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Prenylated flavone from roots of a hybrid between Artocarpus heterophyllus and Artocarpus integer and its biological activities

Abstract

One new prenylated flavone, 2,8-dihydroxy-3,10-dimethoxy-6-(2-methyl-1-propen-1-yl)- 6H,7H-[1]benzopyrano[4,3-b][1]-benzopyran-7-one, together with 24 known compounds were isolated from crude acetone extract from the roots of a hybrid between Artocarpus heterophyllus and Artocarpus integer. Their structures were determined by 1D and 2D nuclear magnetic resonance (NMR) spectroscopic data. The antioxidant and antibacterial activities of the isolated compounds were evaluated. The new compound showed potent antioxidant activity against DPPH Bullet and superoxide with IC{sub 50} values of 0.033 and 0.125 mg mL{sup -1}, respectively. Significant antibacterial activity against Acinetobacter baumannii was observed with MIC value of 50 {mu}g mL{sup -1}. (author)
Authors:
Panthong, Kanda; [1]  Tohdee, Kanogwan; [2]  Hutadilok-Towatana, Nongporn; [3]  Voravuthikunchai, Supayang P.; [4]  Chusri, Sasitorn [5] 
  1. Prince of Songkla University (Thailand). Natural Product Research Center of Excellence
  2. Prince of Songkla University (Thailand). Faculty of Science. Department of Chemistry
  3. Prince of Songkla University (Thailand). Dept. of Biochemistry
  4. Prince of Songkla University (Thailand). Faculty of Science. Department of Microbiology
  5. Prince of Songkla University (Thailand). Faculty of Traditional Thai Medicine
Publication Date:
Oct 15, 2013
Product Type:
Journal Article
Resource Relation:
Journal Name: Journal of the Brazilian Chemical Society; Journal Volume: 24; Journal Issue: 10
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; ACETONE; ANTIOXIDANTS; BENZOPYRENE; CARBON 13; FLAVONES; FURANS; HYDROGEN 1; INFRARED SPECTRA; LIQUID COLUMN CHROMATOGRAPHY; MASS SPECTRA; NMR SPECTRA; RECRYSTALLIZATION; SILANES; THIN-LAYER CHROMATOGRAPHY
OSTI ID:
22146038
Country of Origin:
Brazil
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0103-5053; CODEN: JOCSET; TRN: BR13V0579100687
Availability:
Available from http://www.scielo.br/pdf/jbchs/v24n10/v24n10a14.pdf
Submitting Site:
BRN
Size:
page(s) 1656-1661
Announcement Date:
Nov 14, 2013

Citation Formats

Panthong, Kanda, Tohdee, Kanogwan, Hutadilok-Towatana, Nongporn, Voravuthikunchai, Supayang P., and Chusri, Sasitorn. Prenylated flavone from roots of a hybrid between Artocarpus heterophyllus and Artocarpus integer and its biological activities. Brazil: N. p., 2013. Web.
Panthong, Kanda, Tohdee, Kanogwan, Hutadilok-Towatana, Nongporn, Voravuthikunchai, Supayang P., & Chusri, Sasitorn. Prenylated flavone from roots of a hybrid between Artocarpus heterophyllus and Artocarpus integer and its biological activities. Brazil.
Panthong, Kanda, Tohdee, Kanogwan, Hutadilok-Towatana, Nongporn, Voravuthikunchai, Supayang P., and Chusri, Sasitorn. 2013. "Prenylated flavone from roots of a hybrid between Artocarpus heterophyllus and Artocarpus integer and its biological activities." Brazil.
@misc{etde_22146038,
title = {Prenylated flavone from roots of a hybrid between Artocarpus heterophyllus and Artocarpus integer and its biological activities}
author = {Panthong, Kanda, Tohdee, Kanogwan, Hutadilok-Towatana, Nongporn, Voravuthikunchai, Supayang P., and Chusri, Sasitorn}
abstractNote = {One new prenylated flavone, 2,8-dihydroxy-3,10-dimethoxy-6-(2-methyl-1-propen-1-yl)- 6H,7H-[1]benzopyrano[4,3-b][1]-benzopyran-7-one, together with 24 known compounds were isolated from crude acetone extract from the roots of a hybrid between Artocarpus heterophyllus and Artocarpus integer. Their structures were determined by 1D and 2D nuclear magnetic resonance (NMR) spectroscopic data. The antioxidant and antibacterial activities of the isolated compounds were evaluated. The new compound showed potent antioxidant activity against DPPH Bullet and superoxide with IC{sub 50} values of 0.033 and 0.125 mg mL{sup -1}, respectively. Significant antibacterial activity against Acinetobacter baumannii was observed with MIC value of 50 {mu}g mL{sup -1}. (author)}
journal = []
issue = {10}
volume = {24}
journal type = {AC}
place = {Brazil}
year = {2013}
month = {Oct}
}