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The Technique and Dosimetry of Pituitary Implantation Using Sources of Y{sup 90}; Technique et Dosimetrie de l'Implantation de Sources d'Yttrium-90 dans l'Hypophyse; ДОЗИМЕТРИЯ ИМПЛАНТИРОВАННЫХ В ГИПОФИЗ ИГЛ ИТТРИЯ-90; Dosimetria de la Implantacion de Fuentes de {sup 90}Y en la Hipofisis

Conference:

Abstract

Pituitary ablation by needle implantation of Y{sup 90} is finding increasing use in the treatment of breast and prostatic cancer, as well as diabetic retinopathy, Cushing's disease, acromegaly, and perhaps exophthalmos in Graves' disease. Yttrium-90 is the most suitable radioisotope when complete ablation of the gland is sought. This is because only {beta}-particles are emitted, the maximum range (7mm) of which is comparable with the dimensions of the gland. The implantation of rods of standard activity into the gland, irrespective of its size, does not permit a standard dose level to be delivered to the gland and the method of implantation is to select the size and activity of the source to fit the dimensions of the gland in question. Thus consistency in procedure may be attempted from one implant to another. The shape of the gland and the mode of access to it is such that complete destruction may conveniently be obtained by implanting two.sources. Each source is a rod of sintered Y{sub 2}O{sub 3}, (2-mm diam., and of length cut to suit the individual gland length). The rod activity is also selected to suit the gland dimensions: typically, it is from 2 to 3 me. Radiation dose has  More>>
Authors:
Duggan, Mary H.; Jones, E.; Mallard, J. R.; [1]  Joplin, G. F. [2] 
  1. Department of Physics, Hammersmith Hospital, London (United Kingdom)
  2. Department of Medicine, Postgraduate Medical School, London (United Kingdom)
Publication Date:
Mar 15, 1963
Product Type:
Conference
Resource Relation:
Conference: Seminar on the Practical Applications of Short-Lived Radioisotopes Produced in Small Research Reactors, Vienna (Austria), 5-9 Nov 1962; Other Information: 6 refs., 5 figs., 1 tab.; Related Information: In: Production and Use of Short-Lived Radioisotopes from Reactors. Vol. II. Proceedings of a Seminar on the Practical Applications of Short-Lived Radioisotopes Produced in Small Research Reactors| 292 p.
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 07 ISOTOPES AND RADIATION SOURCES; ACROMEGALY; BRACHYTHERAPY; CARCINOMAS; MAMMARY GLANDS; NECROSIS; PITUITARY GLAND; RADIATION DOSES; RADIATION SOURCE IMPLANTS; RADIOPHARMACEUTICALS; STRONTIUM 90; YTTRIUM 90; YTTRIUM OXIDES
OSTI ID:
22173531
Research Organizations:
International Atomic Energy Agency, Vienna (Austria)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
Other: ISSN 0074-1884; TRN: XA13M4272127988
Submitting Site:
INIS
Size:
page(s) 213-220
Announcement Date:
Dec 16, 2013

Conference:

