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Application of the {beta}-Decay of Te{sup 132} for the Preparation of I{sup 132} -Labelled Molecules; Application de la Desintegration {sup 132}Te {beta}{sup -} -> {sup 132}I a la preparation de Molecules Marquees; ИСПОЛЬЗОВАНИЕ {beta}-РАСПАДА Te{sup 132} - J{sup 132} ДЛЯ ПОЛУЧЕНИЯ МЕЧЕНЫХ МОЛЕКУЛ; Preparacion de Moleculas Marcadas Aplicando la Desintegracion {sup 132}Te {beta}{sup -} {sup 132}I

Conference:

Abstract

The principal advantage of iodine-132 in biological and medical applications, and in uses as a radioactive tracer, lies in its short half-life (T{sub 1/2} = 2.30 h) which, however, represents a serious drawback for the synthesis of labelled molecules. The paper shows that it is possible to take advantage of the chemical reactivity of 'nascent' iodine, formed during {beta}-decay of tellurium-132, for rapidly preparing labelled species with a high specific activity. This reactivity comes partly from the sudden change of the atomic number during the decay, which in turn releases a highly excited iodine atom, and partly from the internal conversion of the {gamma}-ray following the {beta}-emission. Iodine-132 has to be formed within the medium to be labelled: the most convenient chemical form for the parent compound is tellurium-132 tetrachloride, which is soluble in a number of organic liquids. Several systems have been studied (aromatic hydrocarbons and derivatives, alcohols, etc.)- After a few hours of contact, the organic solution is analysed by gaseous phase radiochromatography, and the separation of the various labelled species formed by radiosynthesis can be effected by distillation after addition of carriers. The labelled products may be the results of isotopic exchange or hydrogen abstraction and fragmentation  More>>
Authors:
Adloff, J. -P.; Adloff-Bacher, M. [1] 
  1. Departement de Chimie Nucleaire, Centre de Recherches Nucleaires, Strasbourg (France)
Publication Date:
Mar 15, 1963
Product Type:
Conference
Resource Relation:
Conference: Seminar on the Practical Applications of Short-Lived Radioisotopes Produced in Small Research Reactors, Vienna (Austria), 5-9 Nov 1962; Other Information: 10 refs., 3 figs.; Related Information: In: Production and Use of Short-Lived Radioisotopes from Reactors Vol. I. Proceedings of a Seminar on the Practical Applications of Short-Lived Radioisotopes Produced in Small Research Reactors| 448 p.
Subject:
07 ISOTOPES AND RADIATION SOURCES; EMISSION; HALF-LIFE; INTERNAL CONVERSION; IODINE; IODINE 132; ISOTOPIC EXCHANGE; LABELLING; LIQUIDS; RADIOCHROMATOGRAPHY; REACTIVITY; SYNTHESIS; TELLURIUM 132; TRACER TECHNIQUES
OSTI ID:
22173496
Research Organizations:
International Atomic Energy Agency, Vienna (Austria)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
Other: ISSN 0074-1884; TRN: XA13M4237127953
Submitting Site:
INIS
Size:
page(s) 181-189
Announcement Date:
Dec 16, 2013

Conference:

