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Role of obestatin on growth hormone secretion: An in vitro approach

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Abstract

Obestatin, the ghrelin-associated peptide, showed to activate MAPK signaling with no effect on Akt nor cell proliferating activity in rat tumor somatotroph cells (growth cells, GC). A sequential analysis of the obestatin transmembrane signaling pathway indicated a route involving the consecutive activation of G{sub i}, PI3k, novel PKC{epsilon}, and Src for ERK1/2 activation. Furthermore, obestatin treatment triggers growth hormone (GH) release in the first 30 min, being more acute at 15 min. At 1 h, obestatin treated cells showed the same levels in GH secretion than controls. Added to this functionality, obestatin was secreted by GC cells. Based on the capacity to stimulate GH release from somatotroph cells, obestatin may act directly in the pituitary through an autocrine/paracrine mechanism.
Authors:
Pazos, Yolanda; [1]  CIBER Fisiopatologia de la Obesidad y Nutricion (CB06/03), Instituto de Salud Carlos III (Spain)]; Alvarez, Carlos J.P.; [1]  CIBER Fisiopatologia de la Obesidad y Nutricion (CB06/03), Instituto de Salud Carlos III (Spain); Universidad de Santiago de Compostela (USC), Santiago de Compostela (Spain)]; Camina, Jesus P.; [1]  CIBER Fisiopatologia de la Obesidad y Nutricion (CB06/03), Instituto de Salud Carlos III (Spain)]; Al-Massadi, Omar; [1]  CIBER Fisiopatologia de la Obesidad y Nutricion (CB06/03), Instituto de Salud Carlos III (Spain); Universidad de Santiago de Compostela (USC), Santiago de Compostela (Spain)]; Seoane, Luisa M.; [1]  CIBER Fisiopatologia de la Obesidad y Nutricion (CB06/03), Instituto de Salud Carlos III (Spain)]; Casanueva, Felipe F.; [1]  CIBER Fisiopatologia de la Obesidad y Nutricion (CB06/03), Instituto de Salud Carlos III (Spain); Universidad de Santiago de Compostela (USC), Santiago de Compostela (Spain)]
  1. Area de Endocrinologia Molecular y Celular, Instituto de Investigacion Sanitaria (IDIS), Complejo Hospitalario Universitario de Santiago (CHUS), Santiago de Compostela (Spain)
Publication Date:
Dec 25, 2009
DOI:
https://doi.org/10.1016/J.BBRC.2009.10.163
Product Type:
Journal Article
Resource Relation:
Journal Name: Biochemical and Biophysical Research Communications; Journal Volume: 390; Journal Issue: 4; Other Information: Copyright (c) 2009 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Subject:
60 APPLIED LIFE SCIENCES; ADP; AMP; CATTLE; CHOLERA; EPITHELIUM; GTP-ASES; IN VITRO; NEOPLASMS; PEPTIDES; PHOSPHOTRANSFERASES; PYRIMIDINES; RATS; RECEPTORS; RHODOPSIN; SERINE; STH; TOXINS
OSTI ID:
22199948
Country of Origin:
United States
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0006-291X; CODEN: BBRCA9; Other: PII: S0006-291X(09)02154-8; TRN: US10R0161020771
Availability:
Available from http://dx.doi.org/10.1016/j.bbrc.2009.10.163
Submitting Site:
USN
Size:
page(s) 1377-1381
Announcement Date:
Feb 27, 2014

