You need JavaScript to view this

Respiratory syncytial virus-related encephalitis: magnetic resonance imaging findings with diffusion-weighted study

Abstract

Respiratory syncytial virus (RSV) is a common pathogen causing acute respiratory infection in children. Herein, we describe the incidence and clinical and magnetic resonance imaging (MRI) findings of RSV-related encephalitis, a major neurological complication of RSV infection. We retrospectively reviewed the medical records and imaging findings of the patients over the past 7 years who are admitted to our medical center and are tested positive for RSV-RNA by reverse transcriptase PCR. In total, 3,856 patients were diagnosed with RSV bronchiolitis, and 28 of them underwent brain MRI for the evaluation of neurologic symptoms; 8 of these 28 patients had positive imaging findings. Five of these 8 patients were excluded because of non-RSV-related pathologies, such as subdural hemorrhage, brain volume loss due to status epilepticus, periventricular leukomalacia, preexisting ventriculomegaly, and hypoxic brain injury. The incidence of RSV-related encephalitis was as follows: 3/3,856 (0.08 %) of the patients are positive for RSV RNA, 3/28 (10.7 %) of the patient underwent brain MRI for neurological symptom, and 3/8 (37.5 %) of patients revealed abnormal MR findings. The imaging findings were suggestive of patterns of rhombenmesencephalitis, encephalitis with acute disseminated encephalomyelitis, and limbic encephalitis. They demonstrated no diffusion abnormality on diffusion-weighted image and symptom  More>>
Authors:
Park, Arim; Suh, Sang-il; Seol, Hae-Young; [1]  Son, Gyu-Ri; Lee, Nam-Joon; [2]  Lee, Young Hen; Seo, Hyung Suk; [3]  Eun, Baik-Lin [4] 
  1. Korea University College of Medicine, Department of Radiology, Korea University Guro Hospital, Seoul (Korea, Republic of)
  2. Korea University College of Medicine, Department of Radiology, Korea University Anam Hospital, Seoul (Korea, Republic of)
  3. Korea University College of Medicine, Department of Radiology, Korea University Ansan Hospital, Gyeonggi-do (Korea, Republic of)
  4. Korea University College of Medicine, Department of Pediatrics, Korea University Guro Hospital, Seoul (Korea, Republic of)
Publication Date:
Feb 15, 2014
Product Type:
Journal Article
Resource Relation:
Journal Name: Neuroradiology; Journal Volume: 56; Journal Issue: 2
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRAIN; BRONCHI; DIAGNOSIS; DIFFUSION; ENCEPHALITIS; IMAGE PROCESSING; INJURIES; MYELITIS; NEUROLOGY; NMR IMAGING; RESPIRATION; RESPIRATORY SYSTEM DISEASES; SYMPTOMS; VIRAL DISEASES; WEIGHTING FUNCTIONS
OSTI ID:
22219206
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0028-3940; CODEN: NRDYAB; TRN: DE14F1362040161
Availability:
Available from: http://dx.doi.org/10.1007/s00234-013-1305-z
Submitting Site:
DE
Size:
page(s) 163-168
Announcement Date:
Apr 28, 2014

Citation Formats

Park, Arim, Suh, Sang-il, Seol, Hae-Young, Son, Gyu-Ri, Lee, Nam-Joon, Lee, Young Hen, Seo, Hyung Suk, and Eun, Baik-Lin. Respiratory syncytial virus-related encephalitis: magnetic resonance imaging findings with diffusion-weighted study. Germany: N. p., 2014. Web. doi:10.1007/S00234-013-1305-Z.
Park, Arim, Suh, Sang-il, Seol, Hae-Young, Son, Gyu-Ri, Lee, Nam-Joon, Lee, Young Hen, Seo, Hyung Suk, & Eun, Baik-Lin. Respiratory syncytial virus-related encephalitis: magnetic resonance imaging findings with diffusion-weighted study. Germany. doi:10.1007/S00234-013-1305-Z.
Park, Arim, Suh, Sang-il, Seol, Hae-Young, Son, Gyu-Ri, Lee, Nam-Joon, Lee, Young Hen, Seo, Hyung Suk, and Eun, Baik-Lin. 2014. "Respiratory syncytial virus-related encephalitis: magnetic resonance imaging findings with diffusion-weighted study." Germany. doi:10.1007/S00234-013-1305-Z. https://www.osti.gov/servlets/purl/10.1007/S00234-013-1305-Z.
@misc{etde_22219206,
title = {Respiratory syncytial virus-related encephalitis: magnetic resonance imaging findings with diffusion-weighted study}
author = {Park, Arim, Suh, Sang-il, Seol, Hae-Young, Son, Gyu-Ri, Lee, Nam-Joon, Lee, Young Hen, Seo, Hyung Suk, and Eun, Baik-Lin}
abstractNote = {Respiratory syncytial virus (RSV) is a common pathogen causing acute respiratory infection in children. Herein, we describe the incidence and clinical and magnetic resonance imaging (MRI) findings of RSV-related encephalitis, a major neurological complication of RSV infection. We retrospectively reviewed the medical records and imaging findings of the patients over the past 7 years who are admitted to our medical center and are tested positive for RSV-RNA by reverse transcriptase PCR. In total, 3,856 patients were diagnosed with RSV bronchiolitis, and 28 of them underwent brain MRI for the evaluation of neurologic symptoms; 8 of these 28 patients had positive imaging findings. Five of these 8 patients were excluded because of non-RSV-related pathologies, such as subdural hemorrhage, brain volume loss due to status epilepticus, periventricular leukomalacia, preexisting ventriculomegaly, and hypoxic brain injury. The incidence of RSV-related encephalitis was as follows: 3/3,856 (0.08 %) of the patients are positive for RSV RNA, 3/28 (10.7 %) of the patient underwent brain MRI for neurological symptom, and 3/8 (37.5 %) of patients revealed abnormal MR findings. The imaging findings were suggestive of patterns of rhombenmesencephalitis, encephalitis with acute disseminated encephalomyelitis, and limbic encephalitis. They demonstrated no diffusion abnormality on diffusion-weighted image and symptom improvement on the follow-up study. Encephalitis with RSV bronchiolitis occurs rarely. However, on brain MRI performed upon suspicion of neurologic involvement, RSV encephalitis is not infrequently observed among the abnormal MR findings and may mimic other viral and limbic encephalitis. Physicians should be aware of this entity to ensure proper diagnosis and neurologic care of RSV-positive patients. (orig.)}
doi = {10.1007/S00234-013-1305-Z}
journal = {Neuroradiology}
issue = {2}
volume = {56}
journal type = {AC}
place = {Germany}
year = {2014}
month = {Feb}
}