Abstract
Full text: Allogenic bone-marrow grafting in 24 human leukaemic subjects is described. The graft failed in 7 cases and took in 17 cases. In the latter group, all 17 cases were complicated by the secondary syndrome which was-fatal in 13 cases and controlled in 4 cases. The immunogenetic and immunological factors determining the establishment and evolution of haematological radiochimeras in man are discussed. The choice of donor is fundamental. Three tests are effective in donor selection, the indirect histocompatibility test, the leucocyte antigen test and the reaction of donor and recipient leucocytes in the dermis of an irradiated hamster. When marrow from several donors is transfused, the recipient spontaneously selects the genetically nearest. It seems likely there is more chance of finding a suitable donor among genetically related subjects than among those who are unrelated. The frequency of graft take seems slightly lower in recipients who have previously received blood transfusions. Total bone-marrow graft is associated with specific tolerance towards donor tissues. This is paralleled by the production in the chimera of immunoglobulins produced by the graft. The secondary syndrome seems, as in animals, to be related essentially to the graft-versus-host reaction. It is convenient to distinguish among its various
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Mathe, G.;
Schwarzenberg, L.;
Miel, J.L. A;
Schneider, M.;
Cattan, A.;
Schlumberger, J. R.
[1]
- Institut de cancerologie et immunogenetique, Hopital Paul Brousse, Villejuif (France)
Citation Formats
Mathe, G., Schwarzenberg, L., Miel, J.L. A, Schneider, M., Cattan, A., and Schlumberger, J. R.
Effects and Complications of Bone-Marrow Transplantation in Man.
IAEA: N. p.,
1969.
Web.
Mathe, G., Schwarzenberg, L., Miel, J.L. A, Schneider, M., Cattan, A., & Schlumberger, J. R.
Effects and Complications of Bone-Marrow Transplantation in Man.
IAEA.
Mathe, G., Schwarzenberg, L., Miel, J.L. A, Schneider, M., Cattan, A., and Schlumberger, J. R.
1969.
"Effects and Complications of Bone-Marrow Transplantation in Man."
IAEA.
@misc{etde_22192469,
title = {Effects and Complications of Bone-Marrow Transplantation in Man}
author = {Mathe, G., Schwarzenberg, L., Miel, J.L. A, Schneider, M., Cattan, A., and Schlumberger, J. R.}
abstractNote = {Full text: Allogenic bone-marrow grafting in 24 human leukaemic subjects is described. The graft failed in 7 cases and took in 17 cases. In the latter group, all 17 cases were complicated by the secondary syndrome which was-fatal in 13 cases and controlled in 4 cases. The immunogenetic and immunological factors determining the establishment and evolution of haematological radiochimeras in man are discussed. The choice of donor is fundamental. Three tests are effective in donor selection, the indirect histocompatibility test, the leucocyte antigen test and the reaction of donor and recipient leucocytes in the dermis of an irradiated hamster. When marrow from several donors is transfused, the recipient spontaneously selects the genetically nearest. It seems likely there is more chance of finding a suitable donor among genetically related subjects than among those who are unrelated. The frequency of graft take seems slightly lower in recipients who have previously received blood transfusions. Total bone-marrow graft is associated with specific tolerance towards donor tissues. This is paralleled by the production in the chimera of immunoglobulins produced by the graft. The secondary syndrome seems, as in animals, to be related essentially to the graft-versus-host reaction. It is convenient to distinguish among its various manifestations, on the one hand, those lesions which are readily controlled such as hepatitis or erythrodermia associated with infiltration and proliferation of immunologically competent cells from the graft and, on the other hand, immune insufficiency with regard to micro-organisms, especially viruses and Candida albicans. This latter group, the mechanism of which is complex, still eludes attempts at preventive and curative control. The use of multiple donors and the administration of cortisone during marrow transfusion and A-methopterin and/or cyclophosphamide in the days following transfusions; seem to have reduced the severity of the secondary syndrome, which, however, still cannot be satisfactorily controlled. The graft reaction against the leukaemic cells is utilized as an anti-leukaemic treatment. In the four patients who escaped acute secondary syndrome, survival has been notably longer, in one case being 20 months when death from zoster encephalitis supervened. No clinical signs or histological evidence of leukaemia were present at autopsy. (author)}
place = {IAEA}
year = {1969}
month = {Jul}
}
title = {Effects and Complications of Bone-Marrow Transplantation in Man}
author = {Mathe, G., Schwarzenberg, L., Miel, J.L. A, Schneider, M., Cattan, A., and Schlumberger, J. R.}
abstractNote = {Full text: Allogenic bone-marrow grafting in 24 human leukaemic subjects is described. The graft failed in 7 cases and took in 17 cases. In the latter group, all 17 cases were complicated by the secondary syndrome which was-fatal in 13 cases and controlled in 4 cases. The immunogenetic and immunological factors determining the establishment and evolution of haematological radiochimeras in man are discussed. The choice of donor is fundamental. Three tests are effective in donor selection, the indirect histocompatibility test, the leucocyte antigen test and the reaction of donor and recipient leucocytes in the dermis of an irradiated hamster. When marrow from several donors is transfused, the recipient spontaneously selects the genetically nearest. It seems likely there is more chance of finding a suitable donor among genetically related subjects than among those who are unrelated. The frequency of graft take seems slightly lower in recipients who have previously received blood transfusions. Total bone-marrow graft is associated with specific tolerance towards donor tissues. This is paralleled by the production in the chimera of immunoglobulins produced by the graft. The secondary syndrome seems, as in animals, to be related essentially to the graft-versus-host reaction. It is convenient to distinguish among its various manifestations, on the one hand, those lesions which are readily controlled such as hepatitis or erythrodermia associated with infiltration and proliferation of immunologically competent cells from the graft and, on the other hand, immune insufficiency with regard to micro-organisms, especially viruses and Candida albicans. This latter group, the mechanism of which is complex, still eludes attempts at preventive and curative control. The use of multiple donors and the administration of cortisone during marrow transfusion and A-methopterin and/or cyclophosphamide in the days following transfusions; seem to have reduced the severity of the secondary syndrome, which, however, still cannot be satisfactorily controlled. The graft reaction against the leukaemic cells is utilized as an anti-leukaemic treatment. In the four patients who escaped acute secondary syndrome, survival has been notably longer, in one case being 20 months when death from zoster encephalitis supervened. No clinical signs or histological evidence of leukaemia were present at autopsy. (author)}
place = {IAEA}
year = {1969}
month = {Jul}
}