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Use of a 10-Channel Linear Scanner in the Differential Diagnosis of Arterial Hypertension; Empleo de un Centelleografo Lineal de Diez Canales en el Diagnostico Diferencial de la Hipertension Arterial

Conference:

Abstract

The need for a simple clinical test for singling out patients suffering from arterial hypertension due to renovascular causes has long been recognized. Over the past year, the authors have been using a linear scintillation scanner with ten detectors in parallel for delineating lesions within the kidney and estimating the rate of renal accumulation of {sup 203}Hg-labelled chlormerodrin. With this apparatus one can obtain very satisfactory renal images within two or three minutes after intravenous administration of 100 - 250 mCi of a radioactive drug. Scintigraphic images of both kidneys were obtained at 5, 10, 20, 30, 40, 50 and 60 min after administration of the radioactive compound without supression of the background radioactivity. All data were recorded on magnetic tape to permit subsequent selection of the technical parameters required for the reproduction of an image of optimum contrast and intensity. The pulse integrator included in the instrument was used to assess radioactivity in both kidneys during each scanning. Results were expressed as the ratio of renal radioactivity at a given time (C{sub t}) to renal radioactivity after five minutes (C{sub 5}); this value was called the renal concentration index (RCI). To distinguish bilateral renal ischaemia from essential arterial hypertension,  More>>
Authors:
Cuaron, A.; Ortiz-Quezada, F.; Gordon, F.; Trevino, H. [1] 
  1. Hospital General del Centro Medico Nacional, IMSS, Mexico D.F. (Mexico)
Publication Date:
May 15, 1969
Product Type:
Conference
Report Number:
IAEA-SM-108/171
Resource Relation:
Conference: Symposium on Medical Radioisotope Scintigraphy, Salzburg (Austria), 6-15 Aug 1968; Other Information: 14 refs., 4 figs., 1 tab.; Related Information: In: Medical Radioisotope Scintigraphy. Proceedings of a Symposium on Medical Radioisotope Scintigraphy. V. II| 952 p.
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BLOOD FLOW; DIAGNOSIS; HYPERTENSION; IMAGES; KIDNEYS; MERCURY 203; NEOHYDRIN; PATIENTS; RADIOACTIVITY; SCINTISCANNING
OSTI ID:
22108004
Research Organizations:
International Atomic Energy Agency, Vienna (Austria)
Country of Origin:
IAEA
Language:
Spanish
Other Identifying Numbers:
Other: ISSN 0074-1884; TRN: XA13M0485065815
Submitting Site:
INIS
Size:
page(s) 241-252
Announcement Date:
Jun 27, 2013

Conference:

