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Fast Neutrons - LET Distributions and the Response of Mammalian Cells

Conference:

Abstract

Distributions of stopping power (LET) are given for four beams of fast neutrons, namely, neutrons of 14.6 MeV, neutrons produced by bombarding a thick beryllium target with 15 MeV deuterons, neutrons of 3 MeV, and fast neutrons produced by bombardment of a {sup 235}U converter plate with thermal neutrons. The track average LET is correlated with mean neutron energy, but the dose average is approximately constant. However, neither of these types of average is expected to have much relevance to radiobiology. Further, specification of a ''biologically effective LET'' depends on the biological test used, and is not solely a function of the radiation quality. An attempt has been made to calculate the response of T.I. kidney cells in tissue culture to these four beams of neutrons, based on their response to charged particles using the track-segment method. The calculated RBE's of the neutron beams are lower than the observed values and the calculated values of the oxygen enhancement ratio are higher. These differences seem too great to be explained by errors in dosimetry and in the calculated LET spectra. The suggestion is made that LET is not an adequate criterion of radiation quality, and that the discrepancies may be explained  More>>
Authors:
Bewley, D. K. [1] 
  1. Medical Research Council Cyclotron Unit, Hammersmith Hospital, London (United Kingdom)
Publication Date:
Mar 15, 1968
Product Type:
Conference
Resource Relation:
Conference: Panel on Biophysical Aspects of Radiation Quality, Vienna (Austria), 10-14 Apr 1967; Other Information: 25 refs., 7 tabs., 9 figs.; Related Information: In: Biophysical Aspects of Radiation Quality. Second Panel Report| 196 p.
Subject:
07 ISOTOPES AND RADIATION SOURCES; 63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; BERYLLIUM; DELTA RAYS; DEUTERONS; DOSE-RESPONSE RELATIONSHIPS; DOSIMETRY; ERRORS; FAST NEUTRONS; KIDNEYS; LET; NEUTRON BEAMS; OXYGEN ENHANCEMENT RATIO; PARTICLE TRACKS; RADIATION DOSES; RADIATION QUALITY; RADIOBIOLOGY; SPATIAL DOSE DISTRIBUTIONS; STOPPING POWER; THERMAL NEUTRONS; TISSUE CULTURES; URANIUM 235
OSTI ID:
22190144
Research Organizations:
International Atomic Energy Agency, Vienna (Austria)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
TRN: XA14M0663014629
Submitting Site:
INIS
Size:
page(s) 65-85
Announcement Date:
Feb 13, 2014

Conference:

Citation Formats

Bewley, D. K. Fast Neutrons - LET Distributions and the Response of Mammalian Cells. IAEA: N. p., 1968. Web.
Bewley, D. K. Fast Neutrons - LET Distributions and the Response of Mammalian Cells. IAEA.
Bewley, D. K. 1968. "Fast Neutrons - LET Distributions and the Response of Mammalian Cells." IAEA.
@misc{etde_22190144,
title = {Fast Neutrons - LET Distributions and the Response of Mammalian Cells}
author = {Bewley, D. K.}
abstractNote = {Distributions of stopping power (LET) are given for four beams of fast neutrons, namely, neutrons of 14.6 MeV, neutrons produced by bombarding a thick beryllium target with 15 MeV deuterons, neutrons of 3 MeV, and fast neutrons produced by bombardment of a {sup 235}U converter plate with thermal neutrons. The track average LET is correlated with mean neutron energy, but the dose average is approximately constant. However, neither of these types of average is expected to have much relevance to radiobiology. Further, specification of a ''biologically effective LET'' depends on the biological test used, and is not solely a function of the radiation quality. An attempt has been made to calculate the response of T.I. kidney cells in tissue culture to these four beams of neutrons, based on their response to charged particles using the track-segment method. The calculated RBE's of the neutron beams are lower than the observed values and the calculated values of the oxygen enhancement ratio are higher. These differences seem too great to be explained by errors in dosimetry and in the calculated LET spectra. The suggestion is made that LET is not an adequate criterion of radiation quality, and that the discrepancies may be explained by more detailed consideration of the part played by delta rays and by heavy recoil tracks of short range. (author)}
place = {IAEA}
year = {1968}
month = {Mar}
}