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Electrolyte Concentrations of Intra- and Extracellular Compartments in Some Internal Diseases; Concentration des Electrolytes dans les Compartiments Intra- et Extracellulares, dans Certaines Maladies Internes; ВНУТРИКЛЕТОЧНАЯ И ВНЕКЛЕТОЧНАЯ КОНЦЕНТРАЦИЯ ЭЛЕКТРОЛИТОВ ПРИ НЕКОТОРЫХ ВНУТРЕННИХ ЗАБОЛЕВАНИЯХ; Concentraciones de Electrolitos en Comp Artimientos Intra y Extracelulares en Algunas Enfermedades Internas

Conference:

Abstract

It was reported by the authors, at the Third Japanese Conference on Radioisotopes, held in 1959, that they had measured the total body water (D{sub 2}O space), extracellular fluid volume (mannitol space) and total exchangeable sodium and potassium in oedematous and hypertensive patients. In the present paper, they report their studies of the sodium and potassium concentrations in extra- and intracellular fluids, using Na{sup 24} and K{sup 42}, in patients with essential hypertension, primary aldosteronism and periodic paralysis. The Na{sub e} (expressed as mEq/kg body weight) in ten hypertensive patients was 45.2 (normal 39.5) on an average, and the average value of Ke in 14 of these cases was 32,5 (normal 42.7). The ratio of intracellular concentration K/Na was 1.8 (normal 2.9) and the ratio of intra- and extracellular potassium concentrations was 26.6 (normal 28.4) on an average. It was therefore considered that in these, patients potassium was excreted from the urine by an increase in K- clearance and its content was thus decreased in the total body. In two cases Of primary aldosteronism, one case with paralytic attacks had an increased value (37.2) of this potassium concentration ratio and the other case without paralytic attack had a normal value  More>>
Authors:
Itahara, K.; Ito, K.; Tominaga, T.; Jimbo, T.; Sato, T. [1] 
  1. Tohoku University, Sendai (Japan)
Publication Date:
Mar 15, 1963
Product Type:
Conference
Resource Relation:
Conference: Seminar on the Practical Applications of Short-Lived Radioisotopes Produced in Small Research Reactors, Vienna (Austria), 5-9 Nov 1962; Other Information: 16 refs., 5 figs., 1 tab.; Related Information: In: Production and Use of Short-Lived Radioisotopes from Reactors. Vol. II. Proceedings of a Seminar on the Practical Applications of Short-Lived Radioisotopes Produced in Small Research Reactors| 292 p.
Subject:
60 APPLIED LIFE SCIENCES; 62 RADIOLOGY AND NUCLEAR MEDICINE; ELECTROLYTES; EXCRETION; GLUCOSE; HEAVY WATER; HYPERTENSION; INSULIN; MUSCLES; PATHOGENESIS; PATIENTS; PHYSIOLOGY; POTASSIUM; POTASSIUM 42; SODIUM 24; TRACER TECHNIQUES; URINE
OSTI ID:
22173528
Research Organizations:
International Atomic Energy Agency, Vienna (Austria)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
Other: ISSN 0074-1884; TRN: XA13M4269127985
Submitting Site:
INIS
Size:
page(s) 175-184
Announcement Date:
Dec 13, 2013

Conference:

Citation Formats

Itahara, K., Ito, K., Tominaga, T., Jimbo, T., and Sato, T. Electrolyte Concentrations of Intra- and Extracellular Compartments in Some Internal Diseases; Concentration des Electrolytes dans les Compartiments Intra- et Extracellulares, dans Certaines Maladies Internes; ВНУТРИКЛЕТОЧНАЯ И ВНЕКЛЕТОЧНАЯ КОНЦЕНТРАЦИЯ ЭЛЕКТРОЛИТОВ ПРИ НЕКОТОРЫХ ВНУТРЕННИХ ЗАБОЛЕВАНИЯХ; Concentraciones de Electrolitos en Comp Artimientos Intra y Extracelulares en Algunas Enfermedades Internas. IAEA: N. p., 1963. Web.
