Abstract
Body-surface measurements were performed during {sup 51}Cr-platelet survival studies in patients with a normal or a reduced platelet life-span. As quantification of organ activity from surface recordings is hardly feasible, we tried to reach conclusions from the course of surface activity during platelet destruction. Continuous recording was applied during 30 or 50 min after platelet infusion, in order to avoid the problems raised by variations in counter positioning in spaced recordings. Surface activity was recorded over liver and spleen and/or heart independently by collimated Nal(Tl) crystals, and registered either by a rate-meter and recorder or by a 400-channel analyser. The exponential survival curve and reduced 2-h platelet recovery in patients with reduced platelet life-span suggest that in most cases a substantial destruction occurs in these first 50 min. Detection of platelet destruction in the spleen in this period is obscured, however, by the normal pooling of platelets in the spleen. Over the liver it is more easy to recognize platelet destruction because the rising course of activity differs distinctly from the normal , course. In all five patients with reduced platelet survival after splenectomy, hepatic platelet destruction was demonstrated. In 22 patients with reduced platelet survival and an intact spleen,
More>>
Fontein, D. L.;
Beekhuis, H.;
Woldring, M. G.;
Zanten, A.K. van;
Nieweg, H. O.
[1]
- University of Groningen, Groningen (Netherlands)
Citation Formats
Fontein, D. L., Beekhuis, H., Woldring, M. G., Zanten, A.K. van, and Nieweg, H. O.
A Test for the Effectiveness of Splenectomy in Werlhof's Disease Based on Body-Surface Measurement.
IAEA: N. p.,
1971.
Web.
Fontein, D. L., Beekhuis, H., Woldring, M. G., Zanten, A.K. van, & Nieweg, H. O.
A Test for the Effectiveness of Splenectomy in Werlhof's Disease Based on Body-Surface Measurement.
IAEA.
Fontein, D. L., Beekhuis, H., Woldring, M. G., Zanten, A.K. van, and Nieweg, H. O.
1971.
"A Test for the Effectiveness of Splenectomy in Werlhof's Disease Based on Body-Surface Measurement."
IAEA.
@misc{etde_22127346,
title = {A Test for the Effectiveness of Splenectomy in Werlhof's Disease Based on Body-Surface Measurement}
author = {Fontein, D. L., Beekhuis, H., Woldring, M. G., Zanten, A.K. van, and Nieweg, H. O.}
abstractNote = {Body-surface measurements were performed during {sup 51}Cr-platelet survival studies in patients with a normal or a reduced platelet life-span. As quantification of organ activity from surface recordings is hardly feasible, we tried to reach conclusions from the course of surface activity during platelet destruction. Continuous recording was applied during 30 or 50 min after platelet infusion, in order to avoid the problems raised by variations in counter positioning in spaced recordings. Surface activity was recorded over liver and spleen and/or heart independently by collimated Nal(Tl) crystals, and registered either by a rate-meter and recorder or by a 400-channel analyser. The exponential survival curve and reduced 2-h platelet recovery in patients with reduced platelet life-span suggest that in most cases a substantial destruction occurs in these first 50 min. Detection of platelet destruction in the spleen in this period is obscured, however, by the normal pooling of platelets in the spleen. Over the liver it is more easy to recognize platelet destruction because the rising course of activity differs distinctly from the normal , course. In all five patients with reduced platelet survival after splenectomy, hepatic platelet destruction was demonstrated. In 22 patients with reduced platelet survival and an intact spleen, hepatic platelet destruction was demonstrated in six. Hepatic platelet destruction was observed not only in patients with an extremely short platelet life-span, but also in patients with only moderately impaired platelet survival. The hypothesis that a failure from splenectomy can be predicted from a rising course of activity over the liver was tested in 11 patients. One of these had a failure from splenectomy in spite of a normal preoperative liver curve. Evidence is presented that in this case corticosteroid therapy had obscured hepatic platelet destruction. The results of operation in the other 10 patients (nine remissions and one failure) were in accordance with the hypothesis stated above. Some attention is paid to the information given by methods directed at quantifying organ activity, as well as different methods of presentation of data. (author)}
place = {IAEA}
year = {1971}
month = {Feb}
}
title = {A Test for the Effectiveness of Splenectomy in Werlhof's Disease Based on Body-Surface Measurement}
author = {Fontein, D. L., Beekhuis, H., Woldring, M. G., Zanten, A.K. van, and Nieweg, H. O.}
abstractNote = {Body-surface measurements were performed during {sup 51}Cr-platelet survival studies in patients with a normal or a reduced platelet life-span. As quantification of organ activity from surface recordings is hardly feasible, we tried to reach conclusions from the course of surface activity during platelet destruction. Continuous recording was applied during 30 or 50 min after platelet infusion, in order to avoid the problems raised by variations in counter positioning in spaced recordings. Surface activity was recorded over liver and spleen and/or heart independently by collimated Nal(Tl) crystals, and registered either by a rate-meter and recorder or by a 400-channel analyser. The exponential survival curve and reduced 2-h platelet recovery in patients with reduced platelet life-span suggest that in most cases a substantial destruction occurs in these first 50 min. Detection of platelet destruction in the spleen in this period is obscured, however, by the normal pooling of platelets in the spleen. Over the liver it is more easy to recognize platelet destruction because the rising course of activity differs distinctly from the normal , course. In all five patients with reduced platelet survival after splenectomy, hepatic platelet destruction was demonstrated. In 22 patients with reduced platelet survival and an intact spleen, hepatic platelet destruction was demonstrated in six. Hepatic platelet destruction was observed not only in patients with an extremely short platelet life-span, but also in patients with only moderately impaired platelet survival. The hypothesis that a failure from splenectomy can be predicted from a rising course of activity over the liver was tested in 11 patients. One of these had a failure from splenectomy in spite of a normal preoperative liver curve. Evidence is presented that in this case corticosteroid therapy had obscured hepatic platelet destruction. The results of operation in the other 10 patients (nine remissions and one failure) were in accordance with the hypothesis stated above. Some attention is paid to the information given by methods directed at quantifying organ activity, as well as different methods of presentation of data. (author)}
place = {IAEA}
year = {1971}
month = {Feb}
}