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Patterns of Lethality and Absorbed Dose Distributions in Mice for Monoenergetic Neutrons; Letalite et Distribution de la Dose Absorbee chez la Souris pour des Neutrons Monoenergetiques; Letal'nost' i raspredelenie pogloshchennoj dozy pri obluchenii myshej monoehnergeticheskimi neitronami; Letalidad y Distribucion de las Dosis Absorbidas por el Raton para Neutrones Monoenergeticos

Conference:

Abstract

The presence of strong C, N and O resonances in the 100 to 1500 keV region has permitted the study of specific neutron-nuclide interactions as reflected in lethality, RBE maxima etc. Sixty-two {mu}A of resolved Van de Graaf protons, 1882 to 2738 keV, yielded monoenergetic neutrons via Li{sup 7}(p, n)Be{sup 7}. Virgin female CF-1 mice were exposed in celluloid capsules to the mono-energetic neutrons at distances of 3.1 to 11.3 cm from the source at laboratory angles of 0 to 1 radian. Mice were exposed bilaterally while simultaneously in motion through either circular or elliptical orbits normal to the axis of the beam. Thus, control of dose distribution within the animal was possible. Absolute flux measurements were made with U{sup 235} fission counters and by absolute counting of Au wires and foils activated within Cd covers. Patterns of dose absorption were measured with micro-ionization chambers and with a specially developed FeSO{sub 4}-NH{sub 4}SCN dosimeter of high sensitivity. Relative dose measurements were made with Hurst proton-recoil gas counters and B{sup 10} , Li{sup 6} and proton-recoil scintillators. Neutron-energy distributions were measured with specially developed B{sup 10}, He{sup 3} and Li{sup 6} gas and solid-state spectrometers. Gamma contributions were measured with Ne/Ar  More>>
Authors:
Frigerio, N. A.; Jordan, D. L. [1] 
  1. Argonne National Laboratory, Argonne, IL (United States)
Publication Date:
Mar 15, 1964
Product Type:
Conference
Report Number:
IAEA-SM-44/15
Resource Relation:
Conference: Symposium on Biological Effects of Neutron Irradiations, Upton, NY (United States), 7-11 Dec 1963; Other Information: 19 refs., 2 figs., 6 tabs.; Related Information: In: Biological Effects of Neutron and Proton Irradiations. Vol. I. Proceedings of the Symposium on Biological Effects of Neutron Irradiations| 448 p.
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; ABSOLUTE COUNTING; ABSORBED RADIATION DOSES; AMMONIUM THIOCYANATES; BERYLLIUM 7; BORON 10; BUBBLE DOSEMETERS; ENERGY SPECTRA; FAST NEUTRONS; GAS SCINTILLATION DETECTORS; HE-3 COUNTERS; HELIUM 3; IRON SULFATES; LITHIUM 6; LITHIUM 7; MEV RANGE 01-10; MICE; PROTONS; RADIATION DOSE DISTRIBUTIONS; RADIATION DOSE UNITS; URANIUM 235
OSTI ID:
22141829
Research Organizations:
International Atomic Energy Agency, Vienna (Austria)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
Other: ISSN 0074-1884; TRN: XA13M3431096430
Submitting Site:
INIS
Size:
page(s) 117-127
Announcement Date:
Oct 24, 2013

Conference:

Citation Formats

Frigerio, N. A., and Jordan, D. L. Patterns of Lethality and Absorbed Dose Distributions in Mice for Monoenergetic Neutrons; Letalite et Distribution de la Dose Absorbee chez la Souris pour des Neutrons Monoenergetiques; Letal'nost' i raspredelenie pogloshchennoj dozy pri obluchenii myshej monoehnergeticheskimi neitronami; Letalidad y Distribucion de las Dosis Absorbidas por el Raton para Neutrones Monoenergeticos. IAEA: N. p., 1964. Web.
