Abstract
FDG PET has been suggested to have predictive value in the prognosis of oesophageal carcinoma. However, the retrospective studies reported in the literature have shown discordant results. Additionally, only four studies have evaluated FDG PET during chemoradiotherapy (CRT) in patients with different histological lesions. The purpose of this study was to investigate the predictive value of FDG PET performed early during CRT (on day 21) in a population of patients with oesophageal squamous cell carcinoma. Included in this prospective study were 57 patients with a histological diagnosis of squamous cell carcinoma of the oesophagus. Of these 57 patients, 48 (84 %) were evaluated (aged 63 {+-} 11 years; 44 men, 4 women). Each patient underwent FDG PET (4.5 MBq/kg) before CRT, according to the Herskovic protocol (t0; PET{sub 1}) and on day 21 {+-} 3 from the start of CRT (d21; PET{sub 2}). The response assessment included a clinical examination, CT scan or FDG PET and histological analysis 3 months and 1 year after PET{sub 1}. The patients were classified as showing a complete response (CR) or a noncomplete response. A quantitative analysis was carried out for PET{sub 1} and PET{sub 2} using the following parameters: SUVmax, SUVmean (with SUVmean{sub
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Palie, Odre;
Vera, Pierre;
[1]
Michel, Pierre;
Di Fiore, Frederic;
[2]
Menard, Jean-Francois;
[3]
Rousseau, Caroline;
Bridji, Boumediene;
[4]
Rio, Emmanuel;
[5]
Benyoucef, Ahmed;
[6]
Meyer, Marc-Etienne;
[7]
Jalali, Khadija;
[8]
Bardet, Stephane;
[9]
M'Vondo, Che Mabubu;
[10]
Olivier, Pierre;
[11]
Faure, Guillaume;
[12]
Itti, Emmanuel;
[13]
Diana, Christian;
[14]
Houzard, Claire;
[15]
Mornex, Francoise
[16]
- Henri Becquerel Cancer Center and Rouen University Hospital, and QuantIF - LITIS (EA 4108), University of Rouen, Department of Nuclear Medicine, Faculty of Medicine, Rouen (France)
- Rouen University Hospital and University of Rouen, Digestive Oncology Unit, Hepatogastroenterology Department, Rouen (France)
- Rouen University Hospital and University of Rouen, Department of Biostatistic, Rouen (France)
- Department of Nuclear Medicine, Renee Gauducheau Cancer Center, Nantes (France)
- Department of Radiotherapy, Renee Gauducheau Cancer Center, Nantes (France)
- Department of Radiotherapy, Henri Becquerel Cancer Center, Rouen (France)
- Amiens University Hospital, Department of Nuclear Medicine, Amiens (France)
- Amiens University Hospital, Department of Radiotherapy, Amiens (France)
- Department of Nuclear Medicine, Francois Baclesse Cancer Center, Caen (France)
- Department of radiotherapy, Francois Baclesse Cancer Center, Caen (France)
- Brabois University Hospital, Department of Nuclear Medicine, Nancy (France)
- Department of Radiotherapy, Centre prive de Radiotherapie de Metz, Metz (France)
- Henri Mondor University Hospital, Department of Nuclear Medicine, Creteil (France)
- Henri Mondor University Hospital, Department of Radiotherapy, Creteil (France)
- Department of Nuclear Medicine, Hospices Civils de Lyon, Lyon (France)
- Department of Radiotherapy, Hospices Civils de Lyon, Lyon (France)
Citation Formats
Palie, Odre, Vera, Pierre, Michel, Pierre, Di Fiore, Frederic, Menard, Jean-Francois, Rousseau, Caroline, Bridji, Boumediene, Rio, Emmanuel, Benyoucef, Ahmed, Meyer, Marc-Etienne, Jalali, Khadija, Bardet, Stephane, M'Vondo, Che Mabubu, Olivier, Pierre, Faure, Guillaume, Itti, Emmanuel, Diana, Christian, Houzard, Claire, and Mornex, Francoise.
The predictive value of treatment response using FDG PET performed on day 21 of chemoradiotherapy in patients with oesophageal squamous cell carcinoma. A prospective, multicentre study (RTEP3).
Germany: N. p.,
2013.
Web.
doi:10.1007/S00259-013-2450-7.
Palie, Odre, Vera, Pierre, Michel, Pierre, Di Fiore, Frederic, Menard, Jean-Francois, Rousseau, Caroline, Bridji, Boumediene, Rio, Emmanuel, Benyoucef, Ahmed, Meyer, Marc-Etienne, Jalali, Khadija, Bardet, Stephane, M'Vondo, Che Mabubu, Olivier, Pierre, Faure, Guillaume, Itti, Emmanuel, Diana, Christian, Houzard, Claire, & Mornex, Francoise.
The predictive value of treatment response using FDG PET performed on day 21 of chemoradiotherapy in patients with oesophageal squamous cell carcinoma. A prospective, multicentre study (RTEP3).
