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The Effect of Chlorothiazide on Caesium-137 Excretion in Human Subjects; Effet de la Chiorothiazide sur l'Elimination du Cesium 137 chez l'Homme; 0412 041b 0414 ; Influencia de la Ciorotiazida sobre la Excrecion de Cesio en el Hombre

Conference:

Abstract

The present study was carried out to determine factors that influence caesium metabolism in normal human subjects with particular interest in finding a therapeutic regimen for reducing the body burden of caesium. Since caesium and potassium are chemically similar, and are both localized in the intracellular compartment of the body, principally in muscle, it seemed possible that chlorothiazide, which has a marked potassium diuretic effect, might also increase caesium excretion. Four normal subjects were given a single dose of 0.1 {mu}c of caesium-137 by mouth. Two subjects were given chlorothiazide 2.0 g/d for a total of three consecutive days starting 1 h after the caesium intake. The chlorothiazide dose was repeated at two weeks. The other two subjects were used as controls. The body burden of caesium-137 was measured by a whole-body counter at intervals up to 320 d. Daily urine collections were made for three control days and 20 d following caesium intake. The samples were analysed for electrolytes and caesium activity. Although chlorothiazide increased K excretion to 1. 5 times the control values, it had no significant effect on caesium excretion or in reducing the body burden of caesium. In all subjects a small fraction of caesium (10-20%)  More>>
Authors:
Harrison, Joan; McNeill, K. G. [1] 
  1. Departments of Medicine and Physics, University of Toronto, ON (Canada)
Publication Date:
Nov 15, 1964
Product Type:
Conference
Report Number:
IAEA-SM-52/45
Resource Relation:
Conference: Symposium on the Assessment of Radioactive Body Burdens, Heidelberg (Germany), 11-16 May 1964; Other Information: 11 refs., 2 figs., 2 tabs.; Related Information: In: Assessment of Radioactivity in Man. Vol. II. Proceedings of the Symposium on the Assessment of Radioactive Body Burdens| 671 p.
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; AZIDES; BASAL METABOLISM; BIOLOGICAL HALF-LIFE; BODY BURDEN; CESIUM 137; DIURETICS; ELECTROLYTES; EXCRETION; INTAKE; KIDNEYS; MUSCLES; ORAL CAVITY; POTASSIUM; RADIATION DOSES; RADIONUCLIDE KINETICS; URINE; WHOLE-BODY COUNTERS
OSTI ID:
22200041
Research Organizations:
International Atomic Energy Agency, Vienna (Austria); International Labour Organisation, Geneva (Switzerland); World Health Organization, Geneva (Switzerland)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
Other: ISSN 0074-1884; TRN: XA13M3247020864
Submitting Site:
INIS
Size:
page(s) 89-96
Announcement Date:
Feb 27, 2014

Conference:

