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Comparison of Clinical and Laboratory Responses in Sheep and Dogs following Whole-Body Exposures to 250-Kvp X-Rays and Fission-Spectrum Neutrons; Etude Comparee Clinique et en Laboratoire, des Reactions de Moutons et de Chiens a la Suite d'une Exposition du Corps Entier a des Rayons X de 250 Kv-Crete et a des Neutrons de Fission; Sravnenie klinicheskikh i laboratornykh dannykh o reaktsii ovets i sobak na obluchenie vsego tela rentgenovskimi luchami pri pikovom napryazhenii 250 Kv i nejtronami spektra deleniya; Estudio Comparado, Clinico y de Laboratorio, de las Reacciones de Ovejas y Perros Consecutivas a la Irradiacion del Cuerpo Entero con Rayos X de 250 KVp y Neutrones de Fision

Conference:

Abstract

Fifteen sheep and eight dogs were exposed to 400 rad (air dose) of pulsed fission-spectrum neutrons, and an equal number of sheep and 14 dogs to 400 r (midline air dose) 250 kVp X-rays. Seven additional sheep and four dogs served as un-irradiated controls. Control data were obtained for two weeks preceding the exposures and at frequent and regular intervals after the injury. In sheep, the most consistent clinical change was complete loss of wool by the 51st day post-exposure. The underlying skin was pink in colour closely resembling that of a mild blush sometimes noted in humans. Dogs did not demonstrate loss of hair. Formed blood elements, neutrophils, lymphocytes, and thrombocytes fell rapidly after the radiation in both species. At about post-exposure day 24 recovery in white cell numbers was noted only in the neutron groups. Thrombocyte levels decreased to safe level in both species but somewhat earlier in the dog. Recovery appeared during the third post-exposure week in both species ex posed to neutrons, but not in those given X-rays. Red blood-cell haematocrits showed significant drops in both groups of dogs by the ninth day, but neither group of sheep exhibited significant decrease in haematocrit values. Plasma Fe{sup  More>>
Authors:
Quaife, M. A.; Boer, J. de; Jones, R. K.; Ichiki, A. T.; Godden, W. R.; Davis, H.; Engel, R. E. [1] 
  1. Kirtland AFB, New Mexico (United States)
Publication Date:
May 15, 1964
Product Type:
Conference
Report Number:
IAEA-SM-44/31
Resource Relation:
Conference: Symposium on Biological Effects of Neutron Irradiations, Upton, NY (United States), 7-11 Dec 1963; Other Information: 6 refs., 2 tabs., 14 figs.; Related Information: In: Biological Effects of Neutron and Proton Irradiations. Vol. II. Proceedings of the Symposium on Biological Effects of Neutron Irradiations| 460 p.
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; ARTERIES; BLOOD PLATELETS; CONNECTIVE TISSUE; DOGS; HEMORRHAGE; LUNGS; LYMPHOCYTES; NEUTRONS; NEUTROPHILS; RADIATION DOSES; RADIATION INJURIES; SHEEP; X RADIATION
OSTI ID:
22141856
Research Organizations:
International Atomic Energy Agency, Vienna (Austria)
Country of Origin:
IAEA
Language:
English
Contract Number:
Project 03.030
Other Identifying Numbers:
Other: ISSN 0074-1884; TRN: XA13M3458096457
Submitting Site:
INIS
Size:
page(s) 73-91
Announcement Date:
Oct 24, 2013

Conference:

Citation Formats

Quaife, M. A., Boer, J. de, Jones, R. K., Ichiki, A. T., Godden, W. R., Davis, H., and Engel, R. E. Comparison of Clinical and Laboratory Responses in Sheep and Dogs following Whole-Body Exposures to 250-Kvp X-Rays and Fission-Spectrum Neutrons; Etude Comparee Clinique et en Laboratoire, des Reactions de Moutons et de Chiens a la Suite d'une Exposition du Corps Entier a des Rayons X de 250 Kv-Crete et a des Neutrons de Fission; Sravnenie klinicheskikh i laboratornykh dannykh o reaktsii ovets i sobak na obluchenie vsego tela rentgenovskimi luchami pri pikovom napryazhenii 250 Kv i nejtronami spektra deleniya; Estudio Comparado, Clinico y de Laboratorio, de las Reacciones de Ovejas y Perros Consecutivas a la Irradiacion del Cuerpo Entero con Rayos X de 250 KVp y Neutrones de Fision. IAEA: N. p., 1964. Web.
