Abstract
The authors gave intramuscular injections of iodized oil with a view to studying its prophylactic effects on endemic goitre and related defects (such as endemic cretinism) in isolated areas where more traditional techniques have serious limitations. This system had been tried earlier in New Guinea, where the results showed a reduction in the prevalence of goitre and proved the technique to be both safe and practical. However, because of the remoteness of the population in question it was impossible to continue the observations and no information was obtained regarding the effectiveness of iodized oil in reducing the incidence of defects associated with endemic goitre, Ecuador's program, involving studies of the whole population of two rural communities in the Andes, was begun in March 1966. The final control check came three years later. Ethiodol (37% iodized oil, 450 mg iodine per cm{sup 3}, obtained from Fougera, Hicksville, Long Island, N.Y. United States of America) was injected intramuscularly, 2 cm{sup 3} being administered to subjects 12 years of age and older and proportionately smaller doses to younger children. The ethiodol produced extensive changes in the physiological behaviour of the thyroid. {sup 131}I uptake was depressed for six months and afterwards remained normal.
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Fierro-Benitez, R.;
Ramirez, I.
[1]
- Instituto de Ciencias Nucleares, Escuela Politecnica Nacional y Facultad de Medicina, Universidad Central, Quito (Ecuador)
Citation Formats
Fierro-Benitez, R., and Ramirez, I.
Measurements of {sup 131}I-Labelled Triiodothyronine Uptake by a Resin as a Means of Diagnosing Iodine-Basedow Produced by Intramuscular Administration of Iodized Oil in an Area of Endemic Goitre; Utilidad de la Prueba de la Captacion de Triyodotironina Marcada con {sup 131}I por Resina en el Diagnostico de Yod-Basedow Producido por la Administracion Intramuscular de Aceite Yodado, en una Area de Bocio Endemico.
IAEA: N. p.,
1970.
Web.
Fierro-Benitez, R., & Ramirez, I.
Measurements of {sup 131}I-Labelled Triiodothyronine Uptake by a Resin as a Means of Diagnosing Iodine-Basedow Produced by Intramuscular Administration of Iodized Oil in an Area of Endemic Goitre; Utilidad de la Prueba de la Captacion de Triyodotironina Marcada con {sup 131}I por Resina en el Diagnostico de Yod-Basedow Producido por la Administracion Intramuscular de Aceite Yodado, en una Area de Bocio Endemico.
IAEA.
Fierro-Benitez, R., and Ramirez, I.
1970.
"Measurements of {sup 131}I-Labelled Triiodothyronine Uptake by a Resin as a Means of Diagnosing Iodine-Basedow Produced by Intramuscular Administration of Iodized Oil in an Area of Endemic Goitre; Utilidad de la Prueba de la Captacion de Triyodotironina Marcada con {sup 131}I por Resina en el Diagnostico de Yod-Basedow Producido por la Administracion Intramuscular de Aceite Yodado, en una Area de Bocio Endemico."
IAEA.
@misc{etde_22205117,
title = {Measurements of {sup 131}I-Labelled Triiodothyronine Uptake by a Resin as a Means of Diagnosing Iodine-Basedow Produced by Intramuscular Administration of Iodized Oil in an Area of Endemic Goitre; Utilidad de la Prueba de la Captacion de Triyodotironina Marcada con {sup 131}I por Resina en el Diagnostico de Yod-Basedow Producido por la Administracion Intramuscular de Aceite Yodado, en una Area de Bocio Endemico}
author = {Fierro-Benitez, R., and Ramirez, I.}
abstractNote = {The authors gave intramuscular injections of iodized oil with a view to studying its prophylactic effects on endemic goitre and related defects (such as endemic cretinism) in isolated areas where more traditional techniques have serious limitations. This system had been tried earlier in New Guinea, where the results showed a reduction in the prevalence of goitre and proved the technique to be both safe and practical. However, because of the remoteness of the population in question it was impossible to continue the observations and no information was obtained regarding the effectiveness of iodized oil in reducing the incidence of defects associated with endemic goitre, Ecuador's program, involving studies of the whole population of two rural communities in the Andes, was begun in March 1966. The final control check came three years later. Ethiodol (37% iodized oil, 450 mg iodine per cm{sup 3}, obtained from Fougera, Hicksville, Long Island, N.Y. United