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Novel 3D ultrasound image-based biomarkers based on a feature selection from a 2D standardized vessel wall thickness map: a tool for sensitive assessment of therapies for carotid atherosclerosis

Abstract

With the advent of new therapies and management strategies for carotid atherosclerosis, there is a parallel need for measurement tools or biomarkers to evaluate the efficacy of these new strategies. 3D ultrasound has been shown to provide reproducible measurements of plaque area/volume and vessel wall volume. However, since carotid atherosclerosis is a focal disease that predominantly occurs at bifurcations, biomarkers based on local plaque change may be more sensitive than global volumetric measurements in demonstrating efficacy of new therapies. The ultimate goal of this paper is to develop a biomarker that is based on the local distribution of vessel-wall-plus-plaque thickness change (VWT-Change) that has occurred during the course of a clinical study. To allow comparison between different treatment groups, the VWT-Change distribution of each subject must first be mapped to a standardized domain. In this study, we developed a technique to map the 3D VWT-Change distribution to a 2D standardized template. We then applied a feature selection technique to identify regions on the 2D standardized map on which subjects in different treatment groups exhibit greater difference in VWT-Change. The proposed algorithm was applied to analyse the VWT-Change of 20 subjects in a placebo-controlled study of the effect of atorvastatin (Lipitor).  More>>
Authors:
Chiu, Bernard; Bing, Li; Chow, Tommy W S, E-mail: bcychiu@cityu.edu.hk, E-mail: bingli5@student.cityu.edu.hk, E-mail: eetchow@cityu.edu.hk [1] 
  1. Department of Electronic Engineering, City University of Hong Kong (Hong Kong)
Publication Date:
Sep 07, 2013
Product Type:
Journal Article
Resource Relation:
Journal Name: Physics in Medicine and Biology; Journal Volume: 58; Journal Issue: 17; Other Information: Country of input: International Atomic Energy Agency (IAEA)
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ALGORITHMS; ARTERIOSCLEROSIS; BIOLOGICAL MARKERS; CAROTID ARTERIES; IMAGES; THERAPY; ULTRASONOGRAPHY
OSTI ID:
22128777
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0031-9155; CODEN: PHMBA7; TRN: GB13Q3775083900
Availability:
Available from http://dx.doi.org/10.1088/0031-9155/58/17/5959
Submitting Site:
INIS
Size:
page(s) 5959-5982
Announcement Date:
Sep 19, 2013

Citation Formats

Chiu, Bernard, Bing, Li, and Chow, Tommy W S, E-mail: bcychiu@cityu.edu.hk, E-mail: bingli5@student.cityu.edu.hk, E-mail: eetchow@cityu.edu.hk. Novel 3D ultrasound image-based biomarkers based on a feature selection from a 2D standardized vessel wall thickness map: a tool for sensitive assessment of therapies for carotid atherosclerosis. United Kingdom: N. p., 2013. Web. doi:10.1088/0031-9155/58/17/5959.
Chiu, Bernard, Bing, Li, & Chow, Tommy W S, E-mail: bcychiu@cityu.edu.hk, E-mail: bingli5@student.cityu.edu.hk, E-mail: eetchow@cityu.edu.hk. Novel 3D ultrasound image-based biomarkers based on a feature selection from a 2D standardized vessel wall thickness map: a tool for sensitive assessment of therapies for carotid atherosclerosis. United Kingdom. doi:10.1088/0031-9155/58/17/5959.
Chiu, Bernard, Bing, Li, and Chow, Tommy W S, E-mail: bcychiu@cityu.edu.hk, E-mail: bingli5@student.cityu.edu.hk, E-mail: eetchow@cityu.edu.hk. 2013. "Novel 3D ultrasound image-based biomarkers based on a feature selection from a 2D standardized vessel wall thickness map: a tool for sensitive assessment of therapies for carotid atherosclerosis." United Kingdom. doi:10.1088/0031-9155/58/17/5959. https://www.osti.gov/servlets/purl/10.1088/0031-9155/58/17/5959.
@misc{etde_22128777,
title = {Novel 3D ultrasound image-based biomarkers based on a feature selection from a 2D standardized vessel wall thickness map: a tool for sensitive assessment of therapies for carotid atherosclerosis}
author = {Chiu, Bernard, Bing, Li, and Chow, Tommy W S, E-mail: bcychiu@cityu.edu.hk, E-mail: bingli5@student.cityu.edu.hk, E-mail: eetchow@cityu.edu.hk}
abstractNote = {With the advent of new therapies and management strategies for carotid atherosclerosis, there is a parallel need for measurement tools or biomarkers to evaluate the efficacy of these new strategies. 3D ultrasound has been shown to provide reproducible measurements of plaque area/volume and vessel wall volume. However, since carotid atherosclerosis is a focal disease that predominantly occurs at bifurcations, biomarkers based on local plaque change may be more sensitive than global volumetric measurements in demonstrating efficacy of new therapies. The ultimate goal of this paper is to develop a biomarker that is based on the local distribution of vessel-wall-plus-plaque thickness change (VWT-Change) that has occurred during the course of a clinical study. To allow comparison between different treatment groups, the VWT-Change distribution of each subject must first be mapped to a standardized domain. In this study, we developed a technique to map the 3D VWT-Change distribution to a 2D standardized template. We then applied a feature selection technique to identify regions on the 2D standardized map on which subjects in different treatment groups exhibit greater difference in VWT-Change. The proposed algorithm was applied to analyse the VWT-Change of 20 subjects in a placebo-controlled study of the effect of atorvastatin (Lipitor). The average VWT-Change for each subject was computed (i) over all points in the 2D map and (ii) over feature points only. For the average computed over all points, 97 subjects per group would be required to detect an effect size of 25% that of atorvastatin in a six-month study. The sample size is reduced to 25 subjects if the average were computed over feature points only. The introduction of this sensitive quantification technique for carotid atherosclerosis progression/regression would allow many proof-of-principle studies to be performed before a more costly and longer study involving a larger population is held to confirm the treatment efficacy. (paper)}
doi = {10.1088/0031-9155/58/17/5959}
journal = {Physics in Medicine and Biology}
issue = {17}
volume = {58}
journal type = {AC}
place = {United Kingdom}
year = {2013}
month = {Sep}
}