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Utilization of Basil Extract as a Radioprotector in Male Rats

Journal Article:

Abstract

Man is exposed to natural radiations from cosmic or terrestrial origins. Furthermore, it is well known that the gamma irradiation-induced biochemical alteration depends mostly on oxidative stress. Basil or sweet basil (Ocimum basilicum) is known to have numerous pharmacological activities. Therefore, the present study was carried out to investigate the radioprotective activity of basil in albino rats. The effect of basil aqueous extract (BAE) was evaluated on hepatic marker enzymes, sex hormones, lipid profile and antioxidant status. The results showed that - rays caused a significant increase in serum level of alanine and aspartate aminotransferase, alkaline phosphatase, gamma glutamyl transpeptidase (ALT, AST, ALP and GT), cholesterol (TC), triglyceride (TG), low and very low density lipoprotein cholesterol (LDL-C and VLDL-C) and thiobarbituric acid reactive substances (TBARS). A significant decrease in high density lipoprotein cholesterol (HDL-C), reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) in serum was observed, compared with control group. Moreover, - rays induced a significant drop in the serum sex hormones levels testosterone (T), follicle stimulating hormone (FSH) and luteinizing hormone (LH). The BAE administered orally to rats has significantly modulated all the radiation-induced biochemical alterations. These findings showed that basil would exert a radioprotective properties.
Authors:
Farag, M. F.S. [1] 
  1. Food Irradiation Research Dep. National Centre for Radiation Research and Technology, Atomic Energy Authority, Cairo (Egypt)
Publication Date:
Jan 15, 2013
Product Type:
Journal Article
Resource Relation:
Journal Name: Arab Journal of Nuclear Sciences and Applications; Journal Volume: 46; Journal Issue: 1
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; BLOOD SERUM; CHOLESTEROL; GAMMA RADIATION; GLUTATHIONE; LIVER; LUTEINIZING HORMONE; MALES; RADIOPROTECTIVE SUBSTANCES; RATS; SUPEROXIDE DISMUTASE; TRIGLYCERIDES
OSTI ID:
22180538
Country of Origin:
Egypt
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 1110-0451; CODEN: AJNADV; TRN: EG1400064005028
Submitting Site:
INIS
Size:
page(s) 274-281
Announcement Date:
Jan 23, 2014

Journal Article:

Citation Formats

Farag, M. F.S. Utilization of Basil Extract as a Radioprotector in Male Rats. Egypt: N. p., 2013. Web.
Farag, M. F.S. Utilization of Basil Extract as a Radioprotector in Male Rats. Egypt.
Farag, M. F.S. 2013. "Utilization of Basil Extract as a Radioprotector in Male Rats." Egypt.
@misc{etde_22180538,
title = {Utilization of Basil Extract as a Radioprotector in Male Rats}
author = {Farag, M. F.S.}
abstractNote = {Man is exposed to natural radiations from cosmic or terrestrial origins. Furthermore, it is well known that the gamma irradiation-induced biochemical alteration depends mostly on oxidative stress. Basil or sweet basil (Ocimum basilicum) is known to have numerous pharmacological activities. Therefore, the present study was carried out to investigate the radioprotective activity of basil in albino rats. The effect of basil aqueous extract (BAE) was evaluated on hepatic marker enzymes, sex hormones, lipid profile and antioxidant status. The results showed that - rays caused a significant increase in serum level of alanine and aspartate aminotransferase, alkaline phosphatase, gamma glutamyl transpeptidase (ALT, AST, ALP and GT), cholesterol (TC), triglyceride (TG), low and very low density lipoprotein cholesterol (LDL-C and VLDL-C) and thiobarbituric acid reactive substances (TBARS). A significant decrease in high density lipoprotein cholesterol (HDL-C), reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) in serum was observed, compared with control group. Moreover, - rays induced a significant drop in the serum sex hormones levels testosterone (T), follicle stimulating hormone (FSH) and luteinizing hormone (LH). The BAE administered orally to rats has significantly modulated all the radiation-induced biochemical alterations. These findings showed that basil would exert a radioprotective properties.}
journal = {Arab Journal of Nuclear Sciences and Applications}
issue = {1}
volume = {46}
journal type = {AC}
place = {Egypt}
year = {2013}
month = {Jan}
}