States of America) was injected intramuscularly, 2 cm{sup 3} being administered to subjects 12 years of age and older and proportionately smaller doses to younger children. The ethiodol produced extensive changes in the physiological behaviour of the thyroid. {sup 131}I uptake was depressed for six months and afterwards remained normal. Similarly, BEI and T{sub 4} returned to and stayed at normal levels from the very first control checks onwards, which indicated that even during the first few months the thyroid glands of these subjects were maintaining a normal capacity to secrete thyronines, i.e. that they were not exhibiting the effect described by Wolff and Chaikoff, PBI and BII maintained high livels in all the controls. Urinary excretion of iodine followed a double exponential path: calculations indicated that the subjects would still be excreting significant amounts five years after the injection. Six months after injection there was an unequivocal diagnosis of Iodine-Basedow in three older women with large nodular goitres. Among the indices which proved useful for this diagnosis were BEI, T{sub 4}, BMR and, among the various tests with radioiodine (uptake, conversion ratio, PBI %/1/d, urinary excretion, saliva/total plasma, saliva/PBI, salivary clearance, KSCN suppression test) only the measurements of T{sub 3} - {sup 131}I uptake by resin. (author) [Spanish] Les autores efectuaron la administracion intramuscular de aceite yodado con el fin de estudiar sus efectos profilacticos sobre el bocio endemico y defectos asociados, tales como el cretinismo endemico, etc., en areas en las que por su aislamiento, etc,, los metodos tradicionales ofrecen serias limitaciones. Este sistema se us6 en Nueva Guinea; los resultados alli obtenidos indicaron que el metodo redujo la prevalencia del bocio y que su ejecucion era segura y practica. Mas, dado lo remoto del lugar, fue imposible continuar las observaciones y no hubo informacion en cuanto a la efectividad del aceite yodado en reducir la incidencia de los defectos acociados con la endemia. El programa se inicio en Ecuador en Marzo 1966 en la poblacion total de dos comunidades rurales de la region andina. El ultimo control se efectuo tres anos despues. Se inyecto ethiodol (37% de aceite yodado; cada cm3 con un contenido de 450 mg de yodo; Fougera, Hicksville, L.I., N. Y. EE. UU.) por via intramuscular: 2 cm{sup 3} a los sujetos de 12 anos de edad en adelante, y dosis proporcionalmente menores a los mas jovenes. El ethiodol produjo cambios profundos en el comportamiento fisiologico de la tiroides. La captacion de I se deprimio durante 6 meses, para luego mantenerse normal. Igualmente, y desde los primeros controles, el BEI y la T{sub 4} se tornaron y mantuvieron normales, lo cual demostro que inclusive durante los primeros meses la glandula mantenia una capacidad normal para elaborar tironinas, es decir en ellas no se produjo el efecto descrito por Wolff y Chaikoff. El PBI y BII se mantuvieron altos en todos los controles. La excrecion urinaria de yodo siguio un doble recorrido exponencial: se calculo que cantidades significativas seguirian excretandose hasta cinco anos luego de la inyeccion. Seis meses despues de la inyeccion, en tres mujeres ancianas con bocios nodulares grandes se verifico un diagnostico incuestionable de Yod-Basedow. Fueron utiles para el diagnostico el BEI, T{sub 4}, BMR, y de entre las pruebas con Ral (captacion, relacion de conversion, PBI%/1/d, excresion urinaria, saliva/plasma total, saliva/PBI, clearance salivar, test de supresion con KSCN) tan solo la captacion de T{sub 3} -{sup 131}I por resina. (author)}
place = {IAEA}
year = {1970}
month = {Feb}
}
title = {Measurements of {sup 131}I-Labelled Triiodothyronine Uptake by a Resin as a Means of Diagnosing Iodine-Basedow Produced by Intramuscular Administration of Iodized Oil in an Area of Endemic Goitre; Utilidad de la Prueba de la Captacion de Triyodotironina Marcada con {sup 131}I por Resina en el Diagnostico de Yod-Basedow Producido por la Administracion Intramuscular de Aceite Yodado, en una Area de Bocio Endemico}
author = {Fierro-Benitez, R., and Ramirez, I.}
