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Carbon nanotubes as a novel drug delivery system for anticancer therapy: a review

Abstract

Carbon nanotubes (CNTs) were discovered in 1991 and shown to have certain unique physicochemical properties, attracting considerable interest in their application in various fields including drug delivery. The unique properties of CNTs such as ease of cellular uptake, high drug loading, thermal ablation, among others, render them useful for cancer therapy. Cancer is one of the most challenging diseases of modern times because its therapy involves distinguishing normal healthy cells from affected cells. Here, CNTs play a major role because phenomena such as EPR, allow CNTs to distinguish normal cells from affected ones, the Holy Grail in cancer therapy. Considerable work has been done on CNTs as drug delivery systems over the last two decades. However, concerns over certain issues such as biocompatibility and toxicity have been raised and warrant extensive research in this field. (author)
Authors:
Kushwaha, Swatantra Kumar Singh; Ghoshal, SauravI; Rai, Awani Kumar, E-mail: swatantrakushwaha@yahoo.co.in; [1]  Singh, Satyawan [2] 
  1. Pranveer Singh Institute of Technology, Kanpur (India)
  2. Saroj Institute of Technology and Management, Lucknow (India)
Publication Date:
Oct 15, 2013
Product Type:
Journal Article
Resource Relation:
Journal Name: Brazilian Journal of Pharmaceutical Sciences (Print); Journal Volume: 49; Journal Issue: 4
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CARBON NANOTUBES; CHEMICAL PROPERTIES; CHEMOTHERAPY; DRUGS; NEOPLASMS; PHYSICAL PROPERTIES; TARGETS; TOXICITY
OSTI ID:
22250191
Country of Origin:
Brazil
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 1984-8250; TRN: BR1400245071366
Availability:
Available from http://www.scielo.br/pdf/bjps/v49n4/v49n4a02.pdf
Submitting Site:
BRN
Size:
page(s) 629-643
Announcement Date:
Jul 18, 2014

Citation Formats

Kushwaha, Swatantra Kumar Singh, Ghoshal, SauravI, Rai, Awani Kumar, E-mail: swatantrakushwaha@yahoo.co.in, and Singh, Satyawan. Carbon nanotubes as a novel drug delivery system for anticancer therapy: a review. Brazil: N. p., 2013. Web. doi:10.1590/S1984-82502013000400002.
Kushwaha, Swatantra Kumar Singh, Ghoshal, SauravI, Rai, Awani Kumar, E-mail: swatantrakushwaha@yahoo.co.in, & Singh, Satyawan. Carbon nanotubes as a novel drug delivery system for anticancer therapy: a review. Brazil. doi:10.1590/S1984-82502013000400002.
Kushwaha, Swatantra Kumar Singh, Ghoshal, SauravI, Rai, Awani Kumar, E-mail: swatantrakushwaha@yahoo.co.in, and Singh, Satyawan. 2013. "Carbon nanotubes as a novel drug delivery system for anticancer therapy: a review." Brazil. doi:10.1590/S1984-82502013000400002. https://www.osti.gov/servlets/purl/10.1590/S1984-82502013000400002.
@misc{etde_22250191,
title = {Carbon nanotubes as a novel drug delivery system for anticancer therapy: a review}
author = {Kushwaha, Swatantra Kumar Singh, Ghoshal, SauravI, Rai, Awani Kumar, E-mail: swatantrakushwaha@yahoo.co.in, and Singh, Satyawan}
abstractNote = {Carbon nanotubes (CNTs) were discovered in 1991 and shown to have certain unique physicochemical properties, attracting considerable interest in their application in various fields including drug delivery. The unique properties of CNTs such as ease of cellular uptake, high drug loading, thermal ablation, among others, render them useful for cancer therapy. Cancer is one of the most challenging diseases of modern times because its therapy involves distinguishing normal healthy cells from affected cells. Here, CNTs play a major role because phenomena such as EPR, allow CNTs to distinguish normal cells from affected ones, the Holy Grail in cancer therapy. Considerable work has been done on CNTs as drug delivery systems over the last two decades. However, concerns over certain issues such as biocompatibility and toxicity have been raised and warrant extensive research in this field. (author)}
doi = {10.1590/S1984-82502013000400002}
journal = {Brazilian Journal of Pharmaceutical Sciences (Print)}
issue = {4}
volume = {49}
journal type = {AC}
place = {Brazil}
year = {2013}
month = {Oct}
}