Abstract
Photoscintigrams in black and white and in colour were made of the liver and the hepatic clearance was determined by colloidal {sup 198}Au (dimensions 25 - 30 {mu}m) in 82 patients suffering from chronic hepatitis or cirrhosis confirmed by clinical, humeral and histological criteria. The most characteristic changes in the liver scintigram, found particularly in the cirrhosis patients, were: atrophy of the right lobe (partial or total), sometimes pseudo tumoral in appearance; pale or in- homogeneous left lobe; presence of two centres of maximum radiocolloid uptake (left lobe and right lobe); and extrahepatic fixation (spleen, bone marrow). The colour recording system provided better information than the monochromatic system in the diagnosis of cirrhosis. Hepatic clearance showed a decrease, especially in cases of cirrhosis characterized by extrahepatic uptake of the radiocolloid. In the opinion of the authors, the height of the radioactivity curve registered in the temporal region is an indication, during the stabilization phase, of extrahepatic fixation of the colloidal gold. Its height (h{sub 2}) is greater in those cases where the scintigram indicated higher uptake in the spleen and bone marrow. The T 1/2 study of {sup 51}Cr-labelled erythrocytes and their sequestration in the spleen was made in 30
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Gheorghescu, B.;
Jovin, G.;
Pavel, D.;
Hoanca, O.;
Marculescu, Lidia;
Suseanu, I.;
Sparchez, T.
[1]
- Centre of Gastroenterology, Bucharest (Romania)
Citation Formats
Gheorghescu, B., Jovin, G., Pavel, D., Hoanca, O., Marculescu, Lidia, Suseanu, I., and Sparchez, T.
Interpretation of Scintigraphic Changes during Chronic Hepatitis and Cirrhosis of the Liver.
IAEA: N. p.,
1969.
Web.
Gheorghescu, B., Jovin, G., Pavel, D., Hoanca, O., Marculescu, Lidia, Suseanu, I., & Sparchez, T.
Interpretation of Scintigraphic Changes during Chronic Hepatitis and Cirrhosis of the Liver.
IAEA.
Gheorghescu, B., Jovin, G., Pavel, D., Hoanca, O., Marculescu, Lidia, Suseanu, I., and Sparchez, T.
1969.
"Interpretation of Scintigraphic Changes during Chronic Hepatitis and Cirrhosis of the Liver."
IAEA.
@misc{etde_22108021,
title = {Interpretation of Scintigraphic Changes during Chronic Hepatitis and Cirrhosis of the Liver}
author = {Gheorghescu, B., Jovin, G., Pavel, D., Hoanca, O., Marculescu, Lidia, Suseanu, I., and Sparchez, T.}
abstractNote = {Photoscintigrams in black and white and in colour were made of the liver and the hepatic clearance was determined by colloidal {sup 198}Au (dimensions 25 - 30 {mu}m) in 82 patients suffering from chronic hepatitis or cirrhosis confirmed by clinical, humeral and histological criteria. The most characteristic changes in the liver scintigram, found particularly in the cirrhosis patients, were: atrophy of the right lobe (partial or total), sometimes pseudo tumoral in appearance; pale or in- homogeneous left lobe; presence of two centres of maximum radiocolloid uptake (left lobe and right lobe); and extrahepatic fixation (spleen, bone marrow). The colour recording system provided better information than the monochromatic system in the diagnosis of cirrhosis. Hepatic clearance showed a decrease, especially in cases of cirrhosis characterized by extrahepatic uptake of the radiocolloid. In the opinion of the authors, the height of the radioactivity curve registered in the temporal region is an indication, during the stabilization phase, of extrahepatic fixation of the colloidal gold. Its height (h{sub 2}) is greater in those cases where the scintigram indicated higher uptake in the spleen and bone marrow. The T 1/2 study of {sup 51}Cr-labelled erythrocytes and their sequestration in the spleen was made in 30 patients exhibiting increased extrahepatic uptake of colloidal gold. The sequestration of labelled erythrocytes was observed in patients showing large-scale splenic uptake of the radiocolloid. Some of the patients whose photoscintigrams previously showed atrophy of the lower region of the right lobe of the liver and obvious presence of the spleen received injections of colloidal gold in the spleen. After intrasplenic injection, the authors obtained the same scintigraphic image in cirrhosis patients, with persistence of the colloidal gold in the spleen, whereas the image of the spleen remained normal in normal subjects. This proves the existence of a lamellar circulation in the liver. The splenic blood in normal subjects was directed towards the right lobe of the liver. The authors' studies indicate the existence of anomalies in hepatic circulation and also of hyperactivity of the extrahepatic reticulo-endothelial system, but especially of the spleen. These two elements may explain the anomalies in the distribution of colloidal gold in chronic liver patients. This change is most pronounced in cirrhosis of the liver. (author)}
place = {IAEA}
year = {1969}
month = {May}
}
title = {Interpretation of Scintigraphic Changes during Chronic Hepatitis and Cirrhosis of the Liver}
author = {Gheorghescu, B., Jovin, G., Pavel, D., Hoanca, O., Marculescu, Lidia, Suseanu, I., and Sparchez, T.}
abstractNote = {Photoscintigrams in black and white and in colour were made of the liver and the hepatic clearance was determined by colloidal {sup 198}Au (dimensions 25 - 30 {mu}m) in 82 patients suffering from chronic hepatitis or cirrhosis confirmed by clinical, humeral and histological criteria. The most characteristic changes in the liver scintigram, found particularly in the cirrhosis patients, were: atrophy of the right lobe (partial or total), sometimes pseudo tumoral in appearance; pale or in- homogeneous left lobe; presence of two centres of maximum radiocolloid uptake (left lobe and right lobe); and extrahepatic fixation (spleen, bone marrow). The colour recording system provided better information than the monochromatic system in the diagnosis of cirrhosis. Hepatic clearance showed a decrease, especially in cases of cirrhosis characterized by extrahepatic uptake of the radiocolloid. In the opinion of the authors, the height of the radioactivity curve registered in the temporal region is an indication, during the stabilization phase, of extrahepatic fixation of the colloidal gold. Its height (h{sub 2}) is greater in those cases where the scintigram indicated higher uptake in the spleen and bone marrow. The T 1/2 study of {sup 51}Cr-labelled erythrocytes and their sequestration in the spleen was made in 30 patients exhibiting increased extrahepatic uptake of colloidal gold. The sequestration of labelled erythrocytes was observed in patients showing large-scale splenic uptake of the radiocolloid. Some of the patients whose photoscintigrams previously showed atrophy of the lower region of the right lobe of the liver and obvious presence of the spleen received injections of colloidal gold in the spleen. After intrasplenic injection, the authors obtained the same scintigraphic image in cirrhosis patients, with persistence of the colloidal gold in the spleen, whereas the image of the spleen remained normal in normal subjects. This proves the existence of a lamellar circulation in the liver. The splenic blood in normal subjects was directed towards the right lobe of the liver. The authors' studies indicate the existence of anomalies in hepatic circulation and also of hyperactivity of the extrahepatic reticulo-endothelial system, but especially of the spleen. These two elements may explain the anomalies in the distribution of colloidal gold in chronic liver patients. This change is most pronounced in cirrhosis of the liver. (author)}
place = {IAEA}
year = {1969}
month = {May}
}