Frigerio, N. A., & Jordan, D. L. Patterns of Lethality and Absorbed Dose Distributions in Mice for Monoenergetic Neutrons; Letalite et Distribution de la Dose Absorbee chez la Souris pour des Neutrons Monoenergetiques; Letal'nost' i raspredelenie pogloshchennoj dozy pri obluchenii myshej monoehnergeticheskimi neitronami; Letalidad y Distribucion de las Dosis Absorbidas por el Raton para Neutrones Monoenergeticos. IAEA.
Frigerio, N. A., and Jordan, D. L. 1964. "Patterns of Lethality and Absorbed Dose Distributions in Mice for Monoenergetic Neutrons; Letalite et Distribution de la Dose Absorbee chez la Souris pour des Neutrons Monoenergetiques; Letal'nost' i raspredelenie pogloshchennoj dozy pri obluchenii myshej monoehnergeticheskimi neitronami; Letalidad y Distribucion de las Dosis Absorbidas por el Raton para Neutrones Monoenergeticos." IAEA.
@misc{etde_22141829,
title = {Patterns of Lethality and Absorbed Dose Distributions in Mice for Monoenergetic Neutrons; Letalite et Distribution de la Dose Absorbee chez la Souris pour des Neutrons Monoenergetiques; Letal'nost' i raspredelenie pogloshchennoj dozy pri obluchenii myshej monoehnergeticheskimi neitronami; Letalidad y Distribucion de las Dosis Absorbidas por el Raton para Neutrones Monoenergeticos}
author = {Frigerio, N. A., and Jordan, D. L.}
abstractNote = {The presence of strong C, N and O resonances in the 100 to 1500 keV region has permitted the study of specific neutron-nuclide interactions as reflected in lethality, RBE maxima etc. Sixty-two {mu}A of resolved Van de Graaf protons, 1882 to 2738 keV, yielded monoenergetic neutrons via Li{sup 7}(p, n)Be{sup 7}. Virgin female CF-1 mice were exposed in celluloid capsules to the mono-energetic neutrons at distances of 3.1 to 11.3 cm from the source at laboratory angles of 0 to 1 radian. Mice were exposed bilaterally while simultaneously in motion through either circular or elliptical orbits normal to the axis of the beam. Thus, control of dose distribution within the animal was possible. Absolute flux measurements were made with U{sup 235} fission counters and by absolute counting of Au wires and foils activated within Cd covers. Patterns of dose absorption were measured with micro-ionization chambers and with a specially developed FeSO{sub 4}-NH{sub 4}SCN dosimeter of high sensitivity. Relative dose measurements were made with Hurst proton-recoil gas counters and B{sup 10} , Li{sup 6} and proton-recoil scintillators. Neutron-energy distributions were measured with specially developed B{sup 10}, He{sup 3} and Li{sup 6} gas and solid-state spectrometers. Gamma contributions were measured with Ne/Ar chamber counters. These measurements showed gamma contribution to be less than 0.8%, and thermal-epithermal less than 0.01%, of the total rad dose. Animals were exposed to median midpoint doses ranging from 180 to 1200 rad at neutron energies from 396 to 658 keV {+-} 50 keV to cover the region of N and O resonances. Levels and patterns of lethality proved to be strong functions of neutron energy and equally strong, but independent, functions of dose distribution. Regardless of dose, energy or distribution, however, all animals surviving five days survived at least 144 days, dying then of the usual long-term effects. This suggests that monoenergetic fast neutrons, free of gamma and epithermal contaminations, produce the early ''intestinal death'' almost exclusively. (author) [French] La presence de fortes resonances de C, N et O dans la region du spectre situee entre 100 et 1500 keV a permis d'etudier les interactions specifiques neutrons-nucleides d'apres-la letalite, les valeurs maxima de l'EBR, etc. Grace a la