Abstract
The present study assessed the diagnostic performances of 18F-FDG PET or PET/CT in detecting pelvic and/or paraaortic lymph node metastasis in patients with endometrial cancer. Methods: Through a search of MEDLINE (January 1998 to March 2011), an overall weighted average for sensitivity and specificity as well as pooled estimates of positive and negative likelihood ratios were calculated. A summary receiver-operating-characteristics (sROC) curve was constructed and the area under the sROC curve (AUC) was calculated. I-square was calculated to explore heterogeneity. Results: The present study included 243 patients from seven studies. Results indicated a lack of significant heterogeneity for sensitivity and specificity (I{sup 2} < 50% and p > 0.05). The overall pooled estimates for sensitivity and specificity of FDG-PET or PET/CT scans in the detection of pelvic and/or paraaortic metastasis were 63.0% (95% CI, 48.7-75.7%) and 94.7% (95% CI, 90.4-97.4%), respectively. The positive likelihood ratio was 10.465 (95% CI, 5.646-19.396) and the negative likelihood ratio 0.399 (95% CI, 0.284-0.560). The AUC was 0.9533. The overall diagnostic accuracy (Q* index) was 89.5%. Conclusion The high positive likelihood value confirms the reliability of a positive FDG-PET or PET/CT to detect pelvic and/or paraaortic lymph nodes metastasis in patients with untreated endometrial cancer.
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Chang, Ming-Che;
[1]
Institute of Radiological Science, Central Taiwan University of Science and Technology, Taichung, Taiwan (China)];
Chen, Jin-Hua;
[2]
Liang, Ji-An;
[3]
Department of Radiation Oncology, China Medical University Hospital, Taichung, Taiwan (China)];
Yang, Kuang-Tao;
[1]
Cheng, Kai-Yuan;
[4]
Kao, Chia-Hung;
[3]
Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan (China)]
- Nuclear Medicine Department, Changhua Christian Hospital, Changhua, Taiwan (China)
- Biostatistics Center and Graduate Institute of Biostatistics, China Medical University, Taichung, Taiwan (China)
- School of Medicine, China Medical University, Taichung, Taiwan (China)
- Institute of Radiological Science, Central Taiwan University of Science and Technology, Taichung, Taiwan (China)
Citation Formats
Chang, Ming-Che, Institute of Radiological Science, Central Taiwan University of Science and Technology, Taichung, Taiwan (China)], Chen, Jin-Hua, Liang, Ji-An, Department of Radiation Oncology, China Medical University Hospital, Taichung, Taiwan (China)], Yang, Kuang-Tao, Cheng, Kai-Yuan, Kao, Chia-Hung, and Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan (China)].
18F-FDG PET or PET/CT for detection of metastatic lymph nodes in patients with endometrial cancer: A systematic review and meta-analysis.
Netherlands: N. p.,
2012.
Web.
doi:10.1016/J.EJRAD.2012.01.024.
Chang, Ming-Che, Institute of Radiological Science, Central Taiwan University of Science and Technology, Taichung, Taiwan (China)], Chen, Jin-Hua, Liang, Ji-An, Department of Radiation Oncology, China Medical University Hospital, Taichung, Taiwan (China)], Yang, Kuang-Tao, Cheng, Kai-Yuan, Kao, Chia-Hung, & Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan (China)].
18F-FDG PET or PET/CT for detection of metastatic lymph nodes in patients with endometrial cancer: A systematic review and meta-analysis.
Netherlands.
https://doi.org/10.1016/J.EJRAD.2012.01.024
Chang, Ming-Che, Institute of Radiological Science, Central Taiwan University of Science and Technology, Taichung, Taiwan (China)], Chen, Jin-Hua, Liang, Ji-An, Department of Radiation Oncology, China Medical University Hospital, Taichung, Taiwan (China)], Yang, Kuang-Tao, Cheng, Kai-Yuan, Kao, Chia-Hung, and Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan (China)].
2012.
"18F-FDG PET or PET/CT for detection of metastatic lymph nodes in patients with endometrial cancer: A systematic review and meta-analysis."
Netherlands.
https://doi.org/10.1016/J.EJRAD.2012.01.024.
