Abstract
Lymph node staging in non-small cell lung cancer (NSCLC) is challenging and important for deciding treatment policy. The role of PET/CT scans in lymph node staging of NSCLC remains controversial when comparing TB and non-TB endemic regions. This study systematically reviews the literature regarding the diagnostic performance of PET/CT in lymph node staging of patients with NSCLC, and determines its pooled sensitivity and specificity. Methods: The databases of PubMed, Medline, and Cochrane library were searched for relevant studies. Two reviewers independently assessed the methodological quality of each study. A meta-analysis of the reported sensitivity and specificity of each study was performed. Results: Seven of 86 studies were included. These studies had moderate to good methodological quality. Pooled sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio for patient-based analyses (five studies) were 66%, 92.7%, 5.86%, and 0.41%, respectively, and those for lesion-based analyses (six studies) were 59.4%, 96.5%, 9.37%, and 0.31%, respectively. Subanalysis of endemic regions of tuberculosis (TB) showed that these regions had lower sensitivity and similar specificity to non-TB endemic regions. Conclusion: PET/CT showed high specificity in the lymph node staging of NSCLC and lower sensitivity in TB endemic regions.
Liao, Chih-Ying;
[1]
Institute of Integrated Medicine, China Medical University, Taichung, Taiwan (China)];
Chen, Jin-Hua;
[2]
Liang, Ji-An;
[3]
Department of Radiation Oncology, China Medical University Hospital, Taichung, Taiwan (China)];
Yeh, Jun-Jun;
[3]
Department of Research, PingTung Christian Hospital and Meiho University, Pingtung, Taiwan (China)];
Kao, Chia-Hung;
[3]
Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan (China)]
- Department of Radiation Therapy and Oncology, Taichung Hospital, Department of Health, Executive Yuan, Taiwan (China)
- Biostatistics Center and Graduate Institute of Biostatistics, China Medical University, Taichung, Taiwan (China)
- Institute of Clinical Medicine Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan (China)
Citation Formats
Liao, Chih-Ying, Institute of Integrated Medicine, China Medical University, Taichung, Taiwan (China)], Chen, Jin-Hua, Liang, Ji-An, Department of Radiation Oncology, China Medical University Hospital, Taichung, Taiwan (China)], Yeh, Jun-Jun, Department of Research, PingTung Christian Hospital and Meiho University, Pingtung, Taiwan (China)], Kao, Chia-Hung, and Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan (China)].
Meta-analysis study of lymph node staging by 18 F-FDG PET/CT scan in non-small cell lung cancer: Comparison of TB and non-TB endemic regions.
Netherlands: N. p.,
2012.
Web.
doi:10.1016/J.EJRAD.2012.02.007.
Liao, Chih-Ying, Institute of Integrated Medicine, China Medical University, Taichung, Taiwan (China)], Chen, Jin-Hua, Liang, Ji-An, Department of Radiation Oncology, China Medical University Hospital, Taichung, Taiwan (China)], Yeh, Jun-Jun, Department of Research, PingTung Christian Hospital and Meiho University, Pingtung, Taiwan (China)], Kao, Chia-Hung, & Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan (China)].
Meta-analysis study of lymph node staging by 18 F-FDG PET/CT scan in non-small cell lung cancer: Comparison of TB and non-TB endemic regions.
Netherlands.
https://doi.org/10.1016/J.EJRAD.2012.02.007
Liao, Chih-Ying, Institute of Integrated Medicine, China Medical University, Taichung, Taiwan (China)], Chen, Jin-Hua, Liang, Ji-An, Department of Radiation Oncology, China Medical University Hospital, Taichung, Taiwan (China)], Yeh, Jun-Jun, Department of Research, PingTung Christian Hospital and Meiho University, Pingtung, Taiwan (China)], Kao, Chia-Hung, and Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan (China)].
2012.
"Meta-analysis study of lymph node staging by 18 F-FDG PET/CT scan in non-small cell lung cancer: Comparison of TB and non-TB endemic regions."
Netherlands.
https://doi.org/10.1016/J.EJRAD.2012.02.007.
