You need JavaScript to view this

Diagnosis of Massive Pulmonary Embolism in Man by Radioisotope Scanning; Diagnostic par Scintigraphy de l'Embolie Pulmonaire Massive chez l'Homme; Diagnostika massivnoj legochnoj ehmbolii u cheloveka s pomoshch'yu radioizotopnogo skennirovaniya; Diagnostico de la Embolia Pulmonar Masiva en el Hombre por Exploracion Radioisotopica

Conference:

Abstract

Macroaggregated human-serum albumin particles labelled with either I{sup 131} or chromium-51 have been utilized to determine regional blood flow to the lungs in dogs and man. Following intravenous injection, the particles accumulated in the lung, permitting clear delineation of the lung fields by scintillation scanning. In patients with lung abscess, pneumonia, atelectasis, tumours and thromboembolic disease of the lung, there was a decreased accumulation of the radioactivity in the regions of the lungs involved. The technique was found to be clinically useful in the diagnosis of massive pulmonary emboli in man and in the demonstration of vascular occlusion in certain patients with cor pulmonale. Studies in dogs made possible the determination of the rate at which revascularization occurred following experimental pulmonary emboli. Scintillation scanning was carried out at various times after the removal of the experimental emboli. The circulation was restored through the lungs within a period of several weeks after the removal of chronic pulmonary emboli in dogs. Although aggregated human-serum albumin retained its antigenicity in rabbits, guinea pigs and dogs, extensive studies failed to reveal any antigenicity of the particles to man. Because of the rapid metabolism of the macroaggregated albumin particles, the radiation to the patient was  More>>
Authors:
Wagner, Jr., H. N.; Sabiston, Jr., D. C.; Iio, M.; Langan, J. K. [1] 
  1. Departments of Medicine, Surgery and Radiology, Johns Hopkins University School of Medicine, Baltimore, MD (United States)
Publication Date:
Oct 15, 1964
Product Type:
Conference
Report Number:
IAEA-SM-51/73
Resource Relation:
Conference: Symposium on medical radioisotope scanning, Athens (Greece), 20-24 Apr 1964; Other Information: 8 refs., 11 figs., 3 tabs.; Related Information: In: Medical Radioisotope Scanning, Vol. II. Proceedings of the Symposium on Medical Radioisotope Scanning| 484 p.
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ALBUMINS; ARTERIES; BLOOD FLOW; BLOOD SERUM; CHROMIUM 51; DIAGNOSIS; DOGS; ELECTROCARDIOGRAMS; EMBOLI; GUINEA PIGS; INTRAVENOUS INJECTION; IODINE 131; LUNGS; MAN; PATIENTS; PNEUMONIA; RABBITS; RADIOISOTOPE SCANNING; SCINTILLATIONS
OSTI ID:
22136634
Research Organizations:
International Atomic Energy Agency, Vienna (Austria)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
Other: ISSN 0074-1884; TRN: XA13M3089091292
Submitting Site:
INIS
Size:
page(s) 303-323
Announcement Date:
Oct 03, 2013

Conference:

