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Pulsed Irradiation Studies in Mice, Rats and Dogs; Etudes sur l'Exposition de la Souris, du Rat et du Chien a des Rayonnements Pulses; Impul'snoe obluchenie myshej, krys i sobak; Estudios sobre la Irradiacion Pulsante de Ratones, Ratas y Perros

Conference:

Abstract

Radiation lethality as a function of radiation dose rate has been extensively explored over the range of less than one rad to a few hundreds of rad/min, but comparatively little is known of the biological consequences at exposure intensities of the order of 10{sup 5}-10{sup 6} rad/min. In the present experiments radiations produced by a TRIGA reactor have been used to study the comparative acute-mortality responses (LD{sub 50}/{sub 30}) of mice and dogs irradiated either at moderate dose rates (40 or 100 rad/min for mice and 23 rad/min for dogs) or by a single high dose-rate radiation pulse ({approx} 10{sup 6} rad/min for mice and {approx}2.0 X 10{sup 5} rad/min for dogs). In the mouse experiments, the LD{sub 50}/{sub 30} of animals exposed at the moderate dose rates of 40 rad of n/min or 100 rad for gamma-radiation/min was not significantly different from the LD{sub 50}/{sub 30} of animals exposed to the same radiation given as a pulsed exposure. Likewise, in acute mortality studies conducted with unilaterally neutron-irradiated dogs, no significant differences in LDso/sowere found between groups irradiated at 23 rad/min or exposed to pulsed dose rates in excess of 1.5 x 10{sup 5} rad/min. Other studies have been conducted  More>>
Authors:
Ainsworth, E. J.; Leong, G. F.; Kendall, K.; Alpen, E. L.; Albright, M. L. [1] 
  1. US Naval Radiological Defense Laboratory. San Francisco, CA (United States)
Publication Date:
May 15, 1964
Product Type:
Conference
Report Number:
IAEA-SM-44/28
Resource Relation:
Conference: Symposium on Biological Effects of Neutron Irradiations, Upton, NY (United States), 7-11 Dec 1963; Other Information: 18 refs., 6 tabs., 2 figs.; Related Information: In: Biological Effects of Neutron and Proton Irradiations. Vol. II. Proceedings of the Symposium on Biological Effects of Neutron Irradiations| 460 p.
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; DOGS; DOSE RATES; FRACTIONATED IRRADIATION; MATERIALS RECOVERY; MICE; MORTALITY; NEUTRONS; PULSED IRRADIATION; PULSES; RADIATION DOSE UNITS; RADIATION DOSES; RADIATION INJURIES; RATS; TRIGA TYPE REACTORS
OSTI ID:
22141853
Research Organizations:
International Atomic Energy Agency, Vienna (Austria)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
Other: ISSN 0074-1884; TRN: XA13M3455096454
Submitting Site:
INIS
Size:
page(s) 15-27
Announcement Date:
Oct 24, 2013

Conference:

