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Influence of Annona muricata (soursop) on biodistribution of radiopharmaceuticals in rats

Abstract

Purpose: to evaluate the effect of hydroalcoholic extract of A. muricata on biodistribution of two radiopharmaceuticals: sodium phytate and dimercaptosuccinic acid (DMSA), both labeled with {sup 99m}technetium. Methods: twenty four Wistar rats were divided into two treated groups and two controls groups. The controls received water and the treated received 25mg/kg/day of A. muricata by gavage for ten days. One hour after the last dose, the first treated group received {sup 99m}Tc-DMSA and the second sodium {sup 99m}Tc-phytate (0.66MBq each group), both via orbital plexus. Controls followed the same protocol. Forty min later, all groups were sacrificed and the blood, kidney and bladder were isolated from the first treated group and the blood, spleen and liver isolated from the second treated group. The percentage of radioactivity per gram of tissue (%ATI/g) was calculated using a gamma counter. Results: the statistical analysis showed that there was a statistically significant decrease (p<0.05) in the uptake of %ATI/g in bladder (0.11±0.01and1.60±0.08), kidney (3.52±0.51and11.84±1.57) and blood (0.15±0.01and 0.54±0.05) between the treated group and control group, respectively. Conclusion: the A. muricata hydroalcoholic extract negatively influenced the uptake of {sup 99m}Tc-DMSA in bladder, kidney and blood of rats (author)
Authors:
Holanda, Cecilia Maria de Carvalho Xavier; [1]  Barbosa, Delianne Azevedo; Demeda, Vanessa Favero; Bandeira, Flora Tamires Moura; [2]  Medeiros, Hilkea Carla Souza de; Pereira, Kercia Regina Santos Gomes; [3]  Barbosa, Vanessa Santos de Arruda; [4]  Medeiros, Aldo Cunha [5] 
  1. Universidade Federal do Rio Grande do Norte (UFGN), Natal, RN (Brazil). Lab. de Radiobiologia Experimental e Ensaios Antiparasitarios
  2. Universidade Federal do Rio Grande do Norte (UFGN), Natal, RN (Brazil). Escola de Medicina
  3. Universidade Federal do Rio Grande do Norte (UFGN), Natal, RN (Brazil). Programa de Pos-Graduacao em Bioquimica
  4. Universidade Federal de Campina Grande (UFCG), PB (Brazil)
  5. Universidade Federal do Rio Grande do Norte (UFGN), Natal, RN (Brazil). Nucleo de Cirurgia Experimental
Publication Date:
Mar 01, 2014
Product Type:
Journal Article
Resource Relation:
Journal Name: Acta Cirurgica Brasileira; Journal Volume: 29; Journal Issue: 3
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BIOLOGICAL AVAILABILITY; LABELLING; MICE; RADIOPHARMACEUTICALS; SUCCINIC ACID; TECHNETIUM 99; UPTAKE
OSTI ID:
22216580
Country of Origin:
Brazil
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0102-8650; CODEN: ACIBET; TRN: BR1400116037546
Availability:
Available from http://www.scielo.br/pdf/acb/v29n3/0102-8650-acb-29-03-0145.pdf
Submitting Site:
BRN
Size:
page(s) 145-150
Announcement Date:
Apr 17, 2014

Citation Formats

Holanda, Cecilia Maria de Carvalho Xavier, Barbosa, Delianne Azevedo, Demeda, Vanessa Favero, Bandeira, Flora Tamires Moura, Medeiros, Hilkea Carla Souza de, Pereira, Kercia Regina Santos Gomes, Barbosa, Vanessa Santos de Arruda, and Medeiros, Aldo Cunha. Influence of Annona muricata (soursop) on biodistribution of radiopharmaceuticals in rats. Brazil: N. p., 2014. Web.
Holanda, Cecilia Maria de Carvalho Xavier, Barbosa, Delianne Azevedo, Demeda, Vanessa Favero, Bandeira, Flora Tamires Moura, Medeiros, Hilkea Carla Souza de, Pereira, Kercia Regina Santos Gomes, Barbosa, Vanessa Santos de Arruda, & Medeiros, Aldo Cunha. Influence of Annona muricata (soursop) on biodistribution of radiopharmaceuticals in rats. Brazil.
Holanda, Cecilia Maria de Carvalho Xavier, Barbosa, Delianne Azevedo, Demeda, Vanessa Favero, Bandeira, Flora Tamires Moura, Medeiros, Hilkea Carla Souza de, Pereira, Kercia Regina Santos Gomes, Barbosa, Vanessa Santos de Arruda, and Medeiros, Aldo Cunha. 2014. "Influence of Annona muricata (soursop) on biodistribution of radiopharmaceuticals in rats." Brazil.
@misc{etde_22216580,
title = {Influence of Annona muricata (soursop) on biodistribution of radiopharmaceuticals in rats}
author = {Holanda, Cecilia Maria de Carvalho Xavier, Barbosa, Delianne Azevedo, Demeda, Vanessa Favero, Bandeira, Flora Tamires Moura, Medeiros, Hilkea Carla Souza de, Pereira, Kercia Regina Santos Gomes, Barbosa, Vanessa Santos de Arruda, and Medeiros, Aldo Cunha}
abstractNote = {Purpose: to evaluate the effect of hydroalcoholic extract of A. muricata on biodistribution of two radiopharmaceuticals: sodium phytate and dimercaptosuccinic acid (DMSA), both labeled with {sup 99m}technetium. Methods: twenty four Wistar rats were divided into two treated groups and two controls groups. The controls received water and the treated received 25mg/kg/day of A. muricata by gavage for ten days. One hour after the last dose, the first treated group received {sup 99m}Tc-DMSA and the second sodium {sup 99m}Tc-phytate (0.66MBq each group), both via orbital plexus. Controls followed the same protocol. Forty min later, all groups were sacrificed and the blood, kidney and bladder were isolated from the first treated group and the blood, spleen and liver isolated from the second treated group. The percentage of radioactivity per gram of tissue (%ATI/g) was calculated using a gamma counter. Results: the statistical analysis showed that there was a statistically significant decrease (p<0.05) in the uptake of %ATI/g in bladder (0.11±0.01and1.60±0.08), kidney (3.52±0.51and11.84±1.57) and blood (0.15±0.01and 0.54±0.05) between the treated group and control group, respectively. Conclusion: the A. muricata hydroalcoholic extract negatively influenced the uptake of {sup 99m}Tc-DMSA in bladder, kidney and blood of rats (author)}
journal = {Acta Cirurgica Brasileira}
issue = {3}
volume = {29}
journal type = {AC}
place = {Brazil}
year = {2014}
month = {Mar}
}