaki, Guilherme L., and Kreuger, Maria R.O.}
abstractNote = {The success of cancer treatment is directly related to early detection before symptoms emerge, although nowadays few cancers can be detected early. In this sense, {sup 1}H nuclear magnetic resonance ({sup 1}H NMR)-based metabonomics was used to identify metabolic changes in biofluid as a consequence of tumours growing in mice. Through partial least squares discriminant analysis (PLS-DA) analysis of {sup 1}H NMR spectra from serum samples it was possible to diagnose Ehrlich ascites and Sarcoma 180 tumours five and ten days after cell inoculation, respectively. Lipids, lipoproteins and lactate were the main biomarkers at onset as well as in the progress of carcinogenic process. Thus, NMR-based metabonomics can be a valuable tool to study the effects of tumour establishment on the chemical composition of biofluids. (author)}
journal = []
issue = {5}
volume = {25}
journal type = {AC}
place = {Brazil}
year = {2014}
month = {May}
}
title = {Ehrlich and sarcoma 180 tumour characterisation and early detection by {sup 1}H NMR-based metabonomics of mice serum}
author = {Grandizoli, Caroline W.P. da S., Simonelli, Fabio, Nagata, Noemi, Barison, Andersson, Carrenho, Luise Z.B., Francisco, Thais M.G. de, Campos, Francinete R., Santana Filho, Arquimedes P. de, Sassaki, Guilherme L., and Kreuger, Maria R.O.}
abstractNote = {The success of cancer treatment is directly related to early detection before symptoms emerge, although nowadays few cancers can be detected early. In this sense, {sup 1}H nuclear magnetic resonance ({sup 1}H NMR)-based metabonomics was used to identify metabolic changes in biofluid as a consequence of tumours growing in mice. Through partial least squares discriminant analysis (PLS-DA) analysis of {sup 1}H NMR spectra from serum samples it was possible to diagnose Ehrlich ascites and Sarcoma 180 tumours five and ten days after cell inoculation, respectively. Lipids, lipoproteins and lactate were the main biomarkers at onset as well as in the progress of carcinogenic process. Thus, NMR-based metabonomics can be a valuable tool to study the effects of tumour establishment on the chemical composition of biofluids. (author)}
journal = []
issue = {5}
volume = {25}
journal type = {AC}
place = {Brazil}
year = {2014}
month = {May}
}