Citation Formats

Duggan, Mary H., Jones, E., Mallard, J. R., and Joplin, G. F. The Technique and Dosimetry of Pituitary Implantation Using Sources of Y{sup 90}; Technique et Dosimetrie de l'Implantation de Sources d'Yttrium-90 dans l'Hypophyse; ДОЗИМЕТРИЯ ИМПЛАНТИРОВАННЫХ В ГИПОФИЗ ИГЛ ИТТРИЯ-90; Dosimetria de la Implantacion de Fuentes de {sup 90}Y en la Hipofisis. IAEA: N. p., 1963. Web.
Duggan, Mary H., Jones, E., Mallard, J. R., & Joplin, G. F. The Technique and Dosimetry of Pituitary Implantation Using Sources of Y{sup 90}; Technique et Dosimetrie de l'Implantation de Sources d'Yttrium-90 dans l'Hypophyse; ДОЗИМЕТРИЯ ИМПЛАНТИРОВАННЫХ В ГИПОФИЗ ИГЛ ИТТРИЯ-90; Dosimetria de la Implantacion de Fuentes de {sup 90}Y en la Hipofisis. IAEA.
Duggan, Mary H., Jones, E., Mallard, J. R., and Joplin, G. F. 1963. "The Technique and Dosimetry of Pituitary Implantation Using Sources of Y{sup 90}; Technique et Dosimetrie de l'Implantation de Sources d'Yttrium-90 dans l'Hypophyse; ДОЗИМЕТРИЯ ИМПЛАНТИРОВАННЫХ В ГИПОФИЗ ИГЛ ИТТРИЯ-90; Dosimetria de la Implantacion de Fuentes de {sup 90}Y en la Hipofisis." IAEA.
@misc{etde_22173531,
title = {The Technique and Dosimetry of Pituitary Implantation Using Sources of Y{sup 90}; Technique et Dosimetrie de l'Implantation de Sources d'Yttrium-90 dans l'Hypophyse; ДОЗИМЕТРИЯ ИМПЛАНТИРОВАННЫХ В ГИПОФИЗ ИГЛ ИТТРИЯ-90; Dosimetria de la Implantacion de Fuentes de {sup 90}Y en la Hipofisis}
author = {Duggan, Mary H., Jones, E., Mallard, J. R., and Joplin, G. F.}
abstractNote = {Pituitary ablation by needle implantation of Y{sup 90} is finding increasing use in the treatment of breast and prostatic cancer, as well as diabetic retinopathy, Cushing's disease, acromegaly, and perhaps exophthalmos in Graves' disease. Yttrium-90 is the most suitable radioisotope when complete ablation of the gland is sought. This is because only {beta}-particles are emitted, the maximum range (7mm) of which is comparable with the dimensions of the gland. The implantation of rods of standard activity into the gland, irrespective of its size, does not permit a standard dose level to be delivered to the gland and the method of implantation is to select the size and activity of the source to fit the dimensions of the gland in question. Thus consistency in procedure may be attempted from one implant to another. The shape of the gland and the mode of access to it is such that complete destruction may conveniently be obtained by implanting two.sources. Each source is a rod of sintered Y{sub 2}O{sub 3}, (2-mm diam., and of length cut to suit the individual gland length). The rod activity is also selected to suit the gland dimensions: typically, it is from 2 to 3 me. Radiation dose has been experimentally related to geometry and activity. Mix D wax is used as the tissue- equivalent absorber, film as the detector and a calibrated Sr{sup 90} source (which decays into Y{sup 90}) as the standard. One outcome of this work is that the pituitary gland requires a radiation dose of between 100 000 and 200 000 rad for necrosis and ablation. (author) [French] L'ablation de l'hypophyse par implantation d'aiguilles a l'yttrium-90 est de plus en plus utilisee dans le traitement du cancer du sein et de la prostate, comme dans celui de la retinite diabetique, de la maladie de Cushing, de l'acromegalie, et peut-etre de l'exophthalmie associee a la maladie de Graves. Lorsqu'on recherche l'ablation totale de la glande, l'yttrium- 90 est le radioisotope qui donne les meilleurs resultats car il n'emet que des particules beta, dont le parcours maximum (7 mm) equivaut aux dimensions de la glande. Si l'on implante des aiguilles d'activite standard dans la glande sans tenir compte de ses dimensions, on ne peut pas administrer a la glande une dose standard; il convient donc d'adapter les dimensions et l'activite de la source aux dimensions de la glande. On peut ainsi s'efforcer de rationaliser la methode d'une implantation a l'autre. Etant donne la forme de la glande