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Study on the Localization of Iodine in the Stomach; Etude de la Localisation de l'Iode dans l'Estomac; Izuchenie lokalizatsii joda v zheludke; Estudio de la Localizacion del Yodo en el Estomago

Abstract

The authors have studied the localization of iodine in the stomach after intravenous injection of I{sup 131}-iodide, using a high-contrast photo-scanning system. The study was performed at different times after injection (ordinarily 2, 24 and 48 h) in patients without any gastric disease, in patients with cancer of the stomach and in patients with peptic ulcers. The distribution of radio-iodine was also studied in dog and human stomachs surgically removed at different times after the radio-iodine injection. In the surgically removed stomachs, the specific activity of the tissue corresponding to areas of interest revealed by scanning was determined in order to assist in interpreting the findings. From the results the authors conclude that there are certain areas of the normal stomach which play a particular part in iodine metabolism. Localization of the zones of highest radioactivity concentration suggests more than one mechanism for iodine excretion. These observations support the findings of other workers using different methods. Scanning at 24 h after administration of I{sup 131} allows gastric cancer to be detected in most of the patients with this disease who were studied. The explanation of these results is not only related to the iodine concentration by the tumour cells but  More>>
Authors:
Clode, W. H.; Perez Fernandez, M. A.; Baptista, A. M.; [1]  Simao Rodrigues, M.; Murteira, M. A. [2] 
  1. Comissao de Estudos de Energia Nuclear do Instituto de Alta Cultura, Lisbon (Portugal)
  2. Instituto Portugues de Oncologia, Lisbon (Portugal)
Publication Date:
Oct 15, 1964
Product Type:
Conference
Report Number:
IAEA-SM-51/14
Resource Relation:
Conference: Symposium on medical radioisotope scanning, Athens (Greece), 20-24 Apr 1964; Related Information: In: Medical Radioisotope Scanning, Vol. II. Proceedings of the Symposium on Medical Radioisotope Scanning| 484 p.
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; INTRAVENOUS INJECTION; IODIDES; IODINE; IODINE 131; METABOLISM; NEOPLASMS; PATIENTS; RADIOACTIVITY; RADIOISOTOPE SCANNING; SPATIAL DISTRIBUTION; STOMACH; ULCERS
OSTI ID:
22136628
Research Organizations:
International Atomic Energy Agency, Vienna (Austria)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
Other: ISSN 0074-1884; TRN: XA13M3081091286
Submitting Site:
INIS
Size:
page(s) 175-191
Announcement Date:
Oct 03, 2013

