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Kinetics of Human Haematopoiesis

Abstract

An understanding of the parameters of normal cell proliferation is a prerequisite for the understanding of the disturbances induced by radiation. The disturbances induced by radiation on cell renewal systems has been presented in detail by Bond, Fliedner and Archambeau. In this paper a method of studying the concepts and actual observations on human haemopoiesis will be summarized. Details of the procedures, methods and concepts are published. The method employed is the serial.autoradiographic study of haemopoietic tissues after labelling the DNA of proliferating compartments by intravenous injection of tritiated thymidine (3HTDR) a specific DNA precursor. One can then observe the flow of labelled cells through mitosis, the transit of labelled cells from a proliferating compartment to a non proliferating compartment and the migration of cells from tissues to blood.
Authors:
Cronkite, E. P.; [1]  Medical Research Center, Brookhaven National Laboratory, Upton, Long Island, NY (United States)]
  1. Forschungsgruppe Freiburg, Institut fuer Haematologie der Gesellschaft fuer Strahlenforschung Assoziation mit EURATOM, Freiburg/Breisgau, Federal Republic of Germany (Germany)
Publication Date:
Jul 15, 1967
Product Type:
Conference
Resource Relation:
Conference: Panel on the Effects of Various Types of Ionizing Radiations from Different Sources on Haematopoietic Tissue, Vienna (Austria), 17-20 May 1966; Other Information: 13 refs., 2 tabs., 4 figs.; Related Information: In: Effects of Ionizing Radiations on the Haematopoietic Tissue. Proceedings of a Panel on the Effects of Various Types of Ionizing Radiations from Different Sources on Haematopoietic Tissue| 174 p.
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; BLOOD; BLOOD FORMATION; CELL PROLIFERATION; DNA; INTRAVENOUS INJECTION; LABELLING; MITOSIS; STEM CELLS; THYMIDINE
OSTI ID:
22190120
Research Organizations:
International Atomic Energy Agency, Vienna (Austria)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
TRN: XA14M0639014605
Submitting Site:
INIS
Size:
page(s) 6-11
Announcement Date:
Feb 13, 2014

Citation Formats

Cronkite, E. P., and Medical Research Center, Brookhaven National Laboratory, Upton, Long Island, NY (United States)]. Kinetics of Human Haematopoiesis. IAEA: N. p., 1967. Web.
Cronkite, E. P., & Medical Research Center, Brookhaven National Laboratory, Upton, Long Island, NY (United States)]. Kinetics of Human Haematopoiesis. IAEA.
Cronkite, E. P., and Medical Research Center, Brookhaven National Laboratory, Upton, Long Island, NY (United States)]. 1967. "Kinetics of Human Haematopoiesis." IAEA.
@misc{etde_22190120,
title = {Kinetics of Human Haematopoiesis}
author = {Cronkite, E. P., and Medical Research Center, Brookhaven National Laboratory, Upton, Long Island, NY (United States)]}
abstractNote = {An understanding of the parameters of normal cell proliferation is a prerequisite for the understanding of the disturbances induced by radiation. The disturbances induced by radiation on cell renewal systems has been presented in detail by Bond, Fliedner and Archambeau. In this paper a method of studying the concepts and actual observations on human haemopoiesis will be summarized. Details of the procedures, methods and concepts are published. The method employed is the serial.autoradiographic study of haemopoietic tissues after labelling the DNA of proliferating compartments by intravenous injection of tritiated thymidine (3HTDR) a specific DNA precursor. One can then observe the flow of labelled cells through mitosis, the transit of labelled cells from a proliferating compartment to a non proliferating compartment and the migration of cells from tissues to blood.}
place = {IAEA}
year = {1967}
month = {Jul}
}