Quaife, M. A., Boer, J. de, Jones, R. K., Ichiki, A. T., Godden, W. R., Davis, H., & Engel, R. E. Comparison of Clinical and Laboratory Responses in Sheep and Dogs following Whole-Body Exposures to 250-Kvp X-Rays and Fission-Spectrum Neutrons; Etude Comparee Clinique et en Laboratoire, des Reactions de Moutons et de Chiens a la Suite d'une Exposition du Corps Entier a des Rayons X de 250 Kv-Crete et a des Neutrons de Fission; Sravnenie klinicheskikh i laboratornykh dannykh o reaktsii ovets i sobak na obluchenie vsego tela rentgenovskimi luchami pri pikovom napryazhenii 250 Kv i nejtronami spektra deleniya; Estudio Comparado, Clinico y de Laboratorio, de las Reacciones de Ovejas y Perros Consecutivas a la Irradiacion del Cuerpo Entero con Rayos X de 250 KVp y Neutrones de Fision. IAEA.
Quaife, M. A., Boer, J. de, Jones, R. K., Ichiki, A. T., Godden, W. R., Davis, H., and Engel, R. E. 1964. "Comparison of Clinical and Laboratory Responses in Sheep and Dogs following Whole-Body Exposures to 250-Kvp X-Rays and Fission-Spectrum Neutrons; Etude Comparee Clinique et en Laboratoire, des Reactions de Moutons et de Chiens a la Suite d'une Exposition du Corps Entier a des Rayons X de 250 Kv-Crete et a des Neutrons de Fission; Sravnenie klinicheskikh i laboratornykh dannykh o reaktsii ovets i sobak na obluchenie vsego tela rentgenovskimi luchami pri pikovom napryazhenii 250 Kv i nejtronami spektra deleniya; Estudio Comparado, Clinico y de Laboratorio, de las Reacciones de Ovejas y Perros Consecutivas a la Irradiacion del Cuerpo Entero con Rayos X de 250 KVp y Neutrones de Fision." IAEA.
@misc{etde_22141856,
title = {Comparison of Clinical and Laboratory Responses in Sheep and Dogs following Whole-Body Exposures to 250-Kvp X-Rays and Fission-Spectrum Neutrons; Etude Comparee Clinique et en Laboratoire, des Reactions de Moutons et de Chiens a la Suite d'une Exposition du Corps Entier a des Rayons X de 250 Kv-Crete et a des Neutrons de Fission; Sravnenie klinicheskikh i laboratornykh dannykh o reaktsii ovets i sobak na obluchenie vsego tela rentgenovskimi luchami pri pikovom napryazhenii 250 Kv i nejtronami spektra deleniya; Estudio Comparado, Clinico y de Laboratorio, de las Reacciones de Ovejas y Perros Consecutivas a la Irradiacion del Cuerpo Entero con Rayos X de 250 KVp y Neutrones de Fision}
author = {Quaife, M. A., Boer, J. de, Jones, R. K., Ichiki, A. T., Godden, W. R., Davis, H., and Engel, R. E.}
abstractNote = {Fifteen sheep and eight dogs were exposed to 400 rad (air dose) of pulsed fission-spectrum neutrons, and an equal number of sheep and 14 dogs to 400 r (midline air dose) 250 kVp X-rays. Seven additional sheep and four dogs served as un-irradiated controls. Control data were obtained for two weeks preceding the exposures and at frequent and regular intervals after the injury. In sheep, the most consistent clinical change was complete loss of wool by the 51st day post-exposure. The underlying skin was pink in colour closely resembling that of a mild blush sometimes noted in humans. Dogs did not demonstrate loss of hair. Formed blood elements, neutrophils, lymphocytes, and thrombocytes fell rapidly after the radiation in both species. At about post-exposure day 24 recovery in white cell numbers was noted only in the neutron groups. Thrombocyte levels decreased to safe level in both species but somewhat earlier in the dog. Recovery appeared during the third post-exposure week in both species ex posed to neutrons, but not in those given X-rays. Red blood-cell haematocrits showed significant drops in both groups of dogs by the ninth day, but neither group of sheep exhibited significant decrease in haematocrit values. Plasma Fe{sup 59} clearance rates were determined in the experimental subjects as a