Citation Formats

Adloff, J. -P., and Adloff-Bacher, M. Application of the {beta}-Decay of Te{sup 132} for the Preparation of I{sup 132} -Labelled Molecules; Application de la Desintegration {sup 132}Te {beta}{sup -} -> {sup 132}I a la preparation de Molecules Marquees; ИСПОЛЬЗОВАНИЕ {beta}-РАСПАДА Te{sup 132} - J{sup 132} ДЛЯ ПОЛУЧЕНИЯ МЕЧЕНЫХ МОЛЕКУЛ; Preparacion de Moleculas Marcadas Aplicando la Desintegracion {sup 132}Te {beta}{sup -} {sup 132}I. IAEA: N. p., 1963. Web.
Adloff, J. -P., & Adloff-Bacher, M. Application of the {beta}-Decay of Te{sup 132} for the Preparation of I{sup 132} -Labelled Molecules; Application de la Desintegration {sup 132}Te {beta}{sup -} -> {sup 132}I a la preparation de Molecules Marquees; ИСПОЛЬЗОВАНИЕ {beta}-РАСПАДА Te{sup 132} - J{sup 132} ДЛЯ ПОЛУЧЕНИЯ МЕЧЕНЫХ МОЛЕКУЛ; Preparacion de Moleculas Marcadas Aplicando la Desintegracion {sup 132}Te {beta}{sup -} {sup 132}I. IAEA.
Adloff, J. -P., and Adloff-Bacher, M. 1963. "Application of the {beta}-Decay of Te{sup 132} for the Preparation of I{sup 132} -Labelled Molecules; Application de la Desintegration {sup 132}Te {beta}{sup -} -> {sup 132}I a la preparation de Molecules Marquees; ИСПОЛЬЗОВАНИЕ {beta}-РАСПАДА Te{sup 132} - J{sup 132} ДЛЯ ПОЛУЧЕНИЯ МЕЧЕНЫХ МОЛЕКУЛ; Preparacion de Moleculas Marcadas Aplicando la Desintegracion {sup 132}Te {beta}{sup -} {sup 132}I." IAEA.
@misc{etde_22173496,
title = {Application of the {beta}-Decay of Te{sup 132} for the Preparation of I{sup 132} -Labelled Molecules; Application de la Desintegration {sup 132}Te {beta}{sup -} -> {sup 132}I a la preparation de Molecules Marquees; ИСПОЛЬЗОВАНИЕ {beta}-РАСПАДА Te{sup 132} - J{sup 132} ДЛЯ ПОЛУЧЕНИЯ МЕЧЕНЫХ МОЛЕКУЛ; Preparacion de Moleculas Marcadas Aplicando la Desintegracion {sup 132}Te {beta}{sup -} {sup 132}I}
author = {Adloff, J. -P., and Adloff-Bacher, M.}
abstractNote = {The principal advantage of iodine-132 in biological and medical applications, and in uses as a radioactive tracer, lies in its short half-life (T{sub 1/2} = 2.30 h) which, however, represents a serious drawback for the synthesis of labelled molecules. The paper shows that it is possible to take advantage of the chemical reactivity of 'nascent' iodine, formed during {beta}-decay of tellurium-132, for rapidly preparing labelled species with a high specific activity. This reactivity comes partly from the sudden change of the atomic number during the decay, which in turn releases a highly excited iodine atom, and partly from the internal conversion of the {gamma}-ray following the {beta}-emission. Iodine-132 has to be formed within the medium to be labelled: the most convenient chemical form for the parent compound is tellurium-132 tetrachloride, which is soluble in a number of organic liquids. Several systems have been studied (aromatic hydrocarbons and derivatives, alcohols, etc.)- After a few hours of contact, the organic solution is analysed by gaseous phase radiochromatography, and the separation of the various labelled species formed by radiosynthesis can be effected by distillation after addition of carriers. The labelled products may be the results of isotopic exchange or hydrogen abstraction and fragmentation reactions. Near-specific labelling can be achieved in some cases by the use of a suitable organic medium. (author) [French] La courte periode de l'iode-132 (T{sub 1/2} = 2,30h)qui justifie son interet en biologie, en medecine et comme indicateur radioactif, represente cependant un inconvenient majeur lorsqu'il s'agit de realiser la synthese de molecules marquees. On montre qu'il est possible de tirer profit de la reactivite chimique de l'iode 'naissant ' forme par la desintegration de tellure-132, en vue de preparer rapidement des molecules marquees avec une activite specifique elevee. Cette reactivite provient de l'energie d'excitation de l'iode, due a la brusque variation de la charge nucleaire au cours