Itahara, K., Ito, K., Tominaga, T., Jimbo, T., & Sato, T. Electrolyte Concentrations of Intra- and Extracellular Compartments in Some Internal Diseases; Concentration des Electrolytes dans les Compartiments Intra- et Extracellulares, dans Certaines Maladies Internes; ВНУТРИКЛЕТОЧНАЯ И ВНЕКЛЕТОЧНАЯ КОНЦЕНТРАЦИЯ ЭЛЕКТРОЛИТОВ ПРИ НЕКОТОРЫХ ВНУТРЕННИХ ЗАБОЛЕВАНИЯХ; Concentraciones de Electrolitos en Comp Artimientos Intra y Extracelulares en Algunas Enfermedades Internas. IAEA.
Itahara, K., Ito, K., Tominaga, T., Jimbo, T., and Sato, T. 1963. "Electrolyte Concentrations of Intra- and Extracellular Compartments in Some Internal Diseases; Concentration des Electrolytes dans les Compartiments Intra- et Extracellulares, dans Certaines Maladies Internes; ВНУТРИКЛЕТОЧНАЯ И ВНЕКЛЕТОЧНАЯ КОНЦЕНТРАЦИЯ ЭЛЕКТРОЛИТОВ ПРИ НЕКОТОРЫХ ВНУТРЕННИХ ЗАБОЛЕВАНИЯХ; Concentraciones de Electrolitos en Comp Artimientos Intra y Extracelulares en Algunas Enfermedades Internas." IAEA.
@misc{etde_22173528,
title = {Electrolyte Concentrations of Intra- and Extracellular Compartments in Some Internal Diseases; Concentration des Electrolytes dans les Compartiments Intra- et Extracellulares, dans Certaines Maladies Internes; ВНУТРИКЛЕТОЧНАЯ И ВНЕКЛЕТОЧНАЯ КОНЦЕНТРАЦИЯ ЭЛЕКТРОЛИТОВ ПРИ НЕКОТОРЫХ ВНУТРЕННИХ ЗАБОЛЕВАНИЯХ; Concentraciones de Electrolitos en Comp Artimientos Intra y Extracelulares en Algunas Enfermedades Internas}
author = {Itahara, K., Ito, K., Tominaga, T., Jimbo, T., and Sato, T.}
abstractNote = {It was reported by the authors, at the Third Japanese Conference on Radioisotopes, held in 1959, that they had measured the total body water (D{sub 2}O space), extracellular fluid volume (mannitol space) and total exchangeable sodium and potassium in oedematous and hypertensive patients. In the present paper, they report their studies of the sodium and potassium concentrations in extra- and intracellular fluids, using Na{sup 24} and K{sup 42}, in patients with essential hypertension, primary aldosteronism and periodic paralysis. The Na{sub e} (expressed as mEq/kg body weight) in ten hypertensive patients was 45.2 (normal 39.5) on an average, and the average value of Ke in 14 of these cases was 32,5 (normal 42.7). The ratio of intracellular concentration K/Na was 1.8 (normal 2.9) and the ratio of intra- and extracellular potassium concentrations was 26.6 (normal 28.4) on an average. It was therefore considered that in these, patients potassium was excreted from the urine by an increase in K- clearance and its content was thus decreased in the total body. In two cases Of primary aldosteronism, one case with paralytic attacks had an increased value (37.2) of this potassium concentration ratio and the other case without paralytic attack had a normal value (29.5). In another two patients with non-familial periodic paralysis, this concentration ratio of extra- and intracellular potassium was 42.8 and 48.7 respectively, during the induced attack, while potassium excretion in the urine was not increased. It was demonstrated that transmineralization had developed from extra- into intracellular fluids. When a complete or incomplete paralysis was induced by glucose and insulin in five out of eight patients with a paralytic history, this concentration ratio was over 38.0 during each attack. It was also disclosed that an increase in this value was correlated with the severity of the paralysis. The pathogenesis of paralysis therefore seems to be due to the difference in intra- and extracellular potassium concentrations, in addition to an increase in the resting potential of muscles. Table I gives the electrolytic compositions of these diseases. (author) [French] Les auteurs ont signale, lors de la troisieme Conference japonaise sur les radioisotopes, tenue