abstractNote = {The authors gave intramuscular injections of iodized oil with a view to studying its prophylactic effects on endemic goitre and related defects (such as endemic cretinism) in isolated areas where more traditional techniques have serious limitations. This system had been tried earlier in New Guinea, where the results showed a reduction in the prevalence of goitre and proved the technique to be both safe and practical. However, because of the remoteness of the population in question it was impossible to continue the observations and no information was obtained regarding the effectiveness of iodized oil in reducing the incidence of defects associated with endemic goitre, Ecuador's program, involving studies of the whole population of two rural communities in the Andes, was begun in March 1966. The final control check came three years later. Ethiodol (37% iodized oil, 450 mg iodine per cm{sup 3}, obtained from Fougera, Hicksville, Long Island, N.Y. United States of America) was injected intramuscularly, 2 cm{sup 3} being administered to subjects 12 years of age and older and proportionately smaller doses to younger children. The ethiodol produced extensive changes in the physiological behaviour of the thyroid. {sup 131}I uptake was depressed for six months and afterwards remained normal. Similarly, BEI and T{sub 4} returned to and stayed at normal levels from the very first control checks onwards, which indicated that even during the first few months the thyroid glands of these subjects were maintaining a normal capacity to secrete thyronines, i.e. that they were not exhibiting the effect described by Wolff and Chaikoff, PBI and BII maintained high livels in all the controls. Urinary excretion of iodine followed a double exponential path: calculations indicated that the subjects would still be excreting significant amounts five years after the injection. Six months after injection there was an unequivocal diagnosis of Iodine-Basedow in three older women with large nodular goitres. Among the indices which proved useful for this diagnosis were BEI, T{sub 4}, BMR and, among the various tests with radioiodine (uptake, conversion ratio, PBI %/1/d, urinary excretion, saliva/total plasma, saliva/PBI, salivary clearance, KSCN suppression test) only the measurements of T{sub 3} - {sup 131}I uptake by resin. (author) [Spanish] Les autores efectuaron la administracion intramuscular de aceite yodado con el fin de estudiar sus efectos profilacticos sobre el bocio endemico y defectos asociados, tales como el cretinismo endemico, etc., en areas en las que por su aislamiento, etc,, los metodos tradicionales ofrecen serias limitaciones. Este sistema se us6 en Nueva Guinea; los resultados alli obtenidos indicaron que el metodo redujo la prevalencia del bocio y que su ejecucion era segura y practica. Mas, dado lo remoto del lugar, fue imposible continuar las observaciones y no hubo informacion en cuanto a la efectividad del aceite yodado en reducir la incidencia de los defectos acociados con la endemia. El programa se inicio en Ecuador en Marzo 1966 en la poblacion total de dos comunidades rurales de la region andina. El ultimo control se efectuo tres anos despues. Se inyecto ethiodol (37% de aceite yodado; cada cm3 con un contenido de 450 mg de yodo; Fougera, Hicksville, L.I., N. Y. EE. UU.) por via intramuscular: 2 cm{sup 3} a los sujetos de 12 anos de edad en adelante, y dosis proporcionalmente menores a los mas jovenes. El ethiodol produjo cambios profundos en el comportamiento fisiologico de la tiroides. La captacion de I se deprimio durante 6 meses, para luego mantenerse normal. Igualmente, y desde los primeros controles, el BEI y la T{sub 4} se tornaron y mantuvieron normales, lo cual demostro que inclusive durante los primeros meses la glandula mantenia una capacidad normal para elaborar tironinas, es decir en ellas no se produjo el efecto descrito por Wolff y Chaikoff. El PBI y BII se mantuvieron altos en todos los controles. La excrecion urinaria de yodo siguio un doble recorrido exponencial: se calculo que cantidades significativas seguirian excretandose hasta cinco anos luego de la inyeccion. Seis meses despues de la inyeccion, en tres mujeres ancianas con bocios nodulares grandes se verifico un diagnostico incuestionable de Yod-Basedow. Fueron utiles para el diagnostico el BEI, T{sub 4}, BMR, y de entre las pruebas con Ral (captacion, relacion de conversion, PBI%/1/d, excresion urinaria, saliva/plasma total, saliva/PBI, clearance salivar, test de supresion con KSCN) tan solo la captacion de T{sub 3} -{sup 131}I por resina. (author)}
place = {IAEA}
year = {1970}
month = {Feb}
}