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Tomographic and functional findings in severe COPD: comparison between the wood smoke-related and smoking-related disease

Abstract

Objective: Wood smoke exposure is a risk factor for COPD. For a given degree of airway obstruction, the reduction in DLCO is smaller in individuals with wood smoke-related COPD than in those with smoking-related COPD, suggesting that there is less emphysema in the former. The objective of this study was to compare HRCT findings between women with wood smoke-related COPD and women with smoking-related COPD. Methods: Twenty-two women with severe COPD (FEV1/FVC ratio < 70% and FEV1 < 50%) were divided into two groups: those with wood smoke-related COPD (n = 12) and those with smoking-related COPD (n = 10). The two groups were compared regarding emphysema scores and airway involvement (as determined by HRCT); and functional abnormalities-spirometry results, DLCO, alveolar volume (VA), the DLCO/VA ratio, lung volumes, and specific airway resistance (sRaw). Results: There were no significant differences between the two groups in terms of FEV1, sRaw, or lung hyperinflation. Decreases in DLCO and in the DLCO/VA ratio were greater in the smoking-related COPD group subjects, who also had higher emphysema scores, in comparison with the wood smoke-related COPD group subjects. In the wood smoke-related COPD group, HRCT scans showed no significant emphysema, the main findings being peribronchial thickening,  More>>
Publication Date:
Nov 01, 2013
Product Type:
Journal Article
Resource Relation:
Journal Name: Jornal Brasileiro de Pneumologia (Online); Journal Volume: 39; Journal Issue: 2
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; AIR POLLUTION; BIOMASS; COMPARATIVE EVALUATIONS; EMPHYSEMA; INHALATION; LUNGS; SMOKES; TOBACCO PRODUCTS; TOMOGRAPHY; WOOD
OSTI ID:
22163965
Country of Origin:
Brazil
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 1806-3756; TRN: BR1300266118401
Availability:
Available from http://www.scielo.br/pdf/jbpneu/v39n2/en_v39n2a05.pdf
Submitting Site:
BRN
Size:
page(s) 147-154
Announcement Date:
Dec 05, 2013

Citation Formats

Gonzalez-Garcia, Mauricio, Maldonado Gomez, Dario, Torres-Duque, Carlos A., Barrero, Margarita, Jaramillo Villegas, Claudia, Perez, Juan Manuel, Varon, Humberto, and Department of Radiology and Diagnostic Imaging, Children's Cardiology Foundation, Cardiology Institute, Bogota (Colombia)]. Tomographic and functional findings in severe COPD: comparison between the wood smoke-related and smoking-related disease. Brazil: N. p., 2013. Web.
Gonzalez-Garcia, Mauricio, Maldonado Gomez, Dario, Torres-Duque, Carlos A., Barrero, Margarita, Jaramillo Villegas, Claudia, Perez, Juan Manuel, Varon, Humberto, & Department of Radiology and Diagnostic Imaging, Children's Cardiology Foundation, Cardiology Institute, Bogota (Colombia)]. Tomographic and functional findings in severe COPD: comparison between the wood smoke-related and smoking-related disease. Brazil.
Gonzalez-Garcia, Mauricio, Maldonado Gomez, Dario, Torres-Duque, Carlos A., Barrero, Margarita, Jaramillo Villegas, Claudia, Perez, Juan Manuel, Varon, Humberto, and Department of Radiology and Diagnostic Imaging, Children's Cardiology Foundation, Cardiology Institute, Bogota (Colombia)]. 2013. "Tomographic and functional findings in severe COPD: comparison between the wood smoke-related and smoking-related disease." Brazil.
@misc{etde_22163965,
title = {Tomographic and functional findings in severe COPD: comparison between the wood smoke-related and smoking-related disease}
author = {Gonzalez-Garcia, Mauricio, Maldonado Gomez, Dario, Torres-Duque, Carlos A., Barrero, Margarita, Jaramillo Villegas, Claudia, Perez, Juan Manuel, Varon, Humberto, and Department of Radiology and Diagnostic Imaging, Children's Cardiology Foundation, Cardiology Institute, Bogota (Colombia)]}
abstractNote = {Objective: Wood smoke exposure is a risk factor for COPD. For a given degree of airway obstruction, the reduction in DLCO is smaller in individuals with wood smoke-related COPD than in those with smoking-related COPD, suggesting that there is less emphysema in the former. The objective of this study was to compare HRCT findings between women with wood smoke-related COPD and women with smoking-related COPD. Methods: Twenty-two women with severe COPD (FEV1/FVC ratio < 70% and FEV1 < 50%) were divided into two groups: those with wood smoke-related COPD (n = 12) and those with smoking-related COPD (n = 10). The two groups were compared regarding emphysema scores and airway involvement (as determined by HRCT); and functional abnormalities-spirometry results, DLCO, alveolar volume (VA), the DLCO/VA ratio, lung volumes, and specific airway resistance (sRaw). Results: There were no significant differences between the two groups in terms of FEV1, sRaw, or lung hyperinflation. Decreases in DLCO and in the DLCO/VA ratio were greater in the smoking-related COPD group subjects, who also had higher emphysema scores, in comparison with the wood smoke-related COPD group subjects. In the wood smoke-related COPD group, HRCT scans showed no significant emphysema, the main findings being peribronchial thickening, bronchial dilation, and subsegmental atelectasis. Conclusions: Female patients with severe wood smoke-related COPD do not appear to develop emphysema, although they do show severe airway involvement. The reduction in DLCO and VA, with a normal DLCO/VA ratio, is probably due to severe bronchial obstruction and incomplete mixing of inspired gas during the determination of single-breath DLCO. (author)}
journal = {Jornal Brasileiro de Pneumologia (Online)}
issue = {2}
volume = {39}
journal type = {AC}
place = {Brazil}
year = {2013}
month = {Nov}
}