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Quantitative Nuclear Medicine Imaging: Concepts, Requirements and Methods

Abstract

The absolute quantification of radionuclide distribution has been a goal since the early days of nuclear medicine. Nevertheless, the apparent complexity and sometimes limited accuracy of these methods have prevented them from being widely used in important applications such as targeted radionuclide therapy or kinetic analysis. The intricacy of the effects degrading nuclear medicine images and the lack of availability of adequate methods to compensate for these effects have frequently been seen as insurmountable obstacles in the use of quantitative nuclear medicine in clinical institutions. In the last few decades, several research groups have consistently devoted their efforts to the filling of these gaps. As a result, many efficient methods are now available that make quantification a clinical reality, provided appropriate compensation tools are used. Despite these efforts, many clinical institutions still lack the knowledge and tools to adequately measure and estimate the accumulated activities in the human body, thereby using potentially outdated protocols and procedures. The purpose of the present publication is to review the current state of the art of image quantification and to provide medical physicists and other related professionals facing quantification tasks with a solid background of tools and methods. It describes and analyses the physical  More>>
Authors:
"NONE"
Publication Date:
Jan 15, 2014
Product Type:
Book
Report Number:
STI/PUB-1605
Resource Relation:
Other Information: 172 refs., 22 figs.; Related Information: Series: IAEA Human Health Reports; no. 9
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ACCURACY; ANIMAL TISSUES; COMPUTER CODES; IAEA; IMAGES; ITERATIVE METHODS; POSITRON COMPUTED TOMOGRAPHY; PUBLIC HEALTH; QUALITY CONTROL; RADIONUCLIDE KINETICS; RADIOTHERAPY; REVIEWS; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
OSTI ID:
22208235
Research Organizations:
International Atomic Energy Agency, Division of Human Health, Vienna (Austria)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
Other: ISBN 978-92-0-141510-3; ISSN 2074-7667; TRN: XA14R0278029147
Availability:
Also available on-line: http://www-pub.iaea.org/MTCD/Publications/PDF/Pub1605_web.pdf; Enquiries should be addressed to IAEA, Marketing and Sales Unit, Publishing Section, E-mail: sales.publications@iaea.org; Web site: http://www.iaea.org/books
Submitting Site:
INIS
Size:
79 page(s)
Announcement Date:
Mar 22, 2014

Citation Formats

Quantitative Nuclear Medicine Imaging: Concepts, Requirements and Methods. IAEA: N. p., 2014. Web.
Quantitative Nuclear Medicine Imaging: Concepts, Requirements and Methods. IAEA.
2014. "Quantitative Nuclear Medicine Imaging: Concepts, Requirements and Methods." IAEA.
@misc{etde_22208235,
title = {Quantitative Nuclear Medicine Imaging: Concepts, Requirements and Methods}
abstractNote = {The absolute quantification of radionuclide distribution has been a goal since the early days of nuclear medicine. Nevertheless, the apparent complexity and sometimes limited accuracy of these methods have prevented them from being widely used in important applications such as targeted radionuclide therapy or kinetic analysis. The intricacy of the effects degrading nuclear medicine images and the lack of availability of adequate methods to compensate for these effects have frequently been seen as insurmountable obstacles in the use of quantitative nuclear medicine in clinical institutions. In the last few decades, several research groups have consistently devoted their efforts to the filling of these gaps. As a result, many efficient methods are now available that make quantification a clinical reality, provided appropriate compensation tools are used. Despite these efforts, many clinical institutions still lack the knowledge and tools to adequately measure and estimate the accumulated activities in the human body, thereby using potentially outdated protocols and procedures. The purpose of the present publication is to review the current state of the art of image quantification and to provide medical physicists and other related professionals facing quantification tasks with a solid background of tools and methods. It describes and analyses the physical effects that degrade image quality and affect the accuracy of quantification, and describes methods to compensate for them in planar, single photon emission computed tomography (SPECT) and positron emission tomography (PET) images. The fast paced development of the computational infrastructure, both hardware and software, has made drastic changes in the ways image quantification is now performed. The measuring equipment has evolved from the simple blind probes to planar and three dimensional imaging, supported by SPECT, PET and hybrid equipment. Methods of iterative reconstruction have been developed to allow for more consistent compensation for physical effects and imaging system limitations. On these grounds, quantitative imaging is now a broad field of work for the scientific community, and its current translation to the clinical environment can be undertaken with confidence, for better and more accurate diagnostic and therapeutic applications using consistent and well validated protocols. This publication complements previous efforts of the IAEA related to activity measurement and quantification. The quantitative measurement of tissues and other biological samples is addressed in Technical Reports Series No. 454. The quality control requirements of current PET and SPECT imaging equipment are addressed in IAEA Human Health Series No. 1 and No. 6, respectively. This report does not cover the fields addressed by these publications.}
place = {IAEA}
year = {2014}
month = {Jan}
}