parameter of measurement of haematopoietic function. Prognostic implications of alteration in this parameter of haemapoiesis are discussed. The most significant gross-pathologic changes were confined to the lungs wherein extensive perivascular haemorrhage around the arteries was noted. On microscopic study the area of haemorrhage was observed to be within the advential-connective tissue and periarterial vessels. Thirty-day mortality for dogs was 50% following neutron exposures and 93% after the X-ray insult. In sheep neutrons produced 22% mortality and X-rays 80%. (author) [French] On a expose 15 moutons et 8 chiens a une dose de 400 rad (dose dans l'air) de neutrons de fission puises, ainsi que 15 moutons et 14 chiens a une dose de 400 r (dose mediane dans l'a ir ) de rayons X de 250 kV-crete. Sept moutons et quatre chiens ont servi de temoins. On a fait des observations pendant les deux semaines qui ont precede les expositions, puis a intervalles frequents et reguliers apres l'irradiation. Chez les moutons, l'alteration clinique la plus constante a ete la perte complete de la laine 51 j apres l'exposition. La peau ainsi mise a nu etait d'une couleur rose semblable a celle que produit parfois chez les humains un leger rougissement. Il n'y a pas eu de chute de poils chez les chiens. Le nombre des polynucleaires neutrophiles, des lymphocytes et des plaquettes a baisse rapidement apres l 'irradiation chez les moutons et les chiens. Environ 24 j apres l 'exposition, on a note une restauration du nombre des globules blancs uniquement dans les groupes exposes aux neutrons. Le nombre des plaquettes a baisse dans la meme proportion chez les moutons et les chiens, mais un peu plus tot chez les chiens. Dans les deux cas, une restauration a ete constatee au cours de la troisieme semaine apres l'exposition aux neutrons, mais il n'en a pas ete de meme chez les animaux exposes aux rayons X. Neuf jours apres l 'exposition, le nombre des globules rouges avait sensiblement diminue chez les deux groupes de chiens; on n'a pas constate de diminution notable chez les moutons. On a determine le taux d'elimination du {sup 59}Fe dans le plasma des animaux d'experience, comme parametre de mesure de la fonction hematopoieetique. Les auteurs discutent l'influence sur le pronostic des modifications survenant dans ce parametre de l'hematopoieese. Les modifications pathologiques les plus significatives ont ete limitees aux poumons, ou on a constate une importante hemorragie perivasculaire autour des arteres. L'observation microscopique a revele que la zone d'hemorragie se trouvait dans les tissus conjonctifs adventices et les vaisseaux periarteriels. Au trentieme jour, la mortalite chez les chiens a ete de 50% pour les sujets exposes aux neutrons et de 93% pour les sujets exposes aux rayons X. Chez les moutons, les neutrons ont cause une mortalite de 22% et les rayons X une mortalite de 80%. (author) [Spanish] Los autores expusieron 15 ovejas y 8 perros a una dosis de 400 rad (en el aire) de un espectro pulsante de neutrones de fision y el mismo numero de ovejas y 14 perros a una dosis de 400 r (dosis media, en el aire) de rayos X de 250 kVp. Ademas, emplearon como testigos 7 ovejas y 4 perros sin irradiar. Efectuaron observaciones durante dos semanas, antes de proceder a la exposicion y, luego, a intervalos frecuentes y regulares una vez provocadas las lesiones. En las ovejas, la alteracion clinica mas sistematica fue la perdida total de la lana a los 51 dias de la exposicion. La piel subyacente presentaba un color rosado semejante a la leve erubescencia que se observa a veces en el hombre. Los perros no perdieron el pelo. El numero de polinucleares, neutrofilos, linfocitos y trombocitos disminuyo rapidamente despues de la irradiacion