reaction {sup 7}Li(p, n){sup 7}Be, on a produit des neutrons monoenergetiques avec des protons de 62 {mu}A resolus a leur sortie d*une machine van de Graaf et dont l'energie allait de 1882 a 2738 keV. Des souris femelles vierges CF-1, placees dans des capsules en celluloide, ont ete exposees aux neutrons monoenergetiques, a des distances de 3,1 a 11,3 cm de la source, sous des angles de 0 a 1 radian. On les a exposees bilateralement, au cours d*un deplacement sur une orbite, circulaire ou elliptique, normale a l'axe du faisceau. On pouvait ainsi controler la distribution de la dose dans le corps de l'animal. On a procede a des mesures absolues du flux avec des compteurs a fission a {sup 235}U et par comptage absolu a l'aide de fils et de feuilles d'or actives a revetement de cadmium. On a mesure les doses absorbees a l'aide de chambres a ionisation et d'un dosimetre a FeSO{sub 4}-NH{sub 4}SCN de haute sensibilite, tout specialement etudie a cette fin. On a procede ensuite a des mesures relatives de la dose avec des compteurs de Hurst a gaz et protons de recul et avec des scintillateurs a {sup 10}B, {sup 6}Li et protons de recul. Les energies des neutrons ont ete mesurees avec des spectrometres speciaux a {sup 10}B, {sup 3}H, {sup 6}Li et semi-conducteurs. On a mesure l'action des rayons gamma avec des chamb rescompteuis a Ne/Ar. Ces mesures ont montre que les rayons gamma constituent moins de 0,8% et les neutrons thermo-epithermiques moins de 0 ,01% de la dose totale exprimee en rad. Les animaux ont ete exposes a des doses moyennes dans l'axe median de 180 a 1200 rad, les energies des neutrons s' echelonnant de 396 a 658 keV {+-} 50 keV pour couvrir la region des resonances de N et de O. On a constate que la courbe de letalite est une fonction marquee de Tenergie des neutrons et une fonction egalement marquee mais independante de la distribution de la dose. Toutefois, quelles que soient la dose, l'energie et la distribution, tous les animaux qui ont survecu 5 j ont ensuite survecu au moins 144 j, puis sont morts sous les effets a long terme habituels. Cela donne a penser que les neutrons rapides monoenergetiques n ayant pas subi de contamination gamma ou epithermique produisent presque exclusivement la 'mort intestinale ' precoce. (author) [Spanish] La presencia de intensas resonancias para el C, el N y el O, en el intervalo de 100 a 1500keV, ha permitido estudiar las interacciones especificas neutron-nuclido, que se manifiestan por variaciones de la letalidad, maximos de la EBR, etc. Mediante protones resueltos de 62 {mu}A, procedentes de un acelerador de van de Graaf, de 1882 keV a 2738 keV, se obtuvieron neutrones monoenergeticos por intermedio de la reaccion {sup 7}Li(p, n){sup 7}Be. Los autores expusieron al efecto de los neutrones monoenergeticos a hembras de raton virgenes, CF-1, en capsulas de celuloide, a distancias de 3,1 a 11,3 cm de la fuente, bajo angulos de 0 a 1 radian. Durante la exposicion bilateral, los animales giraban simultaneamente en orbitas circulares o elipticas normales al eje del haz. De esta manera se podia regular la distribucion de la dosis en el cuerpo del animal. Los autores midieron el flujo absoluto con contadores de fision de {sup 235}U y por receuento absoluto mediante alambres y laminas de oro activados, revestidos de Gd. Determinaron las dosis absorbidas con microcamaras de ionizacion y con un dosimetro de FeSO{sub 4}-NH{sub 4}SCN de alta sensibilidad, preparado especialmente para este fin. Para la medicion de las dosis relativas, usaron contadores gaseosos de Hurst para protones de retroceso y centelleadores de {sup 10}B, {sup 6}Li y de protones de retroceso. Determinaron