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A New Technique for Determining the Distribution of Radium and Thorium in Living Persons; Determination de la Repartition du Radium et du Thorium chez les Personnes Vivantes: Une Methode Nouvelle; Novyj metod opredeleniya raspredeleniya radiya i toriya u patsientov; Nueva Tecnica para Determinar la Distribucion del Radio y del Torio en Pacientes

Abstract

Whole-body counters have been traditionally used to measure radioactivity within persons without reference to internal distribution. In the case of bone-seeking radioisotopes, such as radium, it is important to have some knowledge of at least the gross distribution within the skeleton in order to study the nature of the dose response. The techniques described here were developed to detect substantial non-uniformity in distribution of the radium in patients who cannot or will not lie still for more than one hour. A newly-designed right-cylindrical crystal 15 cm diam. and 20 cm long is placed 30 cm above the surface of a rigid bed with the axis of the crystal horizontal and at right angles to the supine patient's vertebral column. This log-shaped crystal is used instead, of the typical vertical squat cylinder in order that the surface areas and cross-sections of the crystal be of the same shape when viewed from any point in the body. The gamma-ray spectra from the supine patient and from point radioactive sources in the centre of Presdwood phantoms are obtained with the crystal located at x number of uniformly-spaced positions along the bed. The counting rates obtained for selected photopeaks from the spectra of the  More>>
Authors:
Miller, C. E. [1] 
  1. Argonne National Laboratory, Health Division, Argonne, IL (United States)
Publication Date:
Oct 15, 1964
Product Type:
Conference
Report Number:
IAEA-SM-52/36
Resource Relation:
Conference: Symposium on the Assessment of Radioactive Body Burdens, Heidelberg (Germany), 11-16 May 1964; Other Information: 1 refs., 4 figs., 2 tabs.; Related Information: In: Assessment of Radioactivity in Man. Vol. I. Proceedings of the Symposium on the Assessment of Radioactive Body Burdens in Man| 408 p.
Subject:
61 RADIATION PROTECTION AND DOSIMETRY; ACTINIUM 228; COUNTING RATES; CROSS SECTIONS; CRYSTALS; GAMMA RADIATION; GAMMA SPECTRA; LEAD 212; PATIENTS; PELVIS; PHANTOMS; POINT SOURCES; RADIATION DOSES; RADIOACTIVITY; RADIUM; SKULL; SPATIAL DISTRIBUTION; THALLIUM 208; THORIUM; THOROTRAST; WHOLE-BODY COUNTERS; WHOLE-BODY COUNTING
OSTI ID:
22134008
Research Organizations:
International Atomic Energy Agency, Vienna (Austria); International Labour Organisation, Geneva (Switzerland); World Health Organization, Geneva (Switzerland)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
Other: ISSN 0074-1884; TRN: XA13M3219089053
Submitting Site:
INIS
Size:
page(s) 67-77
Announcement Date:
Sep 26, 2013

Citation Formats

Miller, C. E. A New Technique for Determining the Distribution of Radium and Thorium in Living Persons; Determination de la Repartition du Radium et du Thorium chez les Personnes Vivantes: Une Methode Nouvelle; Novyj metod opredeleniya raspredeleniya radiya i toriya u patsientov; Nueva Tecnica para Determinar la Distribucion del Radio y del Torio en Pacientes. IAEA: N. p., 1964. Web.
Miller, C. E. A New Technique for Determining the Distribution of Radium and Thorium in Living Persons; Determination de la Repartition du Radium et du Thorium chez les Personnes Vivantes: Une Methode Nouvelle; Novyj metod opredeleniya raspredeleniya radiya i toriya u patsientov; Nueva Tecnica para Determinar la Distribucion del Radio y del Torio en Pacientes. IAEA.
Miller, C. E. 1964. "A New Technique for Determining the Distribution of Radium and Thorium in Living Persons; Determination de la Repartition du Radium et du Thorium chez les Personnes Vivantes: Une Methode Nouvelle; Novyj metod opredeleniya raspredeleniya radiya i toriya u patsientov; Nueva Tecnica para Determinar la Distribucion del Radio y del Torio en Pacientes." IAEA.
