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Radioisotope Scanning of the Pancreas with Selenomethionine-Se{sup 75}; Gammagraphie du Pancreas a l'Aide de la Selenomethionine-{sup 75}Se; Diagnosticheskoe fotoskennirovanie podzheludochnoj zhelezy; Gammagrafia del Pancreas Mediante Radioisotopos

Conference:

Abstract

Photoscanning of the pancreas utilizing selenomethionine- Se{sup 75} has recently been shown to be a practical technique. In a series of 100 patients who underwent 250 such photoscans, the pancreas was visualized in 90% of the cases. The physiological stimulation of the pancreas was found to be the most important factor in pancreatic selenomethionine-Se{sup 75} concentration. Utilizing a 30-g protein meal, physiological stimulation of the pancreas was begun one hour before the intravenous administration of 3 to 4- {mu}c/kg selenomethionine-Se{sup 75}. Fifteen minutes later continued stimulation of the pancreas was ensured by the oral administration of 900 {mu}g of glutamic acid hydrochloride. Before scanning the pancreas, a 3/8 - in curved lead shield was placed over the liver bed previously outlined by an Au{sup 198} liver scan. This lead shield blocks the radiation from the concentration of selenomethionine-Se{sup 75} in the liver that in the past impaired accurate delineation of the pancreas. The authors have recently utilized a 5-in by 3-in crystal and a 121-hole lead collimator with a 5-in focal distance. This has further improved delineation of the pancreas and, as the technique is perfected, smaller lesions at greater depths may be visualized. The results show that pancreatic carcinoma  More>>
Authors:
Sodee, D. B. [1] 
  1. Doctors Hospital and Renner Clinic Foundation, Cleveland Heights, OH (United States)
Publication Date:
Oct 15, 1964
Product Type:
Conference
Report Number:
IAEA-SM-51/76
Resource Relation:
Conference: Symposium on medical radioisotope scanning, Athens (Greece), 20-24 Apr 1964; Other Information: Abstract also available in French; 7 refs., 7 figs., 1 tab.; Related Information: In: Medical Radioisotope Scanning, Vol. II. Proceedings of the Symposium on Medical Radioisotope Scanning| 484 p.
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ADENOMAS; ANIMAL TISSUES; COLLIMATORS; CRYSTALS; DIGESTIVE SYSTEM DISEASES; GLUTAMIC ACID; GOLD 198; LIVER; METHIONINE; ORAL ADMINISTRATION; PANCREAS; PATIENTS; RADIOISOTOPE SCANNING; RADIOPHARMACEUTICALS; SELENIUM 75; STIMULATION
OSTI ID:
22143630
Research Organizations:
International Atomic Energy Agency, Vienna (Austria)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
Other: ISSN 0074-1884; TRN: XA13M3088098336
Submitting Site:
INIS
Size:
page(s) 289-300
Announcement Date:
Oct 31, 2013

Conference:

