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The Biological Effect of Fast Neutrons and High-Energy Protons; Effets Biologiques des Neutrons Rapides et des Protons de Haute Energie; Biologicheskoe dejstvie bystrykh nejtronov i protonov vysokikh ehnergii; Efectos Biologicos de los Neutrones Rapidos y de los Protones de Elevada Energia

Conference:

Abstract

The paper gives the results of comparative experiments on the effects of fast neutrons and high-energy protons (500 MeV) on life expectancy, peripheral blood, incidence and rate of appearance of tumours in the rat as a function of administered dose and time of observation. The neutron experiment was performed on 573 and the proton experiment on 490 white rats. The animals irradiated with fast neutrons were given doses between 8.5 and 510 rad, and those irradiated with protons received doses between 28 and 1008 rad. The effective doses for the acute, sub-acute and chronic forms of sickness were established for fast neutrons and for protons. LD{sub 50/30} for neutrons was 408 and for protons 600 rad, and the corresponding LD{sub 50}/{sub 120} values were 380 and 600 rad. The conditions governing rat mortality were analysed both in the early and the later stages of the experiment. It is shown that the average life expectancy of rats irradiated with fast neutrons does not depend on sex. The shape of the dose-effect curve for the various peripheral-blood indexes is strongly dependent not only on the radiosensitivity of the blood cells in question but also on the time of observation. It may change  More>>
Publication Date:
Mar 15, 1964
Product Type:
Conference
Report Number:
IAEA-SM-44/58
Resource Relation:
Conference: Symposium on Biological Effects of Neutron Irradiations, Upton, NY (United States), 7-11 Dec 1963; Other Information: 22 refs., 16 figs., 4 tabs.; Related Information: In: Biological Effects of Neutron and Proton Irradiations. Vol. I. Proceedings of the Symposium on Biological Effects of Neutron Irradiations| 448 p.
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; BLADDER; BLOOD CELLS; FAST NEUTRONS; IRRADIATION; KIDNEYS; LARGE INTESTINE; LIVER; LUNGS; LYMPH NODES; MAMMARY GLANDS; NEOPLASMS; OVARIES; PANCREAS; PROSTATE; PROTONS; RADIATION DOSES; RADIOSENSITIVITY; RATS; SKIN; THYROID; UTERUS
OSTI ID:
22141835
Research Organizations:
International Atomic Energy Agency, Vienna (Austria)
Country of Origin:
IAEA
Language:
Russian
Other Identifying Numbers:
Other: ISSN 0074-1884; TRN: XA13M3437096436
Submitting Site:
INIS
Size:
page(s) 197-219
Announcement Date:
Oct 24, 2013

Conference:

Citation Formats

Moskalev, Ju. I., Petrovich, I. K., and Strel'cova, V. N. The Biological Effect of Fast Neutrons and High-Energy Protons; Effets Biologiques des Neutrons Rapides et des Protons de Haute Energie; Biologicheskoe dejstvie bystrykh nejtronov i protonov vysokikh ehnergii; Efectos Biologicos de los Neutrones Rapidos y de los Protones de Elevada Energia. IAEA: N. p., 1964. Web.
Moskalev, Ju. I., Petrovich, I. K., & Strel'cova, V. N. The Biological Effect of Fast Neutrons and High-Energy Protons; Effets Biologiques des Neutrons Rapides et des Protons de Haute Energie; Biologicheskoe dejstvie bystrykh nejtronov i protonov vysokikh ehnergii; Efectos Biologicos de los Neutrones Rapidos y de los Protones de Elevada Energia. IAEA.
Moskalev, Ju. I., Petrovich, I. K., and Strel'cova, V. N. 1964. "The Biological Effect of Fast Neutrons and High-Energy Protons; Effets Biologiques des Neutrons Rapides et des Protons de Haute Energie; Biologicheskoe dejstvie bystrykh nejtronov i protonov vysokikh ehnergii; Efectos Biologicos de los Neutrones Rapidos y de los Protones de Elevada Energia." IAEA.
