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Measurement of the Effect of Phenothiazine on the Manganese Concentration in the Basal Ganglia of Sub-Human Primates by Activation Analysis

Abstract

In man toxicity to manganese and phenothiazine drugs is manifested as dyskinesia. Cotzias and co-workers demonstrated that the phenothiazines form a semiquinone radical with manganese suggesting a common mechanism for production of Parkinsonism. Previous measurements of manganese have been made on whole brain. The very sensitive technique of activation analysis was used in the present study to measure manganese concentration in various nuclei of the basal ganglia. Phenothiazine was given to one group of Rhesus monkeys (Macaca mulatta) for one month. One group served as a control. After sacrifice the basal ganglia were dissected out with plastic knives, dried, and duplicate samples exposed to thermal neutrons at a flux of 1.35 x 10{sup 12} n/cm{sup 2}s. Manganese was separated radiochemical and counts under the manganese peak were compared to a standard handled identically. The results are presented. The manganese concentration was significantly increased in the putamen of primates receiving phenothiazine. There was no significant difference in the other nuclei examined. Phenothiazine is concentrated in basal ganglia. Dopamine is found in large quantities in caudate and putamen, and following phenothiazine therapy dopamine was found to be increased slightly. The associated increase of manganese and dopamine following phenothiazine provides some evidence that  More>>
Authors:
Bird, E. D.; Grant, L. G.; Ellis, W. H. [1] 
  1. University of Florida, Gainesville, FL (United States)
Publication Date:
Oct 15, 1967
Product Type:
Conference
Report Number:
IAEA-SM-91/59
Resource Relation:
Conference: Symposium on Nuclear Activation Techniques in the Life Sciences, Amsterdam (Netherlands), 8-12 May 1967; Other Information: 11 refs., 2 tabs., 3 figs.; Related Information: In: Nuclear Activation Techniques in the Life Sciences. Proceedings of the Symposium on Nuclear Activation Techniques in the Life Sciences| 726 p.
Subject:
07 ISOTOPES AND RADIATION SOURCES; 38 RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; ACTIVATION ANALYSIS; DOPAMINE; MAN; MANGANESE; MONKEYS; PHENOTHIAZINES; RADIOCHEMISTRY; THERMAL NEUTRONS
OSTI ID:
22116221
Research Organizations:
International Atomic Energy Agency, Vienna (Austria)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
Other: ISSN 0074-1884; TRN: XA13M1280072876
Submitting Site:
INIS
Size:
page(s) 491-498
Announcement Date:
Jul 26, 2013

Citation Formats

Bird, E. D., Grant, L. G., and Ellis, W. H. Measurement of the Effect of Phenothiazine on the Manganese Concentration in the Basal Ganglia of Sub-Human Primates by Activation Analysis. IAEA: N. p., 1967. Web.
Bird, E. D., Grant, L. G., & Ellis, W. H. Measurement of the Effect of Phenothiazine on the Manganese Concentration in the Basal Ganglia of Sub-Human Primates by Activation Analysis. IAEA.
Bird, E. D., Grant, L. G., and Ellis, W. H. 1967. "Measurement of the Effect of Phenothiazine on the Manganese Concentration in the Basal Ganglia of Sub-Human Primates by Activation Analysis." IAEA.
@misc{etde_22116221,
title = {Measurement of the Effect of Phenothiazine on the Manganese Concentration in the Basal Ganglia of Sub-Human Primates by Activation Analysis}
author = {Bird, E. D., Grant, L. G., and Ellis, W. H.}
abstractNote = {In man toxicity to manganese and phenothiazine drugs is manifested as dyskinesia. Cotzias and co-workers demonstrated that the phenothiazines form a semiquinone radical with manganese suggesting a common mechanism for production of Parkinsonism. Previous measurements of manganese have been made on whole brain. The very sensitive technique of activation analysis was used in the present study to measure manganese concentration in various nuclei of the basal ganglia. Phenothiazine was given to one group of Rhesus monkeys (Macaca mulatta) for one month. One group served as a control. After sacrifice the basal ganglia were dissected out with plastic knives, dried, and duplicate samples exposed to thermal neutrons at a flux of 1.35 x 10{sup 12} n/cm{sup 2}s. Manganese was separated radiochemical and counts under the manganese peak were compared to a standard handled identically. The results are presented. The manganese concentration was significantly increased in the putamen of primates receiving phenothiazine. There was no significant difference in the other nuclei examined. Phenothiazine is concentrated in basal ganglia. Dopamine is found in large quantities in caudate and putamen, and following phenothiazine therapy dopamine was found to be increased slightly. The associated increase of manganese and dopamine following phenothiazine provides some evidence that this drug causes profound biochemical alterations in the basal ganglia resulting in the various dyskinesias that are seen. (author)}
place = {IAEA}
year = {1967}
month = {Oct}
}