Germany.
https://doi.org/10.1007/S00259-013-2450-7
Palie, Odre, Vera, Pierre, Michel, Pierre, Di Fiore, Frederic, Menard, Jean-Francois, Rousseau, Caroline, Bridji, Boumediene, Rio, Emmanuel, Benyoucef, Ahmed, Meyer, Marc-Etienne, Jalali, Khadija, Bardet, Stephane, M'Vondo, Che Mabubu, Olivier, Pierre, Faure, Guillaume, Itti, Emmanuel, Diana, Christian, Houzard, Claire, and Mornex, Francoise.
2013.
"The predictive value of treatment response using FDG PET performed on day 21 of chemoradiotherapy in patients with oesophageal squamous cell carcinoma. A prospective, multicentre study (RTEP3)."
Germany.
https://doi.org/10.1007/S00259-013-2450-7.
@misc{etde_22151250,
title = {The predictive value of treatment response using FDG PET performed on day 21 of chemoradiotherapy in patients with oesophageal squamous cell carcinoma. A prospective, multicentre study (RTEP3)}
author = {Palie, Odre, Vera, Pierre, Michel, Pierre, Di Fiore, Frederic, Menard, Jean-Francois, Rousseau, Caroline, Bridji, Boumediene, Rio, Emmanuel, Benyoucef, Ahmed, Meyer, Marc-Etienne, Jalali, Khadija, Bardet, Stephane, M'Vondo, Che Mabubu, Olivier, Pierre, Faure, Guillaume, Itti, Emmanuel, Diana, Christian, Houzard, Claire, and Mornex, Francoise}
abstractNote = {FDG PET has been suggested to have predictive value in the prognosis of oesophageal carcinoma. However, the retrospective studies reported in the literature have shown discordant results. Additionally, only four studies have evaluated FDG PET during chemoradiotherapy (CRT) in patients with different histological lesions. The purpose of this study was to investigate the predictive value of FDG PET performed early during CRT (on day 21) in a population of patients with oesophageal squamous cell carcinoma. Included in this prospective study were 57 patients with a histological diagnosis of squamous cell carcinoma of the oesophagus. Of these 57 patients, 48 (84 %) were evaluated (aged 63 {+-} 11 years; 44 men, 4 women). Each patient underwent FDG PET (4.5 MBq/kg) before CRT, according to the Herskovic protocol (t0; PET{sub 1}) and on day 21 {+-} 3 from the start of CRT (d21; PET{sub 2}). The response assessment included a clinical examination, CT scan or FDG PET and histological analysis 3 months and 1 year after PET{sub 1}. The patients were classified as showing a complete response (CR) or a noncomplete response. A quantitative analysis was carried out for PET{sub 1} and PET{sub 2} using the following parameters: SUVmax, SUVmean (with SUVmean{sub 40} as the 3-D volume at an SUVmax threshold of 40 % and SUVmean{sub p} as that defined by a physician), tumour volume (TV, with TV{sub 40} defined as the TV at 40 % of SUVmax, and TV{sub p} as that defined by a physician); and the total lesion glycolysis (TLG, SUVmean x TV, with TLG{sub 40} defined as the TLG at 40 % of SUVmax, and TLG{sub p} as that defined by a physician). The differences in responses at 3 months and 1 year between PET{sub 1} (t0) and PET{sub 2} (d21) were assessed in terms of variations in SUV, TV and TLG using a repeated measures of variance (ANOVA). SUVmax, SUVmean and TLG decreased significantly between PET{sub 1} (t0) and PET{sub 2} (d21; p < 0.0001). The TV significantly decreased only when assessed as TV{sub p} (p = 0.02); TV{sub 40} did not decrease significantly. With respect to the predictive value of PET{sub 1}, only TV{sub 40} {sub 1} and TV{sub p} {sub 1} values, and therefore TLG{sub 40} {sub 1} and TLG{sub p} {sub 1}, but not the SUV values, were significantly lower in patients with CR at 3 months. SUVmax{sub 1}, TV{sub p} {sub 1} and TLG{sub p} {sub 1} were significantly lower in patients with CR at 1 year. With respect to the predictive value of PET{sub 2}, only TV{sub 40} {sub 2} and TV{sub p} {sub 2} values, and therefore TLG{sub 40} {sub 2} and TLG{sub p} {sub 2}, but not the SUV values, were significantly lower in patients with CR at 3 months. None of the PET{sub 2} parameters had significant value in predicting patient outcome at 1 year. The changes in SUVmax, TV{sub 40}, TV{sub p}, TLG{sub 40} and TLG{sub p} between PET{sub 1} and PET{sub 2} had no relationship to patient outcome at 3 months or 1 year. This prospective, multicentre study performed in a selected population of patients with oesophageal squamous cell cancer demonstrates that the parameters derived from baseline PET{sub 1} are good predictors of response to CRT. Specifically, a high TV and TLG are associated with a poor response to CRT at 3 months and 1 year, and a high SUVmax is associated with a poor response to CRT at 1 year. FDG PET performed during CRT on day 21 appears to have less clinical relevance. However, patients with a large functional TV on day 21 of CRT have a poor clinical outcome (ClinicalTrials.gov NCT 00934505). (orig.)}
