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Organ Visualization by Photoscanning Using Micro- and Macro-Aggregates of Radioalbumin; Examen d'Organes par Photoscintigraphie (avec des Micro-Agglomerats et des Macroagglomerats de Radioalbumine); Vizualizatsiya organov putem fotoskennirovaniya; Visualizacion de Organos por Fotoexploracion (Empleo de Micro y Macroagregados de Radioalbumina)

Conference:

Abstract

Micro aggregates (10 - 20 nm) of human serum albumin I{sup 131} are shown to be superior to other agents for liver-spleen photoscanning. Radiation exposure to these organs is minimized and the test agent can be prepared with relative ease and simplicity. Also, the heart, stomach and salivary glands may be clearly visualized with the same material. The techniques and physiological basis for performing and interpreting scans of these organs are described. Their diagnostic value is illustrated. The physiological basis for using macro albumin aggregates (1 - 10 {mu}m) for visualization of the lungs is presented, along with typical scans in dogs. Toxicity studies and related pathophysiological investigations in animals demonstrate a wide margin of safety for using the large-particle test agents in man. Preliminary experiments in dogs indicate the feasibility of performing lung scans following the inhalation of an aerosol of the same material. This technique is simple, painless and entirely safe. Photoscans are presented from patients with a wide variety of pulmonary disorders. (author) [French] On a constate que les micro-agglomerats (10 a 20 nm) d'albumine de serum humain marquee avec {sup 131}I sont superieurs a toutes les autres substances pour la photoscintigraphie de la rate et du  More>>
Authors:
Taplin, G. V.; Johnson, D. E.; Dore, E. K.; Kaplan, H. S.; [1]  Los Alamos County Harbor General Hospital, Torrance, CA (United States)]
  1. School of Medicine, University of California, Los Angeles (United States)
Publication Date:
Oct 15, 1964
Product Type:
Conference
Report Number:
IAEA-SM-51/32
Resource Relation:
Conference: Symposium on medical radioisotope scanning, Athens (Greece), 20-24 Apr 1964; Other Information: 26 refs., 20 figs., 1 tab.; Related Information: In: Medical Radioisotope Scanning, Vol. II. Proceedings of the Symposium on Medical Radioisotope Scanning| 484 p.
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; AEROSOLS; ALBUMINS; BLOOD SERUM; DOGS; HEART; INHALATION; IODINE 131; LIVER; LUNGS; PATIENTS; RADIOISOTOPE SCANNING; SALIVARY GLANDS; SPLEEN; STOMACH
OSTI ID:
22136619
Research Organizations:
International Atomic Energy Agency, Vienna (Austria)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
Other: ISSN 0074-1884; TRN: XA13M3071091277
Submitting Site:
INIS
Size:
page(s) 3-27
Announcement Date:
Oct 03, 2013

Conference:

Citation Formats

Taplin, G. V., Johnson, D. E., Dore, E. K., Kaplan, H. S., and Los Alamos County Harbor General Hospital, Torrance, CA (United States)]. Organ Visualization by Photoscanning Using Micro- and Macro-Aggregates of Radioalbumin; Examen d'Organes par Photoscintigraphie (avec des Micro-Agglomerats et des Macroagglomerats de Radioalbumine); Vizualizatsiya organov putem fotoskennirovaniya; Visualizacion de Organos por Fotoexploracion (Empleo de Micro y Macroagregados de Radioalbumina). IAEA: N. p., 1964. Web.
Taplin, G. V., Johnson, D. E., Dore, E. K., Kaplan, H. S., & Los Alamos County Harbor General Hospital, Torrance, CA (United States)]. Organ Visualization by Photoscanning Using Micro- and Macro-Aggregates of Radioalbumin; Examen d'Organes par Photoscintigraphie (avec des Micro-Agglomerats et des Macroagglomerats de Radioalbumine); Vizualizatsiya organov putem fotoskennirovaniya; Visualizacion de Organos por Fotoexploracion (Empleo de Micro y Macroagregados de Radioalbumina). IAEA.
Taplin, G. V., Johnson, D. E., Dore, E. K., Kaplan, H. S., and Los Alamos County Harbor General Hospital, Torrance, CA (United States)]. 1964. "Organ Visualization by Photoscanning Using Micro- and Macro-Aggregates of Radioalbumin; Examen d'Organes par Photoscintigraphie (avec des Micro-Agglomerats et des Macroagglomerats de Radioalbumine); Vizualizatsiya organov putem fotoskennirovaniya; Visualizacion de Organos por Fotoexploracion (Empleo de Micro y Macroagregados de Radioalbumina)." IAEA.
@misc{etde_22136619,
title = {Organ Visualization by Photoscanning Using Micro- and Macro-Aggregates of Radioalbumin; Examen d'Organes par Photoscintigraphie (avec des Micro-Agglomerats et des Macroagglomerats de Radioalbumine); Vizualizatsiya organov putem fotoskennirovaniya; Visualizacion de Organos por Fotoexploracion (Empleo de Micro y Macroagregados de Radioalbumina)}
author = {Taplin, G. V., Johnson, D. E., Dore, E. K., Kaplan, H. S., and Los Alamos County Harbor General Hospital, Torrance, CA (United States)]}
abstractNote = {Micro aggregates (10 - 20 nm) of human serum albumin I{sup 131} are shown to be superior to other agents for liver-spleen photoscanning. Radiation exposure to these organs is minimized and the test agent can be prepared with relative ease and simplicity. Also, the heart, stomach and salivary glands may be clearly visualized with the same material. The techniques and physiological basis for performing and interpreting scans of these organs are described. Their diagnostic value is illustrated. The physiological basis for using macro albumin aggregates (1 - 10 {mu}m) for visualization of the lungs is presented, along with typical scans in dogs. Toxicity studies and related pathophysiological investigations in animals demonstrate a wide margin of safety for using the large-particle test agents in man. Preliminary experiments in dogs indicate the feasibility of performing lung scans following the inhalation of an aerosol of the same material. This technique is simple, painless and entirely safe. Photoscans are presented from patients with a wide variety of pulmonary disorders. (author) [French] On a constate que les micro-agglomerats (10 a 20 nm) d'albumine de serum humain marquee avec {sup 131}I sont superieurs a toutes les autres substances pour la photoscintigraphie de la rate et du foie. Ils permettent de reduire au minimum la radioexposition de ces organes; en outre, leur preparation est relativement facile et simple. La m e m e substance permet d'explorer aussi bien le coeur, l'estomac et les glandes salivaires. Les auteurs exposent les methodes et les bases physiologiques d'execution et d'interpretation des scintigrammes de ces organes. Ils donnent des exemples de leur valeur pour le diagnostic. Les auteurs indiquent ensuite les arguments d'ordre physiologique qui militent en faveur de l'utilisation de macro-agglomerats (1 a 10 {mu}) de radioalbumine pour explorer les poumons et presentent des scintigrammes typiques faits sur des chiens. Les etudes de toxicite et les recherches pathophysiologiques connexes sur des animaux montrent que l 'utilisation de grandes particules dans le cas d e l'homme laissent une bonne marge de securite. Des experiences preliminaires sur des chiens ont permis de constater qu'il est possible de faire des scintigrammes des poumons apres inhalation d'un aerosol contenant la substance indicatrice. Cette methode est simple, indolore et sans danger. Les auteurs presentent des photoscintigrammes de sujets atteints d'une grande diversite d'affections pulmonaires. (author) [Spanish] Los autores demuestran que los microagregados (10 - 20 m{mu}) de seroalbumina humana marcada con {sup 131}I ofrecen para la fotoexploracion del higado y del bazo ventajas sefialadas sobre otros productos. La radioexposicion de dichos organos queda reducida a un mfnimo y la preparacion de la sustancia de ensayo es relativamente faecil. Esa misma sustancia permite visualizar el corazon, el estomago y las glandulas salivales. En la memoria se describen las tecnicas y los principios fisiologicos en que se basan la fotoexploracion de dichos organos y la interpretacion de los resultados obtenidos, y se subraya el valor diagnostico de esas tecnicas. Se exponen los principios fisiologicos del empleo de macroagregados de albumina (1 - 10 {mu}) para la visualizacion de los pulmones, y se presentan centelleogramas tipicos obtenidos con perros. Estudios de la toxicidad e investigaciones fisiopatologicas realizadas en animales demuestran la existencia de un amplio margen de seguridad para el empleo de los macroagregados con fines medicos. Algunos experimentos preliminares realizados con perros indican que es posible la exploracion centelleografica de los pulmones despues de la inhalacion de un aerosol de macroagregados. Esa tecnicaessencillay no ocasiona peligro ni dolor alguno. Los autores presentaraen fotocentelleogramas de una gran variedad de casos de enfermedades pulmonares. (author) [Russian] Pokazano, chto mikrochasticy (10 - 20mmk) al'bumina syvorotki chelovecheskoj krovi,mechenogo jodom-131,javljaetsja nailuchshim indikatorom dlja fotoskennirovanija pecheni i selezenki. Doza obluchenija jetih organov minimal'na, a prigotovlenie indikatora otnositel'no legko i prosto. S pomoshh'ju jetogo zhe veshhestva mozhno poluchit' otchetlivoe vizual'noe predstavlenie o serdce, zheludke i sljunnyh zhelezah. Opisyvajutsja metody i fiziologicheskie osnovy poluchenija i tolkovanija skennogramm jetih organov. Illjustriruetsja ih znachenie dlja postanovki diagnoza. Fiziologicheskie osnovy primenenija al'bumina v vide makrochastic (1-10 mk) dlja vizualizacii legkih pokazany na primere tipichnyh skennogramm sobak. Toksikologicheskoe izuchenie i sootvetstvujushhie patofiziologicheskie issledovanija na zhivotnyh pokazyvajut nalichie shirokih granic bezopasnosti, pozvoljajushhih primenjat' indikatory, sostojashhie iz krupnyh chastic, dlja skennirovanija u ljudej. Predvaritel'nye jeksperimenty na sobakah pokazali vozmozhnost' skennirovanija legkih posle vdyhanija ajerozolej jetogo zhe veshhestva. Jetot metod javljaetsja prostym, bezboleznennym i sovershenno bezopasnym. Budut predstavleny fotosken- nogrammy bol'nyh s raznoobraznymi legochnymi zabolevanijami. (author)}
place = {IAEA}
year = {1964}
month = {Oct}
}