Abstract
Objective: Wood smoke exposure is a risk factor for COPD. For a given degree of airway obstruction, the reduction in DLCO is smaller in individuals with wood smoke-related COPD than in those with smoking-related COPD, suggesting that there is less emphysema in the former. The objective of this study was to compare HRCT findings between women with wood smoke-related COPD and women with smoking-related COPD. Methods: Twenty-two women with severe COPD (FEV1/FVC ratio < 70% and FEV1 < 50%) were divided into two groups: those with wood smoke-related COPD (n = 12) and those with smoking-related COPD (n = 10). The two groups were compared regarding emphysema scores and airway involvement (as determined by HRCT); and functional abnormalities-spirometry results, DLCO, alveolar volume (VA), the DLCO/VA ratio, lung volumes, and specific airway resistance (sRaw). Results: There were no significant differences between the two groups in terms of FEV1, sRaw, or lung hyperinflation. Decreases in DLCO and in the DLCO/VA ratio were greater in the smoking-related COPD group subjects, who also had higher emphysema scores, in comparison with the wood smoke-related COPD group subjects. In the wood smoke-related COPD group, HRCT scans showed no significant emphysema, the main findings being peribronchial thickening,
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Gonzalez-Garcia, Mauricio;
Maldonado Gomez, Dario;
Torres-Duque, Carlos A.;
Barrero, Margarita;
Jaramillo Villegas, Claudia;
Perez, Juan Manuel;
Varon, Humberto;
[1]
Department of Radiology and Diagnostic Imaging, Children's Cardiology Foundation, Cardiology Institute, Bogota (Colombia)]
- Colombian Pulmonology Foundation, Bogota (Colombia)
Citation Formats
Gonzalez-Garcia, Mauricio, Maldonado Gomez, Dario, Torres-Duque, Carlos A., Barrero, Margarita, Jaramillo Villegas, Claudia, Perez, Juan Manuel, Varon, Humberto, and Department of Radiology and Diagnostic Imaging, Children's Cardiology Foundation, Cardiology Institute, Bogota (Colombia)].
Tomographic and functional findings in severe COPD: comparison between the wood smoke-related and smoking-related disease.
Brazil: N. p.,
2013.
Web.
Gonzalez-Garcia, Mauricio, Maldonado Gomez, Dario, Torres-Duque, Carlos A., Barrero, Margarita, Jaramillo Villegas, Claudia, Perez, Juan Manuel, Varon, Humberto, & Department of Radiology and Diagnostic Imaging, Children's Cardiology Foundation, Cardiology Institute, Bogota (Colombia)].
Tomographic and functional findings in severe COPD: comparison between the wood smoke-related and smoking-related disease.
Brazil.
Gonzalez-Garcia, Mauricio, Maldonado Gomez, Dario, Torres-Duque, Carlos A., Barrero, Margarita, Jaramillo Villegas, Claudia, Perez, Juan Manuel, Varon, Humberto, and Department of Radiology and Diagnostic Imaging, Children's Cardiology Foundation, Cardiology Institute, Bogota (Colombia)].
2013.
"Tomographic and functional findings in severe COPD: comparison between the wood smoke-related and smoking-related disease."
Brazil.
@misc{etde_22163965,
title = {Tomographic and functional findings in severe COPD: comparison between the wood smoke-related and smoking-related disease}
author = {Gonzalez-Garcia, Mauricio, Maldonado Gomez, Dario, Torres-Duque, Carlos A., Barrero, Margarita, Jaramillo Villegas, Claudia, Perez, Juan Manuel, Varon, Humberto, and Department of Radiology and Diagnostic Imaging, Children's Cardiology Foundation, Cardiology Institute, Bogota (Colombia)]}
abstractNote = {Objective: Wood smoke exposure is a risk factor for COPD. For a given degree of airway obstruction, the reduction in DLCO is smaller in individuals with wood smoke-related COPD than in those with smoking-related COPD, suggesting that there is less emphysema in the former. The objective of this study was to compare HRCT findings between women with wood smoke-related COPD and women with smoking-related COPD. Methods: Twenty-two women with severe COPD (FEV1/FVC ratio < 70% and FEV1 < 50%) were divided into two groups: those with wood smoke-related COPD (n = 12) and those with smoking-related COPD (n = 10). The two groups were compared regarding emphysema scores and airway involvement (as determined by HRCT); and functional abnormalities-spirometry results, DLCO, alveolar volume (VA), the DLCO/VA ratio, lung volumes, and specific airway resistance (sRaw). Results: There were no significant differences between the two groups in terms of FEV1, sRaw, or lung hyperinflation. Decreases in DLCO and in the DLCO/VA ratio were greater in the smoking-related COPD group subjects, who also had higher emphysema scores, in comparison with the wood smoke-related COPD group subjects. In the wood smoke-related COPD group, HRCT scans showed no significant emphysema, the main findings being peribronchial thickening, bronchial dilation, and subsegmental atelectasis. Conclusions: Female patients with severe wood smoke-related COPD do not appear to develop emphysema, although they do show severe airway involvement. The reduction in DLCO and VA, with a normal DLCO/VA ratio, is probably due to severe bronchial obstruction and incomplete mixing of inspired gas during the determination of single-breath DLCO. (author)}
journal = []
issue = {2}
volume = {39}
journal type = {AC}
place = {Brazil}
year = {2013}
month = {Nov}
}
title = {Tomographic and functional findings in severe COPD: comparison between the wood smoke-related and smoking-related disease}
author = {Gonzalez-Garcia, Mauricio, Maldonado Gomez, Dario, Torres-Duque, Carlos A., Barrero, Margarita, Jaramillo Villegas, Claudia, Perez, Juan Manuel, Varon, Humberto, and Department of Radiology and Diagnostic Imaging, Children's Cardiology Foundation, Cardiology Institute, Bogota (Colombia)]}
abstractNote = {Objective: Wood smoke exposure is a risk factor for COPD. For a given degree of airway obstruction, the reduction in DLCO is smaller in individuals with wood smoke-related COPD than in those with smoking-related COPD, suggesting that there is less emphysema in the former. The objective of this study was to compare HRCT findings between women with wood smoke-related COPD and women with smoking-related COPD. Methods: Twenty-two women with severe COPD (FEV1/FVC ratio < 70% and FEV1 < 50%) were divided into two groups: those with wood smoke-related COPD (n = 12) and those with smoking-related COPD (n = 10). The two groups were compared regarding emphysema scores and airway involvement (as determined by HRCT); and functional abnormalities-spirometry results, DLCO, alveolar volume (VA), the DLCO/VA ratio, lung volumes, and specific airway resistance (sRaw). Results: There were no significant differences between the two groups in terms of FEV1, sRaw, or lung hyperinflation. Decreases in DLCO and in the DLCO/VA ratio were greater in the smoking-related COPD group subjects, who also had higher emphysema scores, in comparison with the wood smoke-related COPD group subjects. In the wood smoke-related COPD group, HRCT scans showed no significant emphysema, the main findings being peribronchial thickening, bronchial dilation, and subsegmental atelectasis. Conclusions: Female patients with severe wood smoke-related COPD do not appear to develop emphysema, although they do show severe airway involvement. The reduction in DLCO and VA, with a normal DLCO/VA ratio, is probably due to severe bronchial obstruction and incomplete mixing of inspired gas during the determination of single-breath DLCO. (author)}
journal = []
issue = {2}
volume = {39}
journal type = {AC}
place = {Brazil}
year = {2013}
month = {Nov}
}