doi = {10.1007/S00259-013-2450-7}
journal = []
issue = {9}
volume = {40}
journal type = {AC}
place = {Germany}
year = {2013}
month = {Sep}
}
title = {The predictive value of treatment response using FDG PET performed on day 21 of chemoradiotherapy in patients with oesophageal squamous cell carcinoma. A prospective, multicentre study (RTEP3)}
author = {Palie, Odre, Vera, Pierre, Michel, Pierre, Di Fiore, Frederic, Menard, Jean-Francois, Rousseau, Caroline, Bridji, Boumediene, Rio, Emmanuel, Benyoucef, Ahmed, Meyer, Marc-Etienne, Jalali, Khadija, Bardet, Stephane, M'Vondo, Che Mabubu, Olivier, Pierre, Faure, Guillaume, Itti, Emmanuel, Diana, Christian, Houzard, Claire, and Mornex, Francoise}
abstractNote = {FDG PET has been suggested to have predictive value in the prognosis of oesophageal carcinoma. However, the retrospective studies reported in the literature have shown discordant results. Additionally, only four studies have evaluated FDG PET during chemoradiotherapy (CRT) in patients with different histological lesions. The purpose of this study was to investigate the predictive value of FDG PET performed early during CRT (on day 21) in a population of patients with oesophageal squamous cell carcinoma. Included in this prospective study were 57 patients with a histological diagnosis of squamous cell carcinoma of the oesophagus. Of these 57 patients, 48 (84 %) were evaluated (aged 63 {+-} 11 years; 44 men, 4 women). Each patient underwent FDG PET (4.5 MBq/kg) before CRT, according to the Herskovic protocol (t0; PET{sub 1}) and on day 21 {+-} 3 from the start of CRT (d21; PET{sub 2}). The response assessment included a clinical examination, CT scan or FDG PET and histological analysis 3 months and 1 year after PET{sub 1}. The patients were classified as showing a complete response (CR) or a noncomplete response. A quantitative analysis was carried out for PET{sub 1} and PET{sub 2} using the following parameters: SUVmax, SUVmean (with SUVmean{sub 40} as the 3-D volume at an SUVmax threshold of 40 % and SUVmean{sub p} as that defined by a physician), tumour volume (TV, with TV{sub 40} defined as the TV at 40 % of SUVmax, and TV{sub p} as that defined by a physician); and the total lesion glycolysis (TLG, SUVmean x TV, with TLG{sub 40} defined as the TLG at 40 % of SUVmax, and TLG{sub p} as that defined by a physician). The differences in responses at 3 months and 1 year between PET{sub 1} (t0) and PET{sub 2} (d21) were assessed in terms of variations in SUV, TV and TLG using a repeated measures of variance (ANOVA). SUVmax, SUVmean and TLG decreased significantly between PET{sub 1} (t0) and PET{sub 2} (d21; p < 0.0001). The TV significantly decreased only when assessed as TV{sub p} (p = 0.02); TV{sub 40} did not decrease significantly. With respect to the predictive value of PET{sub 1}, only TV{sub 40} {sub 1} and TV{sub p} {sub 1} values, and therefore TLG{sub 40} {sub 1} and TLG{sub p} {sub 1}, but not the SUV values, were significantly lower in patients with CR at 3 months. SUVmax{sub 1}, TV{sub p} {sub 1} and TLG{sub p} {sub 1} were significantly lower in patients with CR at 1 year. With respect to the predictive value of PET{sub 2}, only TV{sub 40} {sub 2} and TV{sub p} {sub 2} values, and therefore TLG{sub 40} {sub 2} and TLG{sub p} {sub 2}, but not the SUV values, were significantly lower in patients with CR at 3 months. None of the PET{sub 2} parameters had significant value in predicting patient outcome at 1 year. The changes in SUVmax, TV{sub 40}, TV{sub p}, TLG{sub 40} and TLG{sub p} between PET{sub 1} and PET{sub 2} had no relationship to patient outcome at 3 months or 1 year. This prospective, multicentre study performed in a selected population of patients with oesophageal squamous cell cancer demonstrates that the parameters derived from baseline PET{sub 1} are good predictors of response to CRT. Specifically, a high TV and TLG are associated with a poor response to CRT at 3 months and 1 year, and a high SUVmax is associated with a poor response to CRT at 1 year. FDG PET performed during CRT on day 21 appears to have less clinical relevance. However, patients with a large functional TV on day 21 of CRT have a poor clinical outcome (ClinicalTrials.gov NCT 00934505). (orig.)}
doi = {10.1007/S00259-013-2450-7}
journal = []
issue = {9}
volume = {40}
journal type = {AC}
place = {Germany}
year = {2013}
month = {Sep}
}