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ETDEWEB   /       /    Unlike PPAR{gamma}, PPAR{alpha} or PPAR{beta}/{delta} activation does not promote human monocyte differentiation toward alternative macrophages

Unlike PPAR{gamma}, PPAR{alpha} or PPAR{beta}/{delta} activation does not promote human monocyte differentiation toward alternative macrophages

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Abstract

Macrophages adapt their response to micro-environmental signals. While Th1 cytokines promote pro-inflammatory M1 macrophages, Th2 cytokines promote an 'alternative' anti-inflammatory M2 macrophage phenotype. Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors expressed in macrophages where they control the inflammatory response. It has been shown that PPAR{gamma} promotes the differentiation of monocytes into anti-inflammatory M2 macrophages in humans and mice, while a role for PPAR{beta}/{delta} in this process has been reported only in mice and no data are available for PPAR{alpha}. Here, we show that in contrast to PPAR{gamma}, expression of PPAR{alpha} and PPAR{beta}/{delta} overall does not correlate with the expression of M2 markers in human atherosclerotic lesions, whereas a positive correlation with genes of lipid metabolism exists. Moreover, unlike PPAR{gamma}, PPAR{alpha} or PPAR{beta}/{delta} activation does not influence human monocyte differentiation into M2 macrophages in vitro. Thus, PPAR{alpha} and PPAR{beta}/{delta} do not appear to modulate the alternative differentiation of human macrophages.
Authors:
Bouhlel, Mohamed Amine; [1]  Inserm U545, F-59000 Lille; [2]  UDSL, F-59000 Lille; [2]  Institut Pasteur de Lille, F-59019 Lille (France)]; Brozek, John; [3]  Derudas, Bruno; [1]  Inserm U545, F-59000 Lille; [2]  UDSL, F-59000 Lille; [2]  Institut Pasteur de Lille, F-59019 Lille (France)]; Zawadzki, Christophe; Jude, Brigitte; [4]  Staels, Bart; [1]  Inserm U545, F-59000 Lille; [2]  UDSL, F-59000 Lille; [2]  Institut Pasteur de Lille, F-59019 Lille (France)]; Chinetti-Gbaguidi, Giulia; [1]  Inserm U545, F-59000 Lille; [2]  UDSL, F-59000 Lille; [2]  Institut Pasteur de Lille, F-59019 Lille (France)]
  1. Univ Lille Nord de France, F-59000 Lille (France)
  2. France
  3. Genfit, Loos (France)
  4. Inserm ERI-9 and Equipe d'Accueil 2693, IFR114, Universite de Lille, Lille (France)
Publication Date:
Aug 28, 2009
DOI:
https://doi.org/10.1016/J.BBRC.2009.06.047
Product Type:
Journal Article
Resource Relation:
Journal Name: Biochemical and Biophysical Research Communications; Journal Volume: 386; Journal Issue: 3; Other Information: Copyright (c) 2009 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Subject:
60 APPLIED LIFE SCIENCES; ARTERIOSCLEROSIS; IN VITRO; INFLAMMATION; LIGANDS; LIPIDS; LYMPHOKINES; MACROPHAGES; METABOLISM; MICE; MONOCYTES; PHENOTYPE; RECEPTORS; SIGNALS; TRANSCRIPTION FACTORS
OSTI ID:
22199774
Country of Origin:
United States
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0006-291X; CODEN: BBRCA9; Other: PII: S0006-291X(09)01185-1; TRN: US09R1763020597
Availability:
Available from http://dx.doi.org/10.1016/j.bbrc.2009.06.047
Submitting Site:
USN
Size:
page(s) 459-462
Announcement Date:
Feb 27, 2014