@misc{etde_22206788,
title = {Meta-analysis study of lymph node staging by 18 F-FDG PET/CT scan in non-small cell lung cancer: Comparison of TB and non-TB endemic regions}
author = {Liao, Chih-Ying, Institute of Integrated Medicine, China Medical University, Taichung, Taiwan (China)], Chen, Jin-Hua, Liang, Ji-An, Department of Radiation Oncology, China Medical University Hospital, Taichung, Taiwan (China)], Yeh, Jun-Jun, Department of Research, PingTung Christian Hospital and Meiho University, Pingtung, Taiwan (China)], Kao, Chia-Hung, and Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan (China)]}
abstractNote = {Lymph node staging in non-small cell lung cancer (NSCLC) is challenging and important for deciding treatment policy. The role of PET/CT scans in lymph node staging of NSCLC remains controversial when comparing TB and non-TB endemic regions. This study systematically reviews the literature regarding the diagnostic performance of PET/CT in lymph node staging of patients with NSCLC, and determines its pooled sensitivity and specificity. Methods: The databases of PubMed, Medline, and Cochrane library were searched for relevant studies. Two reviewers independently assessed the methodological quality of each study. A meta-analysis of the reported sensitivity and specificity of each study was performed. Results: Seven of 86 studies were included. These studies had moderate to good methodological quality. Pooled sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio for patient-based analyses (five studies) were 66%, 92.7%, 5.86%, and 0.41%, respectively, and those for lesion-based analyses (six studies) were 59.4%, 96.5%, 9.37%, and 0.31%, respectively. Subanalysis of endemic regions of tuberculosis (TB) showed that these regions had lower sensitivity and similar specificity to non-TB endemic regions. Conclusion: PET/CT showed high specificity in the lymph node staging of NSCLC and lower sensitivity in TB endemic regions.}
doi = {10.1016/J.EJRAD.2012.02.007}
journal = []
issue = {11}
volume = {81}
journal type = {AC}
place = {Netherlands}
year = {2012}
month = {Nov}
}
title = {Meta-analysis study of lymph node staging by 18 F-FDG PET/CT scan in non-small cell lung cancer: Comparison of TB and non-TB endemic regions}
author = {Liao, Chih-Ying, Institute of Integrated Medicine, China Medical University, Taichung, Taiwan (China)], Chen, Jin-Hua, Liang, Ji-An, Department of Radiation Oncology, China Medical University Hospital, Taichung, Taiwan (China)], Yeh, Jun-Jun, Department of Research, PingTung Christian Hospital and Meiho University, Pingtung, Taiwan (China)], Kao, Chia-Hung, and Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan (China)]}
abstractNote = {Lymph node staging in non-small cell lung cancer (NSCLC) is challenging and important for deciding treatment policy. The role of PET/CT scans in lymph node staging of NSCLC remains controversial when comparing TB and non-TB endemic regions. This study systematically reviews the literature regarding the diagnostic performance of PET/CT in lymph node staging of patients with NSCLC, and determines its pooled sensitivity and specificity. Methods: The databases of PubMed, Medline, and Cochrane library were searched for relevant studies. Two reviewers independently assessed the methodological quality of each study. A meta-analysis of the reported sensitivity and specificity of each study was performed. Results: Seven of 86 studies were included. These studies had moderate to good methodological quality. Pooled sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio for patient-based analyses (five studies) were 66%, 92.7%, 5.86%, and 0.41%, respectively, and those for lesion-based analyses (six studies) were 59.4%, 96.5%, 9.37%, and 0.31%, respectively. Subanalysis of endemic regions of tuberculosis (TB) showed that these regions had lower sensitivity and similar specificity to non-TB endemic regions. Conclusion: PET/CT showed high specificity in the lymph node staging of NSCLC and lower sensitivity in TB endemic regions.}
doi = {10.1016/J.EJRAD.2012.02.007}
journal = []
issue = {11}
volume = {81}
journal type = {AC}
place = {Netherlands}
year = {2012}
month = {Nov}
}