@misc{etde_22206787,
title = {18F-FDG PET or PET/CT for detection of metastatic lymph nodes in patients with endometrial cancer: A systematic review and meta-analysis}
author = {Chang, Ming-Che, Institute of Radiological Science, Central Taiwan University of Science and Technology, Taichung, Taiwan (China)], Chen, Jin-Hua, Liang, Ji-An, Department of Radiation Oncology, China Medical University Hospital, Taichung, Taiwan (China)], Yang, Kuang-Tao, Cheng, Kai-Yuan, Kao, Chia-Hung, and Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan (China)]}
abstractNote = {The present study assessed the diagnostic performances of 18F-FDG PET or PET/CT in detecting pelvic and/or paraaortic lymph node metastasis in patients with endometrial cancer. Methods: Through a search of MEDLINE (January 1998 to March 2011), an overall weighted average for sensitivity and specificity as well as pooled estimates of positive and negative likelihood ratios were calculated. A summary receiver-operating-characteristics (sROC) curve was constructed and the area under the sROC curve (AUC) was calculated. I-square was calculated to explore heterogeneity. Results: The present study included 243 patients from seven studies. Results indicated a lack of significant heterogeneity for sensitivity and specificity (I{sup 2} < 50% and p > 0.05). The overall pooled estimates for sensitivity and specificity of FDG-PET or PET/CT scans in the detection of pelvic and/or paraaortic metastasis were 63.0% (95% CI, 48.7-75.7%) and 94.7% (95% CI, 90.4-97.4%), respectively. The positive likelihood ratio was 10.465 (95% CI, 5.646-19.396) and the negative likelihood ratio 0.399 (95% CI, 0.284-0.560). The AUC was 0.9533. The overall diagnostic accuracy (Q* index) was 89.5%. Conclusion The high positive likelihood value confirms the reliability of a positive FDG-PET or PET/CT to detect pelvic and/or paraaortic lymph nodes metastasis in patients with untreated endometrial cancer. FDG-PET or PET/CT may prove beneficial to surgeons when selecting appropriate patients on whom to perform lymphadenectomy.}
doi = {10.1016/J.EJRAD.2012.01.024}
journal = []
issue = {11}
volume = {81}
journal type = {AC}
place = {Netherlands}
year = {2012}
month = {Nov}
}
title = {18F-FDG PET or PET/CT for detection of metastatic lymph nodes in patients with endometrial cancer: A systematic review and meta-analysis}
author = {Chang, Ming-Che, Institute of Radiological Science, Central Taiwan University of Science and Technology, Taichung, Taiwan (China)], Chen, Jin-Hua, Liang, Ji-An, Department of Radiation Oncology, China Medical University Hospital, Taichung, Taiwan (China)], Yang, Kuang-Tao, Cheng, Kai-Yuan, Kao, Chia-Hung, and Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan (China)]}
abstractNote = {The present study assessed the diagnostic performances of 18F-FDG PET or PET/CT in detecting pelvic and/or paraaortic lymph node metastasis in patients with endometrial cancer. Methods: Through a search of MEDLINE (January 1998 to March 2011), an overall weighted average for sensitivity and specificity as well as pooled estimates of positive and negative likelihood ratios were calculated. A summary receiver-operating-characteristics (sROC) curve was constructed and the area under the sROC curve (AUC) was calculated. I-square was calculated to explore heterogeneity. Results: The present study included 243 patients from seven studies. Results indicated a lack of significant heterogeneity for sensitivity and specificity (I{sup 2} < 50% and p > 0.05). The overall pooled estimates for sensitivity and specificity of FDG-PET or PET/CT scans in the detection of pelvic and/or paraaortic metastasis were 63.0% (95% CI, 48.7-75.7%) and 94.7% (95% CI, 90.4-97.4%), respectively. The positive likelihood ratio was 10.465 (95% CI, 5.646-19.396) and the negative likelihood ratio 0.399 (95% CI, 0.284-0.560). The AUC was 0.9533. The overall diagnostic accuracy (Q* index) was 89.5%. Conclusion The high positive likelihood value confirms the reliability of a positive FDG-PET or PET/CT to detect pelvic and/or paraaortic lymph nodes metastasis in patients with untreated endometrial cancer. FDG-PET or PET/CT may prove beneficial to surgeons when selecting appropriate patients on whom to perform lymphadenectomy.}
doi = {10.1016/J.EJRAD.2012.01.024}
journal = []
issue = {11}
volume = {81}
journal type = {AC}
place = {Netherlands}
year = {2012}
month = {Nov}
}