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Two Cases of Chronic Occupational Exposure to Radioactive Materials; Deux Cas d'Exposition Professionnelle Chronique a des Matieres Radioactives; 0414 0412 0414 ; Dos Casos de Exposicion Cronica Profesional a Sustancias Radiactivas

Abstract

This paper describes the results and interpretation of measurements of radioactivity in the bodies and in the excreta of two subjects with a long (up to 16 yr) history of exposure to radium-226, strontium-90 and thorium-228. Measurements were made in 1957, 1959, 1960 and 1963. The radium content of subject A showed no perceptible decrease between 1957 (0.13 {mu}c) and 1963 (0.14 {mu}c), and it was more than 30% higher in 1959. The excretion rate observed in 1957 was consistent, on the power function retention model, with a chronic intake of about 2 nc/d for the previous 10 yr, while the much lower excretion rate in 1963 indicated that there had not been a recent intake. The radium content of subject B decreased from 1.19 {mu}c in 1959 to 1.07 {mu}c in 1963, at a rate corresponding to a biological half-life of about 25 yr, yet the excretion rate in 1963 suggested a much faster fall in body content. This suggested that there had been a small intake of radium not long before. The strontium-90 content of subject A decreased. from 5.0 {mu}c in 1957 to 3.0 {mu}c in 1963, corresponding to a biological half-life of about 9 yr. Consideration  More>>
Authors:
Rundo, J. [1] 
  1. United Kingdom Atomic Energy Authority, Atomic Energy Research Establishment, Harwell, Berks. (United Kingdom)
Publication Date:
Nov 15, 1964
Product Type:
Conference
Report Number:
IAEA-SM-52/5
Resource Relation:
Conference: Symposium on the Assessment of Radioactive Body Burdens, Heidelberg (Germany), 11-16 May 1964; Other Information: 27 refs., 6 figs., 5 figs.; Related Information: In: Assessment of Radioactivity in Man. Vol. II. Proceedings of the Symposium on the Assessment of Radioactive Body Burdens| 671 p.
Subject:
61 RADIATION PROTECTION AND DOSIMETRY; BIOLOGICAL HALF-LIFE; CHRONIC INTAKE; EXCRETION; MAN; NUCLEAR DECAY; OCCUPATIONAL EXPOSURE; RADIOACTIVE MATERIALS; RADIONUCLIDE KINETICS; RADIUM; RADIUM 226; RETENTION; STRONTIUM 90; THORIUM 228
OSTI ID:
22200057
Research Organizations:
International Atomic Energy Agency, Vienna (Austria); International Labour Organisation, Geneva (Switzerland); World Health Organization, Geneva (Switzerland)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
Other: ISSN 0074-1884; TRN: XA13M3263020880
Submitting Site:
INIS
Size:
page(s) 291-306
Announcement Date:
Feb 27, 2014

Citation Formats

Rundo, J. Two Cases of Chronic Occupational Exposure to Radioactive Materials; Deux Cas d'Exposition Professionnelle Chronique a des Matieres Radioactives; 0414 0412 0414 ; Dos Casos de Exposicion Cronica Profesional a Sustancias Radiactivas. IAEA: N. p., 1964. Web.
Rundo, J. Two Cases of Chronic Occupational Exposure to Radioactive Materials; Deux Cas d'Exposition Professionnelle Chronique a des Matieres Radioactives; 0414 0412 0414 ; Dos Casos de Exposicion Cronica Profesional a Sustancias Radiactivas. IAEA.
Rundo, J. 1964. "Two Cases of Chronic Occupational Exposure to Radioactive Materials; Deux Cas d'Exposition Professionnelle Chronique a des Matieres Radioactives; 0414 0412 0414 ; Dos Casos de Exposicion Cronica Profesional a Sustancias Radiactivas." IAEA.