Citation Formats

Harrison, Joan, and McNeill, K. G. The Effect of Chlorothiazide on Caesium-137 Excretion in Human Subjects; Effet de la Chiorothiazide sur l'Elimination du Cesium 137 chez l'Homme; 0412 041b 0414 ; Influencia de la Ciorotiazida sobre la Excrecion de Cesio en el Hombre. IAEA: N. p., 1964. Web.
Harrison, Joan, & McNeill, K. G. The Effect of Chlorothiazide on Caesium-137 Excretion in Human Subjects; Effet de la Chiorothiazide sur l'Elimination du Cesium 137 chez l'Homme; 0412 041b 0414 ; Influencia de la Ciorotiazida sobre la Excrecion de Cesio en el Hombre. IAEA.
Harrison, Joan, and McNeill, K. G. 1964. "The Effect of Chlorothiazide on Caesium-137 Excretion in Human Subjects; Effet de la Chiorothiazide sur l'Elimination du Cesium 137 chez l'Homme; 0412 041b 0414 ; Influencia de la Ciorotiazida sobre la Excrecion de Cesio en el Hombre." IAEA.
@misc{etde_22200041,
title = {The Effect of Chlorothiazide on Caesium-137 Excretion in Human Subjects; Effet de la Chiorothiazide sur l'Elimination du Cesium 137 chez l'Homme; 0412 041b 0414 ; Influencia de la Ciorotiazida sobre la Excrecion de Cesio en el Hombre}
author = {Harrison, Joan, and McNeill, K. G.}
abstractNote = {The present study was carried out to determine factors that influence caesium metabolism in normal human subjects with particular interest in finding a therapeutic regimen for reducing the body burden of caesium. Since caesium and potassium are chemically similar, and are both localized in the intracellular compartment of the body, principally in muscle, it seemed possible that chlorothiazide, which has a marked potassium diuretic effect, might also increase caesium excretion. Four normal subjects were given a single dose of 0.1 {mu}c of caesium-137 by mouth. Two subjects were given chlorothiazide 2.0 g/d for a total of three consecutive days starting 1 h after the caesium intake. The chlorothiazide dose was repeated at two weeks. The other two subjects were used as controls. The body burden of caesium-137 was measured by a whole-body counter at intervals up to 320 d. Daily urine collections were made for three control days and 20 d following caesium intake. The samples were analysed for electrolytes and caesium activity. Although chlorothiazide increased K excretion to 1. 5 times the control values, it had no significant effect on caesium excretion or in reducing the body burden of caesium. In all subjects a small fraction of caesium (10-20%) was excreted rapidly with a biological half-life (T),) of less than 1 d. The remainder was excreted at a constant rate with T{sub b} of 90 to 155 d. More than 70% of the caesium eliminated from the body per day was excreted by the kidney. T{sub b} of K was also calculated by the formula T{sub bK} = Total body K/Urine K x 0,693 x 0,8 assuming 80% of the total potassium excreted is by kidney. Tb of K was 35 to 42 d. The discrimination ratio T{sub bCs}/T{sub bK} was 2.1 to 3.8. These results demonstrate that caesium and potassium are not utilized interchangeably. Caesium is retained preferentially over potassium and changes in potassium turnover have no effect on caesium turnover. Studies are being carried out at the present time to determine the effect of basal metabolism on caesium excretion and these results will also be reported. (author) [French] L'etude avait pour objet de determiner les facteurs qui influent sur le metabolisme du cesium chez des sujets normaux, en vue notamment d'etablir une therapie qui permettrait de reduite la charge corporelle de cesium. Etant donne que le cesium et le potassium sont chimiquement semblables et qu'ils sont localises l'un et l'autre dans le compartiment intracellulaire de l'organisme, principalement dans le tissu musculaire, il a semble aux auteurs que la chlorothiazide, qui stimule fortement l'elimination urinaire du potassium, pouvait augmenter aussi la quantite de cesium elimine. Ils ont administre a quatre sujets normaux une dose unique de 0,1 {mu}c. de cesium 137 par voie buccale. Deux des sujets ont alors recu de la chlorothiazide a raison de 2,0 g/j pendant trois jours consecutifs, a compter d'une heure apres l'absorption du cesium. La dose de chlorothiazide a ete administree a nouveau apres deux semaines. Les deux autres sujets ont servi de temoins. La charge corporelle de cesium 137 a ete mesuree a l'aide d'un anthropogammametre, 3 des intervalles de temps allant jusqu'a 320 j. Les auteurs ont recueilli les urines de 24 h, d'abord pendant trois jours a des fins de controle, puis pendant les 20 j qui ont suivi l'absorption de cesium. Ils ont analyse les echantillons afin de determiner les electrolytes et l'activite du cesium. la chlorothiazide a augmente la quantite de potassium eliminee, qui a atteint jusqu'a 1,5 fois les valeurs temoins, mais elle n'a pas eu d'effet significatif sur l'elimination du cesium et n'a pas non plus reduit sensiblement la charge corporelle de cesium. Chez tous les sujets, une faible fraction de Cs (10 a 20%) a ete eliminee rapidement, la periode biologique (T{sub b}) etant inferieure a 1 j. Le reste a ete elimine a un taux constant, Tb etant de 90 a 155 j. Plus de 70 Degree-Sign jo du cesium elimine quotidiennement par l'organisme a ete evacue par voie renale. Les auteurs ont egalement calcule T{sub b} de K en appliquant la formule T{sub bK} = Total body K/Urine K x 0,693 x 0,8 en supposant