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Citation Formats

Pazos, Yolanda, CIBER Fisiopatologia de la Obesidad y Nutricion (CB06/03), Instituto de Salud Carlos III (Spain)], Alvarez, Carlos J.P., CIBER Fisiopatologia de la Obesidad y Nutricion (CB06/03), Instituto de Salud Carlos III (Spain), Universidad de Santiago de Compostela (USC), Santiago de Compostela (Spain)], Camina, Jesus P., CIBER Fisiopatologia de la Obesidad y Nutricion (CB06/03), Instituto de Salud Carlos III (Spain)], Al-Massadi, Omar, CIBER Fisiopatologia de la Obesidad y Nutricion (CB06/03), Instituto de Salud Carlos III (Spain), Universidad de Santiago de Compostela (USC), Santiago de Compostela (Spain)], Seoane, Luisa M., CIBER Fisiopatologia de la Obesidad y Nutricion (CB06/03), Instituto de Salud Carlos III (Spain)], Casanueva, Felipe F., CIBER Fisiopatologia de la Obesidad y Nutricion (CB06/03), Instituto de Salud Carlos III (Spain), and Universidad de Santiago de Compostela (USC), Santiago de Compostela (Spain)]. Role of obestatin on growth hormone secretion: An in vitro approach. United States: N. p., 2009. Web. doi:10.1016/J.BBRC.2009.10.163.
Pazos, Yolanda, CIBER Fisiopatologia de la Obesidad y Nutricion (CB06/03), Instituto de Salud Carlos III (Spain)], Alvarez, Carlos J.P., CIBER Fisiopatologia de la Obesidad y Nutricion (CB06/03), Instituto de Salud Carlos III (Spain), Universidad de Santiago de Compostela (USC), Santiago de Compostela (Spain)], Camina, Jesus P., CIBER Fisiopatologia de la Obesidad y Nutricion (CB06/03), Instituto de Salud Carlos III (Spain)], Al-Massadi, Omar, CIBER Fisiopatologia de la Obesidad y Nutricion (CB06/03), Instituto de Salud Carlos III (Spain), Universidad de Santiago de Compostela (USC), Santiago de Compostela (Spain)], Seoane, Luisa M., CIBER Fisiopatologia de la Obesidad y Nutricion (CB06/03), Instituto de Salud Carlos III (Spain)], Casanueva, Felipe F., CIBER Fisiopatologia de la Obesidad y Nutricion (CB06/03), Instituto de Salud Carlos III (Spain), & Universidad de Santiago de Compostela (USC), Santiago de Compostela (Spain)]. Role of obestatin on growth hormone secretion: An in vitro approach. United States. https://doi.org/10.1016/J.BBRC.2009.10.163
Pazos, Yolanda, CIBER Fisiopatologia de la Obesidad y Nutricion (CB06/03), Instituto de Salud Carlos III (Spain)], Alvarez, Carlos J.P., CIBER Fisiopatologia de la Obesidad y Nutricion (CB06/03), Instituto de Salud Carlos III (Spain), Universidad de Santiago de Compostela (USC), Santiago de Compostela (Spain)], Camina, Jesus P., CIBER Fisiopatologia de la Obesidad y Nutricion (CB06/03), Instituto de Salud Carlos III (Spain)], Al-Massadi, Omar, CIBER Fisiopatologia de la Obesidad y Nutricion (CB06/03), Instituto de Salud Carlos III (Spain), Universidad de Santiago de Compostela (USC), Santiago de Compostela (Spain)], Seoane, Luisa M., CIBER Fisiopatologia de la Obesidad y Nutricion (CB06/03), Instituto de Salud Carlos III (Spain)], Casanueva, Felipe F., CIBER Fisiopatologia de la Obesidad y Nutricion (CB06/03), Instituto de Salud Carlos III (Spain), and Universidad de Santiago de Compostela (USC), Santiago de Compostela (Spain)]. 2009. "Role of obestatin on growth hormone secretion: An in vitro approach." United States. https://doi.org/10.1016/J.BBRC.2009.10.163.
@misc{etde_22199948,
title = {Role of obestatin on growth hormone secretion: An in vitro approach}
 author = {Pazos, Yolanda, CIBER Fisiopatologia de la Obesidad y Nutricion (CB06/03), Instituto de Salud Carlos III (Spain)], Alvarez, Carlos J.P., CIBER Fisiopatologia de la Obesidad y Nutricion (CB06/03), Instituto de Salud Carlos III (Spain), Universidad de Santiago de Compostela (USC), Santiago de Compostela (Spain)], Camina, Jesus P., CIBER Fisiopatologia de la Obesidad y Nutricion (CB06/03), Instituto de Salud Carlos III (Spain)], Al-Massadi, Omar, CIBER Fisiopatologia de la Obesidad y Nutricion (CB06/03), Instituto de Salud Carlos III (Spain), Universidad de Santiago de Compostela (USC), Santiago de Compostela (Spain)], Seoane, Luisa M., CIBER Fisiopatologia de la Obesidad y Nutricion (CB06/03), Instituto de Salud Carlos III (Spain)], Casanueva, Felipe F., CIBER Fisiopatologia de la Obesidad y Nutricion (CB06/03), Instituto de Salud Carlos III (Spain), and Universidad de Santiago de Compostela (USC), Santiago de Compostela (Spain)]}
 abstractNote = {Obestatin, the ghrelin-associated peptide, showed to activate MAPK signaling with no effect on Akt nor cell proliferating activity in rat tumor somatotroph cells (growth cells, GC). A sequential analysis of the obestatin transmembrane signaling pathway indicated a route involving the consecutive activation of G{sub i}, PI3k, novel PKC{epsilon}, and Src for ERK1/2 activation. Furthermore, obestatin treatment triggers growth hormone (GH) release in the first 30 min, being more acute at 15 min. At 1 h, obestatin treated cells showed the same levels in GH secretion than controls. Added to this functionality, obestatin was secreted by GC cells. Based on the capacity to stimulate GH release from somatotroph cells, obestatin may act directly in the pituitary through an autocrine/paracrine mechanism.}
 doi = {10.1016/J.BBRC.2009.10.163}
 journal = []
 issue = {4}
 volume = {390}
 journal type = {AC}
 place = {United States}
 year = {2009}
 month = {Dec}
 }