en 1959. qu'ils avaient procede a des mesures de la masse totale de l'eau de l'organisme (espace-eau lourde), du volume des liquides extracellulaires (espace-mannitol) et des quantites totales de sodium et de potassium echangeables chez les malades atteints d'oedeme et d'hypertension. Ils etudient maintenant, a l'aide de {sup 24}Na et de {sup 42}K, les concentrations de sodium et de potassium dans les liquides extra- et intracellulaires chez des malades atteints d'hypertension, d*aldosteronisme primaire et de paralysie periodique. Chez dix malades atteints d'hypertension, la valeur moyenne de la concentration du sodium echangeable (Nae), exprimee en mEq/kg de poids du corps, etait de 45,2 (valeur normale: 39,5) et chez 14 autres malades, la valeur moyenne de la concentration du potassium echangeable (Ke) etait de 32,5 (valeur normale: 42,7). Le rapport des concentrations intracellulaires K/Na etait de 1,8 (valeur normale: 2,9) et le rapport des concentrations du potassium intracellulaire et du potassium extracellulaire de 26,6 (valeur normale: 28,4), On estime donc que, chez ces malades, du potassium est elimine dans l'urine par suite d'une augmentation de la 'clearance'de K, et que la teneur en potassium de l'organisme entier diminue. Etudiant deux cas d'aldosteronisme primaire, on a constate que dans le premier cas, accompagne d'attaques de paralysie, le rapport des concentrations du potassium avait augmente (37,2) tandis que dans le second, qui n'etait pas complique d'atteintes de paralysie, sa valeur etait restee normale (29,5). Chez deux autres malades atteints de paralysie periodique non hereditaire, le rapport des concentrations du potassium intracellulaire et du potassium extracellulaire etait de 42,8 et 48,7, respectivement, pendant l'attaque qui avait ete provoquee, tandis que l'elimination de potassium par l'urine n'augmentait pas. Il a ete demontre qu'un transfert de mineraux s'etait produit entre les liquides extiacellulaire et intracellulaire. En provoquant une paralysie complete ou incomplete par le glucose et l'insuline chez des malades ayant deja subi des attaques de paralysie, on a constate dans cinq cas sur huit que le rapport des concentrations depassait 38,0 pendant chacune des attaques. On a aussi constate que l'augmentation de cette valeur etait liee a la gravite de la paralysie. La pathogenese de la paralysie semble donc due non seulement a une augmentation du potentiel de repos des muscles mais aussi a la difference entre les concentrations intra- et extracellulaites du potassium. Tableau I indique les differentes compositions electrolytiques enregistrees dans ces maladies. (author) [Spanish] En la tercera Conferencia sobre Radioisotopos que se celebro en 1959 en el Japon, los autores presentaron una memoria sobre la medicion de la masa total de agua del organismo (espacio D{sub 2}O), del volumen de los fluidos extracelulares (espacio rrianitol), y de las cantidades totales de sodio y potasio intercambiables en enfermos edematosos e hipertensos. La memoria actual describe el estudio de las concentraciones de sodio y potasio en los fluidos extra e intracelulares empleando {sup 24}Na y {sup 42}K en sujetos que padecen hipertension, aldosteronismo primario y paralisis periodica. En 10 hipertensos, el valor medio de la concentracion de sodio intercambiable ( Nae) - expresada en mEq/kg de peso corporal - era de 45,2 (valor normal: 39,5), en tanto que en 14 otros enfermos, el valor medio de la concentracion de potasio intercambiable (Ke) ascendia a 32,5 (valor normal: 42,7). La razon de las concentraciones intracelulares K/Na era de 1,8 (valor normal: 2,9) y la razon de las concentraciones intra y extra- celulares de potasio ascendia a 26,6 (valor normal: 28,4). Por consiguiente, se estima