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A Means for the Scintigraphic Imaging of Regional Brain Dynamics. Regional Cerebral Blood Flow and Regional Cerebral Blood Volume

Conference:

Abstract

The use of freely diffusable inert radioactive gas as a washout indicator to measure regional cerebral blood flow has become a standardized kinetic procedure in many laboratories. Recent investigations with this technique have led us to conclude that we can reliably distinguish regional flow with perfusion against regional flow without perfusion from the early portion of the curve. Based on a detailed study of the early curve kinetics in patients with and without cerebral vascular disease we have defined the sampling duration necessary for application of the Anger gamma camera imaging process to regional changes in cerebral radioactivity. Using a standard camera and a small computer, a procedure has been developed and based upon entire field to determine the time of maximum height followed by analysis of the data in a matrix. This will permit a contour plot presentation of calculated regional cerebral blood flow in millilitres per 100 grams perfused brain per minute. In addition, we propose to augment this data by the display of regional non-perfusion blood flow versus regional cerebral flow with perfusion. Preliminary investigation on sampling duration, and Compton scattering were prerequisite to clinical scintigraphy of regional cerebral blood flow. In addition, the method of interface  More>>
Authors:
Potchen, E. J.; Bentley, R.; Gerth, W.; Hill, R. L.; Davis, D. O. [1] 
  1. Washington University School Of Medicine, St. Louis, MO (United States)
Publication Date:
May 15, 1969
Product Type:
Conference
Report Number:
IAEA-SM-108/79
Resource Relation:
Conference: Symposium on Medical Radioisotope Scintigraphy, Salzburg (Austria), 6-15 Aug 1968; Other Information: 13 refs., 3 figs.; Related Information: In: Medical Radioisotope Scintigraphy. Proceedings of a Symposium on Medical Radioisotope Scintigraphy. V. II| 952 p.
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BLOOD; BLOOD FLOW; BRAIN; COMPTON EFFECT; GAMMA CAMERAS; RADIOACTIVITY; SCINTISCANNING; VASCULAR DISEASES
OSTI ID:
22108025
Research Organizations:
International Atomic Energy Agency, Vienna (Austria)
Country of Origin:
IAEA
Language:
English
Contract Number:
Contract 1P07 FR00396-01; 5 P01 NB0b833-02; AT(11-1)-1653
Other Identifying Numbers:
Other: ISSN 0074-1884; TRN: XA13M0506065836
Submitting Site:
INIS
Size:
page(s) 577-583
Announcement Date:
Jun 27, 2013

Conference:

Citation Formats

Potchen, E. J., Bentley, R., Gerth, W., Hill, R. L., and Davis, D. O. A Means for the Scintigraphic Imaging of Regional Brain Dynamics. Regional Cerebral Blood Flow and Regional Cerebral Blood Volume. IAEA: N. p., 1969. Web.
Potchen, E. J., Bentley, R., Gerth, W., Hill, R. L., & Davis, D. O. A Means for the Scintigraphic Imaging of Regional Brain Dynamics. Regional Cerebral Blood Flow and Regional Cerebral Blood Volume. IAEA.
Potchen, E. J., Bentley, R., Gerth, W., Hill, R. L., and Davis, D. O. 1969. "A Means for the Scintigraphic Imaging of Regional Brain Dynamics. Regional Cerebral Blood Flow and Regional Cerebral Blood Volume." IAEA.
@misc{etde_22108025,
title = {A Means for the Scintigraphic Imaging of Regional Brain Dynamics. Regional Cerebral Blood Flow and Regional Cerebral Blood Volume}
author = {Potchen, E. J., Bentley, R., Gerth, W., Hill, R. L., and Davis, D. O.}
abstractNote = {The use of freely diffusable inert radioactive gas as a washout indicator to measure regional cerebral blood flow has become a standardized kinetic procedure in many laboratories. Recent investigations with this technique have led us to conclude that we can reliably distinguish regional flow with perfusion against regional flow without perfusion from the early portion of the curve. Based on a detailed study of the early curve kinetics in patients with and without cerebral vascular disease we have defined the sampling duration necessary for application of the Anger gamma camera imaging process to regional changes in cerebral radioactivity. Using a standard camera and a small computer, a procedure has been developed and based upon entire field to determine the time of maximum height followed by analysis of the data in a matrix. This will permit a contour plot presentation of calculated regional cerebral blood flow in millilitres per 100 grams perfused brain per minute. In addition, we propose to augment this data by the display of regional non-perfusion blood flow versus regional cerebral flow with perfusion. Preliminary investigation on sampling duration, and Compton scattering were prerequisite to clinical scintigraphy of regional cerebral blood flow. In addition, the method of interface for the conventional Anger gamma camera to digital computers used in this procedure are discussed. Applications to further assess regional cerebral dynamics by scintigraphy are presented. (author)}
place = {IAEA}
year = {1969}
month = {May}
}