Abstract
Bone-marrow and reticulocyte suspensions obtained from rabbits following massive haemorrhage were irradiated by a cobalt source with doses ranging between 1000-10 000 rad. The radiation-induced injury to the nucleic acid synthesizing apparatus and to the haem-and protein-producing activity of the bone-marrow cells, as well as the damage to the haemoglobin synthesizing system of the reticulocytes, was investigated shortly after exposure. The amino-acid incorporation activity into protein was substantially reduced, together with all the other parameters measured in the bone-marrow cells, while globin synthesis was not affected at the same radiation dose in the reticulocytes. On the other hand, incorporation of haem precursors into protoporphyrin and of radio iron into protoporphyrin was inhibited both in the nucleated erythroid precursors and in the reticulocytes, more so in the former than in the latter. The implications of these findings and possible means to repair the biochemical injury are discussed. (author)
Izak, G.;
Karsai, A.;
Eylon, L.;
[1]
Hebrew University-Hadassah Medical School, Jerusalem (Israel)]
- Haematology Research Laboratory, Hadassah University Hospital (Israel)
Citation Formats
Izak, G., Karsai, A., Eylon, L., and Hebrew University-Hadassah Medical School, Jerusalem (Israel)].
Radiation-Induced Changes in Some Biochemical Parameters of the Haemopoietic Tissue of Rabbits.
IAEA: N. p.,
1968.
Web.
Izak, G., Karsai, A., Eylon, L., & Hebrew University-Hadassah Medical School, Jerusalem (Israel)].
Radiation-Induced Changes in Some Biochemical Parameters of the Haemopoietic Tissue of Rabbits.
IAEA.
Izak, G., Karsai, A., Eylon, L., and Hebrew University-Hadassah Medical School, Jerusalem (Israel)].
1968.
"Radiation-Induced Changes in Some Biochemical Parameters of the Haemopoietic Tissue of Rabbits."
IAEA.
@misc{etde_22121048,
title = {Radiation-Induced Changes in Some Biochemical Parameters of the Haemopoietic Tissue of Rabbits}
author = {Izak, G., Karsai, A., Eylon, L., and Hebrew University-Hadassah Medical School, Jerusalem (Israel)]}
abstractNote = {Bone-marrow and reticulocyte suspensions obtained from rabbits following massive haemorrhage were irradiated by a cobalt source with doses ranging between 1000-10 000 rad. The radiation-induced injury to the nucleic acid synthesizing apparatus and to the haem-and protein-producing activity of the bone-marrow cells, as well as the damage to the haemoglobin synthesizing system of the reticulocytes, was investigated shortly after exposure. The amino-acid incorporation activity into protein was substantially reduced, together with all the other parameters measured in the bone-marrow cells, while globin synthesis was not affected at the same radiation dose in the reticulocytes. On the other hand, incorporation of haem precursors into protoporphyrin and of radio iron into protoporphyrin was inhibited both in the nucleated erythroid precursors and in the reticulocytes, more so in the former than in the latter. The implications of these findings and possible means to repair the biochemical injury are discussed. (author)}
place = {IAEA}
year = {1968}
month = {Aug}
}
title = {Radiation-Induced Changes in Some Biochemical Parameters of the Haemopoietic Tissue of Rabbits}
author = {Izak, G., Karsai, A., Eylon, L., and Hebrew University-Hadassah Medical School, Jerusalem (Israel)]}
abstractNote = {Bone-marrow and reticulocyte suspensions obtained from rabbits following massive haemorrhage were irradiated by a cobalt source with doses ranging between 1000-10 000 rad. The radiation-induced injury to the nucleic acid synthesizing apparatus and to the haem-and protein-producing activity of the bone-marrow cells, as well as the damage to the haemoglobin synthesizing system of the reticulocytes, was investigated shortly after exposure. The amino-acid incorporation activity into protein was substantially reduced, together with all the other parameters measured in the bone-marrow cells, while globin synthesis was not affected at the same radiation dose in the reticulocytes. On the other hand, incorporation of haem precursors into protoporphyrin and of radio iron into protoporphyrin was inhibited both in the nucleated erythroid precursors and in the reticulocytes, more so in the former than in the latter. The implications of these findings and possible means to repair the biochemical injury are discussed. (author)}
place = {IAEA}
year = {1968}
month = {Aug}
}