en ambas especies. Solamente en los grupos irradiados con neutrones, alrededor de 24 dias despues de la irradiacion se registro un restablecimiento del numero de globulos blancos. El indice de trombocitos disminuyo en ambas especies, un poco antes en el perro que en la oveja. En ambas especies, a la tercera semana a contar de la irradiacion, se observo que se restablecian los valores normales en los animales expuestos a los neutrones, pero no en aquellos sometidos a la accion de los rayos X. En ambos grupos de perros, al noveno dia se registro una reduccion importante del indice hematocrito, pero no ocurrio lo mismo con ninguno de los grupos de ovejas expuestos. Como parametro para la determinacion de la funcion hematopoyetica, se determinaron los indices de depuracion plasmatica del {sup 59}Fe en los sujetos estudiados. Los autores estudian la posibilidad de aplicar las alteraciones de este parametro de la hematopoyesis con fines diagnosticos. Las alteraciones patologicas mas significativas se circunscribieron a los pulmones, donde se observaron extensas hemorragias perivasculares. Mediante el microscopio se confirmo que la zona hemorragica estaba situada entre el tejido conjuntivo adventicio y los vasos periarteriales. El indice de mortalidad a los 30 dias, en los perros, fue del 50% despues de la exposicion a los neutrones y del 93% despues de la exposicion a los iayos X. En cuanto a las ovejas, los neutrones ocasionaron una mortalidad de 22% y los rayos X, una de 80%. (author) [Russian] Pjatnadcat' ovec i vosem' sobak byli oblucheny dozoj 400 rad (vozdushnaja doza) pul'sirujushhih nejtronov spektra delenija, a takoe zhe kolichestvo ovec i 14 sobak -dozoj 400 rentgen (sredinnaja vozdushnaja doza) rentgenovskih luchej pri pikovom naprjazhenii 250 kv. Sem' ovec i chetyre sobaki byli ostavleny neobluchennymi dlja kontrolja. Kontrol'nye dannye poluchali v techenie dvuh nedel', predshestvovavshih oblucheniju, a takzhe reguljarno i chasto posle n ego . U ovec naibolee opredelennym klinicheskim izmeneniem bylo polnoe vypadenie shersti k 51 dnju posle obluchenija. Obnazhivshajasja kozha byla rozovogo cveta, ochen' napominajushhego slabyj rumjanec. U sobak vypadenija shersti ne bylo. Posle obluchenija u oboih vidov zhivotnyh rezko upalo soderzhanie formennyh jelementov krovi, nejtrofil'nyh lejkocitov, limfocitov i trombocitov. Primerno na 24-j den' posle obluchenija vosstanovlenie kolichestva lejkocitov bylo otmecheno to l'ko u zhivotnyh, podvergshihsja oblucheniju nejtronami. Urovni trombocitov snizilis' do bezopasno go urovnja u oboih vidov zhivotnyh, no u sobak jeto proizoshlo neskol'ko ran'she. Vosstanovlenie nastupilo na tret'ej nedele posle obluchenija u oboih vidov zhivotnyh, podvergshihsja oblucheniju nejtronami, no ne proizoshlo u zhivotnyh, obluchennyh rentgenovskimi luchami. Issledovanija gematokrita pokazali znachitel'noe sokrashhenie gemoglobina u oboih grupp sobak k 9-mu dnju, v to vremja kak ni u odnoj iz grupp ovec znachitel'nogo sokrashhenija gemoglobina o tm e cheno ne bylo. Skorost' ochishhenija plazmy ot Fe{sup 59} byla opredelena u podopytnyh zhivotnyh kak parametr izmerenija krovotvornoj funkcii. Rassmatrivajutsja budushhie posledstvija iz menenija jet o go parametra krovotvorenija. Samye znachitel'nye grubye patologicheskie iz menenija byli ogranicheny legkimi, gde byli otmecheny obshirnye krovotechenija vokrug arterij. Pod mikroskopom oblast' krovotechenija nabljudalas' v predelah pobochnoj soedinitel'noj tkani i okolo arterial'nyh so sudov. V techenie tridcati dnej pogiblo 50%sobak, podvergshihsja oblucheniju nejtronami, i 93%sobak, obluchennyh rentgenovskimi luchami. Dlja ovec smertnost' sostavila 22% i 80% so otv etstvenno. (author)}
place = {IAEA}
year = {1964}
month = {May}
}