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Molecular imaging of brown adipose tissue in health and disease

Abstract

Brown adipose tissue (BAT) has transformed from an interfering tissue in oncological {sup 18}F-fluorodeoxyglucose (FDG) positron emission tomography (PET) to an independent imaging research field. This review takes the perspective from the imaging methodology on which human BAT research has come to rely on heavily. This review analyses relevant PubMed-indexed publications that discuss molecular imaging methods of BAT. In addition, reported links between BAT and human diseases such as obesity are discussed, and the possibilities for imaging in these fields are highlighted. Radiopharmaceuticals aiming at several different biological mechanisms of BAT are discussed and evaluated. Prospective, dedicated studies allow visualization of BAT function in a high percentage of human subjects. BAT dysfunction has been implicated in obesity, linked with diabetes and associated with cachexia and atherosclerosis. Presently, {sup 18}F-FDG PET/CT is the most useful tool for evaluating therapies aiming at BAT activity. In addition to {sup 18}F-FDG, other radiopharmaceuticals such as {sup 99m}Tc-sestamibi, {sup 123}I-metaiodobenzylguanidine (MIBG), {sup 18}F-fluorodopa and {sup 18}F-14(R,S)-[{sup 18}F]fluoro-6-thia-heptadecanoic acid (FTHA) may have a potential for visualizing other aspects of BAT activity. MRI methods are under continuous development and provide the prospect of functional imaging without ionizing radiation. Molecular imaging of BAT can be used to quantitatively  More>>
Publication Date:
Apr 15, 2014
Product Type:
Journal Article
Resource Relation:
Journal Name: European Journal of Nuclear Medicine and Molecular Imaging; Journal Volume: 41; Journal Issue: 4
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ADIPOSE TISSUE; ARTERIOSCLEROSIS; BLOOD CHEMISTRY; COMPUTERIZED TOMOGRAPHY; DECANOIC ACID; DIABETES MELLITUS; DOPA; FAT CELLS; FLUORINE 18; FLUORODEOXYGLUCOSE; HEAT PRODUCTION; IODINE 123; METABOLIC DISEASES; MIBG; NMR IMAGING; NMR SPECTRA; POSITRON COMPUTED TOMOGRAPHY; RADIOPHARMACEUTICALS; SYMPATHOMIMETICS
OSTI ID:
22245302
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 1619-7070; TRN: DE14F2570066435
Availability:
Available from: http://dx.doi.org/10.1007/s00259-013-2611-8
Submitting Site:
DE
Size:
page(s) 776-791
Announcement Date:
Jul 08, 2014

Citation Formats

Bauwens, Matthias, Maastricht University, Research School NUTRIM, Maastricht (Netherlands)], Wierts, Roel, Brans, Boudewijn, Royen, Bart van, Backes, Walter, Bucerius, Jan, Uniklinikum Aachen, Division of Nuclear Medicine, Aachen (Germany), Maastricht University, Research School CARIM, Maastricht (Netherlands)], Mottaghy, Felix, and Uniklinikum Aachen, Division of Nuclear Medicine, Aachen (Germany)]. Molecular imaging of brown adipose tissue in health and disease. Germany: N. p., 2014. Web. doi:10.1007/S00259-013-2611-8.
Bauwens, Matthias, Maastricht University, Research School NUTRIM, Maastricht (Netherlands)], Wierts, Roel, Brans, Boudewijn, Royen, Bart van, Backes, Walter, Bucerius, Jan, Uniklinikum Aachen, Division of Nuclear Medicine, Aachen (Germany), Maastricht University, Research School CARIM, Maastricht (Netherlands)], Mottaghy, Felix, & Uniklinikum Aachen, Division of Nuclear Medicine, Aachen (Germany)]. Molecular imaging of brown adipose tissue in health and disease. Germany. doi:10.1007/S00259-013-2611-8.
Bauwens, Matthias, Maastricht University, Research School NUTRIM, Maastricht (Netherlands)], Wierts, Roel, Brans, Boudewijn, Royen, Bart van, Backes, Walter, Bucerius, Jan, Uniklinikum Aachen, Division of Nuclear Medicine, Aachen (Germany), Maastricht University, Research School CARIM, Maastricht (Netherlands)], Mottaghy, Felix, and Uniklinikum Aachen, Division of Nuclear Medicine, Aachen (Germany)]. 2014. "Molecular imaging of brown adipose tissue in health and disease." Germany. doi:10.1007/S00259-013-2611-8. https://www.osti.gov/servlets/purl/10.1007/S00259-013-2611-8.
@misc{etde_22245302,
title = {Molecular imaging of brown adipose tissue in health and disease}
author = {Bauwens, Matthias, Maastricht University, Research School NUTRIM, Maastricht (Netherlands)], Wierts, Roel, Brans, Boudewijn, Royen, Bart van, Backes, Walter, Bucerius, Jan, Uniklinikum Aachen, Division of Nuclear Medicine, Aachen (Germany), Maastricht University, Research School CARIM, Maastricht (Netherlands)], Mottaghy, Felix, and Uniklinikum Aachen, Division of Nuclear Medicine, Aachen (Germany)]}
abstractNote = {Brown adipose tissue (BAT) has transformed from an interfering tissue in oncological {sup 18}F-fluorodeoxyglucose (FDG) positron emission tomography (PET) to an independent imaging research field. This review takes the perspective from the imaging methodology on which human BAT research has come to rely on heavily. This review analyses relevant PubMed-indexed publications that discuss molecular imaging methods of BAT. In addition, reported links between BAT and human diseases such as obesity are discussed, and the possibilities for imaging in these fields are highlighted. Radiopharmaceuticals aiming at several different biological mechanisms of BAT are discussed and evaluated. Prospective, dedicated studies allow visualization of BAT function in a high percentage of human subjects. BAT dysfunction has been implicated in obesity, linked with diabetes and associated with cachexia and atherosclerosis. Presently, {sup 18}F-FDG PET/CT is the most useful tool for evaluating therapies aiming at BAT activity. In addition to {sup 18}F-FDG, other radiopharmaceuticals such as {sup 99m}Tc-sestamibi, {sup 123}I-metaiodobenzylguanidine (MIBG), {sup 18}F-fluorodopa and {sup 18}F-14(R,S)-[{sup 18}F]fluoro-6-thia-heptadecanoic acid (FTHA) may have a potential for visualizing other aspects of BAT activity. MRI methods are under continuous development and provide the prospect of functional imaging without ionizing radiation. Molecular imaging of BAT can be used to quantitatively assess different aspects of BAT metabolic activity. (orig.)}
doi = {10.1007/S00259-013-2611-8}
journal = {European Journal of Nuclear Medicine and Molecular Imaging}
issue = {4}
volume = {41}
journal type = {AC}
place = {Germany}
year = {2014}
month = {Apr}
}