@misc{etde_22200057,
title = {Two Cases of Chronic Occupational Exposure to Radioactive Materials; Deux Cas d'Exposition Professionnelle Chronique a des Matieres Radioactives; 0414 0412 0414 ; Dos Casos de Exposicion Cronica Profesional a Sustancias Radiactivas}
author = {Rundo, J.}
abstractNote = {This paper describes the results and interpretation of measurements of radioactivity in the bodies and in the excreta of two subjects with a long (up to 16 yr) history of exposure to radium-226, strontium-90 and thorium-228. Measurements were made in 1957, 1959, 1960 and 1963. The radium content of subject A showed no perceptible decrease between 1957 (0.13 {mu}c) and 1963 (0.14 {mu}c), and it was more than 30% higher in 1959. The excretion rate observed in 1957 was consistent, on the power function retention model, with a chronic intake of about 2 nc/d for the previous 10 yr, while the much lower excretion rate in 1963 indicated that there had not been a recent intake. The radium content of subject B decreased from 1.19 {mu}c in 1959 to 1.07 {mu}c in 1963, at a rate corresponding to a biological half-life of about 25 yr, yet the excretion rate in 1963 suggested a much faster fall in body content. This suggested that there had been a small intake of radium not long before. The strontium-90 content of subject A decreased. from 5.0 {mu}c in 1957 to 3.0 {mu}c in 1963, corresponding to a biological half-life of about 9 yr. Consideration of a power function retention model for strontium in man showed that the findings were consistent with a chronic intake for four years up to 1957 and then no further large intake, although as the excretion rate observed in 1963 was at least five times greater than that calculated there may have been a small intake shortly before the measurements in 1963. The retention of strontium-90 by subject B indicated a biological half-life of about 6 yr, agreeing with that deduced from the excretion rate (4.5 - 8.0 yr). After an initial four-fold increase, the thorium-228 content of subject A decreased exponentially between 1959 and 1963 with an effective half-life of at least 1.4 yr. Subject B's content increased from 1959 to 1960, but the decrease from 1960 to 1963 was not significantly different from that due to radioactive decay with a half-life of 1.90 yr. The paper concludes with a discussion of the value of the exponent in the power function retention equation for radium in man. (author) [French] L'auteur donne les resultats et une interpretation de dosages de l'activite du corps et des excreta pour deux sujets qui avaient ete exposes longtemps (jusqu'a 16 a) au radium 226, au strontium 90 et au thorium 228. Les dosages ont ete faits en 1957, 1959, 1960 et 1963. La charge de radium.du sujet A n-'a accuse aucune diminution perceptible entre 1957 (0,13 {mu}c) et 1963 (0,14 {mu}c), et en 1959 elle etait plus elevee dans une proportion superieure a 30%. Le taux d'excretion observe en 1957 etait compatible, selon le modele de retention de la fonction de puissance, avec une absorption chronique d'environ 2 nc/j pendant les 10 annees precedentes, alors que le taux d'excretion beaucoup moins eleve pour 1963 indiquait qu'il n'y avait pas eu absorption recente. La charge de radium du sujet B a passe de 1,19 pc en 1959 a 1,07 {mu}c en 1963, la vitesse de la diminution correspondant a une periode biologique d'environ 25 a, mais le taux d'excretion determine en 1963 donnait a penser que la charge corporelle diminuerait beaucoup plus rapidement et que, par consequent, il y avait eu absorption d'une petite quantite de radium peu de temps auparavant. La charge de strontium 90 chez le sujet A est tombee de 5,0 {mu}c en 1957 a 3,0 {mu}c en 1963, ce qui correspond a une periode biologique d'environ 9 a. L'etude d'une fonction de puissance, comme modele de retention du strontium chez l'homme, a montre que les resultats etaient compatibles avec une absorption chronique pendant 4 a jusqu'en 1957 sans aucune absorption importante apres cette date, bien qu'il ait pU'y avoir une petite absorption peu avant le dosage fait en 1963, le taux d'excretion observe en 1963 etant au moins cinq fois plus important que le taux calcule. La retention du strontium 90 par le sujet B indiquait une periode biologique d'environ six ans, ce qui est conforme a la valeur deduite du taux d'excretion (4,5 - 8,0 a). Apres un accroissement initial quadruple, la charge de thorium 228 chez le sujet A a decru selon une courbe exponentielle entre 1959 et 1963 avec une periode effective d'au moins 1,4 a. La charge chez le sujet B a augmente de 1959 a 1960, mais la diminution de 1960 a la 63 n'etait pas sensiblement differente de celle qui etait due a la decroissance radioactive avec une periode de 1,90 a. L'auteur termine en etudiant la valeur de l'exposant dans la fonction de puissance utilisee comme modele de retention du radium chez l'homme. (author) [Spanish] En la memoria se exponen los resultados y la interpretacion de las mediciones de la radiactividad del organismo y de las excreciones de dos sujetos con un largo historial (hasta 16 anos) de exposicion al'radio-226, al estroncio-90 y al torio-228. Las mediciones se efectuaron en 1957, 1959, 1960 y 1963. 