que 80% potassium elimine l'est-par voie renale. de K etait de 35 a 42 j. Le rapport T{sub bCs}/T{sub bK} etait de 2,1 a 3,8. Il ressort de ces resultats que le cesium et le potassium ne sont pas utilises indifferemment. Le cesium est retenu de preference au potassium et les variations du taux de renouvellement du potassium n'affectent pas le renouvellement du cesium. Les auteurs poursuivent actuellement des etudes, visant a determiner l'effet du metabolisme basai sur l'elimination du cesium; ils en presenteront egalement les conclusions. (author) [Spanish] Los autores procuraron determinar los factores que influyen en el metabolismo del cesio en sujetos humanos normales, y se dedicaran particularmente a encontrar un regimen terapeutico tendiente a reducir la carga corporal de cesio. Dado que el cesio y el potasio son quimicamente semejantes y ambos se localizan en los compartimientos intracelulares del cuerpo, principalmente en los musculos, se estimo posible que la clorotiazida, que ejerce un efecto diuretico notable sobre el potasio, pueda fomentar tambien la excrecion de cesio. Se administro por via oral una dosis unica de 0,1 pe de cesio-137 a 4 sujetos normales, A dos de ellos se les dio clorotiazida a razon de 2,0 g/d, durante tres dias consecutivos en total, comenzando una hora despues de la administracion de cesio. La dosis de clorotiazida se repitio a las dos semanas. Los otros dos sujetos sirvieron de testigos. Mediante un antropogammametro se midio periodicamente la carga corporal de cesio-137 por espacio de 320 d. Se recogieron muestras diarias de orina, primeramente durante 3 d, como referencia, antes del tratamiento, y luego, durante 20 d a contar de la administracion de cesio. En las muestras se determinaron los Inverted-Question-Mark lectrolitos y la actividad del cesio. Por mas que la clorotiazida incremento la excrecion de potasio hasta 1,5 veces con respecto a los valores de referencia, no se comprobo que tuviera ningun efecto apreciable sobre la excrecion de cesio ni que redujera la carga corporal del mismo. Todos los sujetos excretaron rapidamente una pequena fraccion de cesio (10 a 20%) con un perfodo biologico (T{sub b}) inferior aid. El resto fue excretado en proporcion'constante con un de 90 a 155 d. Mas del 70% del cesio se excreto diariamente por via renal. El T{sub b} del potasio se calculo tambien por la formula: T{sub bK} = Total body K/Urine K x 0,693 x 0,8 admitiendo que el 80%-del potasio total excretado lo sea por via renal. El T{sub b} del K fue de 35 a 42 d. La razon de discriminacion T{sub bCs}/T{sub bK} escilo entre 2,1 y 3,8. Estos resultados demuestran que el cesio y el potasio no se utilizan de manera intercambiable. El cesio es retenido con preferencia al potasio y las alteraciones de la renovacion del potasio no ejercen ninguna influencia sobre la del cesio. Los autores prosiguen actualmente sus estudios con el proposito de determinar el efectp del metabolismo basal sobre la excrecion de cesio y oportunamente daran los resultados a que lleguen. (author) [Russian] Cel'ju'raboty javljalos' opredelenie faktorov, vljajushhih na metabolizm cezija u zdorovyh ljudej,i, v chastnosti, opredelenie terapevticheskogo rezhima, vedushhego k umen'sheniju soderzhanija cezija v organizme. Poskol'ku cezij i kalij obladajut shodnymi himicheskimi svojstvami i oba raspolagajutsja vnutrikletochno, glavnym obrazom v myshcah, vpolne vozmozhno, chto hlortiazid, okazyvajushhij vyrazhennyj kalievyj diureticheskij jeffekt, mozhet uvelichivat' i vydelenie cezija. Chetvero obsleduemyh poluchili vnutr' odnokratno po 0,1 mkkjuri cezija-137. Dvoim iz nih davali hlortiazid po 2,0 g v den' v techenie 3 dnej cherez chas posle priema cezija. Priem hlortiazida povtorili cherez dve nedeli. Dvuh drugih obsleduemyh ispol'zovali v kachestve kontrolja. Soderzhanie cejeija-137 v organizme izmerjali s intervalami s pomoshh'ju schetchika dlja izmerenija radioaktivnosti vsego organizma do 320 dnej. Sbor sutochnogo kolichestva mochi proizvodilsja v techenie 3 kontrol'nyh dnej posle priema cezija. Obrazcy mochi issledovalis' na soderzhanie jelektrolitov i uroven' aktivnosti cezija. Hotja hlortiazid i povyshal v 1,5 raza po sravneniju s kontrolem vydelenie K, ok ne okazyval zametnogo vlijanija na vydelenie cezija ili umen'shenie ego soderzhanija v organizme. U vseh obsledovannyh nebol'shie frakcii cezija-137 (10 - 20%) vydeljalis' bystro s periodom poluvyvedenija (T{sub b}) menee odnogo dnja. Ostal'noe kolichestvo vydeljalos' s postojannoj skorost'ju pri T' ot 90 do 155 dnej. Bolee 70% vsego vydeljaemogo organizmom cezija za sutki vydeljaetsja pochkami. T{sub b} Dlja K takzhe vyschityvalos' po formule: T{sub bK} = Total body K/Urine K x 0,693 x 0,8 pri uslovii, chto 80% obshhego kolichestva kalija vydeljaetsja pochkami. T' dlja kalija sostavljalo ot 35 do 42 dnej, Kojefficient diskriminacii T{sub bC}/T{sub bK} sostavljal ot 2,1 do 3,8. Jeti rezul'taty pokazyvajut, chto ne sushhestvuet vzaimozamenjaemogo usvoenija cezija i kalija. Zaderzhka cezija proishodit v bol'shej stepeni po sravneniju s kaliem,i izmenenija v krugooborote kalija ne vlijajut na krugooborot cezija. V nastojashhee vremja provodjatsja issledovanija po opredeleniju vlijanija osnovnogo obmena na vydelenie cezija, o rezul'tatah kotorogo budet takzhe soobshheno. (author)}
place = {IAEA}
year = {1964}
month = {Nov}
}