Citation Formats

Ainsworth, E. J., Leong, G. F., Kendall, K., Alpen, E. L., and Albright, M. L. Pulsed Irradiation Studies in Mice, Rats and Dogs; Etudes sur l'Exposition de la Souris, du Rat et du Chien a des Rayonnements Pulses; Impul'snoe obluchenie myshej, krys i sobak; Estudios sobre la Irradiacion Pulsante de Ratones, Ratas y Perros. IAEA: N. p., 1964. Web.
Ainsworth, E. J., Leong, G. F., Kendall, K., Alpen, E. L., & Albright, M. L. Pulsed Irradiation Studies in Mice, Rats and Dogs; Etudes sur l'Exposition de la Souris, du Rat et du Chien a des Rayonnements Pulses; Impul'snoe obluchenie myshej, krys i sobak; Estudios sobre la Irradiacion Pulsante de Ratones, Ratas y Perros. IAEA.
Ainsworth, E. J., Leong, G. F., Kendall, K., Alpen, E. L., and Albright, M. L. 1964. "Pulsed Irradiation Studies in Mice, Rats and Dogs; Etudes sur l'Exposition de la Souris, du Rat et du Chien a des Rayonnements Pulses; Impul'snoe obluchenie myshej, krys i sobak; Estudios sobre la Irradiacion Pulsante de Ratones, Ratas y Perros." IAEA.
@misc{etde_22141853,
title = {Pulsed Irradiation Studies in Mice, Rats and Dogs; Etudes sur l'Exposition de la Souris, du Rat et du Chien a des Rayonnements Pulses; Impul'snoe obluchenie myshej, krys i sobak; Estudios sobre la Irradiacion Pulsante de Ratones, Ratas y Perros}
author = {Ainsworth, E. J., Leong, G. F., Kendall, K., Alpen, E. L., and Albright, M. L.}
abstractNote = {Radiation lethality as a function of radiation dose rate has been extensively explored over the range of less than one rad to a few hundreds of rad/min, but comparatively little is known of the biological consequences at exposure intensities of the order of 10{sup 5}-10{sup 6} rad/min. In the present experiments radiations produced by a TRIGA reactor have been used to study the comparative acute-mortality responses (LD{sub 50}/{sub 30}) of mice and dogs irradiated either at moderate dose rates (40 or 100 rad/min for mice and 23 rad/min for dogs) or by a single high dose-rate radiation pulse ({approx} 10{sup 6} rad/min for mice and {approx}2.0 X 10{sup 5} rad/min for dogs). In the mouse experiments, the LD{sub 50}/{sub 30} of animals exposed at the moderate dose rates of 40 rad of n/min or 100 rad for gamma-radiation/min was not significantly different from the LD{sub 50}/{sub 30} of animals exposed to the same radiation given as a pulsed exposure. Likewise, in acute mortality studies conducted with unilaterally neutron-irradiated dogs, no significant differences in LDso/sowere found between groups irradiated at 23 rad/min or exposed to pulsed dose rates in excess of 1.5 x 10{sup 5} rad/min. Other studies have been conducted to determine if recovery from radiation injury in mice, as estimated by the split-dose irradiation technique, is influenced by the rate at which the initial sublethal injury is produced. Recovery has been compared at 5 and 14 days post-irradiation in groups of animals exposed at either 40 or 9 x 10{sup 4} rad/min and no dose-rate dependency of recovery has been detected. (author) [French] La letalite due aux rayonnements en fonction du debit de dose a fait l'objet d'etudes approfondies dans la gamme des debits comprise entre moins de un rad et plusieurs centaines de rad/min, mais l 'on sait relativement peu de choses sur les consequences biologiques des debits de dose de l 'ordre de 10{sup 5} a 10{sup 6} rad/min. Les auteurs ont utilise les rayonnements emis par un reacteur TRIGA pour une etude comparative des taux de mortalite (DL{sup 30}{sub 50}) chez la souris et chez le chien exposes a des debits de dose moderes (40 ou 100 rad/min pour la souris et 23 rad/min pour le chien) ou a un rayonnement puise avec un debit de dose eleve ( Tilde-Operator 10{sup 6} rad/min pour la souris et Tilde-Operator 2,0 * 10{sup 5} rad/min pour le chien). Chez la souris, la DL{sup 30}{sub 50} pour des animaux exposes a des debits moderes de 40 rad/min (neutrons) ou de 100 rad/min (rayons gamma) n'etait pas significativement differente de la DL{sup 30}{sub 50} dans le cas d'une exposition au meme rayonnement puise. De meme, chez le chien, a la suite d'expositions aux neutrons seulement, on n'a pas constate de difference significative entre la DL{sup 30}{sub 50} pour les groupes exposes a 23 rad/min et la DL{sup 30}{sub 50} pour ceux qui