que en estos pacientes el potasio se excreta con la orina como consecuencia de un incremento de la depuracion plasmatica, y que el contenido de potasio disminuye en el organismo entero. De dos casos de aldosteronismo primario uno, con ataques de paralisis, presentaba un valor incrementado (37.2) de esta razon de las concentraciones de potasio, y el otro caso que no sufria ataques de paralisis, dio un valor normal (29,5). En otros dos enfermos con paralisis periodica no hereditaria, la razon de concentracion del potasio extra e intracelular era, respectivamente, de 42,8 y 48,7 durante el ataque inducido, mientras que la excrecion del. potasio por la orina no habia aumentado. Se demostro que la transmineralizacion se habia extendjdo de los fluidos extracelulares a los intracelulares. Al inducir con glucosa e insulina una paralisis completa o incompleta en ocho pacientes con antecedentes de paralisis, se encontro en cinco de ellos una razon de concentracion superior a 38,0 durante cada ataque. Tambien se observo que el incremento de este valor guarda una relacion con el grado de paralisis. Por lo tanto, la patogenesis de la paralisis parece ser debida no solamente a un incremento del potencial muscular en reposo sino tambien a la diferencia entre las concentraciones intra y extracelulares del potasio. En el cuadro I se indican las composiciones electroliticas observadas en estas enfermedades. (author) [Russian] V 1959 godu na tret'ej Vsejaponskoj konferencii po radioizotopam nami bylo sdelano soobshhenie ob izmerenii obshhego kolichestva vody v organizme (s pomoshh'ju D{sub 2}0), ob{sup e}ma vnekletochnoj zhidkosti (o pomoshh'ju mannita), obshhego obmenivaemogo natrija i kalija u bol'nyh s otekami i gipertonicheskoj bolezn'ju. V dannoj rabote avtory soobshhajut rezul'taty issledovanij koncentracii natrija i kalija vo vnekletochnoj i vnutrikletochnoj zhidkosti s ispol'zovaniem radioaktivnogo natrija Na{sup 24} i radioaktivnogo kalija K{sup 42} u bol'nyh s jessencial'noj gipertoniej, pervichnym al'dosteroniz- mom i periodicheskim paralichom. Soderzhanie vnekletochnogo Nae (v millijekvivalentah na 1 kg vesa tela) u desjati pacientov, bol'nyh gipertoniej, sostavljalo v srednem 45,2 (v norme 39,5), i srednjaja velichina vnekletochnogo kalija (K{sub e}) pri 14 opredelenijah sostavila 32,5 (v korme 42,7). Sootnoshenie vnutrikletochnyh kon- cengracij K/Na ravnjalos' 1,8 (v norme 2,9), a vnutri- i vnekletochnoj koncentracii kalija sostavilo v srednem 26,6 (v norme 28,4). Pojetomu schitalos', chto u jetih pacientov kalij vydeljalsja s mochoj vsledstvie uvelichenija klirensa kalija i soderzhanie ego v organizme umen'shalos'. Iz dvuh bol'nyh s pervichnym al'dosteronijemom u odnogo s pristupami paralicha kojefficient koncentracii kalija byl povyshen (37,2), a u drugogo, bez pristupa, byl normalen (29,5). U dvuh drugih pacientov s nenasledstvennym periodicheskim paralichom jetot kojefficient kon- cek' racii vne- i vnutrikletochnogo kalija sostavljal sootvetstvenno 42,8 i 48,7 vo vremja provocirovav jugo pristupa, hotja vydelenie kalija s mochoj ne uvelichivalos'. Bylo pokazano,chto transshtaeralzh- jeacija proishodila izvne vo vnutrikletochnuju zhidkost'. Kogda polnyj ili nepolnyj paralich byl vyzvan vvedeniem gljukozy i insulina u pjati iz vos'mi bol'nyh paralichom, jeto otnoshenie koncentracij sostavljalo vo vremja kazhdogo pristupa svyshe 38,0. Bylo obnaruzheno takzhe, chto rost jetoj velichiny sootvetstvoval tjazhesti paralicha. Pojetomu patagoneje paralicha, po-vidimomu, obuslovlen raznicej vnutri- i vnekletochnyh koncentracij kalija v dopolnenie k rostu potenciala pokoja myshc. V tablice, pomeshhennoj v rabote, privoditsja sostav jelektrolitov pri jetih zabolevanijah. (author)}
place = {IAEA}
year = {1963}
month = {Mar}
}