las distribuciones energeticas de los neutrones con unos espectrometros especiales de {sup 10}B, {sup 3}He y {sup 6}Li. Con camaras de recuento Ne/Ar midieron los aportes de rayos {gamma}. Estas determinaciones demostraron que la contribucion de los rayos {gamma} es inferior al 0,8% mientras que la contribucion de los neutrones termicos y epitermicos en conjunto es inferior al 0,01% de la dosis total, expresada en rad. Los sujetos se expusieron a dosis medias en el eje central que variaban entre 180 y 1200 rad, en correspondencia con energias neutronicas comprendidas entre 396 y 658 keV {+-} 50 keV, a fin de abarcar la region de las resonancias del N y del O. Se comprobo que la letalidad varia pronunciadamente con la energia neutronica, siendo igualmente funcion pronunciada, pero independiente de la distribucion de la dosis. Sin embargo, sea cual fuere la dosis, la energia o la distribucion todos los animales que sobrevivieron S dias llegaron a sobrevivir por lo menos 144 dias muriendo luego a consecuencia de los habituales efectos diferidos. Esto indica que los neutrones rapidos monoenergeticos, exentos de contaminacion gamma y de neutrones epitermicos, causan casi exclusivamente la llamada 'muerte intestinal' precoz. (author) [Russian] Nalichie sil'nyh S, Nh O-rezonansov v diapazone jenergij ot 100 do 1500 kjev pozvolilo izuchit' specificheskie vzaimodejstvija nejtrona s jadrom, vlijajushhie na le ta l'nost ' , maksimal'nuju OBJe i t .d . Pri 62 mka na uskoritele Van-de-Graafa protony s jenergiej 1882 - 2738 kjev obrazujut monojenergeticheskie nejtrony v rezu l'tate reakcii L i{sup 7}(p, n)Be{sup 7}. Samok myshej linii CF-1 obluchali v celuloidnyh kapsulah monojenergeticheskimi nejtronami na rasstojanii 3,1 - 11,3 sm ot istochnika pod u gl om ot 0 do 1 radiana. Obluchenie bylo dvustoronnim i proizvodilos' odnovremenno vo vremja dvizhenija po cirkuljarnym ili jellipticheskim orbitam perpendikuljarno k osi puchka. Takim obrazom osushestvljalsja kontrol' raspredelenija dozy vnutri zhivotnogo. Absoljutnoe izmerenie moshhnosti potoka proizvodilos' s pomoshh'ju schetchika delenija uran-235 i absoljutnogo scheta aktivnosti zolotyh provolok i fol'g, aktivirovannyh v kadmievom pokrytii. Pogloshhenie dozy izmerjalos' s pomoshh'ju mikro-ionizacionnoj kamery i special'no razrabotannogo vysokochuvstvitel'nogo dozimetra FeSO{sub 4}- NH{sub 4}SCN. Otnositel'nye izmerenija doz proizvodilis' s pomoshh'ju ga zo v o go schetchika protonov otdachi Hersta i V10, Lie i scintilljatorov protonov otdachi. Raspredelenie jenergii nejtronov izmerjalos' s pomoshh'ju special'no razrabotannyh B{sup 10} , Ne{sup 3} i L i{sup 6} gazovyh spektrometrov i spektrometrov tverdyh tel. Gamma-izluchenie izmerjalos' s pomoshh'ju Ne/Ag schetnyh kamer. Jeti izmerenija pokazali, chto dolja gamma-luchej sostavljala menee 0,8%, a teplovoe-nadteplovoe izluchenie men'she 0,01% obshhej dozy v radah. Zhivotnyh obluchali dozami so srednim znacheniem v sredinnoj tochke ot 180 do 1200 rad pri jenergii nejtronov ot 396 do 658 {+-}50 kjev dlja ohvata o b lasti N i O-rezonansov. Uroven' i harakter letal'nosti strogo zaviseli ot jenergii nejtronov i, v ravnoj s t e peni, no sam ostojat el'no, - ot raspredelenija dozy. Odnako,nezavisimo ot dozy, jenergii ili raspredelenija dozy, vse te zhe zhivotnye, kotorye vyzhili v techenie 5 dnej, prozhili dalee ne menee 144 dnej i pogibli zatem ot obychnyh dlitel'no dejstvujushhih faktorov. Jeto pokazyvaet, chto monojenergeticheskie bystrye nejtrony bez primesi gamma- ili nadteplovyh izluchenij mogut privodit' pochti bez iskljuchenija k rannej ''kishechnoj smerti''. (author)}
place = {IAEA}
year = {1964}
month = {Mar}
}