@misc{etde_22141835,
title = {The Biological Effect of Fast Neutrons and High-Energy Protons; Effets Biologiques des Neutrons Rapides et des Protons de Haute Energie; Biologicheskoe dejstvie bystrykh nejtronov i protonov vysokikh ehnergii; Efectos Biologicos de los Neutrones Rapidos y de los Protones de Elevada Energia}
author = {Moskalev, Ju. I., Petrovich, I. K., and Strel'cova, V. N.}
abstractNote = {The paper gives the results of comparative experiments on the effects of fast neutrons and high-energy protons (500 MeV) on life expectancy, peripheral blood, incidence and rate of appearance of tumours in the rat as a function of administered dose and time of observation. The neutron experiment was performed on 573 and the proton experiment on 490 white rats. The animals irradiated with fast neutrons were given doses between 8.5 and 510 rad, and those irradiated with protons received doses between 28 and 1008 rad. The effective doses for the acute, sub-acute and chronic forms of sickness were established for fast neutrons and for protons. LD{sub 50/30} for neutrons was 408 and for protons 600 rad, and the corresponding LD{sub 50}/{sub 120} values were 380 and 600 rad. The conditions governing rat mortality were analysed both in the early and the later stages of the experiment. It is shown that the average life expectancy of rats irradiated with fast neutrons does not depend on sex. The shape of the dose-effect curve for the various peripheral-blood indexes is strongly dependent not only on the radiosensitivity of the blood cells in question but also on the time of observation. It may change greatly in time for one and the same index. A considerable time after irradiation with either fast neutrons or protons, benign and malignant tumours appear in different tissues of the rats, including the haemopoeitic tissues, mammary glands, pituitary, uterus, ovaries, prostate gland, testicles, liver, kidneys, lungs, gastro-intestinal tract, subcutaneous tissue, lymph nodes, urinary bladder, etc. The over-all incidence of tumours and the number of cases of multi centred neoplasms in females are two to three times higher than in males. The minimum tumour dose for the mammary glands with neutron irradiation is apparently rather less than 42.5 rad. The maximum incidence of tumours of the pituitary is found after irradiation with a dose of 42.5 rad.- At this same dose leucosis and tumour of the thyroid gland also appear. With proton irradiation, the minimum tumour dose for haemopoietic tissue and the thyroid gland is in the neighbourhood of 250 rad, for the testicles 300 rad, for the prostate, the pancreas and the subcutaneous tissue 100 rad. After irradiation with fast neutrons the incidence of tumours of the testicles, the large intestine, the kidneys and the liver is increased at doses between 42.5 and 85 rad. The same is true for tumours of the skin and the subcutaneous tissue at a dose of 85 rad. With fast neutron irradiation tumours appeared at approximately three to five times lower radiation doses than with proton irradiation. (author) [French] Le memoire expose les resultats d'experiences visant a comparer l'e ffe t des neutrons rapides et celui des protons de haute energie (500 MeV) sur la duree de vie, le sang peripherique, la frequence et la rapidite d'apparition des tumeurs chez le rat, en tenant compte de la dose efficace et du delai d'observation. Les travaux ont porte sur 573 rats blancs pour les neutrons et sur 490 rats blancs pour les protons. Les animaux etaient exposes a des doses de neutrons rapides de 8,5 a 510 rad et a des doses de protons de 28 a 1008 rad. Pour les neutrons rapides et les protons, les auteurs ont determine les valeurs des doses effectives aiguees, sub-aiguees et chroniques. La DL{sup 30}{sub 50} est de 408 rad pour les neutrons et de 600 rad pour les protons; la DL{sup 120}{sub 50} s'eleve a 380 et 600 rad, respectivement. On a procede a une etude critique des lois qui