Citation Formats

Wagner, Jr., H. N., Sabiston, Jr., D. C., Iio, M., and Langan, J. K. Diagnosis of Massive Pulmonary Embolism in Man by Radioisotope Scanning; Diagnostic par Scintigraphy de l'Embolie Pulmonaire Massive chez l'Homme; Diagnostika massivnoj legochnoj ehmbolii u cheloveka s pomoshch'yu radioizotopnogo skennirovaniya; Diagnostico de la Embolia Pulmonar Masiva en el Hombre por Exploracion Radioisotopica. IAEA: N. p., 1964. Web.
Wagner, Jr., H. N., Sabiston, Jr., D. C., Iio, M., & Langan, J. K. Diagnosis of Massive Pulmonary Embolism in Man by Radioisotope Scanning; Diagnostic par Scintigraphy de l'Embolie Pulmonaire Massive chez l'Homme; Diagnostika massivnoj legochnoj ehmbolii u cheloveka s pomoshch'yu radioizotopnogo skennirovaniya; Diagnostico de la Embolia Pulmonar Masiva en el Hombre por Exploracion Radioisotopica. IAEA.
Wagner, Jr., H. N., Sabiston, Jr., D. C., Iio, M., and Langan, J. K. 1964. "Diagnosis of Massive Pulmonary Embolism in Man by Radioisotope Scanning; Diagnostic par Scintigraphy de l'Embolie Pulmonaire Massive chez l'Homme; Diagnostika massivnoj legochnoj ehmbolii u cheloveka s pomoshch'yu radioizotopnogo skennirovaniya; Diagnostico de la Embolia Pulmonar Masiva en el Hombre por Exploracion Radioisotopica." IAEA.
@misc{etde_22136634,
title = {Diagnosis of Massive Pulmonary Embolism in Man by Radioisotope Scanning; Diagnostic par Scintigraphy de l'Embolie Pulmonaire Massive chez l'Homme; Diagnostika massivnoj legochnoj ehmbolii u cheloveka s pomoshch'yu radioizotopnogo skennirovaniya; Diagnostico de la Embolia Pulmonar Masiva en el Hombre por Exploracion Radioisotopica}
author = {Wagner, Jr., H. N., Sabiston, Jr., D. C., Iio, M., and Langan, J. K.}
abstractNote = {Macroaggregated human-serum albumin particles labelled with either I{sup 131} or chromium-51 have been utilized to determine regional blood flow to the lungs in dogs and man. Following intravenous injection, the particles accumulated in the lung, permitting clear delineation of the lung fields by scintillation scanning. In patients with lung abscess, pneumonia, atelectasis, tumours and thromboembolic disease of the lung, there was a decreased accumulation of the radioactivity in the regions of the lungs involved. The technique was found to be clinically useful in the diagnosis of massive pulmonary emboli in man and in the demonstration of vascular occlusion in certain patients with cor pulmonale. Studies in dogs made possible the determination of the rate at which revascularization occurred following experimental pulmonary emboli. Scintillation scanning was carried out at various times after the removal of the experimental emboli. The circulation was restored through the lungs within a period of several weeks after the removal of chronic pulmonary emboli in dogs. Although aggregated human-serum albumin retained its antigenicity in rabbits, guinea pigs and dogs, extensive studies failed to reveal any antigenicity of the particles to man. Because of the rapid metabolism of the macroaggregated albumin particles, the radiation to the patient was well within permissible levels. The use of albumin of high specific activity permitted injections of small chemical quantities; consequently no cardiovascular effects, such as increases in pulmonary artery pressure, changes in electrocardiogram or respiratory rate, were noted. (author) [French] Pour determiner chez le chien et chez l'homme le flux sanguin vers les poumons, on a utilise des macroparticules d'albumine de serum humain marquee avec {sup 131}I ou {sup 51}Cr. A la suite d'une injection intraveineuse, les particules s'accumulaient dans les poumons, permettant ainsi de delimiter nettement les regions pulmonaires par scintigraphie. Chez les sujets atteints d'abces pulmonaires, de pneumonie, d'atelectasie, de tumeurs ou dethrombo- embolie des poumons, on observait une accumulation moins intense de la radioactivite dans les regions pulmonaires affectees. Du point de vue clinique, cette methode s'est revelee utile pour le diagnostic des embolies pulmonaires massives chez l'homme et pour la mise en evidence d'une occlusion vasculaire chez certains sujets atteints de coeur pulmonaire. Les etudes sur des chiens ont permis de determiner le rythme auquel une vascularisation nouvelle se produisait a la suite d'embolies pulmonaires induites. On a fait des scintigraphies a diverses reprises apres embolectomie. Chez