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The Let Distribution of Dose in Some Tissue Cylinders; Repartition de la Dose en Fonction du TLE dans Quelques Modeles Cylindriques de Tissus; Raspredelenie linejnoj peredachi ehnergii dozy v nekotorykh tkanevykh tsilindrakh; Distribucion de la Dosis en Funcion de la TLE en Algunos Modelos Cilindricos de Tejidos

Abstract

When neutrons irradiate a tissue phantom, the recoil nuclei that are produced have a continuous spectrum of energies. Even in the case of monoenergetic neutrons, there will be continuous distributions of energy for the various recoil nuclei and, hence, also a-continuous distribution of dose with respect to LET. Using a Monte-Carlo-type programme for the Controlled Data 1604 Computer, the LET spectrum of dose from monoenergetic beams of neutrons has been computed for tissue cylinders simulating a mouse, rat, guinea pig, dog, and man. Tissue was considered to consist of H, C, N, and O, in the proportions given for standard man. The H cross-sections used followed BNL-325 closely, and the cross-sections for O, N, and C were taken from NDA 2111-3, Vol. A; ORNL-2389; and NDA 12-16, respectively. The case of a phantom irradiated by the modified fission spectrum used by Neary is computed also. The LET distributions so obtained are used, together with values of RBE recommended by ICRP, to provide some interpretation of biological effects of neutron irradiation. These distributions are compared with data on biological effects of neutrons from some experiments and support, at least in part, some of the prevalent ideas concerning the dependence of RBE  More>>
Authors:
Snyder, W. S. [1] 
  1. Oak Ridge National Laboratory Oak Ridge, TN (United States)
Publication Date:
Mar 15, 1964
Product Type:
Conference
Report Number:
IAEA-SM-44/37
Resource Relation:
Conference: Symposium on Biological Effects of Neutron Irradiations, Upton, NY (United States), 7-11 Dec 1963; Other Information: 7 refs., 10 figs., 3 tabs.; Related Information: In: Biological Effects of Neutron and Proton Irradiations. Vol. I. Proceedings of the Symposium on Biological Effects of Neutron Irradiations| 448 p.
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; ANIMAL TISSUES; BIOLOGICAL RADIATION EFFECTS; COMPARATIVE EVALUATIONS; CROSS SECTIONS; DISTRIBUTION; DOGS; FISSION SPECTRA; GUINEA PIGS; ICRP; IRRADIATION; LET; MAN; MICE; MONTE CARLO METHOD; NEUTRONS; PHANTOMS; PLANT TISSUES; RADIATION DOSES; RATS
OSTI ID:
22141821
Research Organizations:
International Atomic Energy Agency, Vienna (Austria)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
Other: ISSN 0074-1884; TRN: XA13M3423096422
Submitting Site:
INIS
Size:
page(s) 3-19
Announcement Date:
Oct 24, 2013

Citation Formats

Snyder, W. S. The Let Distribution of Dose in Some Tissue Cylinders; Repartition de la Dose en Fonction du TLE dans Quelques Modeles Cylindriques de Tissus; Raspredelenie linejnoj peredachi ehnergii dozy v nekotorykh tkanevykh tsilindrakh; Distribucion de la Dosis en Funcion de la TLE en Algunos Modelos Cilindricos de Tejidos. IAEA: N. p., 1964. Web.
Snyder, W. S. The Let Distribution of Dose in Some Tissue Cylinders; Repartition de la Dose en Fonction du TLE dans Quelques Modeles Cylindriques de Tissus; Raspredelenie linejnoj peredachi ehnergii dozy v nekotorykh tkanevykh tsilindrakh; Distribucion de la Dosis en Funcion de la TLE en Algunos Modelos Cilindricos de Tejidos. IAEA.
Snyder, W. S. 1964. "The Let Distribution of Dose in Some Tissue Cylinders; Repartition de la Dose en Fonction du TLE dans Quelques Modeles Cylindriques de Tissus; Raspredelenie linejnoj peredachi ehnergii dozy v nekotorykh tkanevykh tsilindrakh; Distribucion de la Dosis en Funcion de la TLE en Algunos Modelos Cilindricos de Tejidos." IAEA.
