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Characteristics of the Biological Effects and the RBE of High Energy Protons; Caracteristiques des Effets Biologiques et EBR des Protons de Haute Energie; Osobennosti biologicheskogo dejstviya i obeh protonov vysokikh ehnergii; Caracteristicas de los Efectos Biologicos y de la EBR de los Protones de Elevada Energia

Abstract

The characteristics of the biological effects of high-energy protons (120, 240 and 510 MeV) were studied in experiments on mice, rats and dogs. It was shown that together with a certain resemblance or identity in radiation damage due to the effects of X-rays and protons, there were certain differences in the case of proton irradiation. In the proton irradiation of dogs the haemorrhagic syndrome was more pronounced. Haemorrhage appeared earlier in the animals and was more abundant. A difference was found in proton RBE levels for small animals (rats, mice) and large animals (dogs). This difference is quite large and equals respectively 0.7 and 1.0 * 1.15. Some considerations are presented in the report on the cause of these differences. (author) [French] Les auteurs ont etudie les caracteristiques des effets biologiques des protons de haute energie (120, 240 et 510 MeV) au cours d'experiences sur des souris, des rats et des chiens. Ils montrent que si les dommages causes par les rayons X et les protons presentent une certaine ressemblance ou des caracteres identiques, on observe des differences dans le cas de l'irradiation par les protons. Chez les chiens exposes aux protons, le syndrome hemorragique etait plus prononce. L'hemorragie s'est  More>>
Publication Date:
Mar 15, 1964
Product Type:
Conference
Report Number:
IAEA-SM-44/62
Resource Relation:
Conference: Symposium on Biological Effects of Neutron Irradiations, Upton, NY (United States), 7-11 Dec 1963; Other Information: 3 refs., 2 figs., 1 tab.; Related Information: In: Biological Effects of Neutron and Proton Irradiations. Vol. I. Proceedings of the Symposium on Biological Effects of Neutron Irradiations| 448 p.
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; DOGS; HEMORRHAGE; IRRADIATION; MEV RANGE 100-1000; MICE; PROTONS; RATS; RBE; X RADIATION
OSTI ID:
22141836
Research Organizations:
International Atomic Energy Agency, Vienna (Austria)
Country of Origin:
IAEA
Language:
Russian
Other Identifying Numbers:
Other: ISSN 0074-1884; TRN: XA13M3438096437
Submitting Site:
INIS
Size:
page(s) 223-229
Announcement Date:
Oct 24, 2013

