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Radioiodinated (I{sup 131} and I{sup 125}) Fibrinogen for the Detection of Malignant Tumours in Man; Emploi de Fibrinogene Marque avec {sup 131}I ou {sup 125}I pour la Detection de Tumeurs Malignes chez l'Homme; Primenenie mechennogo radioaktivnym Jodom-131 i Jodom-125 fibrinogena dlya obnaruzheniya zlokachestvennykh opukholej u cheloveka; Empleo el Fibrinogeno Radioyodado ({sup 131}I y {sup 125}I) para la Deteccion de Tumores Malignos en el Hombre

Conference:

Abstract

A high fibrin content has been shown in a large number of malignant tumours, both experimental and human; this finding has been referred to the high thromboplastin content within the tumour, inducing the polymerization of fibrinogen into fibrin. On the basis of these data, human fibrinogen labelled with I{sup 131} and I{sup 125} has been tested as a possible agent for detecting malignant tumours in man. The uptake of radioiodinate fibrinogen has been studied in malignant and benign tumours, as well as non-neoplastic space-occupying lesions. Seventy-three cases have been so far examined; 53 of these were represented by malignant tumours localized in the skeleton, lungs, brain, abdominal organs etc. The I{sup 131}- fibrinogen uptake test gave correct results in 79% of the cases examined; no false positive results were obtained in the whole series. The technique and the results are briefly discussed. From the data obtained, it seems that fibrinogen-I{sup 131} may be usefully applied for the early detection of malignancies in man; possible improvements of the detection technique may markedly increase the diagnostic value of the method. (author) [French] Une teneur elevee en fibrine a ete mise en evidence dans un grand nombre de tumeurs malignes, tant chez l'homme  More>>
Authors:
Monasterio, G.; Becchini, M. F.; Riccioni, N. [1] 
  1. Centre of Nuclear Medicine, Medical Clinic, University of Pisa (Italy)
Publication Date:
Oct 15, 1964
Product Type:
Conference
Report Number:
IAEA-SM-51/91
Resource Relation:
Conference: Symposium on medical radioisotope scanning, Athens (Greece), 20-24 Apr 1964; Other Information: 11 refs., 6 figs., 7 tabs.; Related Information: In: Medical Radioisotope Scanning, Vol. II. Proceedings of the Symposium on Medical Radioisotope Scanning| 484 p.
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRAIN; FIBRIN; FIBRINOGEN; IODINE 125; IODINE 131; LUNGS; NEOPLASMS; RADIOISOTOPE SCANNING; SKELETON; THROMBOPLASTIN
OSTI ID:
22136627
Research Organizations:
International Atomic Energy Agency, Vienna (Austria)
Country of Origin:
IAEA
Language:
English
Contract Number:
Contract 026-63-4-BlAC
Other Identifying Numbers:
Other: ISSN 0074-1884; TRN: XA13M3080091285
Submitting Site:
INIS
Size:
page(s) 159-171
Announcement Date:
Oct 03, 2013

Conference:

Citation Formats

Monasterio, G., Becchini, M. F., and Riccioni, N. Radioiodinated (I{sup 131} and I{sup 125}) Fibrinogen for the Detection of Malignant Tumours in Man; Emploi de Fibrinogene Marque avec {sup 131}I ou {sup 125}I pour la Detection de Tumeurs Malignes chez l'Homme; Primenenie mechennogo radioaktivnym Jodom-131 i Jodom-125 fibrinogena dlya obnaruzheniya zlokachestvennykh opukholej u cheloveka; Empleo el Fibrinogeno Radioyodado ({sup 131}I y {sup 125}I) para la Deteccion de Tumores Malignos en el Hombre. IAEA: N. p., 1964. Web.
Monasterio, G., Becchini, M. F., & Riccioni, N. Radioiodinated (I{sup 131} and I{sup 125}) Fibrinogen for the Detection of Malignant Tumours in Man; Emploi de Fibrinogene Marque avec {sup 131}I ou {sup 125}I pour la Detection de Tumeurs Malignes chez l'Homme; Primenenie mechennogo radioaktivnym Jodom-131 i Jodom-125 fibrinogena dlya obnaruzheniya zlokachestvennykh opukholej u cheloveka; Empleo el Fibrinogeno Radioyodado ({sup 131}I y {sup 125}I) para la Deteccion de Tumores Malignos en el Hombre. IAEA.
Monasterio, G., Becchini, M. F., and Riccioni, N. 1964. "Radioiodinated (I{sup 131} and I{sup 125}) Fibrinogen for the Detection of Malignant Tumours in Man; Emploi de Fibrinogene Marque avec {sup 131}I ou {sup 125}I pour la Detection de Tumeurs Malignes chez l'Homme; Primenenie mechennogo radioaktivnym Jodom-131 i Jodom-125 fibrinogena dlya obnaruzheniya zlokachestvennykh opukholej u cheloveka; Empleo el Fibrinogeno Radioyodado ({sup 131}I y {sup 125}I) para la Deteccion de Tumores Malignos en el Hombre." IAEA.
@misc{etde_22136627,
title = {Radioiodinated (I{sup 131} and I{sup 125}) Fibrinogen for the Detection of Malignant Tumours in Man; Emploi de Fibrinogene Marque avec {sup 131}I ou {sup 125}I pour la Detection de Tumeurs Malignes chez l'Homme; Primenenie mechennogo radioaktivnym Jodom-131 i Jodom-125 fibrinogena dlya obnaruzheniya zlokachestvennykh opukholej u cheloveka; Empleo el Fibrinogeno Radioyodado ({sup 131}I y {sup 125}I) para la Deteccion de Tumores Malignos en el Hombre}
author = {Monasterio, G., Becchini, M. F., and Riccioni, N.}
abstractNote = {A high fibrin content has been shown in a large number of malignant tumours, both experimental and human; this finding has been referred to the high thromboplastin content within the tumour, inducing the polymerization of fibrinogen into fibrin. On the basis of these data, human fibrinogen labelled with I{sup 131} and I{sup 125} has been tested as a possible agent for detecting malignant tumours in man. The uptake of radioiodinate fibrinogen has been studied in malignant and benign tumours, as well as non-neoplastic space-occupying lesions. Seventy-three cases have been so far examined; 53 of these were represented by malignant tumours localized in the skeleton, lungs, brain, abdominal organs etc. The I{sup 131}- fibrinogen uptake test gave correct results in 79% of the cases examined; no false positive results were obtained in the whole series. The technique and the results are briefly discussed. From the data obtained, it seems that fibrinogen-I{sup 131} may be usefully applied for the early detection of malignancies in man; possible improvements of the detection technique may markedly increase the diagnostic value of the method. (author) [French] Une teneur elevee en fibrine a ete mise en evidence dans un grand nombre de tumeurs malignes, tant chez l'homme que chez des animaux de laboratoire; on a impute ce phenomene au fait que la tumeur contient une forte proportion de thromboplastine qui provoque la formation de fibrine par polymerisation du fibrinogene. Sur cette base, les auteurs ont utilise du fibrinogene humain marque avec {sup 1}'3{sup 1}I ou {sup 125}I pour la detection de tumeurs malignes chez l'homme. Ils ont etudie la fixation du fibrinogene marque dans des tumeurs malignes et des tumeurs benignes, ainsi que dans des lesions en volume non-neoplastiques. Sur les 73 cas examines jusqu'a present, 53 etaient constitues par des tumeurs malignes localisees dans le squelette, les poumons, le cerveau, les organes abdominaux, etc. Le test de fixation du fibrinogene marque avec {sup 1}'3{sup 1}I a donne des resultats corrects dans 79% des cas examines; aucun resultat faussement positif n'a ete enregistre sur toute la serie. Le memoire expose succinctement le procede et les resultats. D'apres les donnees obtenues, il semble que le fibrinogene marque avec {sup 131}l puisse etre utilise avec succes pour la detection precoce de tumeurs malignes chez l'homme; en ameliorant la technique de detection, il sera peut-etre possible d'augmenter sensiblement la valeur du diagnostic etabli par ce procede. (author) [Spanish] Se ha demostrado que en muchos tumores malignos, tanto en los inducidos en animales de laboratorio como en los formados espontaneamente en el hombre, hay un elevado contenido de fibrina-, se ha establecido una relacion entre este hecho y la gran cantidad de tromboplastina presente en el tumor, que seria lo que provoca la formacion de fibrina por polimerizacion del fibrinogeno. Teniendo esto en cuenta, los autores emplearon fibrinogeno humano marcado con {sup 131}I y {sup 125}l para detectar tumores malignos en el hombre. Estudiaron la absorcion del fibrinogeno radioyodado en tumores malignos y benignos y en lesiones no neoplasticas extensas. Han examinado hasta ahora 73 casos, constituidos 53 de ellos por tumores malignos localizados en el esqueleto, los pulmones, el cerebro, el tubo digestivo, etc. El ensayo de absorcion del fibrinogeno-{sup 131}I dio resultados correctos en el 79% de los casos; en toda la serie no se dio ningun resultado erroneamente positivo. Los autores discuten brevemente la tecnica y los resultados obtenidos. Los datos que ha sido posible reunir parecen indicar que el fibrinogeno-{sup 131}I puede utilizarse con exito para la deteccion temprana de formaciones malignas en el hombre; es probable que perfeccionando la tecnica de deteccion se logre aumentar notablemente el valor diagnostico del metodo. (author) [Russian] V bol'shom kolichestve zlokachestvennyh opuholej kak jeksperimental'nym putem, tak i teoreticheski ustanovleno vysokoe soderzhanie fibrina. Jetot vyvod osnovan na tom, chto v zlokachestvennoj opuholi soderzhitsja bol'shoe kolichestvotromboplastina, vyzyvajushhego polimerizaciju fibrinogena v fibrin. Na osnove jetih dannyh fibrinogen chelovecheskogo organizma, mechennyj jodom-131 i jodom-125, byl podvergnut ispytaniju kak vozmozhnyj agent dlja obnaruzhenija zlokachestvennyh opuholej u cheloveka. Pogloshhenie mechennogo radioaktivnym jodom fibrinogena izuchalos' v dobrokachestvennyh i zlokachestvennyh opuholjah, a takzhe i v tkanjah, ne javljajushhihsja novoobrazovanijami, no zanimajushhimi opredelennoe prostranstvo. Do sih por izucheny 73 sluchaja; 53 iz nih sostavljajut zlokachestvennye opuholi, raspolozhennye v skelete, legkih, golovnom mozgu, organah brjushnoj polosti i t.d. Izuchenie pogloshhenija fibrinogena mechennogo jodom-131 dalo tochnye rezul'taty v 79%izuchavshihsja sluchaev. Ni v odnom sluchae ne polucheno nepravil'nyh polozhitel'nyh rezul'tatov. Kratko obsuzhdajutsja metody i rezul'taty. Na osnovanii poluchennyh dannyh javstvuet, chto fibrinogen mechennyj jodom-131 mozhet uspeshno primenjat'sja dlja rannej diagnostiki zlokachestvennyh opuholej u cheloveka. Vozmozhnye usovershenstvovanija metoda obnaruzhenija mogut sushhestvenno povysit' diagnosticheskuju cennost' metoda. (author)}
place = {IAEA}
year = {1964}
month = {Oct}
}