Citation Formats

Clode, W. H., Perez Fernandez, M. A., Baptista, A. M., Simao Rodrigues, M., and Murteira, M. A. Study on the Localization of Iodine in the Stomach; Etude de la Localisation de l'Iode dans l'Estomac; Izuchenie lokalizatsii joda v zheludke; Estudio de la Localizacion del Yodo en el Estomago. IAEA: N. p., 1964. Web.
Clode, W. H., Perez Fernandez, M. A., Baptista, A. M., Simao Rodrigues, M., & Murteira, M. A. Study on the Localization of Iodine in the Stomach; Etude de la Localisation de l'Iode dans l'Estomac; Izuchenie lokalizatsii joda v zheludke; Estudio de la Localizacion del Yodo en el Estomago. IAEA.
Clode, W. H., Perez Fernandez, M. A., Baptista, A. M., Simao Rodrigues, M., and Murteira, M. A. 1964. "Study on the Localization of Iodine in the Stomach; Etude de la Localisation de l'Iode dans l'Estomac; Izuchenie lokalizatsii joda v zheludke; Estudio de la Localizacion del Yodo en el Estomago." IAEA.
@misc{etde_22136628,
title = {Study on the Localization of Iodine in the Stomach; Etude de la Localisation de l'Iode dans l'Estomac; Izuchenie lokalizatsii joda v zheludke; Estudio de la Localizacion del Yodo en el Estomago}
author = {Clode, W. H., Perez Fernandez, M. A., Baptista, A. M., Simao Rodrigues, M., and Murteira, M. A.}
abstractNote = {The authors have studied the localization of iodine in the stomach after intravenous injection of I{sup 131}-iodide, using a high-contrast photo-scanning system. The study was performed at different times after injection (ordinarily 2, 24 and 48 h) in patients without any gastric disease, in patients with cancer of the stomach and in patients with peptic ulcers. The distribution of radio-iodine was also studied in dog and human stomachs surgically removed at different times after the radio-iodine injection. In the surgically removed stomachs, the specific activity of the tissue corresponding to areas of interest revealed by scanning was determined in order to assist in interpreting the findings. From the results the authors conclude that there are certain areas of the normal stomach which play a particular part in iodine metabolism. Localization of the zones of highest radioactivity concentration suggests more than one mechanism for iodine excretion. These observations support the findings of other workers using different methods. Scanning at 24 h after administration of I{sup 131} allows gastric cancer to be detected in most of the patients with this disease who were studied. The explanation of these results is not only related to the iodine concentration by the tumour cells but also t o some retention of iodine in the stomach walls. In most cases the radioiodine concentration in the tumour was not higher than in the normal mucosal areas where increased iodine uptake occurs. (author) [French] A l'aide d'un appareil de photoexploration a fort contraste, les auteurs ont etudie la localisation de l'iode dans l'estomac apres injection intraveineuse d'iodure marquee avec {sup 131}I. Ils ont fait cette etude a differents moments, apres l 'injection (habituellement apres 2, 24 et 48 h) sur des sujets exempts de toute affection gastrique, sur des malades atteints d'u n cancer de l'estomac et sur des malades ayant des ulceres gastriques. Ils ont egalement etudie la distribution du radioiode dans des estomacs humains et canins apres ablation a differents moments apres l'injection du radioiode. Pour faciliter l'interpretation des resultats, ils ont determine dans ces estomacs l'activite specifique du tissu correspondant aux zones d'interet revelees par scintigraphic. Les resultats obtenus ont permis aux auteurs de conclure que certaines zones d'un estomac normal jouent un role particulier dans le metabolisme de l'iode. La localisation de ces zones de concentration de la radioactivite semble indiquer qu'il existe plusieurs mecanismes d'excretion de l'iode. Ces constatations confirment les observations faites par d'autres chercheurs avec des methodes differentes. La scintigraphic 24 h apres l 'injection de {sup 131}I permet de detecter l e cancer de l'estomac chez la plupart des sujets atteints. Les resultats ne s'expliquent pas seulement par l e fait que l'iode se concentre dans les cellules tumorales, mais encore par une certaine retention de l'iode dans les parois de l'estomac. Dans la plupart des cas, la concentration du radioiode dans la tumeur n'etait pas plus forte que dans les regions muqueuses normales, ou se produit une fixation accrue d'iode. (author) [Spanish] Los autores estudiaron con un dispositivo de fotoexploracion de gran contraste la localizacion del yodo en el estomago despues de una inyeccion intravenosa de yoduro marcado con {sup 131}I. El estudio se realizo a diferentes intervalos despues de la inyeccion (por regia general, a las 2, a las 24 y a las 48h) en pacientes sin ninguna a feccion gastrica, en pacientes con cancer de estomago y en pacientes con ulceras gastricas. Estudiaron tambien la distribucion del yodo radiactivo en estomagos humanos y de perro extirpados a diferentes intervalos despues de la inyeccion. Para facilitar la interpretacion de los resultados, midieron la actividad especĂ­fica del tejido correspondiente a las zonas de interes delimitadas por la exploracion. Basandose en los resultados de esos estudios los autores han llegado a la conclusion de que ciertas regiones del estomago normal desempefian un papel importante en el metabolismo del yodo. La localizacion de las zonas en que la concentracion de radiactividad es mas elevada indica que la excrecion de yodo puede ser regida por varios mecanismos. Estas observaciones corroboran los resultados obtenidos por otros investigadores con metodos diferentes. La exploracion efectuada 24 h despues de administrar {sup 131}I permitio detectar el cancer del estomago en la mayorla de los pacientes afectados por esa enfermedad. Estos resultados se explican no solo por el hecho de que el yodo se concentra en las celulas tumorales sino tambien porque las paredes del estomago retienen cierta cantidad de este elemento. En la mayor parte de los casos, la concentracion de yodo radiactivo en el tumor no fue superior a la observada en aquellas regiones de la mucosa gastrica en que se produce una absorcion incrementada de este elemento. (author) [Russian] Avtory izuchali lokalizaciju joda v zheludke posle vnutrivennoj in{sup e}kcii iodida, mechennogo jodom-131, ispol'zuja dlja jetogo vysokokontrastnuju sistemu fotoskennirovanija. Issledovanie provodilos' cherez razlichnye promezhutki vremeni posle in{sup e}kcii (obychno cherez 2, 24 i 48 chasov) u bol'nyh, ne stradajushhih nikakimi zheludochnymi zabolevanijami, bol'nyh s rakom zheludka i bol'nyh s pepticheskoj jazvoj. Izuchalos' takzhe raspredelenie radioaktivnogo joda v zheludkah sobaki i cheloveka, udalennyh hirurgicheskim putem v razlichnoe vremja posle in{sup e}kcii radioaktivnogo joda. V udalennyh hirurgicheskim putem zheludkah dlja ob{sup j}asnenija poluchennyh dannyh opredeljalas' udel'naja aktivnost' tkanej, otnosjashhihsja k predstavljajushhim interes oblastjam, obnaruzhen** nym skennirovaniem. Na osnovanii poluchennyh dannyh avtory delajut vyvod, chto v normal'nom zheludke sushhestvujut oblasti, kotorye igrajut osobuju rol' v metabolizme joda. Lokalizacija zon samoj vysokoj koncentracii radioaktivnyh izotopov predpolagaet sushhestvovanie bolee chem odnogo mehanizma vydelenija joda. Jeti nabljudenija podtverzhdajut vyvody drugih issledovatelej, ispol'zovavshih razlichnye metody. Skennirovanie cherez 24 chasa posle vvedenija joda-131 pozvoljaet obnaruzhit' rak zheludka u bol'shinstva obsledovannyh bol'nyh, stradajushhih jetoj bolezn'ju. Jeti rezul'taty ob{sup j}asnjajutsja ne tol'ko koncentraciej joda kletkami opuholi, no takzhe i nekotoroj zaderzhkoj joda v stenkah zheludka. V bol'shinstve sluchaev koncentracija radioaktivnogo joda v opuholi byla ne vyshe, chem v uchastkah slizistoj obolochki, gde nabljudaetsja povyshennoe pogloshhenie joda. (author)}
place = {IAEA}
year = {1964}
month = {Oct}
}