les chiens, la circulation dans les poumons etait retablie dans les quelques semaines qui suivaient l'embolectomie. Si les macroparticules d'albumine de serum humain gardaient leur caractere antigene chez les lapins, les cobayes et les chiens, des etudes tres poussees n'ont pu deceler un tel caractere chez l'homme. Par suite du metabolisme rapide des macroparticules d'albumine, la dose de radioactivite recue par les sujets restait bien en deca des niveaux admissibles. L'emploi d'albumine a forte activite specifique permettait de faire des injections de petites quantites de produit chimique; de ce fait, on n'a pas releve d'effets cardio-vasculaires, tels que des augmentations de la tension dans l'artere pulmonaire, des modifications de l'electro-cardiogramme ou du rythme respiratoire, etc. (author) [Spanish] Los autores utilizaron macroagregados de particulas de seroalbumina humana marcada con {sup 131}I o con {sup 51}Cr para determinar el caudal sanguineo regional que afluye a los pulmones en el perro y en el hombre. Inyectadas por via intravenosa, las particulas se acumulan en el pulmon y permiten delinear claramente los campos pulmonares por exploracion centelleografica. En pacientes con absceso del pulmon, neumonia, atelectasia, tumores y tromboembolias pulmonares, se observo una acumulacion disminuida de radiactividad en las regiones afectadas. Se comprobo la utilidad clinica de esta tecnica para diagnosticar embolias pulmonares masivas en el hombre y para descubrir oclusiones vasculares en ciertos pacientes afectados de cor pulmonale. Los estudios en perros permitieron determinar la rapidez con que progresa la revascularizacion despues de una embolia pulmonar experimental. Se efectuaron varias exploraciones centelleograficas una vez retirados los embolos experimentales. La circulacion se restablecio en todo el pulmon algunas semanas despues de haber eliminado los embolos pulmonares cronicos en los perros. Los agregados de seroalbumina humana han conservado su poder antigenico en los conejos, los cobayos y los perros, pero los estudios realizados no han permitido comprobar que las particulas tengan poder antigenico alguno en el hombre. Gracias al rapido metabolismo de los macroagregados, la dosis de radiacion recibida por el paciente se mantiene bastante inferior a los valores admisibles. El empleo de albuminas de elevada actividad especifica permite limitar considerablemente las cantidades inyectadas; no se observan, por lo tanto, efectos cardiovasculares tales como aumentos de presion en la arteria pulmonar, ni alteraciones del electrocardiograma o del ritmo respiratorio. (author) [Russian] Krupnye chasticy al'bumina syvorotki cheloveka, mechennye jodom-131 ili hromom-51, ispol'zovalis' dlja opredelenija regional'nogo toka krovi v legkih u sobak i cheloveka. Posle vnutrivennogo vvedenija chasticy, nakaplivajushhiesja v legkih, dajut chetkoe izobrazhenie konturov legkih pri scintilljacionnom skenniro- vanii. U pacientov s legochnymi abscessami, pnevmoniej, atelektazom, rakom legkih i trombojembolicheskoj bolezn'ju legkih nabljudalos' ponizhenie nakoplenija radioaktivnosti v porazhennyh uchastkah. Byl najden metod, kotoryj budet prigoden v klinike dlja diagnostiki massivnoj legochnoj jembolii u cheloveka i demonstracii zakuporki sosudov u nekotoryh pacientov s ''cor pulmonale''. Issledovanija na sobakah sdelali vozmozhnym opredelenie skorosti revaskuljarizacii posle jeksperimental'noj legochnoj jembolii. Scintilljacionnoe skennirovanie provodilos' v razlichnye periody vremeni posle udalenija jeksperimental'nogo jembola. Cirkuljacija krovi v legkih u sobak vosstanavlivalas' v techenie neskol'kih nedel' posle udalenija hronicheskogo legochnogo jembola. Hotja krupnye chasticy al'bumina syvorotki cheloveka sohranjali svoi antigennye svojstva dlja krolikov, morskih svinok i sobak, shirokie issledovanija ne priveli k obnaruzheniju kakih-libo antigennyh svojstv jetih chastic dlja cheloveka. Vvidu bystrogo metabolizma krupnyh chastic al'bumina doza obluchenija pacienta nahodilas' v predelah dopustimyh doz. Ispol'zovanie al'bumina s vysokoj udel'noj aktivnost'ju pozvoljalo vvodit' nebol'shie himicheskie kolichestva; vposledstvii ne otmecheno kakih-libo izmenenij so storony serdechno-sosudistoj sistemy, kak povyshenija davlenija v legochnoj arterii, izmenenija jelektrokardiogrammy ili chastoty dyhanija.}
place = {IAEA}
year = {1964}
month = {Oct}
}