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Chromosome Studies in Patients with Polycythaemia Vera after Treatment with {sup 32}P

Abstract

The chromosomes of bone-marrow cells and blood lymphocytes of forty-six patients with polycythaemia vera were analysed to trace the sequence of events leading to the development of bone-marrow failure or 'leukaemia'. All except one of the patients had received radiophosphorus ({sup 32}P). It might be expected that the yield of chromosomal aberrations of the two-break type (translocations etc.) from the low dose-rate beta radiation of {sup 32}P would be small. However, 'unstable' types of abnormality (dicentrics, fragments) and stable types (translocations, inversions, deletions) were observed in 6-25% of the blood lymphocytes; there was no evidence of clones of abnormal cells. In the majority of patients the bone marrow was predominantly normal diploid; occasional sporadic cells with 'stable' chromosomal abnormalities were seen in two-thirds of the cases, but 'unstable' aberrations were rare. In seven cases there were clones of cells characterised by deletions or translocations. All these chromosomal changes are probably radiation-induced. Clones of cells with a similar abnormality, an apparent deletion of one of the F-group chromosomes, were observed in the bone marrow in ten patients. Eight of these had received {sup 32}P and two busulphan. In two cases the clone appeared to develop after treatment. A similar anomaly has  More>>
Authors:
Millard, Rosemary E.; Kay, H. E.M.; Lawler, S. D. [1] 
  1. Royal Marsden Hospital, London (United Kingdom)
Publication Date:
Nov 15, 1969
Product Type:
Conference
Report Number:
IAEA-SM-118/25
Resource Relation:
Conference: Symposium on Radiation-Induced Cancer, Athens (Greece), 28 Apr - 2 May 1969; Other Information: 40 refs., 1 fig., 3 tabs.; Related Information: In: Radiation-Induced Cancer. Proceedings of a Symposium on Radiation-Induced Cancer| 512 p.
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; BONE MARROW; BONE MARROW CELLS; CHROMOSOMAL ABERRATIONS; CHROMOSOME LOSSES; DICENTRIC CHROMOSOMES; DOSE RATES; IRRADIATION; LEUKEMIA; LYMPHOCYTES; PATIENTS; PHOSPHORUS 32; TRANSLOCATION
OSTI ID:
22182161
Research Organizations:
International Atomic Energy Agency, Vienna (Austria); World Health Organization, Geneva (Switzerland)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
Other: ISSN 0074-1884; TRN: XA13M3976006660
Submitting Site:
INIS
Size:
page(s) 289-301
Announcement Date:
Jan 23, 2014

Citation Formats

Millard, Rosemary E., Kay, H. E.M., and Lawler, S. D. Chromosome Studies in Patients with Polycythaemia Vera after Treatment with {sup 32}P. IAEA: N. p., 1969. Web.
Millard, Rosemary E., Kay, H. E.M., & Lawler, S. D. Chromosome Studies in Patients with Polycythaemia Vera after Treatment with {sup 32}P. IAEA.
Millard, Rosemary E., Kay, H. E.M., and Lawler, S. D. 1969. "Chromosome Studies in Patients with Polycythaemia Vera after Treatment with {sup 32}P." IAEA.
@misc{etde_22182161,
title = {Chromosome Studies in Patients with Polycythaemia Vera after Treatment with {sup 32}P}
author = {Millard, Rosemary E., Kay, H. E.M., and Lawler, S. D.}
abstractNote = {The chromosomes of bone-marrow cells and blood lymphocytes of forty-six patients with polycythaemia vera were analysed to trace the sequence of events leading to the development of bone-marrow failure or 'leukaemia'. All except one of the patients had received radiophosphorus ({sup 32}P). It might be expected that the yield of chromosomal aberrations of the two-break type (translocations etc.) from the low dose-rate beta radiation of {sup 32}P would be small. However, 'unstable' types of abnormality (dicentrics, fragments) and stable types (translocations, inversions, deletions) were observed in 6-25% of the blood lymphocytes; there was no evidence of clones of abnormal cells. In the majority of patients the bone marrow was predominantly normal diploid; occasional sporadic cells with 'stable' chromosomal abnormalities were seen in two-thirds of the cases, but 'unstable' aberrations were rare. In seven cases there were clones of cells characterised by deletions or translocations. All these chromosomal changes are probably radiation-induced. Clones of cells with a similar abnormality, an apparent deletion of one of the F-group chromosomes, were observed in the bone marrow in ten patients. Eight of these had received {sup 32}P and two busulphan. In two cases the clone appeared to develop after treatment. A similar anomaly has been reported in several cases of idiopathic sideroblastic anaemia who had not been irradiated. Progression into the leukaemic phase of the disease is associated in some cases with gross chromosomal abnormalities, such as shift of the stem line chromosome number and bizarre chromosome 'markers'. In other cases, some of whom have not been irradiated for several years, the chromosomal changes are less pronounced and may result from non-disjunctional gain of one or more chromosomes or chromosome loss. One case showed a step-by-step clonal evolution over a two-year period. None of the chromosomal abnormalities in the 'leukaemic' phase appear to be a direct result of radiation-induced chromosomal breakage. (author)}
place = {IAEA}
year = {1969}
month = {Nov}
}