avaient ete exposes a un rayonnement puise avec des debits de dose superieurs a 1,5 x 10{sup 5} rad/min. Les auteurs ont effectue d'autres etudes pour determiner si la guerison des radiolesions chez la souris, evaluee par la methode, est influencee par le debit de dose qui provoque la lesion subletale initiale. Ils ont compare les guerisons constatees 5 j et 14 j apres irradiation chez des groupes d'animaux exposes a des debits de 40 rad/min et de 9 x 10{sup 4} rad/min; ils ont constate que le degre de guerison ne dependait pas du debit de dose. (author) [Spanish] La radioletalidad en funcion de la dosis ha sido objeto de muchos estudios en el intervalo comprendido entre 1 rad/min hasta algunos centenares de rad/min, pero se poseen relativamente pocos datos acerca de las consecuencias biologicas de la exposicion a intensidades del orden de 10{sup 5} a 10{sup 6} rad/min. Los autores emplearon radiaciones emitidas por un reactor TRIGA para efectuar un estudio comparado de las reacciones de mortalidad aguda (DL{sup 30}{sub 50}) en ratones y perros irradiados con intensidades moderadas (40 o 100 rad/min para los ratones y 23 rad/min para los perros) o bien con un impulso de radiacion unico de elevada intensidad ( Tilde-Operator 10{sup 6} rad/min para los ratones y Tilde-Operator 2,0 * 10{sup 5} rad/min para los perro). En los experimentos con ratones, la DL{sup 30}{sub 50} de los animales expuestos a intensidades moderadas (40 rad/min de neutrones o 100 rad/min de rayos gamma) no se diferencia apreciablemente de la DL{sup 30}{sub 50} de los animales expuestos a la misma radiacion aplicada en forma pulsante. Analogamente, en los estudios de mortalidad aguda llevados a cabo con perros irradiados unilateralmente con neutrones, no se observaron diferencias significativas en la DL{sup 30}{sub 50} entre los grupos irradiados con 23 rad/min o expuestos a impulsos de intensidad superior a 1,5 x 10{sup 5} rad/min. Los autores efectuaron otros estudios a fin de determinar si la recuperacion de las radiolesiones en el raton, valorada mediante el procedimiento de irradiacion con dosis fraccionadas, depende o no de la intensidad de dosis que ha producido la lesion subletal inicial. Compararon el restablecimiento a los 5 y a los 14 dias a contar de la irradiacion en grupos de animales expuestos a 40 rad/min o bien a 9 x 10{sup 4} rad/min y no observaron ninguna influencia de la intensidad de la dosis sobre la recuperacion. (author) [Russian] Radiacionnaja letal'nost' kak funkcija moshhnosti dozy obluchenija shiroko izuchalas' v diapazone doz ot menee odnogo rada do neskol'kih soten rad v minutu, no sravnitel'no malo izvestno o biologicheskih posledstvijah obluchenija pri moshhnosti dozy porjadka 10{sup 5} - 10{sup 6} rad/min. V dannoj rabote izluchenie reaktora TRIGA ispol'zovalos' dlja sravnitel'nogo izuchenija reakcii nastuplenija vnezapnoj smerti (DL{sub 30/50}) y myshej i sobak, obluchennyh kak dozami umerennoj moshhnosti (40 ili 100 rad/min dlja myshej i 23 rad/min dlja sobak), tak i pri impul'snom odnokratnom o b l u chenii dozoj vysokoj moshhnosti ( Tilde-Operator 10{sup 6} rad/min dlja myshej i Tilde-Operator 2,0 * 10{sup 5} rad/min dlja s obak ). V opytah na myshah DL{sub 30/50} zhivotnyh , obluchennyh nejtronami pri umerennoj moshhnosti dozy 40 rad/min ili gam m a -luch am i pri 100 rad/min, ne otlichalis' v znachitel'noj stepeni ot DL{sub 30/50} zhivotnyh, podvergnutyh takomu zhe oblucheniju, no v forme impul'snogo obluchenija. Podobno jetomu pri izuchenii vnezapnoj smerti u sobak, podvergnutyh odnostoronnemu nejtronnomu oblucheniju, ne obnaruzheno znachitel'noj raznicy v DL{sub 30/50} mezhdu gruppami, obluchennymi s moshhnost'ju 23 rad/min ili podvergnutymi impul'snomu oblucheniju s moshhnost'ju svyshe 1,5 * 10{sup 5} rad/min. Provedeny drugie issledovanija dlja opredelenija zavisimosti v os stanovlenija luchevogo porazhenija u myshej, sozdannogo po metodu rasshheplenija dozy obluchenija, ot moshhnosti, pri kotoroj sozdaetsja pervichnoe subletal'noe porazhenie. Sravnivalas' stepen' vosstanovlenija na 5 -j i 14-jden' posle obluchenijau grupp zhivotnyh, obluchennyh pri moshhnosti 40 ili 9 * 10{sup 4} rad/min, prichem zavisimosti vosstanovlenija ot moshhnosti dozy ne obnaruzheno. (author)}
place = {IAEA}
year = {1964}
month = {May}
}