regissent la mortalite des rats a breve echeance et apres des delais prolonges. D'apres les constatations, la survie moyenne des rats irradies par des neutrons rapides est independante de leur sexe. En ce qui concerne les differents indices du sang peripherique, la forme de la courbe dose/effet depend dans une forte mesure, non seulement de la radiosensibilite des cellules correspondantes du sang, mais aussi de la duree d'observation. Elle peut subir des variations sensibles en fonction du temps pour un seul et meme indice. Longtemps apres une irradiation par des neutrons rapides ou par des protons, on constate chez le rat l'apparition de tumeurs benignes et malignes dans divers tissus, notamment dans le tissu hematopoie tique, les glandes mammaires, l'hypophyse, l'uterus, les ovaires, la prostate, les testicules, la thyroide, la glande cervicale, le pancreas, les glandes surrenales, le foie, les reins, les poumons, le tractus gastro-intestinal, le tissu cellulaire sous-cutane, les ganglions lymphatiques, la vessie, etc. La frequence globale des tumeurs et le nombre des apparitions simultanees de neoplasmes en plusieurs endroits ont ete deux a trois fois plus eleves chez les femelles que chez les males. La dose minimum de neutrons necessaire pour provoquer une tumeur des glandes mammaires semble legerement inferieure a 42,5rad. La frequence des tumeurs de l'hypophyse est la plus elevee lorsque la dose est de 42,5 rad. A cette meme dose,. on constate l'apparition de leucoses et de tumeurs de la thyroide. Lors d'une irradiation par des protons, la dose minimum necessaire pour provoquer une tumeur est de l'ordre de 250 rad pour le tissu hematopoietique et la thyroide, de 300 rad pour les testicules et de 100 rad pour la prostate et le tissu cellulaire sous-cutane. Lors d'une irradiation par les neutrons rapides, les tumeurs des testicules, du gros intestin, des reins et du foie sont plus frequentes pour 42,5 a 85 rad et les tumeurs de la peau et du tissu cellulaire sous-cutane pour 85 rad. Dans le cas d'une irradiation par neutrons rapides, les tumeurs se produisent a des doses inferieures (d'environ 3 a 5 fois) aux doses de protons. (author) [Spanish] Los autores presentan los resultados de experimentos efectuados con miras a comparar el efecto de los neutrones rapidos y el de los protones de elevada energia (500 MeV) sobre la duracion de la vida, las caracteristicas de la sangre periferica, asi como la frecuencia y rapidez de formacion de tumores en la rata, en funcion de la dosis aplicada y del tiempo transcurrido a partir de' la irradiacion. En el experimento con neutrones utilizaron 573 ratas blancas y en el experimento con protones, 490. Expusieron los animales a dosis neutronicas de 8,5 a 510 rad, y dosis protonicas comprendidas entre 28 y 1008 rad. Tanto para los neutrones rapidos como para los protones, establecieron el valor de la dosis efectiva aguda, subaguda y cronica. La DL{sup 30}{sub 50} para los neutrones asciende a 408 rad y a 600 rad para los protones; las respectivas dosis DL{sup 120}{sub 50} son 380 rad y 600 rad. Los autores estudiaron las leyes que rigen la mortalidad de los sujetos en experimentos breves y prolongados. Demuestran que la sobrevivencia de los mismos, cuando se ios irradia con neutrones rapidos, es independiente del sexo. La forma de la curva dosis/efecto para los diversos Indices de la sangre periferica no solo depende de la radiosensibilidad de las celulas sanguineas correspondientes, sino tambien del perfodo de observacion. Puede sufrir modificaciones sensibles en funcion del tiempo para un mismo indice. Algun tiempo despues de la irradiacion, tanto con neutrones rapidos como con protones, se observan en las ratas tumores de caracter benigno o maligno en diversos tejidos, entre ellos en los de los arganos hematopoyeticos, las glandulas mamarias, la hipofisis, el utero, los ovarios, la prostata, los testiculos, la tiroides, el timo y el pancreas, las glandulas