Citation Formats

Grigor'ev, Ju. G., Darenskaja, N. G., Domshlak, M. M., Lebedinskij, A. V., Nefedov, Ju. G., and Ryzhov, N. I. Characteristics of the Biological Effects and the RBE of High Energy Protons; Caracteristiques des Effets Biologiques et EBR des Protons de Haute Energie; Osobennosti biologicheskogo dejstviya i obeh protonov vysokikh ehnergii; Caracteristicas de los Efectos Biologicos y de la EBR de los Protones de Elevada Energia. IAEA: N. p., 1964. Web.
Grigor'ev, Ju. G., Darenskaja, N. G., Domshlak, M. M., Lebedinskij, A. V., Nefedov, Ju. G., & Ryzhov, N. I. Characteristics of the Biological Effects and the RBE of High Energy Protons; Caracteristiques des Effets Biologiques et EBR des Protons de Haute Energie; Osobennosti biologicheskogo dejstviya i obeh protonov vysokikh ehnergii; Caracteristicas de los Efectos Biologicos y de la EBR de los Protones de Elevada Energia. IAEA.
Grigor'ev, Ju. G., Darenskaja, N. G., Domshlak, M. M., Lebedinskij, A. V., Nefedov, Ju. G., and Ryzhov, N. I. 1964. "Characteristics of the Biological Effects and the RBE of High Energy Protons; Caracteristiques des Effets Biologiques et EBR des Protons de Haute Energie; Osobennosti biologicheskogo dejstviya i obeh protonov vysokikh ehnergii; Caracteristicas de los Efectos Biologicos y de la EBR de los Protones de Elevada Energia." IAEA.
@misc{etde_22141836,
title = {Characteristics of the Biological Effects and the RBE of High Energy Protons; Caracteristiques des Effets Biologiques et EBR des Protons de Haute Energie; Osobennosti biologicheskogo dejstviya i obeh protonov vysokikh ehnergii; Caracteristicas de los Efectos Biologicos y de la EBR de los Protones de Elevada Energia}
author = {Grigor'ev, Ju. G., Darenskaja, N. G., Domshlak, M. M., Lebedinskij, A. V., Nefedov, Ju. G., and Ryzhov, N. I.}
abstractNote = {The characteristics of the biological effects of high-energy protons (120, 240 and 510 MeV) were studied in experiments on mice, rats and dogs. It was shown that together with a certain resemblance or identity in radiation damage due to the effects of X-rays and protons, there were certain differences in the case of proton irradiation. In the proton irradiation of dogs the haemorrhagic syndrome was more pronounced. Haemorrhage appeared earlier in the animals and was more abundant. A difference was found in proton RBE levels for small animals (rats, mice) and large animals (dogs). This difference is quite large and equals respectively 0.7 and 1.0 * 1.15. Some considerations are presented in the report on the cause of these differences. (author) [French] Les auteurs ont etudie les caracteristiques des effets biologiques des protons de haute energie (120, 240 et 510 MeV) au cours d'experiences sur des souris, des rats et des chiens. Ils montrent que si les dommages causes par les rayons X et les protons presentent une certaine ressemblance ou des caracteres identiques, on observe des differences dans le cas de l'irradiation par les protons. Chez les chiens exposes aux protons, le syndrome hemorragique etait plus prononce. L'hemorragie s'est manifestee plus tot chez ces animaux et etait plus abondante. Les auteurs ont decele une difference dans l*EBRdes protons pour les petits animaux (rats, souris) et pour les grands animaux (chiens). Cette difference etait importante: 0,7 dans le premier cas et de 1,0 a 1,15 dans le second cas. On trouve dans le memoire quelques considerations sur la cause de ces differences. (author) [Spanish] Los autores estudiaron las caracteristicas de los efectos biologicos de los protones de elevada energia (120, 240 y 510 MeV) mediante experimentos con ratones, ratas y perros. Comprobaron que a pesar de ciertas semejanzas en las radiolesiones causadas por los rayos X y los protones, los efectos de estos ultimos acusan algunas diferencias. El sindrome hemorragico provocado en el perro por la irradiacion protonica es mas pronunciado. La hemorragia se presenta al cabo de un tiempo mas breve y es mas abundante. Verificaron asimismo que la EBR de los protones es diferente segun se trate de animales pequeflos (ratas o ratones) o de animales grandes (perros). La diferencia es apreciable, ya que los valores respectivos son 0,7 para los primeros y 1,0 o 1,15 para los segundos. En la memoria se examinan las posibles causas de estas diferencias. (author) [Russian] Harakteristiki biologicheskogo dejstvija protonov vysokih jenergij (120, 210 i 510Mjev) izuchalis' v jeksperimentah na myshah, krysah i sobakah. Bylo pokazano, chto narjadu s nekotorym shodstvom ili identichnost'ju radiacionnogo porazhenija pri dejstvii rentgenovskih luchej i protonov imelsja rjad razlichij. Pri protonnom obluchenii sobak byl bolee otchetlivo vyrazhen gemorrogicheskij sindrom. Krovoizlijanija pojavljalis' u zhivotnyh ran'she i byli b olee obil'nymi. Obnaruzhena raznica v urovnjah OBJe protonov dlja melkih (krysy, myshi) i krupnyh zhivotnyh (sobaki). Jeta raznica javljaetsja dovol'no znachitel'noj i ravnjaetsja so otvetstvenno 0,7 i 1,0 - 1,15. V doklade privodjatsja nekotorye soobrazhenija otnositel'no prichiny jetih razlichij. (author)}
place = {IAEA}
year = {1964}
month = {Mar}
}