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Splenic Trapping of Heat-Treated Erythrocytes in Leukaemia and Allied Conditions

Abstract

In a trial to find whether or not the enlarged spleen plays a role in the production of the form of anaemia commonly encountered in leukaemias and allied conditions, 44 patients suffering from these disease states were studied using {sup 51}Cr-labelled erythrocytes heated at 50 Degree-Sign C for 60 min. Cells altered in this manner have been shown by various workers to be selectively sequestered by the spleen. As a control, the test was performed on 24 normal subjects. In these normals, the disappearance half-time of radioactivity from the circulation (T{sub Vulgar-Fraction-One-Half} amounted to 172 {+-} 69 min (mean {+-} 1 S.D.), the lowest limit being 74 min. Accordingly, patients with less than 74 min were considered to have an abnormally rapid disappearance of heat-treated erythrocytes from the circulation and consequently exaggerated splenic sequestration of these altered cells. Splenic trapping of heat-treated erythrocytes was most marked in acute leukaemia (four out of six patients). However, three had associated normoblastic hypoplasia of the sternal marrow. Corticosteroids induced a remission with reversion of both processes responsible for the anaemia in two out of the four patients. In chronic myeloid leukaemia, exaggerated splenic sequestration of altered cells was seen in four of the  More>>
Authors:
Badrawi, H. S.; Razzak, M. A.; Guirgis, B. [1] 
  1. Department of Medicine and Division of Nuclear Medicine, Faculty of Medicine, Cairo University, Cairo, United Arab Republic (Egypt)
Publication Date:
Feb 15, 1971
Product Type:
Conference
Report Number:
IAEA-SM-136/103
Resource Relation:
Conference: Symposium on Dynamics Studies with Radioisotopes in Clinical Medicine and Research, Rotterdam (Netherlands), 31 Aug - 4 Sep 1970; Other Information: 21 refs., 4 tabs.; Related Information: In: Dynamic Studies with Radioisotopes in Medicine. Proceedings of the Symposium on Dynamics Studies with Radioisotopes in Clinical Medicine and Research| 924 p.
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CHROMIUM 51; CORTICOSTEROIDS; ENDOXAN; ERYTHROCYTES; HEAT TREATMENTS; LEUKEMIA; LYMPHOSARCOMAS; PATIENTS; RADIOACTIVITY; SPLEEN; THERAPY; X RADIATION
OSTI ID:
22127347
Research Organizations:
International Atomic Energy Agency, Vienna (Austria)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
Other: ISSN 0074-1884; TRN: XA13M2760082426
Submitting Site:
INIS
Size:
page(s) 427-435
Announcement Date:
Sep 12, 2013

Citation Formats

Badrawi, H. S., Razzak, M. A., and Guirgis, B. Splenic Trapping of Heat-Treated Erythrocytes in Leukaemia and Allied Conditions. IAEA: N. p., 1971. Web.
Badrawi, H. S., Razzak, M. A., & Guirgis, B. Splenic Trapping of Heat-Treated Erythrocytes in Leukaemia and Allied Conditions. IAEA.
Badrawi, H. S., Razzak, M. A., and Guirgis, B. 1971. "Splenic Trapping of Heat-Treated Erythrocytes in Leukaemia and Allied Conditions." IAEA.
@misc{etde_22127347,
title = {Splenic Trapping of Heat-Treated Erythrocytes in Leukaemia and Allied Conditions}
author = {Badrawi, H. S., Razzak, M. A., and Guirgis, B.}
abstractNote = {In a trial to find whether or not the enlarged spleen plays a role in the production of the form of anaemia commonly encountered in leukaemias and allied conditions, 44 patients suffering from these disease states were studied using {sup 51}Cr-labelled erythrocytes heated at 50 Degree-Sign C for 60 min. Cells altered in this manner have been shown by various workers to be selectively sequestered by the spleen. As a control, the test was performed on 24 normal subjects. In these normals, the disappearance half-time of radioactivity from the circulation (T{sub Vulgar-Fraction-One-Half} amounted to 172 {+-} 69 min (mean {+-} 1 S.D.), the lowest limit being 74 min. Accordingly, patients with less than 74 min were considered to have an abnormally rapid disappearance of heat-treated erythrocytes from the circulation and consequently exaggerated splenic sequestration of these altered cells. Splenic trapping of heat-treated erythrocytes was most marked in acute leukaemia (four out of six patients). However, three had associated normoblastic hypoplasia of the sternal marrow. Corticosteroids induced a remission with reversion of both processes responsible for the anaemia in two out of the four patients. In chronic myeloid leukaemia, exaggerated splenic sequestration of altered cells was seen in four of the 15 cases examined. This condition was of extra-erythrocytic origin, since repetition of the test using normal donor heat-treated erythrocytes did not significantly alter the disappearance half-time. However, there was no correlation between the size of the spleen and its avidity for trapping the altered cells. Follow-up studies showed that therapy caused prolongation of the half-time of heat-treated erythrocytes, the effect being more apparent after corticosteroids than with X-rays or Endoxan, In Hodgkin's disease, increased red cell trapping was observed in two out of the seven patients studied. In contrast, five cases of chronic lymphatic leukaemia, six lymphosarcoma and five reticulum cell sarcoma had normal disappearance half-times of heat-treated erythrocytes from the circulation. (author)}
place = {IAEA}
year = {1971}
month = {Feb}
}