@misc{etde_22141821,
title = {The Let Distribution of Dose in Some Tissue Cylinders; Repartition de la Dose en Fonction du TLE dans Quelques Modeles Cylindriques de Tissus; Raspredelenie linejnoj peredachi ehnergii dozy v nekotorykh tkanevykh tsilindrakh; Distribucion de la Dosis en Funcion de la TLE en Algunos Modelos Cilindricos de Tejidos}
author = {Snyder, W. S.}
abstractNote = {When neutrons irradiate a tissue phantom, the recoil nuclei that are produced have a continuous spectrum of energies. Even in the case of monoenergetic neutrons, there will be continuous distributions of energy for the various recoil nuclei and, hence, also a-continuous distribution of dose with respect to LET. Using a Monte-Carlo-type programme for the Controlled Data 1604 Computer, the LET spectrum of dose from monoenergetic beams of neutrons has been computed for tissue cylinders simulating a mouse, rat, guinea pig, dog, and man. Tissue was considered to consist of H, C, N, and O, in the proportions given for standard man. The H cross-sections used followed BNL-325 closely, and the cross-sections for O, N, and C were taken from NDA 2111-3, Vol. A; ORNL-2389; and NDA 12-16, respectively. The case of a phantom irradiated by the modified fission spectrum used by Neary is computed also. The LET distributions so obtained are used, together with values of RBE recommended by ICRP, to provide some interpretation of biological effects of neutron irradiation. These distributions are compared with data on biological effects of neutrons from some experiments and support, at least in part, some of the prevalent ideas concerning the dependence of RBE on LET, e.g. presence of repair and oxygen effect primarily with dose in low ranges of LET. Although these interpretations must be considered as preliminary, these LET distributions provide a basis for further experimental tests of the relation of RBE and LET. (author) [French] Lorsqu'un modele de tissu est expose aux neutrons, les noyaux de recul qui se produisent ont un spectre continu d'energies. Meme s'il s'agit de neutrons monoenergetiques, la repartition de l'energie des differents noyaux de recul sera continue, de sorte que la repartition de la dose en fonction du TLE le sera egalement. Avec une calculatrice 'Controlled Data 1604' , programmee a l'aide d'une methode de Monte-Carlo, on a calcule, en fonction du TLE, le spectre de la dose delivree par des faisceaux de neutrons monoenergetiques a des modeles cylindriques de tissus simulant une souris, un rat, un cobaye, un chien et un homme. On a admis que ces tissus consistaient en H, C, N et C dans les memes proportions que pour l'homme standard. Les sections efficaces de H etaient sensiblement identiques a celles qui sont donnees dans BNL-325 et les sections efficaces de 0 ,N et C ont ete reprises de NDA 2111-3 (volume A ), ORNL-2389 et NDA 12-16, respectivement. On a calcule egalement le cas d'un modele irradie par le spectre de fission modifie utilise par Neary. Les valeurs ainsi obtenues de la repartition de la dose en fonction du TLE, associees aux valeurs de l'EBR recommandees par la CIPR, permettent d'interpreter les effets biologiques de l'exposition aux neutrons. Ces valeurs ont ete comparees aux donnees sur les effets biologiques des neutrons obtenues a la suite de certaines experiences; elles confirment, du moins en partie, les hypotheses generalement admises sur la relation fonctionnelle entre l'EBR et le TLE, par exemple que la possibilite de guerison et l'effet d'oxygene se manifestent essentiellement par les doses a faible TLE. Bien que ces interpretations revetent encore un caractere preliminaire, la repartition de la dose en fonction du TLE pourra servir de base a de