de la desintegration,ainsi que de la conversion interne du rayonnement y succedant l'emission {beta}. L'iode-132 doit se former au sein du systeme a marquer: la forme chimique la plus appropriee du compose parent est le tetrachlorure de tellure-132, soluble dans un certain nombre de liquides organiques. Plusieurs systemes ont ainsi ete etudies (hydrocarbures aromatiques et derives, alcools, etc.). Apres un contactdequelques heures, la solution organique est analysee par chromatographie en phase gazeuse et les differents composes, marques par radiosynthese, sont separes par distillation en presenced'entraineurs. Les produits marques peuvent etre le resultat de reactions d'echanges isotopiques ou de substitution et fragmentation. L'emploi d'un milieu organique convenable permet dans certains cas un marquage pratiquement specifique. (author) [Spanish] El corlo periodo de semidesintegracion del yodo-132 (T{sub 1/2} = 2,30 h), que justifica su interes en biologia, medicina y como indicador radiactivo entrana no obstante un inconveniente grave cuando se trata de sintetizar moleculas marcadas. Los autores demuestran que es posible sacar provecho de la reactividad quimica del yodo 'naciente' formado por desintegracion del teluro-132 para preparar rapidamente moleculas marcadas de elevada actividad especifica. Esta reactividad se debe a la energia de excitacion del yodo, causada por la brusca variacion de la carga nuclear durante la desintegracion, asi como por la conversion interna de las radiaciones y que suceden a la emision {beta}. El yodo-132 tiene que formarse dentro del sistema que se desea marcar; la forma quimica mas adecuada del compuesto madre es el tetracloruro de teluro-132, soluble en algunos liquidos organicos. De este modo se han estudiado varios sistemas (hidrocarburos aromaticos y sus derivados, alcoholes, etc. ...). Despues de un contacto de algunas horas, la solucion organica se analiza por cromatografia de gases y los diversos compuestos, marcados por radiosintesis, se separan por destilacion en presencia de portadores. Los productos marcados pueden resultar de reacciones de intercambio isotopico o de sustitucion y fragmentacion. En ciertos casos, el empleo de un medio organico conveniente permite lograr una marcacion practicamente especifica. (author) [Russian] Korotkij period poluraspada izotopa J{sup 132} (T{sub 1/2} = 2,3 chasa), kotoryj opravdyvaet Interes, projavljaemyj k nemu v biologii i: medicine, i kotoryj javljaetsja svoego roda radioaktivnym indikatorom, predstavljaet vmeste s tem samoe bol'shoe neudobstvo, kogda idet rech' o provedenii sinteza mechenyh molekul. Otmechaetsja vozmozhnost' ispol'zovanija himicheskoj reaktivnosti 'dochernego' izotopa joda, obrazujushhegosja v rezul'tate raspada Te{sup 1}'3{sup 2} dlja bystrogo poluchenija mechenyh molekul s bol'shoj udel'noj aktivnost'ju. Jeta reaktivnost' voznikaet iz jenergii vozbuzhdenija joda, poduchaemoj v rezul'tate rezkogo izmenenija zarjada jadra v processe raspada, a takzhe vnutrennej konversii, soprovozhdajushhejsja {beta}-izlucheniem, sledujushhej za Je-raspadom. Jod-132 obrazuetsja v sisteme, prednaznachennoj dlja mechenija; naibolee podhodjashhej himicheskoj formoj ishodnogo komponenta javljaetsja chetyrehhloristyj Te{sup 132} v opredelennom organichjoskom rastvo rntele. V svjazi o jetim issledovanijam podvergalis' neskol'ko sistem (aromaticheskie uglevodorody i proizvodnye, spirty i pr.), Posde obluchenija v techenie neskol'kih chasov organicheskij rastvor analizirovalsja metodom gazovoj hromatografii. Razlichnye mechenye komponenty otdeljalis' putem distilljacii s nositelem. Mechenye produkty mogut byt' polucheny v rezul'tate reakcij izotopnogo obmena, zameshhenija i razlozhenija. Ispol'zovanie podhodjashhej organicheskoj sredy pozvoljaet v opredelennyh sluchajah proizvodit' na praktike specificheskoe mechenie. (author)}
place = {IAEA}
year = {1963}
month = {Mar}
}