et son mode d'acces, il est possible d'obtenir une destruction totale par implantation de deux sources. Chacune de ces sources est constituee par une aiguille de Y{sub 2}O{sub 3} fritte, d*un diametre de 1 mm et d'une longueur adaptee aux dimensions de la glande. L'activite de l'aiguille est egalement determinee en fonction des dimensions de la glande: elle est en general de 2 a 3 me. La dose de rayonnement a ete calculee experimentalement d'apres la geometrie et l'activite. On a utilise de la cire 'Mix D ' comme absorbant equivalent au tissu, un film comme detecteur et une source au strontium-90 etalonnee- dont l'yttrium- 90 est un descendant-comme etalon. L'une des conclusions auxquelles les presents travaux ont abouti est que la necrose et l'ablation de l'hypophyse exigent une dose de rayonnement comprise entre 100 000 a 200 000 rad. (author) [Spanish] En el tratamiento del cancer mamario y de la prostata,de las retinopatias diabeticas, de la enfermedad de Cushing, de la acromegalia y, ocasionalmente, delas exoftalmia en la enfermedad de Graves, se recurre cada vez mas a la ablacion de la hipofisis por implantacion de agujas de soy. Este radioisotopo es el mas adecuado cuando se procura lograr la ablacion completa, porque solo emite particulas {beta} cuyo alcance maximo (7 mm) es comparable con las dimensiones de la glandula. Si se implantan en la glandula varillas de actividad normalizada, independientemente de su tamano, no se le puede administrar una dosis standard, de modo que el metodo de implantacion consiste en elegir un tamano y una actividad de la fuente adaptados a las dimensiones de la glandula en cuestion. De esta manera, se procura que el procedimiento sea uniforme en todas las implantaciones. La forma de la glandula y el acceso a ella son tales que la mejor manera de lograr su destruccion completa es implantar dos fuentes, consistentes en varillas de Y{sub 2}O{sub 3} sintetizado (de 1 mm de diametro y de longitud adaptada a las dimensiones de la glandula). La actividad de la varilla se elige tambien convenientemente; en los casos caracteristicos esta comprendida entre 2 y 3 me. Los autores han encontrado experimentalmente la relacion entre la dosis de irradiacion por una parte y la geometria y la actividad por otra. Como absorbedor equivalente al tejido, utilizaron cera Mix D; como detector, una pelicula y como patron, una fuente calibrada de {sup 90}Sr ( que se desintegra formando {sup 90}Y). La memoria examina la validez de este procedimiento. Este trabajo permitio comprobar que la necrosis y la ablacion de la hipofisis requieren dosis que oscitan entre 100 000 y 200 000 rad. (author) [Russian] Udalenija gipofiza putem implantacii ittrievoj igly nahodit vse vozrastajushhee primenenie pri lechenii raka grudnoj i predstatel'noj zhelez,tak zhe kak pri lechenii diabeticheskoj retinopatii, bolezni Kushinga, akromegalii i, vozmozhno, jekzoftal'ma pri bazedovoj bolezni. IttriJ-90 javljaetsja naibolee podhodjashhim izotopom, kogda trebuetsja polnoe udalenie zhelezy, tak kejs on ispuskaet tol'ko beta-chasticy, maksimal'nyj radius dejstvija kotoryh (7 mm) soizmerim o razmerami zhelez. Implantacija v zhelezu sterzhnej standartnoj aktivnosti, nezavisimo ot ih velichiny, nedopustima iz-za standartnogo urovnja dozy, vvodimoj v zhelezy, togda kak cel'ju metoda implantacii javljaetsja vozmozhnost' vybora velichiny i aktivnosti istochnika sootvetstvenno razmeram rassmatrivaemoj zhelezy. Takim obrazom kachestvo metodiki mozhet sovershenstvovat'sja ot odnogo implantata k drugomu. Forma zhelezy i dostup k nej takovy, chto polnoe razrushenie zhelezy mozhet byt' dostignuto putem implantacii dvuh istochnikov, kazhdyj iz kotoryh predstavljaet soboj sterzhen' iz spekshegosja Y{sub 2}O{sub 3} (diametrom 1 mm pri dline, sootvetstvujushhej individual'nomu razmeru zhelezy). Aktshvnoot' oterzhnja podbiraetsja v sootvetstvii s razmerami zhelezy: kak pravilo, ona sostavljaet 2-3 millikjuri. (author)}
place = {IAEA}
year = {1963}
month = {Mar}
}