nouvelles experiences sur la relation entre l'EBR et le TLE. (author) [Spanish] Cuando un modelo de tejido se expone a neutrones, los nucleos de retroceso formados presentan un espectro energetico continao. Aun en el caso de los neutrones monoenergeticos, se observaran distribuciones continuas de energia para los distintos nucleos de retroceso y, por lo tanto, tambien sera continua la distribucion de la dosis en funcion de la TLE. Utilizando un programa tipo Montecarlo en la calculadora 'Controlled Data 1604', el autor calculo, en funcion de la TLE, el espectro de la dosis proporcionada por haces monoenergeticos'de neutrones a modelos cilindricos de tejidos que simulan ratones, ratas, cobayos (conejillos de Indias), perros y seres humanos. Se admitio que esos tejidos consistian en H.C.N y O en las mismas proporciones que en el hombre standard. Las secciones eficaces aplicadas para el H se ajustan estrictamente a las especificadas en el informe BNL 325, mientras que las secciones eficaces para el O, el N y el C son las prescritas en los documentos NDA 2111-3 (Vol. A ), ORNL-2389 y NDA 12-16, respectivamente. Tambien se efectuo el calculo para el caso de un modelo irradiado con el espectro de fision modificado, utilizado por Neary. El autor aplico las distribuciones de la TLE obtenidas en esta forma, juntamente con los valores de la EBR recomendados por la CIPR, para interpretar los efectos biologicos de la irradiacion neutronica. Compara dichas distribuciones con los datos sobre los efectos biologicos de los neutrones obtenidos experimentalmente y comprueba que confirman, por lo menos en parte, las hipotesis generalmente admitidas sobre la relacion funcional entre la TLE y la EBR, por ejemplo, que la posibilidad de cura y el efecto del exigenose manifiestan esencialmente con dosis de baja TLE. Aunque estas interpretaciones poseen un caracter preliminar, la distribucion de la dosis en funcion de la TLE podra servir de base para nuevas experiencias sobre la relacion entre la TLE y la EBR. (author) [Russian] Pri nejtronnom obluchenii tkanevogo fantoma obrazujushhiesja jadra otlachi imejut nepreryvnyj spektr jenergii. Dazhe v sluchae obluchenija monojenergeticheskimi nejtronami proishodit nepreryvnoe raspredelenie jenergii dlja razlichnyh jader otdachi i, sledovatel'no, takzhe nepreryvnoe raspredelenie dozy v otnoshenii L P Je . Pri ispol'zovanii programmy tipa Monte-Karlo dlja kontroliruemogo schetno-vychislitel'nogo ustrojstva 1604 vychisljalsja spektr L P Je dozy puchka monojenergeticheskih nejtronov dlja tkanevyh cilindrov, imitirujushhih mysh', krysu, morskuju svinku, sobaku i cheloveka. Tkan' sostojala iz N, S , N i O v proporcijah standartnogo chelovecheskogo or ganizma. Poperechnoe sechenie N strogo sootvetstvovalo B N L -325, sechenija dlja O , N i S byli vzjaty iz NDA 2111-3 (tom A ) , ORNL-2389 i NDA 12-16 sootvetstvenno. Proizvedeny takzhe vychislenija dlja fantoma, o b luchennogo nejtronami modificirovannogo raspredelenija LPJe narjadu s velichinami OBJe , rekomendovannymi MKRZ, ispol'zovalis' dlja interpretacii biologicheskogo dejstvija nejtronnogo obluchenija. Jeti dannye raspredelenija sravnivalis' s nekotorymi jeksperimental'nymi dannymi o biologicheskom dejstvii nejtronov i javljajutsja v nekotoroj stepeni podtverzhdeniem nekotoryh rasprostranennyh idej otnositel'no zavisimosti O BJe ot LP Je : razvitie vosstanovitel'nyh processov i kislorodnyj jeffekt preimushhestvenno pri dozah s nizkoj L P Je . Hotja jeti ob{sup j}asnenija dolzhny schitat'sja predvaritel'nymi, poluchennye velichiny raspredelenija L P Je obespechivajut osnovu dlja dal'nejshih jeksperimental'nyh issledovanij svjazi OB Je i LPJe . (author)}
place = {IAEA}
year = {1964}
month = {Mar}
}