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Citation Formats

Bouhlel, Mohamed Amine, Inserm U545, F-59000 Lille, UDSL, F-59000 Lille, Institut Pasteur de Lille, F-59019 Lille (France)], Brozek, John, Derudas, Bruno, Inserm U545, F-59000 Lille, UDSL, F-59000 Lille, Institut Pasteur de Lille, F-59019 Lille (France)], Zawadzki, Christophe, Jude, Brigitte, Staels, Bart, Inserm U545, F-59000 Lille, UDSL, F-59000 Lille, Institut Pasteur de Lille, F-59019 Lille (France)], Chinetti-Gbaguidi, Giulia, Inserm U545, F-59000 Lille, UDSL, F-59000 Lille, and Institut Pasteur de Lille, F-59019 Lille (France)]. Unlike PPAR{gamma}, PPAR{alpha} or PPAR{beta}/{delta} activation does not promote human monocyte differentiation toward alternative macrophages. United States: N. p., 2009. Web. doi:10.1016/J.BBRC.2009.06.047.
Bouhlel, Mohamed Amine, Inserm U545, F-59000 Lille, UDSL, F-59000 Lille, Institut Pasteur de Lille, F-59019 Lille (France)], Brozek, John, Derudas, Bruno, Inserm U545, F-59000 Lille, UDSL, F-59000 Lille, Institut Pasteur de Lille, F-59019 Lille (France)], Zawadzki, Christophe, Jude, Brigitte, Staels, Bart, Inserm U545, F-59000 Lille, UDSL, F-59000 Lille, Institut Pasteur de Lille, F-59019 Lille (France)], Chinetti-Gbaguidi, Giulia, Inserm U545, F-59000 Lille, UDSL, F-59000 Lille, & Institut Pasteur de Lille, F-59019 Lille (France)]. Unlike PPAR{gamma}, PPAR{alpha} or PPAR{beta}/{delta} activation does not promote human monocyte differentiation toward alternative macrophages. United States. https://doi.org/10.1016/J.BBRC.2009.06.047
Bouhlel, Mohamed Amine, Inserm U545, F-59000 Lille, UDSL, F-59000 Lille, Institut Pasteur de Lille, F-59019 Lille (France)], Brozek, John, Derudas, Bruno, Inserm U545, F-59000 Lille, UDSL, F-59000 Lille, Institut Pasteur de Lille, F-59019 Lille (France)], Zawadzki, Christophe, Jude, Brigitte, Staels, Bart, Inserm U545, F-59000 Lille, UDSL, F-59000 Lille, Institut Pasteur de Lille, F-59019 Lille (France)], Chinetti-Gbaguidi, Giulia, Inserm U545, F-59000 Lille, UDSL, F-59000 Lille, and Institut Pasteur de Lille, F-59019 Lille (France)]. 2009. "Unlike PPAR{gamma}, PPAR{alpha} or PPAR{beta}/{delta} activation does not promote human monocyte differentiation toward alternative macrophages." United States. https://doi.org/10.1016/J.BBRC.2009.06.047.
@misc{etde_22199774,
title = {Unlike PPAR{gamma}, PPAR{alpha} or PPAR{beta}/{delta} activation does not promote human monocyte differentiation toward alternative macrophages}
 author = {Bouhlel, Mohamed Amine, Inserm U545, F-59000 Lille, UDSL, F-59000 Lille, Institut Pasteur de Lille, F-59019 Lille (France)], Brozek, John, Derudas, Bruno, Inserm U545, F-59000 Lille, UDSL, F-59000 Lille, Institut Pasteur de Lille, F-59019 Lille (France)], Zawadzki, Christophe, Jude, Brigitte, Staels, Bart, Inserm U545, F-59000 Lille, UDSL, F-59000 Lille, Institut Pasteur de Lille, F-59019 Lille (France)], Chinetti-Gbaguidi, Giulia, Inserm U545, F-59000 Lille, UDSL, F-59000 Lille, and Institut Pasteur de Lille, F-59019 Lille (France)]}
 abstractNote = {Macrophages adapt their response to micro-environmental signals. While Th1 cytokines promote pro-inflammatory M1 macrophages, Th2 cytokines promote an 'alternative' anti-inflammatory M2 macrophage phenotype. Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors expressed in macrophages where they control the inflammatory response. It has been shown that PPAR{gamma} promotes the differentiation of monocytes into anti-inflammatory M2 macrophages in humans and mice, while a role for PPAR{beta}/{delta} in this process has been reported only in mice and no data are available for PPAR{alpha}. Here, we show that in contrast to PPAR{gamma}, expression of PPAR{alpha} and PPAR{beta}/{delta} overall does not correlate with the expression of M2 markers in human atherosclerotic lesions, whereas a positive correlation with genes of lipid metabolism exists. Moreover, unlike PPAR{gamma}, PPAR{alpha} or PPAR{beta}/{delta} activation does not influence human monocyte differentiation into M2 macrophages in vitro. Thus, PPAR{alpha} and PPAR{beta}/{delta} do not appear to modulate the alternative differentiation of human macrophages.}
 doi = {10.1016/J.BBRC.2009.06.047}
 journal = []
 issue = {3}
 volume = {386}
 journal type = {AC}
 place = {United States}
 year = {2009}
 month = {Aug}
 }