Citation Formats

Sodee, D. B. Radioisotope Scanning of the Pancreas with Selenomethionine-Se{sup 75}; Gammagraphie du Pancreas a l'Aide de la Selenomethionine-{sup 75}Se; Diagnosticheskoe fotoskennirovanie podzheludochnoj zhelezy; Gammagrafia del Pancreas Mediante Radioisotopos. IAEA: N. p., 1964. Web.
Sodee, D. B. Radioisotope Scanning of the Pancreas with Selenomethionine-Se{sup 75}; Gammagraphie du Pancreas a l'Aide de la Selenomethionine-{sup 75}Se; Diagnosticheskoe fotoskennirovanie podzheludochnoj zhelezy; Gammagrafia del Pancreas Mediante Radioisotopos. IAEA.
Sodee, D. B. 1964. "Radioisotope Scanning of the Pancreas with Selenomethionine-Se{sup 75}; Gammagraphie du Pancreas a l'Aide de la Selenomethionine-{sup 75}Se; Diagnosticheskoe fotoskennirovanie podzheludochnoj zhelezy; Gammagrafia del Pancreas Mediante Radioisotopos." IAEA.
@misc{etde_22143630,
title = {Radioisotope Scanning of the Pancreas with Selenomethionine-Se{sup 75}; Gammagraphie du Pancreas a l'Aide de la Selenomethionine-{sup 75}Se; Diagnosticheskoe fotoskennirovanie podzheludochnoj zhelezy; Gammagrafia del Pancreas Mediante Radioisotopos}
author = {Sodee, D. B.}
abstractNote = {Photoscanning of the pancreas utilizing selenomethionine- Se{sup 75} has recently been shown to be a practical technique. In a series of 100 patients who underwent 250 such photoscans, the pancreas was visualized in 90% of the cases. The physiological stimulation of the pancreas was found to be the most important factor in pancreatic selenomethionine-Se{sup 75} concentration. Utilizing a 30-g protein meal, physiological stimulation of the pancreas was begun one hour before the intravenous administration of 3 to 4- {mu}c/kg selenomethionine-Se{sup 75}. Fifteen minutes later continued stimulation of the pancreas was ensured by the oral administration of 900 {mu}g of glutamic acid hydrochloride. Before scanning the pancreas, a 3/8 - in curved lead shield was placed over the liver bed previously outlined by an Au{sup 198} liver scan. This lead shield blocks the radiation from the concentration of selenomethionine-Se{sup 75} in the liver that in the past impaired accurate delineation of the pancreas. The authors have recently utilized a 5-in by 3-in crystal and a 121-hole lead collimator with a 5-in focal distance. This has further improved delineation of the pancreas and, as the technique is perfected, smaller lesions at greater depths may be visualized. The results show that pancreatic carcinoma does not concentrate selenomethionine-Se{sup 75} as well as normal tissue. Five of six patients with pancreatic carcinoma had their disease correctly interpreted by this procedure. The smallest carcinoma not visualized was obscured by an enlarged liver. Acute and chronic pancreatitis are also confirmed by the pancreatic scan as the impaired cells of the pancreas do not concentrate selenomethionine-Se{sup 75}. The author also reports selective uptake of selenomethionine-Se{sup 75} by parathyroid tissue. Utilizing the. same scanning technique parathyroid adenomas in a small group of hyperparathyroid patients have been visualized. Photoscanning of the pancreas is already a practical technique and an investigation of photoscanning of the parathyroid is now being undertaken. With the renewed interest in organs that previously could not be visualized by standard radiographic techniques, selective organ scanning, by means of labelled compounds chosen for their biochemical properties, becomes an important technique of the future. (author) [Spanish] La eficacia de la fotoexploracion del pancreas utilizando selenometionina-{sup 75}Se ha sido recientemente demostrada. Se han efectuado 250 foto- exploraciones de ese tipo en una serie de 100 pacientes y el pancreas se ha visualizado en el 90% de los casos. Se ha observado que el estimulo fisiologico del pancreas es el factor mas importante en la concentracion pancreatica de la selenometionina-{sup 75}Se. Administrando 30 g de comida proteica, el estimulo fisiologico del pancreas empezo una hora antes de inyectar por via intravenosa de 3 a 4 {mu}/kg de selenometionina-{sup 75}Se. Quince minutos despues se logro el estimulo continuo por administracion oral de 900 {mu}g de clorhidrate de acido glutamico. Antes de proceder a la exploracion se coloco un blindaje de plomo de 3/8 pulg de espesor, adaptado a la region hepatica previamente delimitada por una exploracion del higado mediante {sup 198}Au. Este blindaje intercepta la radiacion emitida por