@misc{etde_22134008,
title = {A New Technique for Determining the Distribution of Radium and Thorium in Living Persons; Determination de la Repartition du Radium et du Thorium chez les Personnes Vivantes: Une Methode Nouvelle; Novyj metod opredeleniya raspredeleniya radiya i toriya u patsientov; Nueva Tecnica para Determinar la Distribucion del Radio y del Torio en Pacientes}
author = {Miller, C. E.}
abstractNote = {Whole-body counters have been traditionally used to measure radioactivity within persons without reference to internal distribution. In the case of bone-seeking radioisotopes, such as radium, it is important to have some knowledge of at least the gross distribution within the skeleton in order to study the nature of the dose response. The techniques described here were developed to detect substantial non-uniformity in distribution of the radium in patients who cannot or will not lie still for more than one hour. A newly-designed right-cylindrical crystal 15 cm diam. and 20 cm long is placed 30 cm above the surface of a rigid bed with the axis of the crystal horizontal and at right angles to the supine patient's vertebral column. This log-shaped crystal is used instead, of the typical vertical squat cylinder in order that the surface areas and cross-sections of the crystal be of the same shape when viewed from any point in the body. The gamma-ray spectra from the supine patient and from point radioactive sources in the centre of Presdwood phantoms are obtained with the crystal located at x number of uniformly-spaced positions along the bed. The counting rates obtained for selected photopeaks from the spectra of the patient and the phantom are fed into an electronic computer, which is programmed to calculate a series of point sources that would give the same gamma-ray profile. The results with a number of radium patients have demonstrated that, while the distribution is frequently essentially uniform, some persons contain a concentration two or three times higher than the mean in the lower legs, the pelvis, or in the skull. The sums of the calculated sources agree within a few per cent with the total radium body contents measured with other whole-body counting techniques. Measurements made of two patients who received thorotrast about eighteen years ago and of phantoms containing thorotrast and RdTh have also demonstrated the feasibility of measuring the non-uniformity of distribution of Tl{sup 208} (ThC''), of Ac{sup 228} (MsTh{sup 2}), and possibly of Pb{sup 212} along the axis of the body. (author) [French] En regle generale, on se sert d'anthropogammametres pour doser l'activite du corps humain, sans se preoccuper de sa repartition. Dans le cas des radioisotopes osteotropes comme le radium, il importe d'avoir une idee au moins approximative de leur repartition dans le squelette pour etudier la nature de la reponse a la dose. Les techniques decrites dans le memoire ont pour objet de deceler toute inhomogeneite importante dans la repartition du radium chez des malades qui ne peuvent pas ou ne veulent pas rester allonges et immobilises pendant plus d'une heure. Un cristal de conception nouvelle, en forme de cylindre droit, mesurant 15 cm de diametre sur 20 cm de long, est situe a 30 cm au-dessus de la surface d'un lit rigide, l'axe du cristal etant horizontal et orthogonal par rapport a la colonne vertebrale du malade en supination. Ce cristal horizontal allonge est utilise de preference au cylindre vertical court de type courant, de maniere que la surface et les sections du cristal aient la meme forme, quel que soit le point du corps d'oti on les observe. Le cristal etant place a un nombre x de positions regulierement espacees le long du lit,, on determine les spectres des rayons gamma emis par le malade en supination et par des sources radioactives ponctuelles placees au centre de fantomes en bois artificiel (Presdwood). Les taux de comptage obtenus pour des pics photoelectriques determines provenant des spectres du malade et du fantome sont transmis a une calculatrice electronique, laquelle est programmee de maniere a calculer une serie de sources ponctuelles qui fourniraient le meme profil de rayons gamma. Les resultats obtenus chez un-certain nombre de malades traites au radium montrent que, si la repartition du radioisotope est souvent essentiellement uniforme, chez certaines personnes sa concentration est deux ou trois fois superieure a la moyenne dans la partie inferieure des jambes, dans le pelvis ou dans le crane. Les sommes des sources calculees'concordent, a quelques pour-cents pres, avec'les mesures de la charge corporelle totale de radium obtenues au moyen d'autres techniques d'anthropogammametrie. Les mesures faites sur deux malades qui avaient recu.du thorotrast il y a environ dix-huit ans ainsi que sur des fantomes contenant dli thorotrast et RdTh ont egalement mis en evidence la possibilite de mesurer l'inhomogeneite de la repartition de {sup 208}Tl(ThC{sup )}, {sup 228}Ac (MsTh{sup 2}), et aussi sans doute de {sup 212}Pb, le long de l'axe du corps. (author) [Spanish] Los antropogammametros se vienen usando tradicionalmente para medir la radiactividad de las personas sin atender-a la distribucion interna. En el caso de los radioisotopos osteofilos, tales como el radio, interesa conocer por lo menos su distribucion aproximada dentro del esqueleto, a fin de poder estudiar la naturaleza de la respuesta a la dosis. Las tecnicas descritas en la memoria se idearon para poder descubrir cualquier heterogeneidad sustancial en la distribucion del radio en pacientes que no pueden o no desean yacer inmoviles mas de una hora. Un cristal cilindrico recto, de diseno nuevo, de 15 cm de diametro por 20 cm de longitud,- se coloca a una altura de 30 cm sobre -la superficie de una camilla rigida, con el eje del cristal horizontal y perpendicular a la direccion de la columna vertebral del paciente, acostado en posicion supina. Se usa este cristal en lugar del cilindro vertical chato tipico, con la intencion de que las areas superficiales y las secciones transversales del cristal, observadas desde cualquier punto del cuerpo del paciente, tengan la misma forma. Se obtienen los espectros de rayos gamma del paciente en posicion supina y de las fuentes radiactivas puntiformes ubicadas en el centro de maniquies de madera prensada, con el cristal situado en un numero x de posiciones uniformemente espaciadas a lo largo de la camilla. Los recuentos obtenidos en correspondencia con determinados picos fotoelectricos de los espectros del paciente y del maniqui se-pasan a una calculadora electronica cuyo programa se establece a fin de'calcular una serie de fuentes puntiformes que darian el mismo perfil de rayos gamma. Los resultados obtenidos con cierto numero de pacientes tratados con radio han demostrado que, si bien la distribucion es con frecuencia esencialmente uniforme, en algunas personas la concentracion en los extremos de las piernas, la pelvis, o el craneo es dos o tres veces superior al valor medio. La suma de las fuentes calculadas concuerda, con error inferior a algunas unidades por ciento, con el contenido total de radio, medido por otras tecnicas antropogammametricas. Las determinaciones efectuadas en dos pacientes a los cuales se les habia suministrado una solucion de torotrasto unos dieciocho anos atras y en maniquies que contienen torotrasto y RdTh han demonstrado que tambien es posible evaluar la heterogeneidad en la distribucion del {sup 208}Tl(ThC''), del {sup 228}Ac (MsTh{sup 2}) y, quizas, tambien del {sup 212}Pb a lo largo del eje corporal. (author) [Russian] Obychno dlja izmerenija radioaktivnosti u cheloveka bez ucheta raspredelenija vnutri organizma primenjalis' schetchiki dlja izmerenija aktivnosti vsego organizma. Kogda rech' idet o takih osedajushhih v kostjah radioizotopah, kak radij, vazhno imet' nekotorye svedenija po krajnej mere ob obshhem raspredelenii ih v skelete dlja togo, chtoby izuchit' otnoshenie dozy i jeffekta. Opisyvaemaja metodika byla razrabotana dlja opredelenija sushhestvennoj neodnorodnosti raspredelenija radija u pacientov, kotorye ne mogut ili ne hotjat lezhat' spokojno bol'she chasa. Zanovo skonstruirovannyj prjamoj cilindricheskij kristall diametrom 15.i dlinoju 20 sm pomestili po gorizontal'noj osi na rasstojanii 30 sm nad poverhnost'ju special'no ustroennoj zhestkoj krovati pod prjamym uglom k pozvonochniku lezhashhego pacienta. Jeta vytjanutaja forma kristalla byla primenena vmesto obychnogo vertikal'no raspolozhennogo korotkogo cilindra dlja togo,-chtoby ploshhad' poverhnosti i poperechnoe sechenie kristalla imeli odinakovuju formu po otnosheniju k ljuboj tochke tela. Spektry gamma-luchej, ishodjashhih ot pozvonochnika pacienta i ot radioaktivnyh istochnikov v centre fantoma iz pressovannoj drevesiny, byli polucheny pri pomoshhi kristalla, pomeshhaemogo v h-chisle polozhenij s odinakovymi intervalami vdol' krovati. Skorosti scheta, poluchennye dlja otobrannyh fotopikov iz spektrov pacienta i fantoma, byli vvedeny v jelektronnoschetnoe ustrojstvo, zaprogrammirovannoe dlja podscheta serii tochechnyh istochnikov, chto daet tot zhe samyj profil' gamma-luchej. Rezul'taty, poluchennye pri issledovanii rjada pacientov, svidetel'stvujut o tom. chto hotja raspredelenie chashhe vsego v osnovnom odnorodno, u nekotoryh lic koncentracija v dva ili tri raza vyshe srednej v nogah, tazu ili v cherepe. Itogi vychislennyh istochnikov sootvetstvujut v predelah'neskol'kih procentov obshhemu soderzhaniju radija v organizme, podschitannomu na osnovanii drugih metodik izmerenija aktivnosti vsego organizma. Izmerenija, provedennye u dvuh pacientov, poluchavshih torotrast bolee devjatnadcati let nazad, i na fantomah, soderzhashhih torotrast i radij-torij, takzhe svidetel'stvovali o vozmozhnosti izmerenija neodnorodnogo raspredelenija Tl{sup 208} (ThC''), Ac{sup 228}(MsTh{sup 2}) i, vozmozhno, Pb{sup 212} vdol' osi tela. (author)}
place = {IAEA}
year = {1964}
month = {Oct}
}