4 El contenido de radio del sujeto A no acuso ninguna disminucion apreciable entre 1957 (0,13 {mu}c) y 1963 (0,14 {mu}c), en 1959 presento en cambio un aumento superior al 30%. La velocidad de excrecion observada en 1957 era compatible, con arreglo al modelo de retencion exponencial, con una absorcion de caracter cronico de unos 2 nc/d durante los 10 a precedentes, mientras que la velocidad de excrecion mucho mas baja-observada en 1963 indicaba la ausencia'de absorcion reciente. Por su parte el contenido de radio del sujeto B disminuyo de 1,19 {mu}c en 1959 a 1,07 {mu}c en 1963, a un ritmo que corresponde a un periodo biologico de 25 a; no obstante la velocidad de excrecion observada en 1963 parece indicar una disminucion mucho-mas rapida dela carga corporal. Este hecho sugiere que se habia producido una pequena absorcion de radio poco tiempo antes. El contenido de estroncio-90 del sujeto A paso de 5,0 {mu}c en 1957 a 3,0 {mu}c en 1963, lo que corresponde a un periodo biologico de unos 9. a. La aplicacion de un modelo de retencion exponencial para calcular el contenido de estroncio en el organismo humano mostro que los resultados eran compatibles con una absorcion cronica que duro 4 anos (hasta 1957), y que despues de esta ultima fecha no habia habido absorcion considerable, sin embargo como la velocidad de excrecion observada en 1963 fue cinco veces mayor, como minimo, que la calculada, pudiera haber habido alguna pequefla absorcion poco antes de efectuar las mediciones en 1963. La retencion de estroncio-90 por el sujeto B puso de manifiesto un perfodo biologico de unos 6 a, lo que concuerda con el valor calculado a partir de la velocidad de excrecion (4,5 a 8,0 a). Despues de un aumento inicial del cuadruple, el contenido de torio-228 del sujeto A disminuyo exponencialmente entre 1959 y 1963 con un periodo efectivo de 1,4 a, como mfnimo. El contenido del sujeto B aumento de 1959 a 1960, pero la disminucion registrada de 1950 a 1963 no se diferencio apreciablemente de la debida a la desintegracion radiactiva con un perfodo de 1,90 a. La memoria termina con una discusion del valor del exponente de la ecuacion que expresa en forma exponencial la retencion de radio en el organismo humano. (author) [Russian] V doklade privodjatsja rezul'taty i interpretacija izmerenij radioaktivnosti organizma i vydelenij u dvuh chelovek s dlitel'noj (do 16 let) istoriej obluchenija radiem-226, stronciem-90 i toriem-228. Izmerenija proizvodilis' v techenie 1957, 1959, 1960 i 1963 godov. U pacienta A ne obnaruzheno zametnogo snizhenija soderzhanija radija v period mezhdu 1957 (0,13 mkkju.ri) i 1963 (0.14 mkkjuri), v 1959 ono bylo na 30%vyshe. Skorost' vydelenija v 1957 godu byla znachitel'noj soglasno modeli zaderzhki, vychislennoj s pomoshh'ju uravnenija silovoj funkcii, pri hronicheskom pogloshhenii porjadka 2 mkkjuri v den' v techenie predydushhih desjati let. Znachitel'no bolee nizkaja skorost' vydelenija nabljudalas' v 1963 godu, chto ukazyvaet na otsutstvie novogo postuplenija izotopa. Soderzhanie radija u pacienta V snizilos' s 1,19 mkkjuri v 1959 godu do 1,07 mkkjuri v 1963 godu so skorost'ju, sootvetstvujushhej periodu poluvyvedenija okolo 25 let, hotja skorost' vydelenija v 1963 godu ukazyvala na znachitel'no bolee bystroe umen'shenie soderzhanija izotopa v organizme. Jeto ukazyvaet na to, chto nezadolgo do jetogo imelo mesto pogloshhenie malyh kolichestv radija. Soderzhanie stroncija-90 u pacienta A snizilos' s 5,0 mkkjuri v 1957 godu do 3,0 mkkjuri v 1963 godu, chto sootvetstvuet periodu poluvyvedenija v 9 let. Rassmotrenie modeli zaderzhki stroncija u cheloveka s pomoshh'ju uravnenija silovyh funkcij pokazalo, chto jeti dannye sootvetstvujut hronicheskomu pogloshheniju v techenie 4 let do 1957 goda, i chto zatem ne proishodilo znachitel'nogo pogloshhenija, hotja, poskol'ku skorost' vydelenija v 1963 godu byla po men'shej mere v 5 raz bol'she ras schitannoj, moglo imet' mesto pogloshhenie malyh kolichestv izotopa do nachala izmerenij v 1963 godu. Zaderzhka stroncija-90 u pacienta V sootvetstvuet periodu poluvyvedenija okolo 6 let, chto soglasuetsja s velichinoj, poluchennoj na osnovanii skorosti vydelenija (4,5-8 let). Posle nachal'nogo chetyrehkratnogo povyshenija soderzhanija torija-228 u pacienta A snizhalos' jeksponencial'no v period mezhdu 1959 i 1963 godami s jeffektivnym periodom poluvyvedenija ne menee 1,4 goda. Soderzhanie ego u pacienta V povysilos' v period s 1959 do 1963 goda, no snizhenie v period s 1960 po 1963 ne otlichalos' znachitel'no ot urovnja, opredeljaemogo radioaktivnym raspadom s periodom poluraspada 1,9 let. Obsuzhdaetsja znachenie jeksponenty v uravnenii silovoj funkcii dlja zaderzhki radija u cheloveka. (author)}
place = {IAEA}
year = {1964}
month = {Nov}
}