suprarrenales, el higado, los rinones, los pulmones, el tracto gastrointestinal, el tejido hipodermico, los ganglios linfaticos, la vejiga, etc. La frecuencia total de los tumores y el numero de casos de formacion multicentrica de neoplasias es de 2 a 3 veces mayor en las hembras que en los machos. La dosis tumorigena minima en las glandulas mamarias, en la irradiacion neutronica, parece ser algo inferior a 42,5 rad. La frecuencia maxima de los tumores de la hipofisis se observa despues de la irradiacion con una dosis de 42,5 rad. Con la misma dosis tambien se manifiestan leucosis y tumores de la tiroides. En la irradiacion protonica, la dosis tumorigena minima es del orden de 250 rad para lee tejidos hematopoyeticos y la tiroides, de 300 rad para los testiculos, y de unos 100 rad para la prostata, el pancreas y el tejido hipodermico. Despues de la irradiacion con neutrones rapidos, la frecuencia de la aparicion de tumores en los testiculos, el intestino grueso, los rinones y el higado, presenta un aumento para dosis entre 42,5 y 85 rad, y en la piel y el tejido hipodermico ocurre lo mismo para dosis de 85 rad. En el caso de la irradiacion con neutrones rapidos, los tumores aparecen con dosis de 3 a 5 veces inferiores a las dosis protonicas. (author) [Russian] Predstavljajutsja rezul'taty sravnitel'nyh jeksperimentov po izucheniju dejstvija bystryh nejtronov i protonov vysokih jenergij (500 Mjev) na prodolzhitel'nost' zhizni, perifericheskuju krov', cha sto tu i skorost' pojavlenija opuholej u krys v zavisimosti o t dozy vozdejstvija i sroka nabljudenija. Opyt s nejtronami postavlen na 573, s protonami na 490 belyh krysah. Bystrymi nejtronami zhivotnyh obluchali v dozah ot 8,5 do 510 rad, protonami ot 28 do 1008 rad. Dlja bystryh nejtronov i protonov ustanovleny velichiny ostro, podostro i hronicheski jeffektivnyh d o z . LD{sub 50/30} dlja nejtronov ravna 408, dlja protonov 600 rad, a LD{sub 50/120} so otvetstvenno 380 i 600 rad. Proanalizirovany zakonomernosti vymiranija krys v rannie i pozdnie sroki jeksperimenta. Pokazano, chto srednjaja prodolzhitel'nost' zhizni krys, obluchennyh bystrymi nejtronami, ne zavisit ot pola. Forma krivoj doza-jeffekt dlja otdel'nyh pokazatelej perifericheskoj krovi sushhestvenno zavisit ne tol'ko ot radiochuvstvitel'nosti sootvetstvujushhih kletok krovi, no i ot sroka nabljudenija. Ona mozhet sushhestvenno izmenjat'sja vo vremeni dlja odnogo i t o go zhe pokazatelja. V otdalennye sroki posle obluchenija kak bystrymi nejtronami, tak i protonami u krys voznikajut dobrokachestvennye i zlokachestvennye opuholi razlichnyh tkanej, v tom chisle krovotvornoj, molochnyh zhelez, gipofiza, matki, jaichnikov predstatel'noj zhelezy, semennikov, shhitovidnoj zhelezy, zobnoj i podzheludochnoj zhelez, nadpochechnikov, pecheni, pochek, l e g kih, zheludochno-kishechnogo trakta, podkozhnoj kletchatki, limfaticheskih u z lov, mochevogo puzyrja i drugih. Summarnaja chastota opuholej i chislo sluchaev mul'ticentricheskogo vozniknovenija novoobrazovanij u samok v 2 - 3 raza vyshe, chem u samcov. Minimal'naja opuholevaja doza dlja molochnyh zhelez pri obluchenii nejtronami, po-vidimomu, neskol'ko nizhe 42,5 rad. Maksimal'naja chastota opuholej gipofiza obnaruzhivaetsja posle obluchenija v doze 42,5 rad. Pri jetoj zhe doze voznikajut lejkozy i opuholi shhitovidnoj zhelezy. Pri obluchenii protonami minimal'naja opuholevaja doza dlja krovotvornoj tkani i shhitovidnoj zhelezy nahoditsja v predelah 250 rad, dlja semennikov - 300 rad, dlja predstatel'noj, podzheludochnoj zhelez , podkozhnoj kletchatki - 100 rad. Posle obluchenija bystrymi nejtronami chastota opuholej semennikov, tolsto go kishechnika, pochek, pecheni okazyvaetsja uvelichennoj pri dozah 42,5 - 85 rad, kozhi i podkozhnoj kletchatki pri doze - 85 rad. Po sravneniju s protonami pri obluchenii bystrymi nejtronami opuholi voznikajut ot men'shih (primerno v 3 - 5 raz) doz obluchenija. (author)}
place = {IAEA}
year = {1964}
month = {Mar}
}