Citation Formats

Cuaron, A., Ortiz-Quezada, F., Gordon, F., and Trevino, H. Use of a 10-Channel Linear Scanner in the Differential Diagnosis of Arterial Hypertension; Empleo de un Centelleografo Lineal de Diez Canales en el Diagnostico Diferencial de la Hipertension Arterial. IAEA: N. p., 1969. Web.
Cuaron, A., Ortiz-Quezada, F., Gordon, F., & Trevino, H. Use of a 10-Channel Linear Scanner in the Differential Diagnosis of Arterial Hypertension; Empleo de un Centelleografo Lineal de Diez Canales en el Diagnostico Diferencial de la Hipertension Arterial. IAEA.
Cuaron, A., Ortiz-Quezada, F., Gordon, F., and Trevino, H. 1969. "Use of a 10-Channel Linear Scanner in the Differential Diagnosis of Arterial Hypertension; Empleo de un Centelleografo Lineal de Diez Canales en el Diagnostico Diferencial de la Hipertension Arterial." IAEA.
@misc{etde_22108004,
title = {Use of a 10-Channel Linear Scanner in the Differential Diagnosis of Arterial Hypertension; Empleo de un Centelleografo Lineal de Diez Canales en el Diagnostico Diferencial de la Hipertension Arterial}
author = {Cuaron, A., Ortiz-Quezada, F., Gordon, F., and Trevino, H.}
abstractNote = {The need for a simple clinical test for singling out patients suffering from arterial hypertension due to renovascular causes has long been recognized. Over the past year, the authors have been using a linear scintillation scanner with ten detectors in parallel for delineating lesions within the kidney and estimating the rate of renal accumulation of {sup 203}Hg-labelled chlormerodrin. With this apparatus one can obtain very satisfactory renal images within two or three minutes after intravenous administration of 100 - 250 mCi of a radioactive drug. Scintigraphic images of both kidneys were obtained at 5, 10, 20, 30, 40, 50 and 60 min after administration of the radioactive compound without supression of the background radioactivity. All data were recorded on magnetic tape to permit subsequent selection of the technical parameters required for the reproduction of an image of optimum contrast and intensity. The pulse integrator included in the instrument was used to assess radioactivity in both kidneys during each scanning. Results were expressed as the ratio of renal radioactivity at a given time (C{sub t}) to renal radioactivity after five minutes (C{sub 5}); this value was called the renal concentration index (RCI). To distinguish bilateral renal ischaemia from essential arterial hypertension, the RCI of the right kidney (RK) was divided by the RCI of the left kidney (LK), which gave a comparative index for the two kidneys (I{sub comp}.). The authors conclude that the procedure as described could be used as a selective test for arterial hypertension of renovascular origin, since it furnishes an index directly correlated with the individual renal plasma flow and a series of images representative of the regional blood flow in each of the kidneys. As renal concentration of chlormerodrin requires both good renal blood flow and tubular cell efficiency, in cases of unilateral tubular necrosis results will be obtained similar to those for cases of unilateral renal ischaemia. The authors believe that in the study of arterial hypertension scintigraphic scanning should be carried out in conjunction with the plot of a curve showing renal concentration of chlormerodrin. This is to avoid possible errors due to differences in geometry of the two kidneys in relation to the detector. (author) [Spanish] Durante mucho tiempo se ha reconocido la necesidad de una prueba clinica sencilla que permita seleccionar a los pacientes cuya hipertension arterial tenga un origen renovascular. Durante el ultimo ano hemos empleado un centelleografo lineal con diez detectores en paralelo, para la delineacion de las lesiones localizadas en el rinon y para la estimacion de la velocidad de la concentracion renal de la cloromerodrina marcada con {sup 203}Hg. Este centelleografo nos permite obtener imagenes renales muy satisfactorias en 263 min, despues de la administracion endovenosa de 100 a 250 {mu}Ci del radiofarmaco. Despues de la administracion del compuesto radiactivo se obtuvieron imagenes centelleograficas de ambos rinones a los 5, 10, 20, 30, 40, 50 y 60 min, sin suprimir la radiactividad de fondo. Todos los datos fueron registrados en una cinta magnetica para posteriormente seleccionar los factores tecnicos necesarios para reproducir una imagen con cualidades optimas de contraste e intensidad. El integrador de pulsos, incluido en el instrumento, fue empleado para estimar la radiactividad en cada uno de los rinones durante cada exploracion centelleografica. Los resultados fueron expresados como la relacion de la radiactividad renal a un tiempo dado (C{sub t}) sobre la radiactividad renal a los 5 min (C{sub 5}), (C{sub t}/C{sub 5}); este valor fue denominado indice de la concentracion renal (ICR). Para diferenciar la isquemia renal bilateral de la hipertension arterial esencial, el ICR del rinon derecho (RD) fue dividido por el ICR del rinon izquierdo (RI), obteniendose un indice de comparacion entre ambos rinones (comp. I). Se concluye que el procedimiento aqui descrito puede ser empleado como una prueba filtro de la hipertension arterial de origen renovascular, pues ofrece un indice correlacionado en forma directa con el flujo plasmatico renal individual y una serie de imagenes representativas del flujo sanguineo regional en cada uno de los rinones. Como la concentracion renal de la cloromerodrina requiere tanto de un buen flujo sanguineo renal como de la eficiencia de la celula tubular, en los casos de necrosis tubular unilateral se obtendran resultados similares a los obtenidos en los casos de isquemia renal unilateral. En el estudio de la hipertension arterial creemos que el estudio centelleografico necesita ir acompanado del trazado de una curva de concentracion renal de la cloromerodrina para evitar posibles errores causados por diferentes geometrias de ambos rinones con respecto al detector. (author)}
place = {IAEA}
year = {1969}
month = {May}
}