la selenometionina-{sup 75}Se concentrada en el higado, radiacion que antes impedia la delimitacion exacta del pancreas. El autor ha utilizado recientemente un cristal de 5 x 3 pulg y un colimador de plomo de 121 canales, con una distancia focal de 5 pulg. Este instrumento ha permitido mejorar la delimitacion del pancreas y localizar lesiones mas pequenas situadas a mayor profundidad. Los resultados obtenidos demuestran que la concentracion de la selenometionina-{sup 75}Se es menor en los carcinomas pancreaticos que en el tejido normal. Examinados con esa tecnica seis pacientes afectados de carcinoma pancreatico se diagnostico correctamente le enfermedad en cinco casos. El carcinoma mas pequeno que no pudo visualizarse estaba ocultado por el higado hipertrofiado. La exploracion pancreatica permite tambien confirmar la pancreatitis aguda y cronica, ya que las celulas lesionadas no concentran la selenometionina-{sup 75}Se. El autor trata ademas de la concentracion selectiva de la selenometionina{sup 75}Se en el tejido paratiroideo. Con la misma tecnica de expioracion se han visualizado adenomas paratiroideos en un pequeno grupo de enfermos de hiperparatiroidismo. La fotoexploracion del pancreas es ya una tecnica de uso corriente; actualmente se estudia la posibilidad de una fotoexploracion de la paratiroides. Debido a la mayor importancia medica atribuida a organos que antes no podian visualizarse con las tecnicas radiograficas tradicionales, la exploracion selectiva de organos por medio de compuestos marcados, elegidos segun sus propiedades bioquimicas, va adquiriendo cada vez mayor importancia. (author) [Russian] Nedavno bylo pokazano, chto fotoskennirovanie podzheludochnoj zhelezy s pomoshh'ju selenometionina, mechennogo {sup 75}Se , javljaetsja prakticheskim metodom. U 90%iz 100 bol'nyh, u kotoryh bylo polucheno 250 podobnyh fotoskennogramm, mozhno bylo otchetlivo videt' podzheludochnuju zhelezu. Bylo obnaruzheno, chto fiziologicheskaja stimuljacija podzheludochnoj zhelezy javljaetsja glavnym faktorom koncentracii selenometionina -Se15 v podzheludochnoj zheleze. Za chas do vnutrivennogo vvedenija v organizm 3-4 mkk/kg selenometionina-Ze75 s pomoshh'ju 30 grammov belkovoj pishhi byla nachata fiziologicheskaja stimuljacija podzheludochnoj zhelezy. Cherez 15 minut byla dostignuta nepreryvnaja stimuljacija podzheludochnoj zhelezy putem vvedenija cherez rot 900 mkg gidrohlorida glutaminovoj kisloty. Do skennirovanija podzheludochnoj zhelezy nad oblast'ju pecheni, predvaritel'no opredelennoj pri skennirovanii s pomoshh'ju zolota-198, byl pomeshhen izognutyj zashhitnyj jekran iz svinca razmerom 0,9 sm, Jetot jekran blokiruet voznikajushhee v rezul'tate koncentraciiselenometionina - {sup 75}Se v pecheni izluchenie, kotoroe v proshlom meshalo tochnomu opredeleniju kontura podzheludochnoj zhelezy. Nedavno avtory ispol'zovali kristall razmerom 12,5 h 7,5 sm i 121-kanal'nyj svincovyj kollimator s fokusnym rasstojaniem 12,5 sm. Jeto uluchshilo kachestvo izobrazhenija, i po mere usovershenstvovanija metodiki mozhno budet, verojatno, videt' men'shie povrezhdenija na bol'shej glubine. Okazalos',chto karcinoma podzheludochnoj zhelezy koncentriruet selenometionina -Se75 . huzhe, chem normal'naja tkan'. S pomoshh'ju jetoj metodiki udalos' pravil'no istolkovat' zabolevanie u 5 iz 6 bol'nyh, stradajushhih karcinomoj podzheludochnoj zhelezy. Nepoddajushhiesja obnaruzheniju Mel'chajshie karcinomatoznye uzly byli zatemneny uvelichennoj pechen'ju. Diagnoz ostrogo i hronicheskogo pankreatita takzhe podtverzhdaetsja skennirovaniem podzheludochnoj zhelezy, poskol'ku povrezhdennye kletki podzheluzhochnoj zhelezy ne koncentrirujut selenometionin -{sup 75}Se. Avtor takzhe opisyvaet izbiratel'noe pogloshhenie selenometionina -{sup 75}Se tkan'ju para- shhitovidnoj zhelezy . S pomoshh'ju jetogo zhe metoda skennirovanija byli obnaruzheny adenomy parashhitovidnoj zhelezy u nebol'shoj gruppy bol'nyh s povyshennoj funkciej parashhitovid- noj zhelezy. Fotoskennirovanie podzheludochnoj zhelezy uzhe javljaetsja prakticheskim metodom, i v nastojashhee vremja vedetsja izuchenie fotoskennirovanija parashhitovidnoj zhelezy. Narjadu s vnov' probudivshimsja interesom k organam, kotorye byli nevidimy pri obychnyh radiograficheskih metodah, selektivnoe skennirovanie organov s pomoshh'ju soedinenij,soderzhashhih mechenye atomy i podobrannyh po ih biohemicheskim svojstvam, stanovitsja vazhnym metodom budushhego. (author)}
place = {IAEA}
year = {1964}
month = {Oct}
}