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Synthesis and quality control of {sup 13}C-enriched urea for Helicobacter pylori (HP) diagnosis

Abstract

The aim of the study was to synthesize the urea ({sup 13}CO(NH{sub 2}){sub 2}), with 99% {sup 13}C atoms, and to perform a quality analysis for the diagnosis (breath test) of Helicobacter pylori. Furthermore, the process was submitted to economic analysis. The reaction was performed in a stainless steel reactor, lined with polytetrafluoroethylene, under low pressure and temperature. The synthesis method was shown to be appropriate (2.35 g; 81.9% yield), evidenced by physico-chemical and microbiological results, according to Brazilian legislation. The production and diagnosis costs were competitive compared with national and international market values, rendering this a valuable tool in clinical medicine. (author)
Authors:
Sant Ana Filho, Carlos R.; Tavares, Claudineia R.O.; Ferreira, Andre V.; Prestes, Cleber V.; Bendassolli, Jose A., E-mail: jab@cena.usp.br [1] 
  1. Centro de Energia Nuclear na Agricultura (CENA/USP), Piracicaba, SP (Brazil)
Publication Date:
Aug 01, 2013
Product Type:
Journal Article
Resource Relation:
Journal Name: Quimica Nova; Journal Volume: 36; Journal Issue: 1
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; BACTERIAL DISEASES; BARIUM; BORON; CARBON 13; CARBON DIOXIDE; DIAGNOSIS; ETHYLENE; LEAD; MASS SPECTRA; METHANOL; NITROGEN; SULFUR; TEMPERATURE DEPENDENCE; UREA; UREASE
OSTI ID:
22125517
Country of Origin:
Brazil
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0100-4042; TRN: BR13V0116080263
Availability:
Available from http://quimicanova.sbq.org.br/qn/qnol/2013/vol36n1/19-AR12563.pdf
Submitting Site:
BRN
Size:
page(s) 107-113
Announcement Date:
Sep 12, 2013

Citation Formats

Sant Ana Filho, Carlos R., Tavares, Claudineia R.O., Ferreira, Andre V., Prestes, Cleber V., and Bendassolli, Jose A., E-mail: jab@cena.usp.br. Synthesis and quality control of {sup 13}C-enriched urea for Helicobacter pylori (HP) diagnosis. Brazil: N. p., 2013. Web. doi:10.1590/S0100-40422013000100020.
Sant Ana Filho, Carlos R., Tavares, Claudineia R.O., Ferreira, Andre V., Prestes, Cleber V., & Bendassolli, Jose A., E-mail: jab@cena.usp.br. Synthesis and quality control of {sup 13}C-enriched urea for Helicobacter pylori (HP) diagnosis. Brazil. doi:10.1590/S0100-40422013000100020.
Sant Ana Filho, Carlos R., Tavares, Claudineia R.O., Ferreira, Andre V., Prestes, Cleber V., and Bendassolli, Jose A., E-mail: jab@cena.usp.br. 2013. "Synthesis and quality control of {sup 13}C-enriched urea for Helicobacter pylori (HP) diagnosis." Brazil. doi:10.1590/S0100-40422013000100020. https://www.osti.gov/servlets/purl/10.1590/S0100-40422013000100020.
@misc{etde_22125517,
title = {Synthesis and quality control of {sup 13}C-enriched urea for Helicobacter pylori (HP) diagnosis}
author = {Sant Ana Filho, Carlos R., Tavares, Claudineia R.O., Ferreira, Andre V., Prestes, Cleber V., and Bendassolli, Jose A., E-mail: jab@cena.usp.br}
abstractNote = {The aim of the study was to synthesize the urea ({sup 13}CO(NH{sub 2}){sub 2}), with 99% {sup 13}C atoms, and to perform a quality analysis for the diagnosis (breath test) of Helicobacter pylori. Furthermore, the process was submitted to economic analysis. The reaction was performed in a stainless steel reactor, lined with polytetrafluoroethylene, under low pressure and temperature. The synthesis method was shown to be appropriate (2.35 g; 81.9% yield), evidenced by physico-chemical and microbiological results, according to Brazilian legislation. The production and diagnosis costs were competitive compared with national and international market values, rendering this a valuable tool in clinical medicine. (author)}
doi = {10.1590/S0100-40422013000100020}
journal = {Quimica Nova}
issue = {1}
volume = {36}
journal type = {AC}
place = {Brazil}
year = {2013}
month = {Aug}
}