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Study on radioprotective effects of GANRA-like medicine

Journal Article:

Abstract

After three days of medicine administrated, Kunming mice were exposed to 8 Gy of 100 kVp X-rays. Hemogram, viscere, survival, MDA yields and SOD activity were examined. Results showed that, (1) Survival of medicine-administrated mice were similar to the control group. After irradiation, survival dropped significantly. It took 20 days for the control group to reach to 50% survival, while 9 days for DMSO group 29 days for drug group 1, and 24 days for drug group 5. (2) The medicine per se had no obvious impacts on visceral indexes. Liver index and spleen index of the control group and DMSO group were elevated after irradiated, while those of medicine-administrated group did not change much. (3) The groups treated by DMSO and drug group 1 had high yield of MDA, but low activity of SOD. Compared with DMSO group, drug group 5 had high SOD activity while low MDA level. Irradiation increased MDA level but decreased SOD activity of every group, However, group drug 5 still showed higher SOD activity and lower MDA level than DMSO group. (4) The medicine did not show distinctive contributions to variation of hemogram. In summary, our results demonstrated that GANRA-like group drug 1 and  More>>
Authors:
Mingyue, Zhu; Hailong, Pei; Wenling, Ye; [1]  others, and
  1. Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou (China)
Publication Date:
Mar 15, 2012
Product Type:
Journal Article
Resource Relation:
Journal Name: Nuclear Physics Review; Journal Volume: 29; Journal Issue: 1; Other Information: 3 figs., 4 tabs., 9 refs.
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; DMSO; DRUGS; INDEXES; IRRADIATION; LIVER; MEDICINE; MICE; RADIATION PROTECTION; RADICALS; RADIOPROTECTIVE SUBSTANCES; SPLEEN; SUPEROXIDE DISMUTASE; X RADIATION; YIELDS
OSTI ID:
22238141
Country of Origin:
China
Language:
Chinese
Other Identifying Numbers:
Journal ID: ISSN 1007-4627; TRN: CN1401300059217
Submitting Site:
INIS
Size:
page(s) 109-113
Announcement Date:
Jun 12, 2014

Journal Article:

Citation Formats

Mingyue, Zhu, Hailong, Pei, Wenling, Ye, and others, and. Study on radioprotective effects of GANRA-like medicine. China: N. p., 2012. Web.
Mingyue, Zhu, Hailong, Pei, Wenling, Ye, & others, and. Study on radioprotective effects of GANRA-like medicine. China.
Mingyue, Zhu, Hailong, Pei, Wenling, Ye, and others, and. 2012. "Study on radioprotective effects of GANRA-like medicine." China.
@misc{etde_22238141,
title = {Study on radioprotective effects of GANRA-like medicine}
author = {Mingyue, Zhu, Hailong, Pei, Wenling, Ye, and others, and}
abstractNote = {After three days of medicine administrated, Kunming mice were exposed to 8 Gy of 100 kVp X-rays. Hemogram, viscere, survival, MDA yields and SOD activity were examined. Results showed that, (1) Survival of medicine-administrated mice were similar to the control group. After irradiation, survival dropped significantly. It took 20 days for the control group to reach to 50% survival, while 9 days for DMSO group 29 days for drug group 1, and 24 days for drug group 5. (2) The medicine per se had no obvious impacts on visceral indexes. Liver index and spleen index of the control group and DMSO group were elevated after irradiated, while those of medicine-administrated group did not change much. (3) The groups treated by DMSO and drug group 1 had high yield of MDA, but low activity of SOD. Compared with DMSO group, drug group 5 had high SOD activity while low MDA level. Irradiation increased MDA level but decreased SOD activity of every group, However, group drug 5 still showed higher SOD activity and lower MDA level than DMSO group. (4) The medicine did not show distinctive contributions to variation of hemogram. In summary, our results demonstrated that GANRA-like group drug 1 and group drug 5 medicine had radioprotective effects and their mechanisms might be related to the scavenging ability of free radicals. (authors)}
journal = {Nuclear Physics Review}
issue = {1}
volume = {29}
journal type = {AC}
place = {China}
year = {2012}
month = {Mar}
}