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ETDEWEB   /       /    Radiation Effect on Secondary Cancerization by Tumour Cell Grafts. Take of Irradiated Tumour Cells in Irradiated and Non-Irradiated Animals

Radiation Effect on Secondary Cancerization by Tumour Cell Grafts. Take of Irradiated Tumour Cells in Irradiated and Non-Irradiated Animals

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Abstract

This study was designed to determine the ability of haemocytoblastoma, SME and Jensen tumours, which had been irradiated in vitro, to take in C{sub 57}BL/6 mice or Wistar rats that were whole-body irradiated at 0.4 kR and 0.6 kR respectively. It was found-that the take of tumour cell grafts irradiated in vitro increased in whole-body irradiated mice and rats but not in non-irradiated ones. When Wistar rats, that had been whole-body irradiated with 0.7 and 0.8 kR 1 - 7 months earlier and survived after treatment, were grafted with Jensen tumour cells irradiated in vitro with 3 kR they were found to develop tumours and lung metastases (in contrast to non-irradiated rats). A cross resistance against non-irradiated Jensen tumour cells was obtained in non- irradiated Wistar rats by grafting irradiated Jensen tumour cells. Chromosomal analysis showed two supplementary giant markers in the Jensen tumour cells that had been irradiated in vitro before grafting. (author)
Authors:
Costachel, O.; Sandru, Gh.; Kitzulescu, I. [1] 
  1. Oncological Institute, Bucharest (Romania)
Publication Date:
Nov 15, 1969
Product Type:
Conference
Report Number:
IAEA-SM-118/40
Resource Relation:
Conference: Symposium on Radiation-Induced Cancer, Athens (Greece), 28 Apr - 2 May 1969; Other Information: 24 refs., 4 figs., 8 tabs.; Related Information: In: Radiation-Induced Cancer. Proceedings of a Symposium on Radiation-Induced Cancer| 512 p.
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; CARCINOGENESIS; DOSE-RESPONSE RELATIONSHIPS; GRAFTS; IN VITRO; IRRADIATION; LUNGS; METASTASES; MICE; RATS
OSTI ID:
22182145
Research Organizations:
International Atomic Energy Agency, Vienna (Austria); World Health Organization, Geneva (Switzerland)
Country of Origin:
IAEA
Language:
English
Contract Number:
Contract 226/RB
Other Identifying Numbers:
Other: ISSN 0074-1884; TRN: XA13M3960006644
Submitting Site:
INIS
Size:
page(s) 67-80
Announcement Date:
Jan 23, 2014

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Citation Formats

Costachel, O., Sandru, Gh., and Kitzulescu, I. Radiation Effect on Secondary Cancerization by Tumour Cell Grafts. Take of Irradiated Tumour Cells in Irradiated and Non-Irradiated Animals. IAEA: N. p., 1969. Web.
Costachel, O., Sandru, Gh., & Kitzulescu, I. Radiation Effect on Secondary Cancerization by Tumour Cell Grafts. Take of Irradiated Tumour Cells in Irradiated and Non-Irradiated Animals. IAEA.
Costachel, O., Sandru, Gh., and Kitzulescu, I. 1969. "Radiation Effect on Secondary Cancerization by Tumour Cell Grafts. Take of Irradiated Tumour Cells in Irradiated and Non-Irradiated Animals." IAEA.
@misc{etde_22182145,
title = {Radiation Effect on Secondary Cancerization by Tumour Cell Grafts. Take of Irradiated Tumour Cells in Irradiated and Non-Irradiated Animals}
 author = {Costachel, O., Sandru, Gh., and Kitzulescu, I.}
 abstractNote = {This study was designed to determine the ability of haemocytoblastoma, SME and Jensen tumours, which had been irradiated in vitro, to take in C{sub 57}BL/6 mice or Wistar rats that were whole-body irradiated at 0.4 kR and 0.6 kR respectively. It was found-that the take of tumour cell grafts irradiated in vitro increased in whole-body irradiated mice and rats but not in non-irradiated ones. When Wistar rats, that had been whole-body irradiated with 0.7 and 0.8 kR 1 - 7 months earlier and survived after treatment, were grafted with Jensen tumour cells irradiated in vitro with 3 kR they were found to develop tumours and lung metastases (in contrast to non-irradiated rats). A cross resistance against non-irradiated Jensen tumour cells was obtained in non- irradiated Wistar rats by grafting irradiated Jensen tumour cells. Chromosomal analysis showed two supplementary giant markers in the Jensen tumour cells that had been irradiated in vitro before grafting. (author)}
 place = {IAEA}
 year = {1969}
 month = {Nov}
 }