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Stem-Cell Inactivation on Transplantation of Haemopoietic Cell Suspensions from Genetically Different Donors

Conference:

Abstract

The transplantation of a mixture of haemopoietic or lymphoid cells from two genetically different mice into lethally irradiated F{sub 1} recipients results in marked or total inactivation of the colony-forming units of the graft. This phenomenon is observed following transplantation of mixtures of spleen cells or bone-marrow cells from animals of different genotypes: CBA + C57BL, A + CBA, A + C57BL, C3H + C57BL, CBA + (CBA x C57BL) F{sub 1}. Maximum inactivation is observed when lymph-node cells of one genotype are transplanted with spleen or bone-marrow cells of another genotype. Use of non-syngenic kidney cells or lymphoid cells inactivated by irradiation as one component of the mixture shows that inactivation of genetically heterogeneous stem cells requires the participation of viable lymphoid cells. The inactivation phenomenon is also observed with Jerne's method. This shows that inactivation affects not only colony-forming cells but also the immunologically competent precursors of antibody-producing cells. (author)
Authors:
Petrov, R. V. [1] 
  1. Institute of Biophysics, Ministry of Public Health of the USSR, Moscow, USSR (Russian Federation)
Publication Date:
Jul 15, 1969
Product Type:
Conference
Resource Relation:
Conference: Panel on Current Problems of Bone-Marrow Cell Transplantation with Special Emphasis on Conservation and Culture, Moscow (Russian Federation), 22-26 Jul 1968; Other Information: 7 refs., 3 tabs., 2 figs.; Related Information: In: Bone-Marrow Conservation, Culture and Transplantation. Proceedings of a Panel on Current Problems of Bone-Marrow Cell Transplantation with Special Emphasis on Conservation and Culture| 211 p.
Subject:
60 APPLIED LIFE SCIENCES; 62 RADIOLOGY AND NUCLEAR MEDICINE; ANTIBODIES; BONE MARROW CELLS; COLONY FORMING UNITS; GENOTYPE; GRAFTS; INACTIVATION; KIDNEYS; LYMPH NODES; LYMPHOCYTES; MICE; RADIOSTERILIZATION; SPLEEN; SPLEEN CELLS; STEM CELLS; TRANSPLANTS
OSTI ID:
22192473
Research Organizations:
International Atomic Energy Agency, Vienna (Austria)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
TRN: XA14M0710016962
Submitting Site:
INIS
Size:
page(s) 59-66
Announcement Date:
Feb 20, 2014

Conference:

Citation Formats

Petrov, R. V. Stem-Cell Inactivation on Transplantation of Haemopoietic Cell Suspensions from Genetically Different Donors. IAEA: N. p., 1969. Web.
Petrov, R. V. Stem-Cell Inactivation on Transplantation of Haemopoietic Cell Suspensions from Genetically Different Donors. IAEA.
Petrov, R. V. 1969. "Stem-Cell Inactivation on Transplantation of Haemopoietic Cell Suspensions from Genetically Different Donors." IAEA.
@misc{etde_22192473,
title = {Stem-Cell Inactivation on Transplantation of Haemopoietic Cell Suspensions from Genetically Different Donors}
author = {Petrov, R. V.}
abstractNote = {The transplantation of a mixture of haemopoietic or lymphoid cells from two genetically different mice into lethally irradiated F{sub 1} recipients results in marked or total inactivation of the colony-forming units of the graft. This phenomenon is observed following transplantation of mixtures of spleen cells or bone-marrow cells from animals of different genotypes: CBA + C57BL, A + CBA, A + C57BL, C3H + C57BL, CBA + (CBA x C57BL) F{sub 1}. Maximum inactivation is observed when lymph-node cells of one genotype are transplanted with spleen or bone-marrow cells of another genotype. Use of non-syngenic kidney cells or lymphoid cells inactivated by irradiation as one component of the mixture shows that inactivation of genetically heterogeneous stem cells requires the participation of viable lymphoid cells. The inactivation phenomenon is also observed with Jerne's method. This shows that inactivation affects not only colony-forming cells but also the immunologically competent precursors of antibody-producing cells. (author)}
place = {IAEA}
year = {1969}
month = {Jul}
}